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1. 发明申请

WO2019028196A1 SYSTEM AND METHOD FOR EARLY PREDICTION OF A PREDISPOSITION OF DEVELOPING PREECLAMPSIA WITH SEVERE FEATURES 审中-公开
公开(公告)号：WO2019028196A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/044897
申请日：2018-08-01
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CONVERGENT ENGINEERING, INC.
发明人： EULIANO, Neil Russell , EULIANO, Tammy Y. , MICHALOPOULOS, Konstantinos , SINGH, Savyasachi
IPC分类号： A61B5/00 , A61B5/021 , A61B5/024
摘要： A system and method for diagnosing and classifying preeclampsia-related conditions in a patient is provided. Also provided is a system and method for distinguishing preeclampsia-related conditions from other forms of hypertension that may be present in labor and delivery as well as distinguishing patients who will develop the more severe form of preeclampsia. The preeclampsia diagnosis and classification system utilizes non-invasive tests and comprises at least one sensor and a processor comprising a preeclampsia recognizer. In certain embodiments, the system further comprises a user interface.

2. 发明申请

WO2006116469A2 METHOD AND APPARATUS FOR DIAGNOSING RESPIRATORY DISORDERS AND DETERMINING THE DEGREE OF EXACERBATIONS 审中-公开
标题翻译：诊断呼吸系统疾病的方法和装置，并确定传播程度
公开(公告)号：WO2006116469A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015763
申请日：2006-04-25
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CONVERGENT ENGINEERING, INC. , MELKER, Richard, J. , EULIANO, Neil, R.
发明人： MELKER, Richard, J. , EULIANO, Neil, R.
IPC分类号： A61B5/08
CPC分类号： A61B5/4884 , A61B5/0205 , A61B5/02416 , A61B5/08 , A61B5/085 , A61B5/1073 , A61B5/14551 , A61B5/14552 , A61B5/411 , A61B5/4836 , A61B2560/0223 , A61M16/0069 , A61M16/1005 , A61M2205/3303 , A61M2205/3306 , A61M2205/502 , A61M2230/205
摘要： Disclosed herein are apparatuses and methods to monitor respiration and abnormal respiration events utilizing plethysmography. The apparatuses and methods provide an alternative to conventional respiration monitoring methods while enabling accurate yet minimally interruptive and invasive monitoring of respiration. The methods and apparatuses may be employed in the context of sleep studies to determine respiratory related sleep disorders.
摘要翻译：本文公开了利用体积描记法监测呼吸和异常呼吸事件的装置和方法。这些装置和方法提供了常规呼吸监测方法的替代方案，同时能够进行精确的，最小的中断和有创性的呼吸监测。可以在睡眠研究的上下文中使用方法和装置来确定呼吸相关的睡眠障碍。

3. 发明申请

WO2008073491A1 SYSTEM AND METHOD FOR ANALYZING PROGRESS OF LABOR AND PRETERM LABOR 审中-公开
标题翻译：用于分析劳动者和先进劳动者进步的系统和方法
公开(公告)号：WO2008073491A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/025495
申请日：2007-12-11
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CONVERGENT ENGINEERING, INC. , PRINCIPE, Jose, C. , MAROSERRO, Dorothee , EULIANO, Tammy, Y. , EULIANO, Neil, Russell, II
发明人： PRINCIPE, Jose, C. , MAROSERRO, Dorothee , EULIANO, Tammy, Y. , EULIANO, Neil, Russell, II
IPC分类号： A61B5/02 , A61B5/20
CPC分类号： A61B5/4356 , A61B5/04882 , A61B5/1107 , A61B5/7264 , A61B2503/02 , A61B2562/046 , G06F19/00
摘要： Systems and methods for monitoring uterus contraction activity and progress of labor. The system of the subject invention can comprises (1) a plurality of sensors; (2) an amplifying/filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, progress of labor, prediction and monitoring of preterm labor, and intrauterine pressure prediction. In a preferred embodiment, the system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis as well as delivery strategy.
摘要翻译：监测子宫收缩活动和劳动进展的系统和方法。本发明的系统可以包括（1）多个传感器; （2）放大/滤波装置; （3）计算装置; 和（4）图形用户界面。可以使用本发明的系统实时提取和提供给用户的准确临床数据包括但不限于劳动进展，早产预测和监测以及子宫内压力预测。在优选实施例中，本发明的系统包括智能手段，例如神经网络系统，用于分析和解释用于临床诊断的临床数据以及递送策略。

