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1. 发明申请

WO2011156590A4 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT COMPOSITIONS 审中-公开
标题翻译：抗微生物，抗血栓形成组合物
公开(公告)号：WO2011156590A4
公开(公告)日：2012-07-05
申请号：PCT/US2011039792
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/14 , A61L29/04 , A61L29/08 , A61L31/04 , A61L31/10
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
摘要： The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
摘要翻译：本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。表面抗生物材料的粘附。

2. 发明申请

WO2011156589A4 NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS 审中-公开
标题翻译：非污染，抗微生物，抗血栓形成的移植物从组合物
公开(公告)号：WO2011156589A4
公开(公告)日：2012-06-28
申请号：PCT/US2011039790
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L29/08 , A61L29/02 , A61L29/04 , A61L29/14 , A61L29/16
CPC分类号： C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
摘要： A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37 C in 70 µg/mL fibrinogen derived from human plasma containing 1.4 µg/mL I-125 radiolabeled fibrinogen.
摘要翻译：用于制备和生成的制品的方法包括具有表面，表面下的块体和基体表面上的接枝聚合物层的基材，基材表面和接枝聚合物层组合构成改性表面，所述改性表面具有在纤维蛋白原结合试验中纤维蛋白原吸附小于约125ng / cm 2，其中修饰的表面在37℃下在70μg/ mL源自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。

3. 发明申请

WO2011156603A3 ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开
标题翻译：具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：WO2011156603A3
公开(公告)日：2012-04-26
申请号：PCT/US2011039806
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface
摘要翻译：本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层

4. 发明申请

WO2011156603A2 ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开
标题翻译：具有非浮选表面的制品及其制备方法，不改变物理性质
公开(公告)号：WO2011156603A2
公开(公告)日：2011-12-15
申请号：PCT/US2011039806
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP , WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
发明人： WEAVER DOUGLAS J K , LI JUN , ZHANG ZHENG , DELEAULT ABBY N , MARCHESE ERIC W , NGUYEN PHU C , HUVAL CHAD C , BOUCHARD MICHAEL A , COURY ARTHUR J , LOOSE CHRISTOPHER R
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface
摘要翻译：本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层

5. 发明申请

WO2013090801A1 MULTISTEP UV PROCESS TO CREATE SURFACE MODIFIED CONTACT LENSES 审中-公开
标题翻译： MULTISTEP UV工艺创建表面改性接触镜
公开(公告)号：WO2013090801A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069874
申请日：2012-12-14
申请人： SEMPRUS BIOSCIENCES CORP. , ZHANG, Zheng , COOK, Alonzo , SCHULTZ, Karen Ann , LI, Jun , LOOSE, Christopher R. , COURY, Arthur J.
发明人： ZHANG, Zheng , COOK, Alonzo , SCHULTZ, Karen Ann , LI, Jun , LOOSE, Christopher R. , COURY, Arthur J.
IPC分类号： C08G77/00 , C08J7/16 , C08J7/18 , C08F20/10 , G02C7/04
CPC分类号： C08G77/00 , B29D11/00038 , C08F265/00 , C08F290/068 , C08F290/148 , C08G77/06 , C08G77/442 , C08K5/0025
摘要： A process for modifying the surface of a silicon-containing polymer is presented, the process comprising the steps of: forming a silicon-containing polymer containing a photoinitiator in a first polymerization reaction mixture; forming a second polymerization reaction mixture comprising the silicon polymer, a polymerization monomer, a free radical initiator system and a solvent system; and polymerizing the monomer in the second reaction mixture to form a surface modification of the silicon-containing polymer. Such a process is useful in controlling the hydrophilicity of a surface, and can be applied to prepare medical devices such as contact lens having a wettable, biocompatible surface.
摘要翻译：提出了一种改性含硅聚合物表面的方法，该方法包括以下步骤：在第一聚合反应混合物中形成含有光引发剂的含硅聚合物; 形成包含硅聚合物，聚合单体，自由基引发剂体系和溶剂体系的第二聚合反应混合物; 并在第二反应混合物中聚合单体以形成含硅聚合物的表面改性。这种方法在控制表面的亲水性方面是有用的，并且可以用于制备诸如具有可湿性，生物相容性表面的隐形眼镜的医疗装置。

