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1. 发明申请

WO2017083843A1 DRIVEN FLOW AND VOLUMETRIC CONTROL DEVICES AND METHODS 审中-公开
标题翻译：驱动流量和体积控制装置和方法
公开(公告)号：WO2017083843A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061880
申请日：2016-11-14
申请人： DNT SCIENTIFIC RESEARCH, LLC
发明人： WANG, Naishu , CHANG-CHIEN, Michael
IPC分类号： G01N21/77 , G01N21/78 , G01N31/22 , G01N33/48 , G01N33/49 , G01N33/493
CPC分类号： G01N21/77 , G01N21/78 , G01N33/4875 , G01N33/48778
摘要： Disclosed herein are diagnostic devices, in particular, specimen cups, for harmonization of enforcing driven flow and volumetric control of biological fluid mechanisms. The specimen cups include an outer cup, an inner cup with a metering hole, a crush sleeve, and a cap, where the inner cup can receive biological fluids.
摘要翻译：这里公开了诊断装置，特别是标本杯，用于协调生物流体机构的强制驱动流量和体积控制。标本杯包括一个外杯，一个带有计量孔的内杯，一个挤压套和一个杯盖，内杯可以接受生物液体。

2. 发明申请

WO2017070245A1 PROGRESSIVE COMPRESSION DRIVEN FLOW CARTRIDGE FOR ANALYTE DETECTING STRIP AND METHOD 审中-公开
标题翻译：用于分析物检测条带的渐进式压缩驱动流动盒及方法
公开(公告)号：WO2017070245A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/057761
申请日：2016-10-19
申请人： DNT SCIENTIFIC RESEARCH, LLC
发明人： WANG, Naishu , ZHOU, David
IPC分类号： G01N21/77 , G01N33/543
CPC分类号： G01N33/54386 , G01N21/78 , G01N21/8483 , G01N33/558 , G01N33/56983 , G01N2021/7759
摘要： A cartridge (1) and method for conducting a labeled molecular affinity binding test such as antibody/antigen, ligand/receptor, and colorometric reactions, and other chemical reactions for which one or more analytes is present in a liquid sample formate. A progressive compression structure (22,36) progressively forces a liquid flow out of a conjugate pad (26) toward a reaction region (27) to more thoroughly and rapidly mix the liquid, encouraging specific first affinity binding to the analytes in question. A specially dimensioned constricting passageway (35) surrounding the reaction region including the result zones (28,29) provides an additional siphoning force to the flow. These combined forces rapidly and more evenly guide the flow of liquid through the reaction region so that the rushed rate of uptake of analytes at the strip lines are more evenly distributed, adhesive attachment of non-specific molecules is largely avoided, vastly improving sensitivity and specificity, and providing quantitative results in some tests.
摘要翻译：（1）和用于进行标记的分子亲和力结合测试（例如抗体/抗原，配体/受体和比色反应）以及其中一种或多种分析物存在于其中的其他化学反应的方法液体样品甲酸盐。渐进压缩结构（22,36）逐渐迫使液体从共轭垫（26）流出到反应区域（27）以更彻底和快速地混合液体，从而促进特定的第一亲和性结合至所讨论的分析物。围绕包括结果区域（28,29）的反应区域的特定尺寸的收缩通道（35）为流动提供额外的虹吸力。这些结合力迅速且更均匀地引导液体流动通过反应区域，使得带状线处的分析物的匆忙吸收速率更均匀地分布，基本上避免了非特异性分子的粘附附着，极大地提高了灵敏度和特异性，并在一些测试中提供定量结果。

3. 发明申请

WO2018128749A1 RAPID DIAGNOSTIC TEST DEVICE BY DRIVEN FLOW TECHNOLOGY 审中-公开
公开(公告)号：WO2018128749A1
公开(公告)日：2018-07-12
申请号：PCT/US2017/065390
申请日：2017-12-08
申请人： DNT SCIENTIFIC RESEARCH, LLC
发明人： WANG, Naishu , CHANG CHIEN, Michael
IPC分类号： G01N33/543 , G01N33/558 , G01N33/536
摘要： A rapid diagnostic test device uses driven flow technology to significantly expedite the testing time of a sample. The rapid diagnostic test device can be used to analyze liquids, such as some body fluids, by using labeled molecular affinity binding, such as immunochromatography. The test device can detect an analyte, such as an antibody or antigen, which may indicate a particular condition, the presence of a particular drug, or the like. The device includes a cover and base that combine to form an internal cavity for receiving a test strip. Compression bars in the cover and a compression cushion in the base sandwich a conjugate pad of the test strip to accelerate chemical mixtures to flow from the conjugate pad of the test strip toward fixed sites along the strip from which readings are taken.

4. 发明申请

WO2019027660A1 RAPID DIAGNOSTIC TEST DEVICE BY DRIVEN FLOW TECHNOLOGY 审中-公开
公开(公告)号：WO2019027660A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/042160
申请日：2018-07-13
申请人： DNT SCIENTIFIC RESEARCH, LLC
发明人： WANG, Naishu , CHANG CHIEN, Michael , YING, Jiwei
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/54386 , B01L3/5023 , B01L3/5025 , B01L2300/0825 , B01L2300/123 , B01L2400/0406 , C12Q1/00 , G01N33/558
摘要： A test device uses driven flow technology in a simplified testing format, such as dip format, to provide a rapid diagnostic test device that shortens the interpretation time of the test result to less than one minute and minimizes manufacturing costs. The test device shortens the distance between the opening on the front side housing and the conjugate pad without squeezing the sample pad and without requiring a separate component, such as a cap, to squeeze the sample pad. The test device utilizes a single, integral housing made from, for example, a flexible transparent material, such as polyethylene terephthalate (PET) that integrates the traditional base and top, or inner and outer tubes, into one to save the manufacturing costs.

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