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2. 发明申请

WO2008143863A1 WOUND AND CUTANEOUS INJURY HEALING WITH A NUCLEIC ACID ENCODING A PROTEOGLYCAN POLYPEPTIDE 审中-公开
标题翻译：伤口和伤口愈合与核酸编码一种蛋白多糖
公开(公告)号：WO2008143863A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006139
申请日：2008-05-14
申请人： AGENTA BIOTECHNOLOGIES , DECARLO, Arthur A. , WHITELOCK, John , ELLIS, April L.
发明人： DECARLO, Arthur A. , WHITELOCK, John , ELLIS, April L.
IPC分类号： A61K31/70 , C12N5/00
CPC分类号： C07K14/4725 , A61K38/00 , A61K38/14 , A61K38/177 , A61K38/179 , A61K48/005
摘要： The present disclosure provides nucleic acid constructs encoding one or more polypeptides containing at least one glycosaminoglycan chain, such as, but not limited to, a proteoglycan polypeptide, and methods for delivering to the site of a wound or cutaneous injury at least one nucleic acid construct encoding one or more such polypeptides, such that the expressed polypeptide is glycated by glycosaminoglycan chains through the normal physiological processes of the subject at the site of administration to produce a functional proteoglycan polypeptide for the healing of the wound or other cutaneous injury. The delivered nucleic acid construct is transcribed, translated and post-translationally modified by the addition of glycosaminoglycan chains (referred herein as "decoration" or "glycation") to produce a decorated polypeptide. The decorated polypeptide is then secreted from the cell in which it was produced to provide treatment of wounds and/or cutaneous injury in the subject and/or prevention of cutaneous injury in a subject.
摘要翻译：本公开内容提供了编码一种或多种含有至少一种糖胺聚糖链的多肽的核酸构建体，所述多肽包括但不限于蛋白聚糖多肽，以及用于将至少一种核酸构建体递送至伤口或皮肤损伤部位的方法编码一种或多种这样的多肽，使得所表达的多肽在施用部位通过受试者的正常生理过程被糖胺聚糖链糖化，以产生用于伤口愈合或其它皮肤损伤的功能性蛋白多糖多肽。递送的核酸构建体通过加入糖胺聚糖链（本文称为“装饰”或“糖基化”）被转录，翻译和翻译后修饰以产生装饰的多肽。然后将装饰的多肽从其产生的细胞分泌，以在受试者中提供伤口和/或皮肤损伤的治疗和/或预防受试者的皮肤损伤。

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