6. 发明申请

WO2013090790A1 SILICONE HYDROGEL CONTACT LENS MODIFIED USING LANTHANIDE OR TRANSITION METAL OXIDANTS 审中-公开
标题翻译：硅胶氢氧化物接触透镜改性使用土耳其或过渡金属氧化物
公开(公告)号：WO2013090790A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069859
申请日：2012-12-14
申请人： SEMPRUS BIOSCIENCES CORP. , JUN, Li , ZHANG, Zheng , LOOSE, Christopher R. , COURY, Arthur J.
发明人： JUN, Li , ZHANG, Zheng , LOOSE, Christopher R. , COURY, Arthur J.
IPC分类号： C08G77/38 , C08J7/16 , C08F20/10 , C08J5/00 , G02C7/04
CPC分类号： G02B1/043 , C08F20/10 , C08G77/38 , C08J7/16 , C08J2383/04 , G02C7/04 , C08L83/04 , C08L101/14
摘要： A process for modifying the surface of a silicon-containing polymer is presented, the process comprising the steps of: forming a reaction mixture comprising the silicon polymer, a polymerization monomer, a free radical initiator system, and a solvent system, the polymerization monomer comprising a zwitterionic monomer and the free radical redox initiator system comprising a Lanthanide or Transition metal oxidant; and polymerizing the monomer in the reaction mixture to form a surface modification polymer on the surface of the silicon-containing polymer. Such a process can be applied to prepare medical devices such as contact lens having a wettable, biocompatible surface.
摘要翻译：提出了一种改性含硅聚合物表面的方法，该方法包括以下步骤：形成包含硅聚合物，聚合单体，自由基引发剂体系和溶剂体系的反应混合物，所述聚合单体包含两性离子单体和包含镧系元素或过渡金属氧化剂的自由基氧化还原引发剂体系; 并在反应混合物中聚合单体以在含硅聚合物的表面上形成表面改性聚合物。这种方法可以应用于制备诸如具有可湿性，生物相容性表面的隐形眼镜的医疗装置。

7. 发明申请

WO2013090780A1 SURFACE MODIFIED CONTACT LENSES 审中-公开
标题翻译：表面改性接触镜
公开(公告)号：WO2013090780A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069846
申请日：2012-12-14
申请人： SEMPRUS BIOSCIENCES CORP. , ZHANG, Zheng , COOK, Alonzo , SCHULTZ, Karen Ann , LI, Jun , SKINNER, Matt , WEINSTOCK, B. Andre' , GUINEY, Linda, M. , WANG, Hao , LOOSE, Christopher, R. , COURY, Arthur, J.
发明人： ZHANG, Zheng , COOK, Alonzo , SCHULTZ, Karen Ann , LI, Jun , SKINNER, Matt , WEINSTOCK, B. Andre' , GUINEY, Linda, M. , WANG, Hao , LOOSE, Christopher, R. , COURY, Arthur, J.
IPC分类号： C08J7/04 , G02C7/04 , C08F20/10 , C09D133/04
CPC分类号： G02C7/049 , G02B1/043 , C08L83/04 , C08L101/14
摘要： Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.
摘要翻译：具有可湿性，生物相容性表面的医疗装置在本文中描述。还描述了用于制造这种装置的方法。

8. 发明申请

WO2011156603A4 ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES 审中-公开
公开(公告)号：WO2011156603A4
公开(公告)日：2011-12-15
申请号：PCT/US2011/039806
申请日：2011-06-09
申请人： SEMPRUS BIOSCIENCES CORP. , WEAVER, Douglas J.K. , LI, Jun , ZHANG, Zheng , DELEAULT, Abby N. , MARCHESE, Eric W. , NGUYEN, Phu C. , HUVAL, Chad C. , BOUCHARD, Michael A. , COURY, Arthur J. , LOOSE, Christopher R.
发明人： WEAVER, Douglas J.K. , LI, Jun , ZHANG, Zheng , DELEAULT, Abby N. , MARCHESE, Eric W. , NGUYEN, Phu C. , HUVAL, Chad C. , BOUCHARD, Michael A. , COURY, Arthur J. , LOOSE, Christopher R.
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L27/54 , A61L29/16 , A61L31/16
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.

