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    • 3. 发明申请
    • NON-INVASIVE DETERMINATION OF OXYGEN SATURATION IN BLOOD IN DEEP TISSUE
    • 深层组织中血液中氧气饱和度的非侵入性测定
    • WO1998017174A1
    • 1998-04-30
    • PCT/AU1997000232
    • 1997-04-14
    • CARDIAC CRC NOMINEES PTY. LIMITEDCOOPER, Philip, George
    • CARDIAC CRC NOMINEES PTY. LIMITED
    • A61B05/14
    • A61B5/6838A61B5/14551A61B5/6814A61B5/6816A61B5/6826
    • A non-invasive method for determining the absolute level of oxygen saturation in blood in deep tissue including the steps of irradiating a target area of tissue with radiation of at least two distinct wavelengths at rest and after voluntarily hydrostatically perturbating the venous blood volume in the target tissue, providing a first set of signals that represents the absorption of the radiation at each wavelength at rest and a second set of signals that represents the absorption of the radiation at each wavelength after perturbation of the blood, subtracting the first set of signals from the second set of signals to provide a difference signal for each wavelength that represents the venous blood volume change as a consequence of the perturbation, and determining the ratio of the difference signals and comparing that ratio with the ratio determined in vitro to provide the absolute level of blood oxygen concentration. The method is carried out using a spectrometer (40) having three transmitting optodes (41, 42, 43) and a receiving optode (44).
    • 一种用于确定深部组织中血液中氧饱和度绝对水平的非侵入性方法,包括以下步骤:静息照射具有至少两个不同波长的辐射的组织的靶区域,并且在自愿地静态扰动靶中的静脉血容量 组织,提供表示在静止时的每个波长处的辐射的吸收的第一组信号和表示在扰动血液之后的每个波长处的辐射的吸收的第二组信号,从第二组信号中减去来自 第二组信号,作为扰动的结果,为表示静脉血容量变化的每个波长提供差分信号,并确定差异信号的比率,并将该比率与体外确定的比率进行比较,以提供绝对水平 血氧浓度。 该方法使用具有三个发射光电极(41,42,43)和接收光电(44)的光谱仪(40)进行。