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1. 发明申请

WO2012123570A1 CONTROL OF PHAGOCYTOSIS 审中-公开
标题翻译： PHAGOCYTOSIS的控制
公开(公告)号：WO2012123570A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054663
申请日：2012-03-16
申请人： UNIVERSITEIT GENT , DELPUTTE, Peter , DE BAERE, Miet Inne , NAUWYNCK, Hans , VERMAELEN, Karim
发明人： DELPUTTE, Peter , DE BAERE, Miet Inne , NAUWYNCK, Hans , VERMAELEN, Karim
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , C07K2317/22 , C07K2317/569
摘要： The present invention relates to a method to treat uncontrolled phagocytosis, especially diseases caused by uncontrolled phagocytosis such as Hemophagocytic lymphohistiocytosis (HLH), or for inhibiting unwanted phagocytosis to boost immunogenic properties of specific cancer therapies. The invention relates further to a sialoadhesin binding antibody for use as a medicament to treat uncontrolled phagocytosis, and to a pharmaceutical composition comprising a sialoadhesin binding antibody.
摘要翻译：本发明涉及治疗不受控制的吞噬作用的方法，特别是由不受控制的吞噬作用如血细胞淋巴组织细胞增多症（HLH）引起的疾病，或用于抑制不需要的吞噬作用以提高特异性癌症疗法的免疫原性。本发明还涉及用作治疗不受控制的吞噬作用的药物的唾液酸粘附素结合抗体，以及包含唾液酸粘附素结合抗体的药物组合物。

2. 发明申请

WO2009106629A1 VIRAL INACTIVATION PROCESS 审中-公开
标题翻译：病毒灭活过程
公开(公告)号：WO2009106629A1
公开(公告)日：2009-09-03
申请号：PCT/EP2009/052403
申请日：2009-02-27
申请人： UNIVERSITEIT GENT , DELPUTTE, Peter , NAUWYNCK, Hans , DELRUE, Iris , VANHEE, Merijn
发明人： DELPUTTE, Peter , NAUWYNCK, Hans , DELRUE, Iris , VANHEE, Merijn
IPC分类号： G01N33/569 , C12N7/04 , A61K35/76
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , C12N2770/10032 , C12N2770/10034 , G01N33/56983
摘要： The invention relates generally to the field of virology. More particularly, the present invention relates to methods for determining the effect of a viral inactivation procedure on the antigenicity of the inactivated virus. In particular for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The invention further provides methods to determine the antigenicity of an inactivated virus as well as methods to screen for anti-viral compounds using any one of the aforementioned methods Methods of using the inactivated and immunogenic virus thus obtained, in particular in the manufacture of a vaccine are also provided by the present invention.
摘要翻译：本发明一般涉及病毒学领域。更具体地，本发明涉及用于确定病毒灭活程序对灭活病毒的抗原性的影响的方法。特别是对于作为动物病毒科或冠状病毒科或亚病毒科的病毒，特别是猪繁殖与呼吸综合征病毒（PRRSV）的病毒。本发明还提供了确定灭活病毒的抗原性的方法以及使用上述方法中任一种来筛选抗病毒化合物的方法。使用如此获得的灭活和免疫原性病毒的方法，特别是制造疫苗也由本发明提供。

3. 发明申请

WO2011128415A1 CROSS-PROTECTING VACCINE FOR PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS 审中-公开
标题翻译：交叉保护疫苗用于生殖和呼吸道综合症病毒
公开(公告)号：WO2011128415A1
公开(公告)日：2011-10-20
申请号：PCT/EP2011/055941
申请日：2011-04-14
申请人： UNIVERSITEIT GENT , DELPUTTE, Peter , NAUWYNCK, Hans , GELDHOF, Marc
发明人： DELPUTTE, Peter , NAUWYNCK, Hans , GELDHOF, Marc
IPC分类号： A61K39/12 , C07K14/08 , A61P31/14
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/552 , A61K2039/55566 , C07K14/005 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10064
摘要： The present invention relates to a vaccine for prevention of viremia induced by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection. More specifically, it relates to a vaccine that is protecting against infections with the European PRRSV type strain and derivatives thereof, as well as against infections with isolates where normal vaccines, based on the European type strain do not offer an efficient protection. The invention relates further to methods for preparing said vaccine, and methods to protect pigs from reproductive and respiratory syndrome, with the use of this vaccine.
摘要翻译：本发明涉及用于预防由猪繁殖与呼吸综合征病毒（PRRSV）感染引起的病毒血症的疫苗。更具体地说，本发明涉及一种能够防止欧洲PRRSV型菌株及其衍生物感染的疫苗，以及基于欧洲型菌株的正常疫苗不提供有效保护的分离物感染。本发明进一步涉及制备所述疫苗的方法，以及使用该疫苗保护猪免于生殖和呼吸综合征的方法。

