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1. 发明申请

WO2009011804A3 REDUCED ELEVATION CATALYST RETURN LINE FOR A FLUID CATALYTIC CRACKING UNIT 审中-公开
标题翻译：用于流体催化裂化装置的减压高温催化剂返回管
公开(公告)号：WO2009011804A3
公开(公告)日：2009-12-10
申请号：PCT/US2008008548
申请日：2008-07-11
申请人： EXXONMOBIL RES & ENG CO , CUNNINGHAM BRIAN A , SMALLEY CHRISTOPER G , DAVULURI RATHNA P , NOURI DANA W
发明人： CUNNINGHAM BRIAN A , SMALLEY CHRISTOPER G , DAVULURI RATHNA P , NOURI DANA W
IPC分类号： B01J8/00 , B01J8/26 , C10G11/18
CPC分类号： B01J8/0015 , C10G11/18 , C10G11/182 , C10G2300/301
摘要： The present invention is an improved regenerated catalyst bend assembly for a fluid catalytic cracking unit. In one embodiment, the regenerated catalyst conduit (200) for fluidly connecting a regenerator standpipe (55) to a reactor riser (1) of a fluid catalytic cracking unit comprises: a) a first bend with a bend radious, R1, and an inlet end and an outlet end; and b) a second bend with a bend radious, R2, and an inlet end and an outlet end; wherein the inlet end of the first bend is physically connected to the outlet end of the regenerator standpipe (55), the outlet end of the first bend is physically connected to the inlet end of the second bend, the outlet end of the second bend is physically connected to the inlet end of the reactor riser (1), and R1 is not equal to R2. I another embodiment, the conduit comprises a bend with radius, RREL, and a bend inlet end and a bend outlet end; and b) a conduit inlet end and a conduit outlet end; wherein the inlet end of the conduit is physically connected to the outlet end of the regenerator standpipe, and the outlet end of the conduit is physically connected to the reactor riser, wherein the centerline of the reactor riser and the centerline of the outlet end of the conduit are at substantially a 90° angle. The present invention is especially useful in the modification of existing fluid catalytic cracking units to lower the elevation of the outlet of the regenerated catalyst return line assembly, thereby providing needed space to increase the fluid catalytic cracking reactor riser length.
摘要翻译：本发明是用于流化催化裂化装置的改进的再生催化剂弯曲组件。在一个实施例中，用于将再生器立管（55）流体连接到流化催化裂化装置的反应器提升管（1）的再生催化剂导管（200）包括：a）具有弯曲的第一弯曲，R1和入口端部和出口端; 和b）具有弯曲的第二弯曲部R2，以及入口端和出口端; 其中所述第一弯管的入口端物理连接到所述再生器立管（55）的出口端，所述第一弯头的出口端物理连接到所述第二弯管的入口端，所述第二弯管的出口端物理连接到反应器提升管（1）的入口端，R1不等于R2。在另一个实施例中，导管包括具有半径的弯曲部，RREL以及弯曲入口端部和弯曲出口端部; 和b）导管入口端和导管出口端; 其中导管的入口端物理地连接到再生器立管的出口端，并且导管的出口端物理连接到反应器提升管，其中反应器提升管的中心线和出口端的中心线管道基本上为90°角。本发明特别可用于改进现有的流化催化裂化装置以降低再生催化剂返回管线组件的出口的高度，从而提供所需的空间以增加流化催化裂化反应器提升管的长度。

2. 发明申请

WO2009089006A1 LABEL-FREE BIOSENSORS BASED UPON DISTRIBUTED FEEDBACK LASER 审中-公开
标题翻译：基于分布式反馈激光器的无标签生物传感器
公开(公告)号：WO2009089006A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/000073
申请日：2009-01-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , CUNNINGHAM, Brian, T. , LU, Meng
发明人： CUNNINGHAM, Brian, T. , LU, Meng
IPC分类号： C12M1/34
CPC分类号： G01N21/7743 , G01N2021/7709
摘要： A biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two- dimensional dielectric grating coated with a laser dye-doped polymer as the gain medium. A sensor is also described in which the grating layer and the active layer are combined into a single layer. DFB lasers using an inorganic or organic thin film with alternating regions of high and low index of refraction as the active layer are also disclosed. The sensor actively generates its own narrowband high intensity light output without stringent requirements for coupling alignment, thereby resulting in a simple, robust illumination and detection configuration.
摘要翻译：公开了一种基于垂直发射分布反馈（DFB）激光器的生物传感器。在一种配置中，DFB激光器包括涂覆有激光染料掺杂聚合物作为增益介质的复制模制的一维或二维介质光栅。还描述了传感器，其中光栅层和有源层被组合成单层。还公开了使用具有高折射率和低折射率的交替区域的无机或有机薄膜作为活性层的DFB激光器。传感器主动产生自己的窄带高强度光输出，无需对耦合对准的严格要求，从而产生简单，鲁棒的照明和检测配置。

