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1. 发明申请

WO2010132479A2 METHODS FOR THE DIAGNOSIS OF METABOLIC DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS 审中-公开
标题翻译：使用EPIMETABOLIC SHIFTERS，多发性细胞内分子或环境影响因素诊断代谢性疾病的方法
公开(公告)号：WO2010132479A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034420
申请日：2010-05-11
申请人： CYTOTECH LABS, LLC , NARAIN, Niven, Rajin , MCCOOK, John, Patrick , SARANGARAJAN, Rangaprasad
发明人： NARAIN, Niven, Rajin , MCCOOK, John, Patrick , SARANGARAJAN, Rangaprasad
IPC分类号： G01N33/68 , C12Q1/68 , C40B40/10 , C40B40/08
CPC分类号： C12Q1/6886 , A61K31/00 , A61K31/122 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5735 , G01N33/57484 , G01N2570/00 , G01N2800/042 , G01N2800/52
摘要： Methods and formulations for diagnosing metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
摘要翻译：描述了使用代谢转移酶，多维细胞内分子或环境影响因子诊断人类代谢紊乱的方法和制剂。

2. 发明申请

WO2011112900A2 INTRAVENOUS FORMULATIONS OF COENZYME Q10 (COQ10) AND METHODS OF USE THEREOF 审中-公开
标题翻译： COENZYME Q10（COQ10）的内在配方及其使用方法
公开(公告)号：WO2011112900A2
公开(公告)日：2011-09-15
申请号：PCT/US2011028042
申请日：2011-03-11
申请人： CYTOTECH LABS LLC , NARAIN NIVEN RAJIN , MCCOOK JOHN PATRICK
发明人： NARAIN NIVEN RAJIN , MCCOOK JOHN PATRICK
IPC分类号： A61K9/127 , A61K9/107 , A61K31/122 , A61K47/30 , A61P35/00
CPC分类号： A61K31/122 , A61K9/0019 , A61K9/10 , A61K47/24 , A61K47/34
摘要： Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogenization by (1) adding hydrophobic active agent to a 65°C bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65°C to form a hydrophobic active agent/water/stabilizer mixture; (3) adding an opsonization reducer to form a hydrophobic active agent/water/stabilizer/reducer mixture; (4) pre-heating a Microfluidizer to 65°C; and (5) processing by mixing the hydrophobic active agent/water/stabilizer/reducer mixture in the Microfluidizer at 65°C such that a hydrophobic active agent colloidal nano-dispersion having a mean particle size less than 200-nm is formed. Provided herein are also methods of treating oncological disorders by administering formulations described herein to a subject such that treatment or prevention of the oncological disorder occurs.
摘要翻译：本文公开了适用于胃肠外施用某些疏水活性剂如辅酶Q10的制剂。本发明还提供了制备方法和使用其的肿瘤疾病治疗方法。制剂包含水溶液; 分散以形成粒子的胶态纳米分散体的疏水性活性剂; 和分散稳定剂和调理剂还原剂中的至少一种，其中活性剂的胶体纳米分散体分散在平均粒度小于200nm的纳米分散体颗粒中。制备肠胃外制剂的方法包括通过（1）向65℃的水浴中加入疏水活性剂并混合以形成疏水活性剂/水混合物，通过高压均质分散疏水活性剂; （2）向疏水活性剂/水混合物中加入分散稳定剂，并在65℃下混合形成疏水活性剂/水/稳定剂混合物; （3）加入调理剂还原剂以形成疏水活性剂/水/稳定剂/还原剂混合物; （4）将微流化器预热至65℃; 和（5）通过将微流化剂中的疏水性活性剂/水/稳定剂/还原剂混合物在65℃下混合进行处理，从而形成平均粒度小于200nm的疏水性活性剂胶体纳米分散体。本文还提供了通过将本文所述的制剂施用于受试者来治疗肿瘤疾病的方法，使得发生肿瘤病症的治疗或预防。

