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1. 发明申请

WO2009052200A2 HUMAN ADAM-10 INHIBITORS 审中-公开
标题翻译：人ADAM-10抑制剂
公开(公告)号：WO2009052200A2
公开(公告)日：2009-04-23
申请号：PCT/US2008080021
申请日：2008-10-15
申请人： EXELIXIS INC , NAGANATHAN SRIRAM , WILSON JOANN , DICKMAN DANIEL A
发明人： NAGANATHAN SRIRAM , WILSON JOANN , DICKMAN DANIEL A
CPC分类号： C07D241/04 , C07D401/12
摘要： Magnesium salts/complexes of compounds useful for inhibiting the ADAM-IO protein and methods of making and purifying them are provided. Further provided are compositions comprising magnesium salts/complexes of the compounds in combination with a pharmaceutically acceptable carrier. The compounds well as such compositions comprising them are useful for the treatment of cancer, arthritis, diseases related to angiogenesis, such as renal diseases, heart diseases, such as heart failure, atherosclerosis, and stroke, inflammation, ulcer, infertility, scleroderma, endometriosis, mesothelioma, and diabetes. In addition, methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM- 10 plays a critical role are provided.
摘要翻译：提供了可用于抑制ADAM-10蛋白的化合物的镁盐/络合物及其制备和纯化方法。还提供了包含化合物的镁盐/复合物与药学上可接受的载体组合的组合物。与包含它们的组合物一样，这些化合物可用于治疗癌症，关节炎，与血管生成有关的疾病，例如肾脏疾病，心脏病如心力衰竭，动脉粥样硬化和中风，炎症，溃疡，不育症，硬皮病，子宫内膜异位症，间皮瘤和糖尿病。此外，还提供了治疗形式的癌症，关节炎和与其中ADAM-10起关键作用的血管发生相关的疾病的方法。

2. 发明申请

WO2005118554A3 FACTOR VIIA INHIBITOR 审中-公开
标题翻译：因子VIIA抑制剂
公开(公告)号：WO2005118554A3
公开(公告)日：2006-05-18
申请号：PCT/US2005019394
申请日：2005-06-02
申请人： AXYS PHARM INC , DICKMAN DANIEL A , KUMAR DANGE VIJAY , O'BRYAN COLIN , RAI ROOPA , SHRADER WILLIAM DVORAK
发明人： DICKMAN DANIEL A , KUMAR DANGE VIJAY , O'BRYAN COLIN , RAI ROOPA , SHRADER WILLIAM DVORAK
IPC分类号： C07D235/00 , C07D235/18 , C07F5/02
CPC分类号： C07D235/18
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
摘要翻译：本发明涉及因子VIIa，IXa，Xa，XIa（特别是因子VIIa）的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞病症，癌症或类风湿性关节炎的方法。还公开了制备这些抑制剂的方法。

3. 发明申请

WO2005118554A2 FACTOR VIIA INHIBITOR 审中-公开
标题翻译：因子VIIA抑制剂
公开(公告)号：WO2005118554A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019394
申请日：2005-06-02
申请人： AXYS PHARMACEUTICALS, INC. , DICKMAN, Daniel, A. , KUMAR, Dange Vijay , O'BRYAN, Colin , RAI, Roopa , SHRADER, William, Dvorak
发明人： DICKMAN, Daniel, A. , KUMAR, Dange Vijay , O'BRYAN, Colin , RAI, Roopa , SHRADER, William, Dvorak
IPC分类号： C07D235/00
CPC分类号： C07D235/18
摘要： The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.
摘要翻译：本发明涉及因子VIIa，IXa，Xa，XIa（特别是因子VIIa）的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎。还公开了制备这些抑制剂的方法。

4. 发明申请

WO2007008627A3 APOPTOSIS PROMOTERS 审中-公开
公开(公告)号：WO2007008627A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026424
申请日：2006-07-07
申请人： ABBOTT LABORATORIES , WENDT, Michael, D. , SHEN, Wang , DICKMAN, Daniel, A. , DING, Hong , THOMAS, Sheela, A. , AUGERI, David , ELMORE, Steven, W.
发明人： WENDT, Michael, D. , SHEN, Wang , DICKMAN, Daniel, A. , DING, Hong , THOMAS, Sheela, A. , AUGERI, David , ELMORE, Steven, W.
IPC分类号： A61K31/192 , C07C15/12 , A61P35/00
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl- 1 protein are disclosed.

