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1. 发明申请

WO2013006336A3 METHODS AND COMPOSITIONS USEFUL FOR TREATING FITZPATRICK TYPE IV, V OR VI SKIN 审中-公开
标题翻译：方法和组合物可用于治疗FITZPATRICK IV型，V型或VI型皮肤
公开(公告)号：WO2013006336A3
公开(公告)日：2013-04-25
申请号：PCT/US2012044384
申请日：2012-06-27
申请人： ELC MAN LLC , GHERSIN MURIEL , DECLERCQ LIEVE , DE SAINT MICHEL LOUIS , GRIGSBY JOSEPH SCOTT
发明人： GHERSIN MURIEL , DECLERCQ LIEVE , DE SAINT MICHEL LOUIS , GRIGSBY JOSEPH SCOTT
IPC分类号： A61K36/53 , A61K8/97 , A61K36/49 , A61P17/00 , A61Q19/02
CPC分类号： A61K8/975 , A61K8/891 , A61K8/97 , A61K2800/28 , A61K2800/5922 , A61Q1/02 , A61Q19/00 , A61Q19/007 , A61Q19/008
摘要： Compositions comprising a moisturizing agent, a desquamating agent, a mattifying agent and an agent that increases skin luminosity are disclosed herein. The compositions are useful for moisturizing, desquamating, mattifying, and increasing the luminosity in skin of an individual having a Fitzpatrick Skin Type IV, V, or VI. Also disclosed are methods for moisturizing, desquamating, mattifying, and increasing the luminosity in skin, comprising administering to an individual having a Fitzpatrick Skin Type IV, V, or VI, the present compositions.
摘要翻译：本文公开了包含增湿剂，脱屑剂，增效剂和增加皮肤光度的试剂的组合物。该组合物可用于具有Fitzpatrick皮肤IV型，V型或VI型的个体的皮肤中的保湿，脱屑，发光以及增加皮肤的发光度。还公开了用于保湿，脱屑，增光和增加皮肤亮度的方法，其包括向具有Fitzpatrick皮肤IV型，V型或VI型的个体施用本发明组合物。

2. 发明申请

WO2012125183A1 USE OF ANOGEISSUS EXTRACT FOR FIBRILLIN PRODUCTION IN SKIN 审中-公开
标题翻译：使用抗生素提取物在皮肤中生产纤维素
公开(公告)号：WO2012125183A1
公开(公告)日：2012-09-20
申请号：PCT/US2011/052188
申请日：2011-09-19
申请人： ELC MANAGEMENT LLC , DALY, Susan M. , DECLERCQ, Lieve
发明人： DALY, Susan M. , DECLERCQ, Lieve
IPC分类号： A61K36/185 , A61K8/97 , A61P17/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K8/66 , A61K8/4913 , A61K8/97 , A61K36/185 , A61K2800/5922 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： Use of at least one extract from the Anogeissus genus for treating human skin by producing fibrillin and thereby increasing skin elasticity.
摘要翻译：使用来自Anogeissus属的至少一种提取物通过产生原纤维蛋白来治疗人皮肤，从而增加皮肤弹性。

3. 发明申请

WO2012122091A3 METHOD FOR COSMETICALLY TREATING CASPASE-14 DEFICIENCY 审中-公开
公开(公告)号：WO2012122091A3
公开(公告)日：2012-09-13
申请号：PCT/US2012/027702
申请日：2012-03-05
申请人： ELC MANAGEMENT LLC , CORSTJENS, Hugo A. , DECLERCQ, Lieve , EYCKMANS, Gerry , VAN OVERLOOP, Luc F.J.
发明人： CORSTJENS, Hugo A. , DECLERCQ, Lieve , EYCKMANS, Gerry , VAN OVERLOOP, Luc F.J.
IPC分类号： A61K8/97 , A61Q19/00
摘要： A method of cosmetic care comprising activating capsase-14 expression in skin deficient in caspase-14 expression by applying, on at least one skin zone in need thereof, an effective amount of a plant extract selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof, to activate caspase-14 expression in said skin.