4. 发明申请

WO2005117692A3 MATERNAL-FETAL MONITORING SYSTEM 审中-公开
标题翻译：子宫监测系统
公开(公告)号：WO2005117692A3
公开(公告)日：2006-04-27
申请号：PCT/US2005018753
申请日：2005-05-27
申请人： UNIV FLORIDA , CONVERGENT ENGINEERING INC , MAROSSERO DOROTHEE , EULIANO TAMMY Y , EULIANO NEIL RUSSELL II , PRINCIPE JOSE C
发明人： MAROSSERO DOROTHEE , EULIANO TAMMY Y , EULIANO NEIL RUSSELL II , PRINCIPE JOSE C
IPC分类号： A61B5/0444 , A61B5/00 , A61B5/024 , A61B5/03 , A61B5/04 , A61B5/0452 , A61B5/0488 , A61B5/103 , A61B5/117 , A61B10/00 , G06F17/00
CPC分类号： A61B5/04882 , A61B5/0011 , A61B5/02411 , A61B5/033 , A61B5/0444 , A61B5/0452 , A61B5/4362 , A61B5/6805 , A61B5/6831 , A61B5/7264
摘要： A maternal-fetal monitoring system for use during all stages of pregnancy, including antepartum and intrapartum stages. The maternal-fetal monitoring system of the subject invention comprises (1) a set of sensors; (2) an amplifying/filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, maternal electrocardiogram (ECG) signals, maternal uterine activity signals (EHG), maternal heart rate, fetal ECG signals, and fetal heart rate. In a preferred embodiment, the maternal-fetal monitoring system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis antepartum, intrapartum and postpartum, as well as delivery strategy.
摘要翻译：孕产妇监测系统，用于怀孕期间的所有阶段，包括产前和产后阶段。本发明的母胎监测系统包括（1）一组传感器; （2）放大/滤波装置; （3）计算装置; 和（4）图形用户界面。可以使用本发明的系统实时提取和提供给用户的准确临床数据包括但不限于母体心电图（ECG）信号，母体子宫活动信号（EHG），母亲心率，胎儿心电图信号，和胎儿心率。在一个优选实施例中，本发明的母胎监测系统包括诸如神经网络系统的智能手段，用于分析和解释用于临床诊断产前，产后和产后的临床数据以及递送策略。

5. 发明申请

WO2013071095A1 SENSOR INTERFACE SYSTEM 审中-公开
标题翻译：传感器接口系统
公开(公告)号：WO2013071095A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064436
申请日：2012-11-09
申请人： CONVERGENT ENGINEERING, INC.
发明人： EULIANO, Neil, Russell , MAROSSERO, Dorothee , DARMANJIAN, Shalom , MCKENNA, Daniel, Patrick
IPC分类号： A61B8/02
CPC分类号： A61B5/7278 , A61B5/0011 , A61B5/02411 , A61B5/033 , A61B5/0444 , A61B5/0448 , A61B5/4356 , A61B5/4362 , A61B2560/045 , A61B2562/227 , F04C2270/041
摘要： A sensor interface system for providing a connection between at least one sensor and a maternal-fetal monitor, wherein the interface system converts electrical muscle activity captured by the sensor(s) into uterine activity data signals for use by the maternal-fetal monitor. The sensor interface system of the invention preferably includes a conversion means for converting the signals from the sensor(s) into signals similar to those produced by a tocodynamometer.
摘要翻译：一种传感器接口系统，用于提供至少一个传感器和母胎监护仪之间的连接，其中所述接口系统将由所述传感器捕获的电肌肉活动转换为子宫活动数据信号以供母胎监护仪使用。本发明的传感器接口系统优选地包括转换装置，用于将来自传感器的信号转换成类似于由变速器计算机产生的信号。