3. 发明申请

WO2011031503A2 METHODS FOR TREATMENT OF A SARCOMA USING AN EPIMETABOLIC SHIFTER (COENZYME Q10) 审中-公开
标题翻译：治疗SARCOMA的方法使用EPIMETABOLIC SHIFTER（COENZYME Q10）
公开(公告)号：WO2011031503A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/046711
申请日：2010-08-25
申请人： CYTOTECH LABS, LLC , SARANGARAJAN, Rangaprasad , NARAIN, Niven, Rajin , MCCOOK, John, Patrick
发明人： SARANGARAJAN, Rangaprasad , NARAIN, Niven, Rajin , MCCOOK, John, Patrick
IPC分类号： A61K31/122 , A61P35/00
CPC分类号： A61K31/122 , A61K9/0014 , A61K9/06 , A61K35/12 , A61K39/395 , A61K47/10 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/57407 , G01N2800/50 , G01N2800/52 , G01N2800/54 , G01N2800/56 , G01N2800/60 , A61K2300/00
摘要： Methods and formulations for treating a sarcoma in humans using an epimetabolic shifter, such as Coenzyme QlO, a building block of CoQlO, a derivative of CoQlO, an analog of CoQlO, a metabolite of CoQlO, or an intermediate of the coenzyme biosynthesis pathway, are described. Methods for assessing the efficacy of treatment of, diagnosing, and prognosing sarcoma are also provided.
摘要翻译：使用表面代谢转移剂如辅酶Q10，CoQ10的构建块，CoQ10的衍生物，CoQ10的类似物，CoQ10的代谢物或辅酶生物合成途径的中间体来治疗人的肉瘤的方法和制剂是描述。还提供了评估治疗，诊断和预后肉瘤功效的方法。

4. 发明申请

WO2011112900A3 INTRAVENOUS FORMULATIONS OF COENZYME Q10 (COQ10) AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2011112900A3
公开(公告)日：2011-09-15
申请号：PCT/US2011/028042
申请日：2011-03-11
申请人： CYTOTECH LABS, LLC , NARAIN, Niven, Rajin , MCCOOK, John, Patrick
发明人： NARAIN, Niven, Rajin , MCCOOK, John, Patrick
IPC分类号： A61K9/127 , A61K9/107 , A61K47/30 , A61K31/122 , A61P35/00
摘要： Disclosed herein are formulations suitable for parenteral administration of certain hydrophobic active agents such as Coenzyme Q10. Methods of preparing the same and methods of treatment of oncological disorders using the same are also provided herein. The formulations comprise an aqueous solution; a hydrophobic active agent dispersed to form a colloidal nano-dispersion of particles; and at least one of a dispersion stabilizing agent and an opsonization reducer wherein the colloidal nano-dispersion of the active agent is dispersed into nano-dispersion particles having a mean size of less than 200-nm. Methods of preparing the parenteral formulations comprise dispersing the hydrophobic active agent by high pressure homogenization by (1) adding hydrophobic active agent to a 65°C bath of water and mixing to form a hydrophobic active agent/water mixture; (2) adding a dispersion stabilizing agent to the hydrophobic active agent/water mixture and mix at 65°C to form a hydrophobic active agent/water/stabilizer mixture; (3) adding an opsonization reducer to form a hydrophobic active agent/water/stabilizer/reducer mixture; (4) pre-heating a Microfluidizer to 65°C; and (5) processing by mixing the hydrophobic active agent/water/stabilizer/reducer mixture in the Microfluidizer at 65°C such that a hydrophobic active agent colloidal nano-dispersion having a mean particle size less than 200-nm is formed. Provided herein are also methods of treating oncological disorders by administering formulations described herein to a subject such that treatment or prevention of the oncological disorder occurs.