9. 发明申请

WO2005115489A3 ADHERENT POLYMERIC COMPOSITIONS 审中-公开
标题翻译：附加聚合物组合物
公开(公告)号：WO2005115489A3
公开(公告)日：2006-04-27
申请号：PCT/US2005018159
申请日：2005-05-23
申请人： GENZYME CORP , JARRETT PETER K , MILLER ROBERT J , MESSIER KENNETH A , PHILBROOK C MICHAEL , KRAMER HILDEGARD M , KABLIK J JEFFREY , JOHNSTON ERIKA E , AVILA LUIS Z , COURY ARTHUR J
发明人： JARRETT PETER K , MILLER ROBERT J , MESSIER KENNETH A , PHILBROOK C MICHAEL , KRAMER HILDEGARD M , KABLIK J JEFFREY , JOHNSTON ERIKA E , AVILA LUIS Z , COURY ARTHUR J
IPC分类号： A61L15/16 , A61L24/00 , A61L24/04 , A61L27/34 , A61L31/06 , A61L31/10
CPC分类号： A61L31/06 , A61L24/0042 , A61L24/043 , A61L27/34 , A61L31/10 , C08L71/02
摘要： Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.
摘要翻译：本文描述的是粘合聚合物组合物和使用该组合物的方法。组合物附着在所施加的表面上。在某些实施方案中，组合物是可生物降解的和生物相容的，并且可以设计成具有针对不同手术和治疗应用的选择性的适应性和弹性。粘附的聚合物组合物包含聚合的大分子单体网络和在聚合的大分子单体中混合或缠结的添加剂。添加剂通过至少一个共价键或通过二次相互作用结合到表面上，并且不共价键合到聚合的大分子单体网络上。或者，添加剂通过至少一个共价键与表面键合，并且也结合到大分子单体网络上。所公开的组合物可以用作改进的屏障，涂层或药物递送系统，由于添加剂与施加的表面高度粘附。根据所使用的大分子单体和添加剂，本发明的组合物通常是无毒的，水可混溶的并具有适应性的特征。例如，特定的大分子单体可用于所施用组合物的靶向生物再吸收速率和/或降解速率。

10. 发明申请

WO2013090813A1 REDOX PROCESSES FOR CONTACT LENS MODIFICATION 审中-公开
标题翻译：用于接触镜片修改的REDOX工艺
公开(公告)号：WO2013090813A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069901
申请日：2012-12-14
申请人： SEMPRUS BIOSCIENCES CORP. , ZHANG, Zheng , LI, Jun , SKINNER, Matt , LOOSE, Christopher R. , COURY, Arthur J.
发明人： ZHANG, Zheng , LI, Jun , SKINNER, Matt , LOOSE, Christopher R. , COURY, Arthur J.
IPC分类号： C08G77/38 , C08J7/16 , C08F20/10 , C08J5/00 , G02C7/04
CPC分类号： G02B1/043 , B05D5/06 , G02C7/049 , C08L83/04 , C08L101/14
摘要： A process for modifying the surface of a silicon-containing polymer is presented, the process comprising the steps of: forming a reaction mixture comprising the silicon polymer, a polymerization monomer, a free radical initiator system and a solvent system, the polymerization monomer comprising a zwitterionic monomer and the free radical redox initiator system comprising a peroxide in the presence of a metal ion; and polymerizing the monomer in the reaction mixture to form a surface modification of the silicon-containing polymer. Such a process is useful in controlling the hydrophilicity of a surface, and can be applied to prepare medical devices such as contact lens having a wettable, biocompatible surface.
摘要翻译：提出了一种改性含硅聚合物表面的方法，该方法包括以下步骤：形成包含硅聚合物，聚合单体，自由基引发剂体系和溶剂体系的反应混合物，所述聚合单体包括两性离子单体和在金属离子存在下包含过氧化物的自由基氧化还原引发剂体系; 并在反应混合物中聚合单体以形成含硅聚合物的表面改性。这种方法在控制表面的亲水性方面是有用的，并且可以用于制备诸如具有可湿性，生物相容性表面的隐形眼镜的医疗装置。

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