4. 发明申请

WO2010019413A3 COMPOSITE PARTICLES HAVING AN ANTIOXIDANT-BASED PROTECTIVE SYSTEM, AND TOPICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：具有基于抗氧化剂的保护系统的复合颗粒以及包含该组合物的局部用组合物
公开(公告)号：WO2010019413A3
公开(公告)日：2010-04-22
申请号：PCT/US2009052683
申请日：2009-08-04
申请人： ELC MAN LLC , SENTE ILSE , DECLERCQ LIEVE , MAES DANIEL H , SOJKA MILAN FRANZ , CUMMINS PHILLIP , FTHENAKIS CHRISTINA G , PERNODET NADINE A , LEE DR WILSON A , NAJDEK LINDA , MCKEEVER-ALFIERI MARYANN , TETA LAWRENCE P
发明人： SENTE ILSE , DECLERCQ LIEVE , MAES DANIEL H , SOJKA MILAN FRANZ , CUMMINS PHILLIP , FTHENAKIS CHRISTINA G , PERNODET NADINE A , LEE DR WILSON A , NAJDEK LINDA , MCKEEVER-ALFIERI MARYANN , TETA LAWRENCE P
IPC分类号： A61K8/11 , A61K8/27 , A61K8/29 , A61K8/34 , A61K9/48 , A61P17/18 , A61Q17/04
CPC分类号： A61K8/27 , A61K8/11 , A61K8/29 , A61K8/347 , A61K8/365 , A61K8/447 , A61K8/498 , A61K8/63 , A61K8/676 , A61K8/678 , A61K8/97 , A61K8/9706 , A61K2800/522 , A61K2800/56 , A61Q17/04 , A61Q19/001
摘要： The present invention relates to topical compositions containing a dispersion of composite particles. Each of such composite particles contains one or more core particles encapsulated or entrapped in a polymeric shell. At least some of the core particles are formed of a material capable of causing generation of reactive oxygen species (ROS). Each of the composite particles further contains: (1) a first antioxidant co-encapsulated or co-entrapped with the core particles inside the polymeric shell for quenching or scavenging ROS generated in the vicinity of the core particles, and (2) a second antioxidant coated over the polymeric shell for preventing or reducing oxidative damage to the skin, such as lipid peroxidation. The particle dispersion of the present invention therefore can be readily formulated into topical sunscreen compositions with organic sunscreen agents susceptible to oxidative decomposition or degradation to provide improved protection against skin damage caused by exposure to UV light.
摘要翻译：本发明涉及含有复合颗粒分散体的局部组合物。每个这种复合颗粒含有一个或多个包封或包埋在聚合物壳中的核心颗粒。至少一些核心颗粒由能够产生活性氧（ROS）的材料形成。每种复合颗粒进一步含有：（1）第一抗氧化剂，与聚合物壳内的核心颗粒共包封或共同包埋，用于猝灭或清除核心颗粒附近产生的ROS;以及（2）第二抗氧化剂涂覆在聚合物外壳上以防止或减少对皮肤的氧化损伤，例如脂质过氧化。因此，本发明的颗粒分散体可以容易地配制成具有对氧化分解或降解敏感的有机防晒剂的局部防晒组合物，以提供改善的保护，防止暴露于紫外光引起的皮肤损伤。

5. 发明申请

WO2012122082A2 METHODS FOR ACTIVATING CASPASE-14 EXPRESSION IN HUMAN SKIN 审中-公开
标题翻译：活化人皮肤中CASPASE-14表达的方法
公开(公告)号：WO2012122082A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/027676
申请日：2012-03-05
申请人： ELC MANAGEMENT LLC , CORSTJENS, Hugo A. , DECLERCQ, Lieve , EYCKMANS, Gerry , VAN OVERLOOP, Luc F.J.
发明人： CORSTJENS, Hugo A. , DECLERCQ, Lieve , EYCKMANS, Gerry , VAN OVERLOOP, Luc F.J.
IPC分类号： A61K36/42 , A61K36/185 , A61K36/736 , A61P17/00
CPC分类号： A61K36/77 , A61K36/185 , A61K36/21 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/708 , A61K36/73 , A61K36/736 , A61K36/752 , A61K36/8962
摘要： A method for treating human skin comprising the steps of a) identifying a subject deficient in caspase-14; wherein the caspase-14 deficiency is identified by the presence of a skin condition selected from the group consisting of eczema, xerotic skin, and skin dryness in at least one skin zone of the subject; and b) activating caspase-14 in human skin by administering to a subject in need thereof a therapeutically effective amount of a composition comprising one or more extracts selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof.
摘要翻译：一种治疗人类皮肤的方法，包括以下步骤：a）鉴定caspase-14缺陷的受试者; 其中所述半胱氨酸天冬氨酸蛋白酶14缺陷通过在所述受试者的至少一个皮肤区域中存在选自由湿疹，干燥皮肤和皮肤干燥组成的组中的皮肤病症来鉴定; 和b）通过向有需要的受试者施用治疗有效量的组合物来激活人皮肤中的胱天蛋白酶-14，所述组合物包含一种或多种选自荔枝，玻璃汁，桃，大豆种子，甜罗勒，黄瓜，鸡油菌，韭菜，猕猴桃，大黄，葡萄柚，小麦，覆盆子，李子，以及它们的混合物。