5. 发明申请

WO2010088304A1 VITAMIN D3 AND ANALOGS THEREOF FOR ALLEVIATING SIDE EFFECTS ASSOCIATED WITH CHEMOTHERAPY 审中-公开
标题翻译：维生素D3及其与化疗相关的副作用的模拟
公开(公告)号：WO2010088304A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022284
申请日：2010-01-27
申请人： CYTOTECH LABS, LLC , JIMENEZ, Joaquin, J. , MCCOOK, John, Patrick , NARAIN, Niven, Rajin
发明人： JIMENEZ, Joaquin, J. , MCCOOK, John, Patrick , NARAIN, Niven, Rajin
IPC分类号： A61K31/593 , A61K45/06 , A61K38/18 , A61K38/19 , A61P7/06 , A61P7/04 , A61P35/00
CPC分类号： A61K31/593 , A61K38/1816 , A61K38/193 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to the use of vitamin D compounds, such as vitamin D3, or analogs and/or metabolites thereof, to modulate bone marrow progenitors and stromal cells prior to the administration of antineoplastic agents. The methods of the present disclosure may ameliorate myelosuppression by increasing the availability of pluripotent stem cell progenitors, and can be used in combination with standard therapy (e.g. granulocyte stimulating factor) to increase proliferation of myeloid cells and/or improve their mobilization from the bone marrow, thereby diminishing the dose and administration of colony- stimulating factors (CSFs) as well as the recuperation time following chemotherapy.
摘要翻译：本公开涉及维生素D化合物（例如维生素D3或其类似物和/或代谢物）在施用抗肿瘤剂之前调节骨髓祖细胞和基质细胞的用途。本公开的方法可以通过增加多能干细胞祖细胞的可用性来改善骨髓抑制，并且可以与标准治疗（例如粒细胞刺激因子）组合使用以增加骨髓细胞的增殖和/或改善其从骨髓的动员，从而减少了集落刺激因子（CSF）的剂量和施用以及化疗后的恢复时间。

6. 发明申请

WO2009094619A1 ASSAY SYSTEM FOR THE ASSESSMENT OF ONCOGENICITY, TUMOR PROGRESSION, AND TREATMENT EFFICACY 审中-公开
标题翻译：用于评估致敏性，肿瘤进展和治疗效果的测定系统
公开(公告)号：WO2009094619A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031957
申请日：2009-01-26
申请人： CYTOTECH LABS, LLC , NARAIN, Niven, Rajin , PERSAUD, Indushekhar
发明人： NARAIN, Niven, Rajin , PERSAUD, Indushekhar
IPC分类号： G01N33/53 , G01N33/48
CPC分类号： G01N33/574
摘要： Systems and kits are provided which are capable of determining the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment. Such systems and kits utilize assays to examine the levels of apoptotic markers, angiogenesis markers, immunomodulation markers, and cell cycle markers and can compare samples from a patient taken at different times to determine the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment. Methods for determining the oncogenicity of a cancer, tumor progression, and effectiveness of a cancer treatment with such systems and kits are also provided.
摘要翻译：提供了能够确定癌症的致癌性，肿瘤进展和癌症治疗的有效性的系统和试剂盒。这样的系统和试剂盒利用测定法来检测凋亡标志物，血管生成标志物，免疫调节标记物和细胞周期标记物的水平，并且可以比较在不同时间拍摄的患者的样品，以确定癌症的致癌性，肿瘤进展和有效性癌症治疗。还提供了用这种系统和试剂盒测定癌症的致癌性，肿瘤进展和癌症治疗的有效性的方法。

7. 发明申请

WO2011019617A2 VITAMIN D3 AND ANALOGS THEREOF FOR TREATING ALOPECIA 审中-公开
标题翻译：维生素D3及其治疗ALOPECIA的模拟物
公开(公告)号：WO2011019617A2
公开(公告)日：2011-02-17
申请号：PCT/US2010/044765
申请日：2010-08-06
申请人： CYTOTECH LABS, LLC , JIMENEZ, Joaquin, J. , NARAIN, Niven, Rajin , MCCOOK, John, Patrick
发明人： JIMENEZ, Joaquin, J. , NARAIN, Niven, Rajin , MCCOOK, John, Patrick
IPC分类号： A61K31/593 , A61K31/592 , A61K31/59 , A61K8/67 , A61P17/14 , A61Q9/04
CPC分类号： A61K45/06 , A61K8/67 , A61K31/59 , A61K31/592 , A61K31/593 , A61Q7/00 , A61K2300/00
摘要： The invention provides methods and pharmaceutical compositions for preventing or treating alopecia, such as chemotherapy-induced alopecia (CIA). The pharmaceutical compositions of the invention comprises an effective amount of a vitamin D compound in a formulation that topically delivers the vitamin D compound to the epidermis layer but substantially avoids the dermis layer. In chemotherapy patients, the pharmaceutical compositions of the invention can be administered either before or concurrent with the chemotherapy medication.
摘要翻译：本发明提供了用于预防或治疗脱发的方法和药物组合物，例如化学疗法诱发的脱发（CIA）。本发明的药物组合物包含有效量的维生素D化合物，该制剂将维生素D化合物局部递送至表皮层，但基本上避免了真皮层。在化疗患者中，本发明的药物组合物可以在化疗药物之前或同时施用。

