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1. 发明申请

WO1997003060A1 PIPERAZINE DERIVATIVES AND USE OF THE SAME 审中-公开
标题翻译：哌嗪衍生物及其用途
公开(公告)号：WO1997003060A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001884
申请日：1996-07-04
申请人： SENJU PHARMACEUTICAL CO., LTD. , INOUE, Jun , YOSHIDA, Yuka , CUI, Ying-She , AZUMA, Mitsuyoshi
发明人： SENJU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D303/48
CPC分类号： C07D303/48
摘要： Compounds represented by general formula (I) or salts thereof and a process for producing the same wherein R represents carboxy or carboxamide; R represents hydrogen or lower alkyl, or R may be bonded to R or R to thereby form a ring; R and R represent each hydrogen, lower alkyl or sulfide, or R and R may be bonded to each other to thereby form a ring; R represents substituted phenyl or substituted sulfonyl represented by general formula (III): -SO2-R (wherein R represents aryl or amino); and n is 0 or 1. Because of having the effect of inhibiting cysteine protease, the compounds are useful as a preventive or remedy for various diseases in which cysteine protease participates, for example, ischemic diseases, inflammation, muscular dystrophy, immunologic diseases, essential hypertension, Alzheimer's disease, subarachnoidal bleeding, osteoporosis, etc.
摘要翻译：由通式（I）表示的化合物或其盐及其制备方法，其中R 1表示羧基或羧酰胺; R 2表示氢或低级烷基，或R 2可以与R 3或R 4键合，从而形成环; R 3和R 4各自代表氢，低级烷基或硫化物，或者R 3和R 4可以彼此键合，从而形成环; R 5表示取代的苯基或由通式（III）表示的取代的磺酰基：-SO 2 -R 7（其中R 7表示芳基或氨基）; 并且n为0或1.由于具有抑制半胱氨酸蛋白酶的作用，所述化合物可用作预防或治疗半胱氨酸蛋白酶参与的各种疾病，例如缺血性疾病，炎症，肌营养不良症，免疫疾病，必需的高血压，阿尔茨海默病，蛛网膜下出血，骨质疏松症等

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