6. 发明申请

WO2011143171A3 COMPOSITIONS CONTAINING DNA REPAIR ENZYME AND ANOGEISSUS EXTRACT 审中-公开
标题翻译：含有DNA修复酶和抗病毒提取物的组合物
公开(公告)号：WO2011143171A3
公开(公告)日：2012-03-08
申请号：PCT/US2011035857
申请日：2011-05-10
申请人： ELC MAN LLC , STARR ELIZABETH I , DECLERCQ LIEVE , WARREN MATTHEW RONALD , BAIER CHRISTINE MARIE
发明人： STARR ELIZABETH I , DECLERCQ LIEVE , WARREN MATTHEW RONALD , BAIER CHRISTINE MARIE
IPC分类号： A61K8/97 , A61K8/64 , A61K8/66 , A61K8/89 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/97 , A61K8/66 , A61Q19/00 , A61Q19/08
摘要： A topical composition comprising at least one extract from the Anogeissus genus and at least one DNA repair enzyme and a method for treating human skin for improvement comprising applying to the skin a topical composition comprising at least one extract from the Anogeissus genus and at least one DNA repair enzyme.
摘要翻译：包含至少一种来自Anogeissus属的提取物和至少一种DNA修复酶的局部组合物和用于治疗人类皮肤以改善的方法，包括向皮肤施用包含至少一种来自Anogeissus属的提取物和至少一种DNA的局部组合物修复酶。

7. 发明申请

WO2011143171A2 COMPOSITIONS CONTAINING DNA REPAIR ENZYME AND ANOGEISSUS EXTRACT 审中-公开
标题翻译：含有DNA修复酶和抗病毒提取物的组合物
公开(公告)号：WO2011143171A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/035857
申请日：2011-05-10
申请人： ELC MANAGEMENT LLC , STARR, Elizabeth I. , DECLERCQ, Lieve , WARREN, Matthew Ronald , BAIER, Christine Marie
发明人： STARR, Elizabeth I. , DECLERCQ, Lieve , WARREN, Matthew Ronald , BAIER, Christine Marie
IPC分类号： A61K8/97 , A61K8/66 , A61K8/64 , A61K8/89 , A61Q19/00 , A61Q5/00
CPC分类号： A61K8/97 , A61K8/66 , A61Q19/00 , A61Q19/08
摘要： A topical composition comprising at least one extract from the Anogeissus genus and at least one DNA repair enzyme and a method for treating human skin for improvement comprising applying to the skin a topical composition comprising at least one extract from the Anogeissus genus and at least one DNA repair enzyme.
摘要翻译：包含至少一种来自Anogeissus属的提取物和至少一种DNA修复酶的局部组合物和用于治疗人类皮肤以改善的方法，包括向皮肤施用包含至少一种来自Anogeissus属的提取物和至少一种DNA的局部组合物修复酶。