8. 发明申请

WO2010132507A2 METHODS FOR TREATMENT OF DISEASE USING AN EPIMETABOLIC SHIFTER (COENZYME Q10) 审中-公开
标题翻译：使用EPIMETABOLIC SHIFTER治疗疾病的方法（COENZYME Q10）
公开(公告)号：WO2010132507A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034453
申请日：2010-05-11
申请人： CYTOTECH LABS, LLC , NARAIN, Niven, Rajin , MCCOOK, John, Patrick
发明人： NARAIN, Niven, Rajin , MCCOOK, John, Patrick
IPC分类号： A61K31/122 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/00 , A61K31/122 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5735 , G01N33/57484 , G01N2570/00 , G01N2800/042 , G01N2800/52
摘要： Methods and formulations for treating oncological disorders in humans using Coenzyme Q10 are described.
摘要翻译：描述了使用辅酶Q10治疗人类肿瘤疾病的方法和制剂。

9. 发明申请

WO2010132440A2 METHODS FOR TREATMENT OF ONCOLOGICAL DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS 审中-公开
标题翻译：使用EPIMETABOLIC SHIFTERS，多发性细胞内分子或环境影响因子治疗肿瘤疾病的方法
公开(公告)号：WO2010132440A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/034376
申请日：2010-05-11
申请人： CYTOTECH LABS, LLC , NARAIN, Niven, Rajin , MCCOOK, John, Patrick , SARANGARAJAN, Rangaprasad
发明人： NARAIN, Niven, Rajin , MCCOOK, John, Patrick , SARANGARAJAN, Rangaprasad
IPC分类号： A61K31/122 , A61P35/00
CPC分类号： C12Q1/6886 , A61K31/00 , A61K31/122 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N33/5735 , G01N33/57484 , G01N2570/00 , G01N2800/042 , G01N2800/52
摘要： Methods and formulations for treating oncological disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
摘要翻译：描述了使用外消旋移位器，多维细胞内分子或环境影响剂治疗人类肿瘤疾病的方法和制剂。

10. 发明申请

WO2009073843A1 INHALABLE COMPOSITIONS HAVING ENHANCED BIOAVAILABILITY 审中-公开
标题翻译：具有增强生物利用度的可吸收组合物
公开(公告)号：WO2009073843A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085669
申请日：2008-12-05
申请人： CYTOTECH LABS, LLC , PERSAUD, Indushekhar , McCOOK, John, Patrick , NARAIN, Niven, Rajin
发明人： PERSAUD, Indushekhar , McCOOK, John, Patrick , NARAIN, Niven, Rajin
IPC分类号： A01N43/16 , A61K31/35
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/127 , A61K9/1617 , A61K9/1623
摘要： The present disclosure provides methods and compositions suitable for delivering lipophilic bioactive agents. The compositions may be utilized to treat numerous diseases and conditions that would benefit from the application of a lipophilic bioactive agent. In embodiments the compositions may be introduced by inhalation.
摘要翻译：本公开提供适于递送亲脂性生物活性剂的方法和组合物。组合物可以用于治疗可以从应用亲脂性生物活性剂中受益的许多疾病和病症。在实施方案中，可以通过吸入引入组合物。

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