3. 发明申请

WO2008123927A1 BIOSENSORS WITH POROUS DIELECTRIC SURFACE FOR FLUORESCENCE ENHANCEMENT AND METHODS OF MANUFACTURE 审中-公开
标题翻译：用于荧光增强的多孔介电表面生物传感器及其制造方法
公开(公告)号：WO2008123927A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/003854
申请日：2008-03-24
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , ZHANG, Wei , CUNNINGHAM, Brian, T.
发明人： ZHANG, Wei , CUNNINGHAM, Brian, T.
IPC分类号： C12Q1/00
CPC分类号： G01N21/648 , B82Y15/00 , B82Y20/00 , G01N21/7743 , G01N2021/7726 , G02B6/1226
摘要： Biosensors are disclosed which include a surface for binding to sample molecule to the biosensor in the form of a porous, thin film of dielectric material, e.g., TiO2. In one example the porous, thin film is in the form of a multitude of sub-micron sized rod-like structures ("nanorods") projecting therefrom. In one embodiment, the biosensor is in the form of a photonic crystal biosensor. The approach of depositing a thin film of dielectric nanorods may be applied to any enhanced fluorescence biosensor surface structure, including 1 -dimensional photonic crystals, 2-dimensional photonic crystals, 3-dimensional photonic crystals, surface plasmon resonance surfaces, planar waveguides, and grating-coupled waveguides. The dielectric nanorod structures can be fabricated on the surface of a biosensor by the glancing angle deposition technique (GLAD).
摘要翻译：公开了生物传感器，其包括以多孔的电介质材料薄膜（例如TiO 2）的形式将样品分子结合到生物传感器的表面。在一个示例中，多孔薄膜是从其突出的多个亚微米尺寸的棒状结构（“纳米棒”）的形式。在一个实施例中，生物传感器是光子晶体生物传感器的形式。沉积电介质纳米棒薄膜的方法可以应用于任何增强的荧光生物传感器表面结构，包括1维光子晶体，2维光子晶体，3维光子晶体，表面等离子体共振表面，平面波导和光栅耦合波导。介电纳米棒结构可以通过扫眼角沉积技术（GLAD）在生物传感器的表面上制造。

4. 发明申请

WO2008008247A3 NEAR ULTRAVIOLET-WAVELENGTH PHOTONIC-CRYSTAL BIOSENSOR WITH ENHANCED SURFACE TO BULK SENSITIVITY RATIO 审中-公开
公开(公告)号：WO2008008247A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/015448
申请日：2007-07-02
申请人： The Board of Trustees of the University of Illinois , SRU BIOSYSTEMS, INC. , CUNNINGHAM, Brian, T. , BLOCK, Ian, D. , GANESH, Nikhil
发明人： CUNNINGHAM, Brian, T. , BLOCK, Ian, D. , GANESH, Nikhil
IPC分类号： G01N21/47 , G01N21/25 , G02B5/18 , G01N33/551 , B01L3/00 , G01N33/552
摘要： Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled- Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.

5. 发明申请

WO2007008440A2 PHOTONIC CRYSTAL BIOSENSOR STRUCTURE AND FABRICATION METHOD 审中-公开
标题翻译：光电晶体生物传感器结构与制造方法
公开(公告)号：WO2007008440A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/025400
申请日：2006-06-29
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , CUNNINGHAM, Brian, T. , BLOCK, Ian , CHAN, Leo Li-Ying
发明人： CUNNINGHAM, Brian, T. , BLOCK, Ian , CHAN, Leo Li-Ying
IPC分类号： B01L3/00 , G01N21/25 , G01N21/47
CPC分类号： G01N21/7743 , B82Y20/00 , C12M23/20 , C12M41/36 , G01N2021/7776 , G02B6/1225
摘要： The invention provides sensor compositions and method of making sensors.
摘要翻译：本发明提供了传感器组成和制造传感器的方法。