8. 发明申请

WO2010028247A2 AN OBJECTIVE MODEL OF APPARENT AGE, METHODS AND USE 审中-公开
标题翻译：视觉年龄，方法和使用的目标模型
公开(公告)号：WO2010028247A2
公开(公告)日：2010-03-11
申请号：PCT/US2009056043
申请日：2009-09-04
申请人： ELC MAN LLC , DICANIO DENISE , SPARACIO ROSE MARIE , DECLERCQ LIEVE , MAES DANIEL , NEELAM MUIZZUDDIN
发明人： DICANIO DENISE , SPARACIO ROSE MARIE , DECLERCQ LIEVE , MAES DANIEL , NEELAM MUIZZUDDIN
IPC分类号： G06F17/10 , A61B5/00 , A61B10/00 , G06F19/00
CPC分类号： G06Q99/00 , A61B5/441 , A61B8/0858 , G16H10/20 , G16H50/50
摘要： Methods of developing equations for objectively assigning or predicting an apparent age are disclosed. Advantageously, the equations of objective apparent age may be based on a relatively small number of critical parameters combined in a way that accounts for all or most of the apparent skin aging in a defined population or sub-population. Despite the relatively small data collection requirements, the present invention includes an objective model of apparent age that is useful for evaluation of products, useful for predicting treatment outcomes and useful for predicting the effects of deteriorative factors. The formalization of an Objective Apparent Age Score allows one to identify the biophysical and biochemical parameters that mostly influence an individual's apparent age, and can be used to select specific anti-aging treatments with increased chances of visible success. The Objective Apparent Age Score may also be used to support marketing claims.
摘要翻译：公开了用于客观地分配或预测表观年龄的方程式的方法。有利的是，客观表观年龄的方程式可以基于相对少量的关键参数，所述关键参数以在所定义的群体或子群体中占所有或大部分表观皮肤老化的方式进行组合。尽管数据收集要求相对较小，但本发明包括对产品评估有用的表观年龄客观模型，可用于预测治疗结果并可用于预测恶化因素的影响。客观表观年龄分数的形式化使得人们能够确定主要影响个体明显年龄的生物物理学和生物化学参数，并且可以用于选择特定的抗衰老治疗以增加可见成功的可能性。客观表观年龄得分也可用于支持营销索赔。

9. 发明申请

WO2009017866A1 COSMETIC COMPOSITIONS CONTAINING RESVERATROL DERIVATIVES 审中-公开
标题翻译：含有RESVERATROL衍生物的化妆品组合物
公开(公告)号：WO2009017866A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/063610
申请日：2008-05-14
申请人： ELC MANAGEMENT LLC , MAES, Daniel , MOHAMMADI, Fatemeh , CZARNOTA, Anna , MAMMONE, Thomas , DECLERCQ, Lieve , QU, Lisa , ZECCHINO, Jules
发明人： MAES, Daniel , MOHAMMADI, Fatemeh , CZARNOTA, Anna , MAMMONE, Thomas , DECLERCQ, Lieve , QU, Lisa , ZECCHINO, Jules
IPC分类号： A61K8/89 , A61K8/19
CPC分类号： A61Q1/08 , A61K8/347
摘要： A cosmetic composition in the aqueous based, emulsion, or anhydrous form comprising at least one resveratrol derivative.
摘要翻译：包含至少一种白藜芦醇衍生物的水性，乳液或无水形式的化妆品组合物。

10. 发明申请

WO2012122091A9 METHOD FOR COSMETICALLY TREATING CASPASE-14 DEFICIENCY 审中-公开
公开(公告)号：WO2012122091A9
公开(公告)日：2012-09-13
申请号：PCT/US2012/027702
申请日：2012-03-05
申请人： ELC MANAGEMENT LLC , CORSTJENS, Hugo A. , DECLERCQ, Lieve , EYCKMANS, Gerry , VAN OVERLOOP, Luc F.J.
发明人： CORSTJENS, Hugo A. , DECLERCQ, Lieve , EYCKMANS, Gerry , VAN OVERLOOP, Luc F.J.
IPC分类号： A61K8/97 , A61Q19/00
摘要： A method of cosmetic care comprising activating capsase-14 expression in skin deficient in caspase-14 expression by applying, on at least one skin zone in need thereof, an effective amount of a plant extract selected from the group consisting of litchi, glasswort, peach, soja seed, sweet basil, cucumber, chanterelle, leek, kiwi fruit, rhubarb, grapefruit, wheat, raspberry, plum, and mixtures thereof, to activate caspase-14 expression in said skin.

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