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1. 发明申请

WO9631603A3 METHODS AND COMPOSITIONS FOR REGULATING FADD 审中-公开
标题翻译：用于调节FADD的方法和组合物
公开(公告)号：WO9631603A3
公开(公告)日：1996-12-05
申请号：PCT/US9602857
申请日：1996-02-28
申请人： UNIV MICHIGAN , DIXIT VISHVA M , ROURKE KAREN O
发明人： DIXIT VISHVA M , O'ROURKE KAREN
IPC分类号： C07K14/47 , C12N15/12 , C07K16/18 , C12N5/20 , G01N33/50
CPC分类号： C07K14/4747
摘要： This invention provides a novel protein designated FADD, FADD fragments, and anti-FADD antibodies which are useful to modulate FADD-associated cellular functions such as apoptosis. Also provided are nucleic acid molecules coding for these proteins and antibodies as well as process for making these compositions. Further provided are diagnostic and therapeutic utilities for these compositions.

2. 发明申请

WO1996031603A2 METHODS AND COMPOSITIONS FOR REGULATING FADD 审中-公开
标题翻译：用于调节FADD的方法和组合物
公开(公告)号：WO1996031603A2
公开(公告)日：1996-10-10
申请号：PCT/US1996002857
申请日：1996-02-28
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , DIXIT, Vishva, M. , O'ROURKE, Karen
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： C12N15/12
CPC分类号： C07K14/4747
摘要： This invention provides a novel protein designated FADD, FADD fragments, and anti-FADD antibodies which are useful to modulate FADD-associated cellular functions such as apoptosis. Also provided are nucleic acid molecules coding for these proteins and antibodies as well as process for making these compositions. Further provided are diagnostic and therapeutic utilities for these compositions.
摘要翻译：本发明提供了可用于调节FADD相关细胞功能如凋亡的FADD，FADD片段和抗FADD抗体的新型蛋白质。还提供编码这些蛋白质和抗体的核酸分子以及制备这些组合物的方法。进一步提供这些组合物的诊断和治疗用途。

3. 发明申请

WO2013022848A1 ANTI-POLYUBIQUITIN ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：抗多肽抗体及其使用方法
公开(公告)号：WO2013022848A1
公开(公告)日：2013-02-14
申请号：PCT/US2012/049771
申请日：2012-08-06
申请人： GENENTECH, INC. , KELLEY, Robert F. , MATSUMOTO, Marissa L. , DIXIT, Vishva
发明人： KELLEY, Robert F. , MATSUMOTO, Marissa L. , DIXIT, Vishva
IPC分类号： C07K16/08 , A61K39/395
CPC分类号： C07K16/18 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/92 , G01N33/68
摘要： The invention provides anti-polyubiquitin antibodies and methods of using the same.
摘要翻译：本发明提供抗多聚遍在蛋白抗体及其使用方法。

4. 发明申请

WO2008121813A2 MODULATION OF CYTOKINE PRODUCTION 审中-公开
标题翻译：细胞因子生产的调节
公开(公告)号：WO2008121813A2
公开(公告)日：2008-10-09
申请号：PCT/US2008/058648
申请日：2008-03-28
申请人： GENENTECH, INC. , DIXIT, Vishva , KAYAGAKI, Nobuhiko
发明人： DIXIT, Vishva , KAYAGAKI, Nobuhiko
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： A61K31/713 , C12N9/6421 , C12N15/1137 , C12N2310/14 , C12Y304/19012
摘要： Methods of using DUBA polypeptides and nucleic acids in modulating cytokine production and in modulating immune response are provided. Methods of diagnosing and treating certain pathophysiological conditions using the DUBA polypeptides and nucleic acids of the invention are also provided.
摘要翻译：提供了使用DUBA多肽和核酸调节细胞因子产生和调节免疫应答的方法。还提供了使用本发明的DUBA多肽和核酸诊断和治疗某些病理生理条件的方法。

