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1. 发明申请

WO2015077578A1 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOENCAPSULATED PROTEINS ACROSS BLOOD-BRAIN AND RETINAL BARRIERS 审中-公开
标题翻译：用于在血脑屏障和肾脏屏障之间递送生物体膜蛋白的组合物和方法
公开(公告)号：WO2015077578A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/066851
申请日：2014-11-21
申请人： TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , DANIELL, Henry
发明人： DANIELL, Henry
IPC分类号： A61K38/17 , A61K38/00
CPC分类号： A61K38/1709 , A61K9/0053 , A61K9/19 , A61K9/5068 , A61K38/164 , A61K38/17 , A61K47/6415 , A61K47/6811 , C07K14/28 , C07K14/4713 , C07K2319/00 , C07K2319/55 , C12N15/8257 , Y02A50/471
摘要： Compositions and methods effective to provide therapeutic benefit for disorders of the central nervous system via oral or systemic delivery of therapeutic proteins produced in plastids are disclosed.
摘要翻译：公开了通过口服或全身递送在质体中产生的治疗性蛋白质有效地为中枢神经系统疾病提供治疗益处的组合物和方法。

2. 发明申请

WO2012006622A3 IMPROVED AGRONOMIC TRAITS VIA GENETICALLY INDUCED ELEVATION OF PHYTOHORMONE LEVELS IN PLANTS 审中-公开
公开(公告)号：WO2012006622A3
公开(公告)日：2012-01-12
申请号：PCT/US2011/043565
申请日：2011-07-11
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , DANIELL, Henry
发明人： DANIELL, Henry
IPC分类号： A01H5/00 , C12N15/82 , C12N15/56
摘要： Disclosed herein are transgenic plants that have been modified to express β-glucosidase, and methods and materials for making same. The transgenic plants possess several advantageous features including increased biomass, increased trichome density and increased parasite resistance.

3. 发明申请

WO2006031721A2 GENETIC ENGINEERING OF MALE STERILITY IN PLANTS 审中-公开
标题翻译：植物中雄性不育遗传工程
公开(公告)号：WO2006031721A2
公开(公告)日：2006-03-23
申请号：PCT/US2005/032402
申请日：2005-09-13
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , DANIELL, Henry
发明人： DANIELL, Henry
IPC分类号： A01H1/00
CPC分类号： C12N15/8214 , C12N15/8289
摘要： Disclosed herein are methods of achieving male sterility in plants. Specifically exemplified herein is the transformation of the plastid genome with a vector expressing the phaA gene. Expression of the phaA gene in plastids results in plants that do not exhibit pleiotropic effects with the exception of male sterility. Also disclosed are stably transformed plants and cells, as well as example vectors for expressing the phaA gene in plastids.
摘要翻译：本文公开的是在植物中实现雄性不育的方法。本文具体示例的是用表达phaA基因的载体转化质体基因组。 phaA基因在质体中的表达导致除了雄性不育之外不表现多效作用的植物。还公开了稳定转化的植物和细胞，以及用于在质体中表达phaA基因的实例载体。

