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1. 发明申请

WO2006019962A1 COMPOSITIONS AND METHODS FOR TREATMENT OF COLITIS 审中-公开
标题翻译：用于治疗结肠炎的组合物和方法
公开(公告)号：WO2006019962A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/025067
申请日：2005-07-14
申请人： INTERTHYR CORPORATION , KOHN, Leonard, D. , GOETZ, Douglas, J. , BENAVIDES-PERALTA, Uruguaysito , GONZALEZ-MURGUIONDO, Marianna , HARII, Norikazu , LEWIS, Christopher, J. , NAPOLITANO, Giorgio , DAGIA, Nilesh, D.
发明人： KOHN, Leonard, D. , GOETZ, Douglas, J. , BENAVIDES-PERALTA, Uruguaysito , GONZALEZ-MURGUIONDO, Marianna , HARII, Norikazu , LEWIS, Christopher, J. , NAPOLITANO, Giorgio , DAGIA, Nilesh, D.
IPC分类号： A61K31/4164
CPC分类号： A61K31/4164 , Y02A50/402 , Y02A50/411
摘要： The present invention relates to the treatment of inflammatory bowel disease (IBD) and related gastrointestinal pathologies. This invention also relates to the treatment of cytokine-mediated diseases, including tumor necrosis factor-α (TNFα)-induced diseases and/or chemokine-mediated diseases. This invention also relates to treating an animal having a disease or condition associated with Toll-like receptor (4). Specifically, the present invention relates to the treatment of inflammatory bowel disease (IBD) and related gastrointestinal pathologies that are cytokine-mediated or associated with Toll-like receptor (4). More specifically, this invention is directed to methods for treating or preventing IBD and related gastrointestinal pathologies using methimazole derivatives and tautomeric cyclic thiones. This invention is also directed to pharmaceutical compositions containing methimazole derivatives and tautomeric cyclic thiones, which are useful for the treatment or prophylaxis of IBD and related gastrointestinal pathologies. This invention also relates to pharmaceutical formulations capable of inhibiting tumor necrosis factor-α (TNFα)-induced vascular cell adhesion molecule-1 (VCAM-1) expression and the resulting leukocyte-endothelial cell adhesion for the inhibition and prevention of inflammatory bowel syndrome and related gastrointestinal pathologies.
摘要翻译：本发明涉及治疗炎性肠病（IBD）和相关的胃肠病理。本发明还涉及治疗细胞因子介导的疾病，包括肿瘤坏死因子-α（TNFα）诱导的疾病和/或趋化因子介导的疾病。本发明还涉及治疗具有与Toll样受体（4）相关的疾病或病症的动物。具体而言，本发明涉及炎症性肠病（IBD）和细胞因子介导的或与Toll样受体（4）相关的相关胃肠病理的治疗。更具体地，本发明涉及使用甲巯咪唑衍生物和互变异构环状硫酮治疗或预防IBD和相关胃肠病理的方法。本发明还涉及含有甲巯咪唑衍生物和互变异构环状硫堇的药物组合物，其可用于治疗或预防IBD和相关的胃肠病理。本发明还涉及能够抑制肿瘤坏死因子-α（TNFα） - 诱导的血管细胞粘附分子-1（VCAM-1）表达和由此产生的白细胞 - 内皮细胞粘附的药物制剂，用于抑制和预防炎性肠综合征和相关的胃肠病变。

2. 发明申请

WO2006019962B1 COMPOSITIONS AND METHODS FOR TREATMENT OF COLITIS 审中-公开
标题翻译：用于治疗患者的组合物和方法
公开(公告)号：WO2006019962B1
公开(公告)日：2006-04-20
申请号：PCT/US2005025067
申请日：2005-07-14
申请人： INTERTHYR CORP , KOHN LEONARD D , GOETZ DOUGLAS J , BENAVIDES-PERALTA URUGUAYSITO , GONZALEZ-MURGUIONDO MARIANNA , HARII NORIKAZU , LEWIS CHRISTOPHER J , NAPOLITANO GIORGIO , DAGIA NILESH D
发明人： KOHN LEONARD D , GOETZ DOUGLAS J , BENAVIDES-PERALTA URUGUAYSITO , GONZALEZ-MURGUIONDO MARIANNA , HARII NORIKAZU , LEWIS CHRISTOPHER J , NAPOLITANO GIORGIO , DAGIA NILESH D
IPC分类号： A61K31/4164 , A61P1/04
CPC分类号： A61K31/4164
摘要： The present invention relates to the treatment of inflammatory bowel disease (IBD) and related gastrointestinal pathologies. This invention also relates to the treatment of cytokine-mediated diseases, including tumor necrosis factor-a (TNFa)-induced diseases and/or chemokine-mediated diseases. This invention also relates to treating an animal having a disease or condition associated with Toll-like receptor (4). Specifically, the present invention relates to the treatment of inflammatory bowel disease (IBD) and related gastrointestinal pathologies that are cytokine-mediated or associated with Toll-like receptor (4). More specifically, this invention is directed to methods for treating or preventing IBD and related gastrointestinal pathologies using methimazole derivatives and tautomeric cyclic thiones. This invention is also directed to pharmaceutical compositions containing methimazole derivatives and tautomeric cyclic thiones, which are useful for the treatment or prophylaxis of IBD and related gastrointestinal pathologies. This invention also relates to pharmaceutical formulations capable of inhibiting tumor necrosis factor-a (TNFa)-induced vascular cell adhesion molecule-1 (VCAM-1) expression and the resulting leukocyte-endothelial cell adhesion for the inhibition and prevention of inflammatory bowel syndrome and related gastrointestinal pathologies.
摘要翻译：本发明涉及炎症性肠病（IBD）和相关胃肠道病理学的治疗。本发明还涉及细胞因子介导的疾病的治疗，包括肿瘤坏死因子-α（TNFα）诱导的疾病和/或趋化因子介导的疾病。本发明还涉及治疗具有与Toll样受体相关的疾病或病症的动物（4）。具体地，本发明涉及炎性肠病（IBD）和细胞因子介导的或与Toll样受体相关的相关胃肠道病理学的治疗（4）。更具体地，本发明涉及使用甲巯咪唑衍生物和互变异构环状硫堇治疗或预防IBD和相关胃肠道病理学的方法。本发明还涉及含有甲巯咪唑衍生物和互变异构环状硫堇的药物组合物，其可用于治疗或预防IBD和相关的胃肠道病理。本发明还涉及能够抑制肿瘤坏死因子-α（TNFα）诱导的血管细胞粘附分子-1（VCAM-1）表达的药物制剂以及由此产生的白细胞内皮细胞粘附以抑制和预防炎症性肠综合征，相关的胃肠道病变。

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