6. 发明申请

WO2004102193A2 DETECTION OF BIOCHEMICAL INTERACTIONS ON A BIOSENSOR USING TUNABLE FILTERS AND TUNABLE LASERS 审中-公开
标题翻译：使用TUNABLE过滤器和柔性激光检测生物传感器的生物化学相互作用
公开(公告)号：WO2004102193A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014262
申请日：2004-05-07
申请人： SRU BIOSYSTEMS, LLC , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CUNNINGHAM, Brian, T. , LI, Peter, Y , CHANG-HASNAIN, Constance , MATEUS, Carlos
发明人： CUNNINGHAM, Brian, T. , LI, Peter, Y , CHANG-HASNAIN, Constance , MATEUS, Carlos
IPC分类号： G01N33/50
CPC分类号： G01N21/45 , G01N21/39 , G01N21/75 , G01N21/7743 , G01N33/54373
摘要： An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor. Molecular binding on the surface of the biosensor is indicated by a shift in the peak wavelength value of reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.
摘要翻译：提供了使用可调滤波器和可调谐激光器检测比色共振光学生物传感器的峰值波长值的装置和方法。可以在生物传感器上通过将准直的白光指向生物传感器的表面来检测生物分子相互作用。生物传感器表面上的分子结合由来自生物传感器的反射光或透射光的峰值波长值的偏移表示，而波长的增加对应于分子吸收的增加。可调谐激光源可以产生准直的白光，并且可调滤光器可以接收反射或透射的光并将光传递到光电二极管传感器。然后光电二极管传感器根据可调谐滤波器的调谐电压量化反射或透过可调谐滤波器的光量。

8. 发明申请

WO03064995A2 A GUIDED MODE RESONANT FILTER BIOSENSOR USING A LINEAR GRATING SURFACE STRUCTURE 审中-公开
标题翻译：引导模式谐振滤波器生物传感器使用线性光栅表面结构
公开(公告)号：WO03064995A2
公开(公告)日：2003-08-07
申请号：PCT/US0301175
申请日：2003-01-16
申请人： SRU BIOSYSTEMS LLC , CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , QIU JEAN , PIEN HOMER
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , QIU JEAN , PIEN HOMER
IPC分类号： B01L3/00 , G01N21/25 , G01N21/27 , G01N21/35 , G01N21/47 , G01N33/543 , G02B5/18 , G01N
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10S435/808 , Y10S436/805
摘要： Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high−throughput manner. The invention also provides optical devices useful as narrow band filters.
摘要翻译：提供了用于检测生物分子相互作用的方法和组合物。不需要使用标签，并且可以以高通量的方式执行方法。本发明还提供用作窄带滤波器的光学装置。

9. 发明申请

WO0244128A3 SALICYLATE ANALOGS AS INTERLEUKIN-4 ANTAGONISTS 审中-公开
标题翻译：脂质体模拟物作为白细胞介素-4拮抗剂
公开(公告)号：WO0244128A3
公开(公告)日：2003-03-13
申请号：PCT/US0144643
申请日：2001-11-27
申请人： SUNESIS PHARMACEUTICALS INC , BARR KENNETH J , CUNNINGHAM BRIAN C , FLANAGAN WILLIAM MICHAEL , LU WANLI , RAIMUNDO BRIAN C , WAAL NATHAN D , WILKINSON JENNIFER , ZHU JIANG , YANG WENJIN
发明人： BARR KENNETH J , CUNNINGHAM BRIAN C , FLANAGAN WILLIAM MICHAEL , LU WANLI , RAIMUNDO BRIAN C , WAAL NATHAN D , WILKINSON JENNIFER , ZHU JIANG , YANG WENJIN
IPC分类号： A61P19/00 , A61P29/00 , A61P37/00 , C07C65/105 , C07C65/19 , C07C233/87 , C07C235/42 , C07C235/48 , A61K31/166 , A61K31/192
CPC分类号： C07C235/48 , C07C65/105 , C07C65/19 , C07C233/87 , C07C235/42
摘要： Salicycate analogs of formula, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are interleukin-4 antagonists, and are useful for the treatment of asthma and allergies.
摘要翻译：式的脂环类似物，其制备方法，含有它们的药物组合物及其使用方法。化合物是白细胞介素-4拮抗剂，可用于治疗哮喘和过敏。

10. 发明申请

WO1997011178A1 HUMAN GROWTH HORMONE VARIANTS 审中-公开
标题翻译：人类生长激素变异
公开(公告)号：WO1997011178A1
公开(公告)日：1997-03-27
申请号：PCT/US1996014830
申请日：1996-09-20
申请人： GENENTECH, INC. , CUNNINGHAM, Brian, C. , LOWMAN, Henry, B. , WELLS, James, A. , CLARK, Ross, G. , OLSON, Kenneth , FUH, Germaine, G.
发明人： GENENTECH, INC.
IPC分类号： C12N15/18
CPC分类号： C07K14/61 , A61K38/00 , A61K47/60 , C07K2319/00 , Y10S514/866 , Y10S930/12
摘要： Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the in vivo half-life of the variants.
摘要翻译：公开了对生长激素受体具有增强的亲和力的人生长激素变体。还公开了与一种或多种化学基团缀合的人生长激素变体，例如聚（乙二醇），其被认为延长了变体的体内半衰期。

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