6. 发明申请

WO2008048760A1 ELECTRODE INTERFACE SYSTEM 审中-公开
标题翻译：电接口系统
公开(公告)号：WO2008048760A1
公开(公告)日：2008-04-24
申请号：PCT/US2007/078870
申请日：2007-09-19
申请人： CONVERGENT ENGINEERING, INC. , EULIANO, Neil, Russell, II , MAROSSERO, Dorothee
发明人： EULIANO, Neil, Russell, II , MAROSSERO, Dorothee
IPC分类号： A61B5/03 , A61B5/04 , A61B5/024
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/033 , A61B5/04004 , A61B5/04012 , A61B5/0444 , A61B5/0448 , A61B5/0488 , A61B2562/227
摘要： An electrode interface system for providing a connection between at least one electrode and a maternal-fetal monitor, wherein the interface system converts electrical muscle activity captured by the electrode(s) into uterine activity data signals for use by the maternal-fetal monitor. The electrode interface system of the invention preferably includes a conversion means for converting the signals from the electrode(s) into signals similar to those produced by a tocodynometer.
摘要翻译：一种用于在至少一个电极和母体胎儿监测器之间提供连接的电极接口系统，其中所述界面系统将由所述电极捕获的电肌肉活动转化为子宫活动数据信号以供母胎监护仪使用。本发明的电极接口系统优选地包括用于将来自电极的信号转换成类似于由轨道计产生的信号的信号的转换装置。

7. 发明申请

WO2005117692A2 MATERNAL-FETAL MONITORING SYSTEM 审中-公开
标题翻译：子宫监测系统
公开(公告)号：WO2005117692A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/018753
申请日：2005-05-27
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , CONVERGENT ENGINEERING, INC. , MAROSSERO, Dorothee , EULIANO, Tammy, Y. , EULIANO, Neil, Russell, II , PRINCIPE, Jose, C.
发明人： MAROSSERO, Dorothee , EULIANO, Tammy, Y. , EULIANO, Neil, Russell, II , PRINCIPE, Jose, C.
IPC分类号： A61B5/0444
CPC分类号： A61B5/04882 , A61B5/0011 , A61B5/02411 , A61B5/033 , A61B5/0444 , A61B5/0452 , A61B5/4362 , A61B5/6805 , A61B5/6831 , A61B5/7264
摘要： A maternal-fetal monitoring system for use during all stages of pregnancy, including antepartum and intrapartum stages. The maternal-fetal monitoring system of the subject invention comprises (1) a set of sensors; (2) an amplifying/filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, maternal electrocardiogram (ECG) signals, maternal uterine activity signals (EHG), maternal heart rate, fetal ECG signals, and fetal heart rate. In a preferred embodiment, the maternal-fetal monitoring system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis antepartum, intrapartum and postpartum, as well as delivery strategy.
摘要翻译：孕产妇监测系统，用于怀孕期间的所有阶段，包括产前和产后阶段。本发明的母胎监测系统包括（1）一组传感器; （2）放大/滤波装置; （3）计算装置; 和（4）图形用户界面。可以使用本发明的系统实时提取和提供给用户的准确临床数据包括但不限于母体心电图（ECG）信号，母体子宫活动信号（EHG），母亲心率，胎儿心电图信号，和胎儿心率。在一个优选实施例中，本发明的母胎监测系统包括诸如神经网络系统的智能手段，用于分析和解释用于临床诊断产前，产后和产后的临床数据以及递送策略。

8. 发明申请

WO2021011748A1 ESOPHAGEAL PRESSURE CLINICAL DECISION SUPPORT SYSTEM 审中-公开
公开(公告)号：WO2021011748A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042287
申请日：2020-07-16
申请人： CONVERGENT ENGINEERING, INC.
发明人： EULIANO, II, Neil Russell
IPC分类号： A61B5/03 , A61B5/087 , A61B90/40 , A61F2/20 , A61M16/04 , A61M16/20
摘要： A novel clinical decision support system (CDS) helps the clinician setup, maintain, and interpret aesophageal pressure measurement. The esophageal pressure CDS (Pes CDS) would remind the clinician to do an occlusion test whenever the balloon is first inserted or changes dramatically. It could monitor the occlusion test and provide feedback on the performance and success of the occlusion test. Changes in the patient or monitored data can be tracked by looking for changes in the balloon baseline pressure, changes in the amplitude of the pressure waveform, or changes in the pattern of the Pes waveform. Having information from the ventilator will further increase the ability of the system to determine when Pes is changing unexpectedly.