5. 发明申请

WO1997046663A1 INTERLEUKIN-1 BETA CONVERTING ENZYME LIKE APOPTOTIC PROTEASE-6 审中-公开
标题翻译： INTERLEUKIN-1转化酶类似APOPTOTIC PROTEASE-6
公开(公告)号：WO1997046663A1
公开(公告)日：1997-12-11
申请号：PCT/US1996009702
申请日：1996-06-05
申请人： SMITHKLINE BEECHAM CORPORATION , HUMAN GENOME SCIENCES, INC. , DIXIT, Vishva, M. , KIKLY, Kristine, K. , HE, Wei-Wu , RUBEN, Steven
发明人： SMITHKLINE BEECHAM CORPORATION , HUMAN GENOME SCIENCES, INC.
IPC分类号： C12N01/11
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00
摘要： Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility. Antagonists against such ICE LAP-6 and their use as a therapeutic to treat Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, septic shock, sepsis, stroke, chronic inflammation, acute inflammation, CNS inflammation, osteoporosis, ischemia reperfusion injury, cell death associated with cardiovascular disease, polycystic kidney disease, apoptosis of endothelial cells in cardiovascular disease, degenerative liver disease, MS, ALS, cererbellar degeneration, ischemic injury, myocardial infarction, AIDS, myelodysplastic syndromes, aplastic anemia, male pattern baldness, and head injury damage are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the interleukin-1 beta converting enzyme apoptosis proteases and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人ICE LAP-6多肽和编码这种ICE LAP-6的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种ICE LAP-6来治疗对病毒感染，肿瘤发生的易感性以及控制胚胎发生和组织内环境稳定中的疾病和缺陷的方法，并且上述核酸序列可用于确定这种敏感性。对抗这种ICE LAP-6的拮抗剂及其作为治疗性阿尔茨海默病，帕金森病，类风湿性关节炎，败血性休克，败血症，中风，慢性炎症，急性炎症，CNS炎症，骨质疏松症，缺血再灌注损伤，与心血管疾病，多囊肾病，心血管疾病中的内皮细胞凋亡，退行性肝病，MS，ALS，小脑变性，缺血性损伤，心肌梗死，AIDS，骨髓增生异常综合征，再生障碍性贫血，男性型秃发和头部损伤也是披露。还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。还公开了用于检测编码白细胞介素-1β转换酶凋亡蛋白酶的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

6. 发明申请

WO2011130499A1 ANTI-POLYUBIQUITIN ANTIBODIES AND METHODS OF USE 审中-公开
标题翻译：抗多肽抗体及其使用方法
公开(公告)号：WO2011130499A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/032468
申请日：2011-04-14
申请人： GENENTECH, INC. , DIXIT, Vishva , KELLEY, Robert F. , MATSUMOTO, Marissa L.
发明人： DIXIT, Vishva , KELLEY, Robert F. , MATSUMOTO, Marissa L.
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , C07K14/4702 , C07K2317/24 , C07K2317/30 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N15/1037 , G01N33/68 , G01N2333/4703 , G01N2440/36
摘要： The invention provides anti-polyubiquitin antibodies and methods of using the same.
摘要翻译：本发明提供抗多聚遍在蛋白抗体及其使用方法。

7. 发明申请

WO2007117763A2 METHODS AND COMPOSITIONS FOR TARGETING RELT 审中-公开
标题翻译：目标对象的方法和组合
公开(公告)号：WO2007117763A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/061988
申请日：2007-02-12
申请人： GENENTECH, INC. , WU, Yan , DIXIT, Vishva , KAYAGAKI, Nobuhiko
发明人： DIXIT, Vishva , KAYAGAKI, Nobuhiko
IPC分类号： C07K16/28 , C12N15/13 , G01N33/577 , A61K39/395 , A01K67/027
CPC分类号： G01N33/6893 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/70575 , C07K16/2878 , C07K2317/24 , C07K2317/54 , C07K2317/565 , C07K2317/75 , C07K2317/92 , C12N15/8509 , G01N33/564 , G01N33/56972 , G01N33/57492 , G01N2800/104 , G01N2800/24
摘要： Anti-RELT monoclonal antibodies, and methods for using the antibodies, are provided. Methods of using RELT polypeptides and nucleic acids in modulating immune cell development and in modulating cytokine production are also provided.
摘要翻译：提供抗RELT单克隆抗体，以及使用抗体的方法。还提供了使用RELT多肽和核酸调节免疫细胞发育和调节细胞因子产生的方法。