4. 发明申请

WO2004005467A3 EXPRESSION OF HUMAN INTERFERON IN TRANSGENIC CHLOROPLASTS 审中-公开
标题翻译：人类干扰素在转基因烟草中的表达
公开(公告)号：WO2004005467A3
公开(公告)日：2004-04-08
申请号：PCT/US0320869
申请日：2003-07-02
申请人： UNIV CENTRAL FLORIDA , DANIELL HENRY
发明人： DANIELL HENRY
IPC分类号： A61K38/00 , C07K14/56 , C12N15/82 , A61K38/28 , C07K1/00 , C12N15/09 , C12N15/63 , C12N15/87
CPC分类号： C07K14/56 , A61K38/00 , C12N15/8214 , C12N15/8257
摘要： A plastid transformation vector for a stably transforming a plastid genome is provided. The vector includes, as operably-linked components, a first flanking sequence, a DNA sequence coding for a therapeutic human IFN, which is capable of expression in the plastid and a second flanking sequence. The invention also provides isolated and purified IFN, wherein the IFN is configured in a monomeric or multimeric form and is a structural equivalent to orally administered human IFN. Also provided are methods for variable-expressing biopharmaceutical proteins in plants suitable for mammal consumption. The method includes integrating a plastid transformation vector into a plastid genome of a plant cell; growing the plant cell to express a biopharmaceutical protein, such as therapeutic human interferon IFN. Also disclosed are plants transformed with the aforementioned vectors, and the progeny thereof. Also, disclosed is the IFN, which is IFNalpha2b.
摘要翻译：提供了用于稳定转化质体基因组的质体转化载体。载体包括作为可操作地连接的组分的第一侧翼序列，编码治疗性人IFN的DNA序列，其能够在质体和第二侧翼序列中表达。本发明还提供分离和纯化的IFN，其中IFN被配置为单体或多聚体形式，并且是等同于口服施用人IFN的结构。还提供了适于哺乳动物消耗的植物中可变表达生物药物蛋白质的方法。该方法包括将质体转化载体整合到植物细胞的质体基因组中; 生长植物细胞以表达生物制药蛋白，例如治疗性人干扰素IFN。还公开了用前述载体转化的植物及其后代。此外，公开了IFN，其是IFNα2b。

5. 发明申请

WO2011057243A2 ADMINISTRATION OF PLANT EXPRESSED ORAL TOLERANCE AGENTS 审中-公开
标题翻译：植物表达口服剂的管理
公开(公告)号：WO2011057243A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/055978
申请日：2010-11-09
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , DANIELL, Henry , HERZOG, Roland, W.
发明人： DANIELL, Henry , HERZOG, Roland, W.
IPC分类号： A61K38/56 , A61K48/00 , A61K38/16 , A61P3/00 , A61P9/10 , A61P43/00
CPC分类号： A61K39/0008 , A61K38/4846 , C07K2319/55 , C12N9/644 , C12N15/8214 , C12N15/8257 , C12Y304/21022
摘要： Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is often complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine hemophilia B as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. Oral delivery of coagulation factor IX (F. IX) expressed in chloroplasts, bioencapsulated in plant cells, effectively blocked formation of inhibitory antibodies in protein replacement therapy. Inhibitor titers were mostly undetectable and up to 100-fold lower in treated mice when compared to controls. Moreover, this treatment eliminated fatal anaphylactic reactions that occurred after 4 to 6 exposures to intravenous F. IX protein. While only 20-25% of control animals survived after 6-8 F. IX doses, 90-95% of tolerized mice survived 12 injections without signs of allergy or anaphylaxis. This high-responder strain of hemophilia B mice represents the first hemophilic animal model to study anaphylactic reactions. The plant material was effective over a range of oral antigen doses (equivalent to 5-80 μg recombinant F.IX/kg), and controlled inhibitor formation and anaphylaxis long-term, up to 7 months. Oral antigen administration caused a deviant immune response that suppressed formation of IgE and inhibitory antibodies. This cost-effective and efficient approach to oral delivery of protein antigens to the gut should be applicable to several genetic diseases that are prone to pathogenic antibody responses during treatment.
摘要翻译：血友病或其他遗传性蛋白质缺陷患者的蛋白质替代疗法通常与致病性抗体应答相复杂，包括中和治疗性蛋白质的抗体或易形成IgE的可能危及生命的过敏反应。使用鼠血友病B作为模型，我们制定了针对这种非侵入性应答的预防性方案，其不包括患者细胞的免疫抑制或遗传操作。在植物细胞中生物包被的叶绿体中表达的凝血因子IX（F-IX）的口服递送有效地阻止蛋白质替代疗法中抑制性抗体的形成。与对照组相比，抑制剂滴度在治疗的小鼠中大部分是不可检测的并且高达100倍。此外，这种治疗方法消除了静脉注射F. IX蛋白4至6次后发生的致命性过敏反应。在6-8F IX剂量后，只有20-25％的对照动物存活，90-95％的耐受小鼠在12次注射后存活，没有过敏症状或过敏症状。这种高反应性的血友病B小鼠品系代表了研究过敏反应的第一个血友病动物模型。植物材料在一系列口服抗原剂量（相当于5-80μg重组体F.IX / kg）内是有效的，并且长期控制的抑制剂形成和过敏反应长达7个月。口服抗原施用引起异常免疫应答，其抑制IgE和抑制性抗体的形成。这种将蛋白质抗原口服递送至肠道的经济有效的方法应该适用于在治疗过程中易发生致病性抗体应答的几种遗传疾病。

