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1. 发明申请

WO2007020453A2 ASSAY 审中-公开
公开(公告)号：WO2007020453A2
公开(公告)日：2007-02-22
申请号：PCT/GB2006/003089
申请日：2006-08-17
申请人： UNIVERSITY OF WARWICK , DILLY, Suzanne, Jane , TAYLOR, Paul, Christopher , CLARK, Andrew, James , MARSH, Andrew , NAPIER, Richard , THOMPSON, Andrew
发明人： DILLY, Suzanne, Jane , TAYLOR, Paul, Christopher , CLARK, Andrew, James , MARSH, Andrew , NAPIER, Richard , THOMPSON, Andrew
IPC分类号： G01N33/50
CPC分类号： G01N33/6845 , G01N33/54353 , G01N2500/04
摘要： The invention provides a method of identifying a peptide or protein capable of binding a ligand which comprises: (i) providing a support, the support comprising a photoreactive group; (ii) reacting the photoreactive group with a ligand to attach the ligand to the support and produce a supported ligand; (iii) providing an expression library comprising a plurality of members, each member expressing a different peptide or protein; (iv) screening the expression library to identify one or more peptides or proteins which bind to the ligand; (v) isolating the member or each member of the library which expresses a peptide or protein which binds to the ligand; and (vi) identifying the peptide or protein which binds to the ligand. Supported photo-reactive compounds are disclosed comprising a photo-reactive group attached to a support via a spacer and a dendritic group, the dendritic group comprising attached thereto, optionally via a spacer, at least one further photo-reactive group and/or a second functional group. Compounds comprising photo-reactive groups attached to a support and a protein resistant group attached to the support are also provided, together with kits for carrying out the method of the invention.
摘要翻译：本发明提供了鉴定能够结合配体的肽或蛋白质的方法，其包括：（i）提供载体，所述载体包含光反应性基团; （ii）使光反应性基团与配体反应以将配体连接到载体上并产生负载的配体; （iii）提供包含多个成员的表达文库，每个成员表达不同的肽或蛋白质; （iv）筛选表达文库以鉴定结合配体的一种或多种肽或蛋白质; （v）分离表达与配体结合的肽或蛋白质的文库的成员或每个成员; 和（vi）鉴定与配体结合的肽或蛋白质。公开了负载的光反应性化合物，其包括经由间隔基和树枝状基团连接到载体的光反应性基团，所述树枝状基团可任选地经由间隔基，至少一个另外的光反应性基团和/或第二功能组。还提供了包含连接到载体上的光反应性基团和与载体连接的抗蛋白质基团的化合物以及用于实施本发明方法的试剂盒。

2. 发明申请

WO2012104654A1 COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR DISEASES 审中-公开
标题翻译：用于治疗心血管疾病的组合物和方法
公开(公告)号：WO2012104654A1
公开(公告)日：2012-08-09
申请号：PCT/GB2012/050241
申请日：2012-02-03
申请人： BIOCOPEA LIMITED , BANNISTER, Robin Mark , BREW, John , DILLY, Suzanne Jane , STOLOFF, Gregory Alan , CAPARROS-WANDERLEY, Wilson
发明人： BANNISTER, Robin Mark , BREW, John , DILLY, Suzanne Jane , STOLOFF, Gregory Alan , CAPARROS-WANDERLEY, Wilson
IPC分类号： A61K9/06 , A61K9/00 , A61K31/00 , A61K47/10 , A61K47/12 , A61K47/44
CPC分类号： A61K9/06 , A61K47/10 , A61K47/12 , A61K47/44 , Y02A50/414 , Y02A50/463
摘要： The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a cardiovascular disease in an individual using such pharmaceutical compositions.
摘要翻译：本说明书公开了药物组合物，制备这种药物组合物的方法，以及使用这种药物组合物治疗个体心血管疾病的方法和用途。