4. 发明申请

WO2008093166A2 SIALOADHESIN-RELATED COMPOSITIONS AND METHODS 审中-公开
标题翻译： SIALOADHESIN相关组合物和方法
公开(公告)号：WO2008093166A2
公开(公告)日：2008-08-07
申请号：PCT/IB2007/004499
申请日：2007-05-11
申请人： GHENT UNIVERSITY , NAUWYNCK, HANS , DELPUTTE, PETER
发明人： NAUWYNCK, HANS , DELPUTTE, PETER
CPC分类号： A61K47/6849 , A61K47/646 , A61K47/6811 , A61K47/6813 , A61K47/6825
摘要： Methods of delivering a cargo moiety to a cell is provided according to embodiments of the present invention which includes contacting a cell expressing sialoadhesin with a conjugate including a sialoadhesin binding moiety and a cargo moiety. The sialoadhesin binding moiety binds to the sialoadhesin expressed by the cell and is internalized along with the cargo, delivering the cargo moiety to the cell. Particular methods provided by the present invention include induction or enhancement of sialoadhesin expression in a cell which naturally produces little or no sialoadhesin. Induction or enhancement of sialoadhesin expression includes transfection of a sialoadhesin expression construct and/or administration of an agent effective to induce or enhance sialoadhesin expression. Methods and compositions for stimulating an immune response in a subject are detailed. Particular methods and compositions for stimulating an immune response to a virus are provided by the present invention.
摘要翻译：根据本发明的实施方案提供将货物部分递送至细胞的方法，其包括使表达唾液酸粘附素的细胞与包含唾液酸粘附素结合部分和货物部分的缀合物接触。唾液酸粘附素结合部分结合由细胞表达的唾液酸粘附素，并与货物一起内化，将货物部分输送至细胞。本发明提供的特定方法包括在天然产生很少或不含唾液酸粘蛋白的细胞中诱导或增强唾液酸粘附素表达。唾液酸粘附素表达的诱导或增强包括转染唾液酸粘附素表达构建体和/或施用有效诱导或增强唾液酸粘附素表达的试剂。详细说明刺激受试者免疫应答的方法和组合物。用于刺激对病毒的免疫应答的特定方法和组合物由本发明提供。

5. 发明申请

WO2008093166A3 TARGETING MACROPHAGES THROUGH SIALOADHESIN 审中-公开
标题翻译：通过SIALOADHESIN来达到目标
公开(公告)号：WO2008093166A3
公开(公告)日：2009-11-19
申请号：PCT/IB2007004499
申请日：2007-05-11
申请人： UNIV GHENT , NAUWYNCK HANS , DELPUTTE PETER
发明人： NAUWYNCK HANS , DELPUTTE PETER
IPC分类号： A61K47/48 , A61P35/00 , A61P37/04
CPC分类号： A61K47/6849 , A61K47/646 , A61K47/6811 , A61K47/6813 , A61K47/6825
摘要： Methods of delivering a cargo moiety to a cell is provided according to embodiments of the present invention which includes contacting a cell expressing sialoadhesin with a conjugate including a sialoadhesin binding moiety and a cargo moiety. The sialoadhesin binding moiety binds to the sialoadhesin expressed by the cell and is internalized along with the cargo, delivering the cargo moiety to the cell. Particular methods provided by the present invention include induction or enhancement of sialoadhesin expression in a cell which naturally produces little or no sialoadhesin. Induction or enhancement of sialoadhesin expression includes transfection of a sialoadhesin expression construct and/or administration of an agent effective to induce or enhance sialoadhesin expression. Methods and compositions for stimulating an immune response in a subject are detailed. Particular methods and compositions for stimulating an immune response to a virus are provided by the present invention.
摘要翻译：根据本发明的实施方案提供将货物部分递送至细胞的方法，其包括使表达唾液酸粘附素的细胞与包含唾液酸粘附素结合部分和货物部分的缀合物接触。唾液酸粘附素结合部分结合由细胞表达的唾液酸粘附素，并与货物一起内化，将货物部分输送至细胞。本发明提供的特定方法包括在天然产生很少或不含唾液酸粘蛋白的细胞中诱导或增强唾液酸粘附素表达。唾液酸粘附素表达的诱导或增强包括转染唾液酸粘附素表达构建体和/或施用有效诱导或增强唾液酸粘附素表达的试剂。详细说明刺激受试者免疫应答的方法和组合物。用于刺激对病毒的免疫应答的特定方法和组合物由本发明提供。