6. 发明申请

WO2010033275A2 ORALLY ADMINISTERABLE VACCINE FOR YERSINIA PESTIS 审中-公开
标题翻译：对耶尔森氏菌PESTIS ORALLY可治疗的疫苗
公开(公告)号：WO2010033275A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/045215
申请日：2009-05-27
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , DANIELL, Henry
发明人： DANIELL, Henry
IPC分类号： A61K36/28 , A61K38/16 , A61K39/00 , A61P31/04
CPC分类号： C07K14/24 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K36/23 , A61K36/28 , A61K36/81 , A61K39/025 , A61K2039/517 , C12N15/8214 , C12N15/8257 , C12N15/8258 , Y02A50/407
摘要： Disclosed herein is the successful expression of the plague Fl-V fusion antigen in chloroplasts. Parenteral and/or oral administration of chloroplast produced antigens effectively elicit protective immune responses in vivo. Disclosed herein is the first report of a plant-derived oral vaccine that protected animals from live Y. pestis challenge, bringing the likelihood of lower-cost vaccines closer to reality.
摘要翻译：本文公开了鼠疫Fl-V融合抗原在叶绿体中的成功表达。非体内和/或口服给予叶绿体产生的抗原有效引发体内保护性免疫应答。本文公开了保护动物免受活Y感染的植物来源的口服疫苗的首次报道。 pestis挑战，使低成本疫苗的可能性更接近现实。

7. 发明申请

WO2009108941A2 PRODUCTION AND USE OF PLANT DEGRADING MATERIALS 审中-公开
标题翻译：植物降解材料的生产和使用
公开(公告)号：WO2009108941A2
公开(公告)日：2009-09-03
申请号：PCT/US2009035753
申请日：2009-03-02
申请人： UNIV CENTRAL FLORIDA RES FOUND , DANIELL HENRY
发明人： DANIELL HENRY
IPC分类号： A01H5/00
CPC分类号： C12N15/8214 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12N15/8242 , C12N15/8257 , C12P7/12 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01091
摘要： Disclosed herein are materials useful for degrading plant biomass material. In exemplary embodiments, the plant material comprises one or more enzymes that are expressed in plants and/or bacteria. Specifically exemplified herein are plant degrading enzymes expressed in chloroplasts. The chloroplast expressed enzymes may be provided as cocktails for use in conjunction with conventional methods of converting biomass into biofuels, such as cellulosic ethanol.
摘要翻译：本文公开了可用于降解植物生物质材料的材料。在示例性实施方案中，植物材料包含在植物和/或细菌中表达的一种或多种酶。本文具体举例说明了在叶绿体中表达的植物降解酶。叶绿体表达的酶可以作为鸡尾酒提供，用于将生物质转化为生物燃料如纤维素乙醇的常规方法。

8. 发明申请

WO2007053182A3 PLANT PRODUCED VACCINE FOR AMEBIASIS 审中-公开
标题翻译：植物生产用于美食的疫苗
公开(公告)号：WO2007053182A3
公开(公告)日：2007-09-27
申请号：PCT/US2006021020
申请日：2006-05-30
申请人： UNIV CENTRAL FLORIDA RES FOUND , DANIELL HENRY
发明人： DANIELL HENRY
IPC分类号： A01H1/00 , A61K39/00 , C12N15/82
CPC分类号： A61K39/002 , A01H5/10 , A01H5/12 , A61K2039/517 , C07K14/44 , C12N15/8214 , C12N15/8258 , C12N15/8281 , C12N15/8282
摘要： Disclosed herein are methods of making a vaccine against Entamoeba histolytica and methods of immunizing a subject using such vaccine. Specifically exemplified are plants expressing a LecA polypeptide and plant material obtained from such plant being used as a basis for vaccination.
摘要翻译：本文公开了制备疫苗针对溶组织内溶阿米巴的方法和使用这种疫苗免疫受试者的方法。具体举例说明了表达LecA多肽的植物和从该植物获得的植物材料作为疫苗接种的基础。