5. 发明申请

WO2007008627A2 APOPTOSIS PROMOTERS 审中-公开
标题翻译： APOPTOSIS促销者
公开(公告)号：WO2007008627A2
公开(公告)日：2007-01-18
申请号：PCT/US2006026424
申请日：2006-07-07
申请人： ABBOTT LAB , WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W
发明人： WENDT MICHAEL D , SHEN WANG , DICKMAN DANIEL A , DING HONG , THOMAS SHEELA A , AUGERI DAVID , ELMORE STEVEN W
IPC分类号： A61K31/192 , A61P35/00 , C07C15/12
CPC分类号： C07C311/41 , C07C63/48 , C07C63/49 , C07C65/26 , C07C65/28 , C07C205/58 , C07C229/52 , C07C229/56 , C07C233/81 , C07C311/13 , C07C311/18 , C07C311/21 , C07C311/37 , C07C311/44 , C07C323/20 , C07C323/25 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D207/30 , C07D213/53 , C07D215/12 , C07D215/48 , C07D333/34
摘要： Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
摘要翻译：公开了抑制抗细胞凋亡Mcl-1蛋白活性的化合物，含有该化合物的组合物和治疗疾病的方法，其表达为Mcl-1蛋白。

6. 发明申请

WO2009052200A3 HUMAN ADAM-10 INHIBITORS 审中-公开
公开(公告)号：WO2009052200A3
公开(公告)日：2009-04-23
申请号：PCT/US2008/080021
申请日：2008-10-15
申请人： EXELIXIS, INC. , NAGANATHAN, Sriram , WILSON, JoAnn , DICKMAN, Daniel, A.
发明人： NAGANATHAN, Sriram , WILSON, JoAnn , DICKMAN, Daniel, A.
IPC分类号： C07D241/04 , C07D401/12 , A61P19/02 , A61K31/33 , A61P35/00
摘要： Magnesium salts/complexes of compounds useful for inhibiting the ADAM-IO protein and methods of making and purifying them are provided. Further provided are compositions comprising magnesium salts/complexes of the compounds in combination with a pharmaceutically acceptable carrier. The compounds well as such compositions comprising them are useful for the treatment of cancer, arthritis, diseases related to angiogenesis, such as renal diseases, heart diseases, such as heart failure, atherosclerosis, and stroke, inflammation, ulcer, infertility, scleroderma, endometriosis, mesothelioma, and diabetes. In addition, methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM- 10 plays a critical role are provided.

7. 发明申请

WO2012083178A1 METHODS AND DEVICES FOR USING ISOPERILLYL ALCOHOL 审中-公开
标题翻译：使用异丙醇的方法和装置
公开(公告)号：WO2012083178A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/065513
申请日：2011-12-16
申请人： NEO ONCOLOGY INC. , CHEN, Thomas , LEVIN, Daniel , PUPPALI, Satish , DICKMAN, Daniel, A.
发明人： CHEN, Thomas , LEVIN, Daniel , PUPPALI, Satish , DICKMAN, Daniel, A.
IPC分类号： C07C35/18
CPC分类号： A61K31/045 , A61K31/05 , A61K31/165 , A61K31/325 , A61K31/4015 , A61K31/415 , A61K31/4188 , A61K45/06 , A61K47/54 , A61K47/55 , A61N5/10 , C07B2200/07 , C07C271/22 , C07D207/26 , C07D231/12 , C07D487/04 , A61K2300/00
摘要： The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
摘要翻译：本发明提供了治疗诸如癌症的疾病的方法，包括向患者施用治疗有效量的单萜或倍半萜烯（或其衍生物）的异构体或类似物，例如异环戊醇。本发明还提供了治疗疾病的方法，其包括向患者施用治疗有效量的单萜或倍半萜的异构体或类似物的衍生物，例如异哌环醇氨基甲酸酯的步骤。衍生物可以是与治疗剂如化学治疗剂缀合的异环戊醇。给药途径可以变化，包括吸入，鼻内，口服，透皮，静脉内，皮下或肌内注射。

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