3. 发明申请

WO2007020453A3 PEPTIDE / PROTEIN IDENTIFICATION USING PHOTOREACTIVE CARRIERS FOR THE IMMOBILISATION OF THE LIGANDS 审中-公开
标题翻译：肽类/蛋白质鉴定使用光电子载体进行配体化
公开(公告)号：WO2007020453A3
公开(公告)日：2007-05-31
申请号：PCT/GB2006003089
申请日：2006-08-17
申请人： UNIV WARWICK , DILLY SUZANNE JANE , TAYLOR PAUL CHRISTOPHER , CLARK ANDREW JAMES , MARSH ANDREW , NAPIER RICHARD , THOMPSON ANDREW
发明人： DILLY SUZANNE JANE , TAYLOR PAUL CHRISTOPHER , CLARK ANDREW JAMES , MARSH ANDREW , NAPIER RICHARD , THOMPSON ANDREW
IPC分类号： G01N33/50
CPC分类号： G01N33/6845 , G01N33/54353 , G01N2500/04
摘要： The invention provides a method of identifying a peptide or protein capable of binding a ligand which comprises: (i) providing a support, the support comprising a photoreactive group; (ii) reacting the photoreactive group with a ligand to attach the ligand to the support and produce a supported ligand; (iii) providing an expression library comprising a plurality of members, each member expressing a different peptide or protein; (iv) screening the expression library to identify one or more peptides or proteins which bind to the ligand; (v) isolating the member or each member of the library which expresses a peptide or protein which binds to the ligand; and (vi) identifying the peptide or protein which binds to the ligand. Supported photo-reactive compounds are disclosed comprising a photo-reactive group attached to a support via a spacer and a dendritic group, the dendritic group comprising attached thereto, optionally via a spacer, at least one further photo-reactive group and/or a second functional group. Compounds comprising photo-reactive groups attached to a support and a protein resistant group attached to the support are also provided, together with kits for carrying out the method of the invention.
摘要翻译：本发明提供了鉴定能够结合配体的肽或蛋白质的方法，其包括：（i）提供载体，所述载体包含光反应性基团; （ii）使光反应性基团与配体反应以将配体连接到载体上并产生负载的配体; （iii）提供包含多个成员的表达文库，每个成员表达不同的肽或蛋白质; （iv）筛选表达文库以鉴定结合配体的一种或多种肽或蛋白质; （v）分离表达与配体结合的肽或蛋白质的文库的成员或每个成员; 和（vi）鉴定与配体结合的肽或蛋白质。公开了支持的光反应性化合物，其包括通过间隔基和树枝状基团连接到载体上的光反应性基团，所述树枝状基团任选地经由间隔基，至少一个另外的光反应性基团和/或第二功能组。还提供了包含连接到载体上的光反应性基团和连接到载体上的蛋白质抗性基团的化合物以及用于实施本发明方法的试剂盒。

4. 发明申请

WO2012104655A3 COMPOSTIONS AND METHODS FOR TREATING CHRONIC INFLAMMATION AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗慢性炎症和炎症疾病的组合物和方法
公开(公告)号：WO2012104655A3
公开(公告)日：2013-03-14
申请号：PCT/GB2012050242
申请日：2012-02-03
申请人： BIOCOPEA LTD , BANNISTER ROBIN MARK , BREW JOHN , CAPARROS-WANDERLEY WILSON , STOLOFF GREGORY ALAN , DILLY SUZANNE JANE , SZUCS GEMMA , PLEGUEZUELOS MATEO OLGA
发明人： BANNISTER ROBIN MARK , BREW JOHN , CAPARROS-WANDERLEY WILSON , STOLOFF GREGORY ALAN , DILLY SUZANNE JANE , SZUCS GEMMA , PLEGUEZUELOS MATEO OLGA
IPC分类号： A61K9/06 , A61K9/00 , A61K31/00 , A61K47/10 , A61K47/12 , A61K47/44
CPC分类号： A61K9/06 , A61K47/10 , A61K47/12 , A61K47/44
摘要： The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
摘要翻译：本说明书公开了药物组合物，制备这种药物组合物的方法，以及使用这种药物组合物治疗个体的慢性炎症和/或炎性疾病的方法和用途。

5. 发明申请

WO2012104655A2 COMPOSTIONS AND METHODS FOR TREATING CHRONIC INFLAMMATION AND INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗慢性炎症和炎症疾病的组合物和方法
公开(公告)号：WO2012104655A2
公开(公告)日：2012-08-09
申请号：PCT/GB2012/050242
申请日：2012-02-03
申请人： BIOCOPEA LIMITED , BANNISTER, Robin Mark , BREW, John , CAPARROS-WANDERLEY, Wilson , STOLOFF, Gregory Alan , DILLY, Suzanne Jane , SZUCS, Gemma , PLEGUEZUELOS MATEO, Olga
发明人： BANNISTER, Robin Mark , BREW, John , CAPARROS-WANDERLEY, Wilson , STOLOFF, Gregory Alan , DILLY, Suzanne Jane , SZUCS, Gemma , PLEGUEZUELOS MATEO, Olga
IPC分类号： A61K9/06 , A61K9/00 , A61K31/00
CPC分类号： A61K9/06 , A61K47/10 , A61K47/12 , A61K47/44 , Y02A50/414 , Y02A50/463
摘要： The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
摘要翻译：本说明书公开了药物组合物，制备这种药物组合物的方法，以及使用这种药物组合物治疗个体的慢性炎症和/或炎性疾病的方法和用途。

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