9. 发明申请

WO0164024B1 MULTIPLE GENE EXPRESSION FOR ENGINEERING NOVEL PATHWAYS AND HYPEREXPRESSION OF FOREIGN PROTEINS IN PLANTS 审中-公开
标题翻译：工程新途径多种基因表达及外源蛋白在植物中的表达
公开(公告)号：WO0164024B1
公开(公告)日：2001-11-01
申请号：PCT/US0106276
申请日：2001-02-28
申请人： UNIV AUBURN , UNIV CENTRAL FLORIDA , DANIELL HENRY , MOAR WILLIAM
发明人： DANIELL HENRY , MOAR WILLIAM
IPC分类号： C07K14/325 , C12N15/79 , C12N15/82 , A01H5/02 , A01H5/10 , A01H13/00 , C12N1/12 , C12N1/20 , C12N5/04 , C12N15/13 , C12N15/17 , C12N15/29 , C12N15/31 , C12N15/32 , C12N15/52 , C12N15/63 , C12N15/74
CPC分类号： C07K14/325 , C12N15/79 , C12N15/8214 , C12N15/8241 , C12N15/8259 , C12N15/8271 , C12N15/8286 , Y02A40/162
摘要： Introducing blocks of foreign genes in a single operon would avoid complications such as position effect and gene silencing inherent in putting one gene at a time into random locations in the nuclear genome. Cloning several genes into a single T-DNA does not avoid the compounded variable expression problem encountered in nuclear transgenic plants. This disclosure shows that a bacterial operon can be expressed in a single integration event as opposed to multiple events requiring several years to accomplish. Expression of multiple genes via a single transformation event opens the possibility of expressing foreign pathways or pharmaceutical proteins involving multiple genes. Expressing the Cry2aA2 operon, including a putative chaperonin to aid in protein folding, in the chloroplast via a single transformation event leads to production of crystalized insecticidal proteins. Expressing the Mer operon via a single transformation event leads to a phytoremediation system.
摘要翻译：在单个操纵子中引入外来基因块可以避免诸如位置效应和将一个基因一次置于核基因组随机位置中固有的基因沉默的并发症。将几个基因克隆成单个T-DNA不能避免在核转基因植物中遇到的复合变量表达问题。本公开表明，细菌操纵子可以在单个整合事件中表达，而不是需要几年才能完成的多个事件。通过单一转化事件表达多个基因，揭示了表达涉及多个基因的外源途径或药物蛋白的可能性。通过单一转化事件表达Cry2aA2操纵子，包括推定的伴侣蛋白以帮助蛋白质折叠，从而产生结晶杀虫蛋白质。通过单一转化事件表达Mer操纵子，导致植物修复系统。

10. 发明申请

WO2012006622A2 IMPROVED AGRONOMIC TRAITS VIA GENETICALLY INDUCED ELEVATION OF PHYTOHORMONE LEVELS IN PLANTS 审中-公开
标题翻译：改良的农业旅游通过遗传性诱导植物中的植酸盐水平升高
公开(公告)号：WO2012006622A2
公开(公告)日：2012-01-12
申请号：PCT/US2011043565
申请日：2011-07-11
申请人： UNIV CENTRAL FLORIDA RES FOUND , DANIELL HENRY
发明人： DANIELL HENRY
IPC分类号： A01H5/00 , C12N15/56 , C12N15/82
CPC分类号： C12N15/8261 , C12N9/2445 , C12N15/827 , C12N15/8286 , C12N15/8291 , C12N15/8297 , C12Y302/01021 , Y02A40/146 , Y02A40/162
摘要： Disclosed herein are transgenic plants that have been modified to express ß-glucosidase, and methods and materials for making same. The transgenic plants possess several advantageous features including increased biomass, increased trichome density and increased parasite resistance.
摘要翻译：本文公开了已经被修饰以表达β-葡糖苷酶的转基因植物，以及用于制备其的方法和材料。转基因植物具有几个有利的特征，包括增加的生物量，增加的绒毛密度和增加的寄生虫抗性。

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