9. 发明申请

WO2006086010A2 METHODS AND DEVICES FOR COUNTERING GRAVITY INDUCED LOSS OF CONSCIOUSNESS AND NOVEL PULSE OXIMETER PROBES 审中-公开
标题翻译：用于防止重力感觉损失和新脉冲氧饱和度探针的方法和装置
公开(公告)号：WO2006086010A2
公开(公告)日：2006-08-17
申请号：PCT/US2005/028355
申请日：2005-08-10
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , BETA BIOMED SERVICES, INC. , CONVERGENT ENGINEERING, INC. , MELKER, Richard, J. , BANNER, Michael, J. , FUEHRLEIN, Brian, S. , WORLEY, George, E. , EULIANO, Neil, R.
发明人： MELKER, Richard, J. , BANNER, Michael, J. , FUEHRLEIN, Brian, S. , WORLEY, George, E. , EULIANO, Neil, R.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0261 , A61B5/0816 , A61B5/6816 , A61B5/6817 , A61B5/6819
摘要： Disclosed herein are methods and devices of obtaining plethysmograph readings and utilizing plethysomography to identify when pilots are about to experience GLOC. Furthermore, in other embodiments, the invention pertains to methods and devices designed to warn a pilot that he/she is about to enter GLOC and/or automatically averting catastrophic damage or injuries by directing a plane being piloted to take predetermined corrective actions. Specifically disclosed is a system embodiment for assisting in the prevention of gravity induced loss of consciousness. The system comprises at least one pulse oximeter probe 10 configured for securing to a central source site of a pilot and to generate signals indicative of blood flow at said central source site, an analyzer unit 58 communicatingly connected to said at least one pulse oximeter probe 10, said analyzer unit comprising at least one processing module 56 configured to determine whether said blood flow is approaching a predefined level, and an aircraft computer 51 communicatingly connected to said analyzer unit 58, said aircraft computer 51 comprising at least one processing module 59 configured to effect a predetermined reaction responsive to said blood flow falling below a predetermined level.
摘要翻译：本文公开了获得体积描记器读数并利用体积描记法来识别飞行员何时将要经历GLOC的方法和设备。此外，在其他实施例中，本发明涉及被设计成通过引导飞机被引导以采取预定的纠正措施来警告飞行员他/她将要进入GLOC和/或自动避免灾难性损坏或伤害的方法和设备。具体公开了一种用于辅助防止由重力引起的意识丧失的系统实施例。该系统包括至少一个脉搏血氧计探头10，该脉搏血氧计探头10被配置用于固定到飞行员的中央源位置并且生成指示在所述中央源位置处的血流的信号;分析器单元58，其通信地连接到所述至少一个脉搏血氧计探头10 ，所述分析仪单元包括至少一个处理模块56和至少一个处理模块59，所述至少一个处理模块56被配置为确定所述血流是否接近预定水平，所述飞行器计算机51通信连接到所述分析仪单元58，所述飞行器计算机51包括至少一个处理模块59，响应于所述血流降至预定水平以下而产生预定反应。

10. 发明申请

WO2013175314A3 SYSTEM AND METHOD FOR DETECTING PREECLAMPSIA 审中-公开
标题翻译：用于检测前体的系统和方法
公开(公告)号：WO2013175314A3
公开(公告)日：2014-04-10
申请号：PCT/IB2013001729
申请日：2013-05-24
申请人： CONVERGENT ENGINEERING INC , UNIV FLORIDA
发明人： EULIANO TAMMY Y , EULIANO NEIL RUSSELL III , DARMANJIAN SHALOM
IPC分类号： A61B5/02 , A61B5/0452
CPC分类号： A61B5/4356 , A61B5/02125 , A61B5/02405 , A61B5/02411 , A61B5/02416 , A61B5/0285 , A61B5/0444 , A61B5/0452 , A61B5/14551 , A61B5/4343 , A61B5/6824 , A61B5/7264 , A61B5/7275 , A61B5/7278 , A61B2560/0214
摘要： A system and method for detecting preeclampsia in a patient is provided. Also provided is a system and method for diagnosing preeclampsia in a patient prior to the detection of conventional symptoms and/or clinical signs associated with preeclampsia. The preeclampsia detection system of the invention comprises at least one sensor and a processor comprising a preeclampsia recognizer. In certain embodiments, the system farther comprises a user interface.
摘要翻译：提供了一种用于检测患者中先兆子痫的系统和方法。还提供了用于在检测与先兆子痫相关的常规症状和/或临床体征之前诊断患者先兆子痫的系统和方法。本发明的先兆子痫检测系统包括至少一个传感器和包括先兆子痫识别器的处理器。在某些实施例中，系统进一步包括用户界面。

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