8. 发明申请

WO2006043938A1 COP1 MOLECULES AND USES THEREOF 审中-公开
标题翻译： COP1分子及其用途
公开(公告)号：WO2006043938A1
公开(公告)日：2006-04-27
申请号：PCT/US2004/034174
申请日：2004-10-14
申请人： GENENTECH, INC. , DORNAN, David , FRENCH, Dorothy , DIXIT, Vishva
发明人： DORNAN, David , FRENCH, Dorothy , DIXIT, Vishva
IPC分类号： G01N33/574
CPC分类号： G01N33/57496 , G01N33/574 , G01N2333/9015 , G01N2500/02 , G01N2800/52
摘要： The invention provides diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers. The methods and uses can further include detecting p53 expression. The invention also provides reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding.
摘要翻译：本发明提供用于检测多种癌症中COP1过表达的诊断，预后和治疗用途。所述方法和用途还可包括检测p53表达。本发明还提供用于筛选干扰COP1和p53结合的测试化合物的试剂和试剂盒。

9. 发明申请

WO2013040433A1 METHODS OF PROMOTING DIFFERENTIATION 审中-公开
标题翻译：促进差异的方法
公开(公告)号：WO2013040433A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/055539
申请日：2012-09-14
申请人： GENENTECH, INC. , F. HOFFMANN-LA ROCHE AG , DIXIT, Vishva M. , FRENCH, Dorothy M. , MAECKER, Heather L. , WILLIAMS, Samuel A.
发明人： DIXIT, Vishva M. , FRENCH, Dorothy M. , MAECKER, Heather L. , WILLIAMS, Samuel A.
IPC分类号： G01N33/50
CPC分类号： G01N33/502 , G01N33/5011 , G01N33/5073 , G01N2333/948
摘要： Provided herein are methods of promoting cell fate change, particularly differentiation of tumor cells, by inhibition of USP1, UAF1, and/or ID (e.g., ID1, ID2, and/or ID3).
摘要翻译：本文提供通过抑制USP1，UAF1和/或ID（例如，ID1，ID2和/或ID3）促进细胞命运变化，特别是肿瘤细胞分化的方法。

10. 发明申请

WO2008121813A3 MODULATION OF CYTOKINE PRODUCTION 审中-公开
标题翻译：细胞因子生产的调节
公开(公告)号：WO2008121813A3
公开(公告)日：2009-02-05
申请号：PCT/US2008058648
申请日：2008-03-28
申请人： GENENTECH INC , DIXIT VISHVA , KAYAGAKI NOBUHIKO
发明人： DIXIT VISHVA , KAYAGAKI NOBUHIKO
IPC分类号： A61K31/713 , C12N9/64 , C12N15/113
CPC分类号： A61K31/713 , C12N9/6421 , C12N15/1137 , C12N2310/14 , C12Y304/19012
摘要： Methods of using DUBA polypeptides and nucleic acids in modulating cytokine production and in modulating immune response are provided. Methods of diagnosing and treating certain pathophysiological conditions using the DUBA polypeptides and nucleic acids of the invention are also provided.
摘要翻译：提供了使用DUBA多肽和核酸调节细胞因子产生和调节免疫应答的方法。还提供了使用本发明的DUBA多肽和核酸诊断和治疗某些病理生理条件的方法。

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