6. 发明申请

WO2009024239A3 PERMISSIVE CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2009024239A3
公开(公告)日：2009-02-26
申请号：PCT/EP2008/006045
申请日：2008-07-23
申请人： GHENT UNIVERSITY , DELPUTTE, Peter , NAUWYNCK, Hans , VAN GORP, Hanne
发明人： DELPUTTE, Peter , NAUWYNCK, Hans , VAN GORP, Hanne
IPC分类号： G01N33/569 , C12N15/00 , C12N5/00 , A61K39/12 , C12Q1/68
摘要： The invention relates generally to the field of virology. More particularly, the present invention relates to methods for determining the permissiveness of a cell for a virus that is a member of the family Arteriviridae or Coronaviridae or Asf arviridae, in particular for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The invention further provides methods and compositions related to the generation of host cells permissive for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Methods of using said cells thus identified or thus generated, in preparing a culture of a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, as well as the use of said virus for the purpose of vaccine production or diagnosis, are also provide by the present invention.

7. 发明申请

WO2009024239A2 PERMISSIVE CELLS AND USES THEREOF 审中-公开
标题翻译：适用的细胞及其用途
公开(公告)号：WO2009024239A2
公开(公告)日：2009-02-26
申请号：PCT/EP2008006045
申请日：2008-07-23
申请人： UNIV GHENT , DELPUTTE PETER , NAUWYNCK HANS , VAN GORP HANNE
发明人： DELPUTTE PETER , NAUWYNCK HANS , VAN GORP HANNE
IPC分类号： G01N33/569 , A61K39/12 , C12N5/00 , C12N15/00 , C12Q1/68
CPC分类号： C12N7/025 , A61K2039/525 , C07K14/705 , C07K14/70596 , C12N7/04 , C12N2770/10011 , C12Q1/06 , C12Q1/6881 , C12Q2600/158 , G01N33/56983 , G01N2500/10
摘要： The invention relates generally to the field of virology. More particularly, the present invention relates to methods for determining the permissiveness of a cell for a virus that is a member of the family Arteriviridae or Coronaviridae or Asf arviridae, in particular for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The invention further provides methods and compositions related to the generation of host cells permissive for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). Methods of using said cells thus identified or thus generated, in preparing a culture of a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, as well as the use of said virus for the purpose of vaccine production or diagnosis, are also provide by the present invention.
摘要翻译：本发明一般涉及病毒学领域。更具体地说，本发明涉及用于确定作为动物病毒科或冠状病毒科或Asf arviridae，尤其是猪繁殖与呼吸综合征病毒（PRRSV）的病毒的病毒的细胞的容许度的方法。本发明进一步提供与产生对于病毒的宿主细胞的方法和组合物，所述病毒是动物病毒科或冠状病毒科或亚病毒科，尤其是猪繁殖与呼吸综合征病毒（PRRSV）的成员。在制备作为动物病毒科或冠状病毒科或亚病毒科的成员的病毒的培养物以及为了疫苗生产或诊断的目的而使用所述病毒时，使用由此鉴定或由此产生的所述细胞的方法也是通过本发明提供。

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