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1. 发明申请

WO2011047161A1 PHARMACEUTICAL FORMULATIONS OF NITRITE AND USES THEREOF 审中-公开
标题翻译：硝酸盐的药物制剂及其用途
公开(公告)号：WO2011047161A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052683
申请日：2010-10-14
申请人： THERAVASC, LLC , KEVIL, Christopher , GIORDANO, Anthony , FLANAGAN, Douglas, R. , CONSTANTINIDES, Panayiotis, P.
发明人： KEVIL, Christopher , GIORDANO, Anthony , FLANAGAN, Douglas, R. , CONSTANTINIDES, Panayiotis, P.
IPC分类号： A01N59/00 , A61K33/00
CPC分类号： A61K33/00 , A61K9/0053 , A61K9/2068 , A61K9/2866 , A61K9/5042
摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO 2 "). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
摘要翻译：本发明涉及亚硝酸盐如无机亚硝酸盐的药物组合物或其任何药学上可接受的盐，溶剂合物或前药，以及这些组合物的医疗用途。可以配制用于口服给药的药物组合物可以提供亚硝酸根离子（NO 2“）的即时释放或延长释放。本发明的药物组合物可用于例如治疗慢性组织缺血。

2. 发明申请

WO2006113505A2 PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME 审中-公开
标题翻译：用于疏水性药物的药物输送系统及包含其的组合物
公开(公告)号：WO2006113505A2
公开(公告)日：2006-10-26
申请号：PCT/US2006014207
申请日：2006-04-14
申请人： CLARUS THERAPEUTICS INC , DUDLEY ROBERT E , CONSTANTINIDES PANAYIOTIS P
发明人： DUDLEY ROBERT E , CONSTANTINIDES PANAYIOTIS P
IPC分类号： A61K31/573
CPC分类号： A61K31/568 , A61K9/0053 , A61K9/06 , A61K9/1075 , A61K9/4858 , A61K31/22 , A61K31/573 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/44 , C07J1/00 , A61K2300/00
摘要： A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.
摘要翻译：提供了用于口服给药具有增强和延长的吸收和改善的药代动力学的疏水性药物的药物递送系统。在一个实施方案中，公开了包含睾酮和睾酮酯的制剂，例如棕榈酸睾酮。还提供了用本发明制剂治疗激素缺乏或影响男性避孕的方法。

3. 发明申请

WO2008147468A3 COMPOSITIONS COMPRISING VIRUS-INTERACTING LAYERED PHYLLOSILICATES AND A THERAPEUTIC AGENT, AND METHODS OF USE 审中-公开
标题翻译：包含病毒相互作用的层状硅藻土和治疗剂的组合物及其使用方法
公开(公告)号：WO2008147468A3
公开(公告)日：2009-02-12
申请号：PCT/US2007087922
申请日：2007-12-18
申请人： AMCOL INTERNAT , DARLINGTON JERALD W , HUGHES JOHN , CONSTANTINIDES PANAYIOTIS P , FANG MINGMING , ST ONGE JASON HAROLD
发明人： DARLINGTON JERALD W , HUGHES JOHN , CONSTANTINIDES PANAYIOTIS P , FANG MINGMING , ST ONGE JASON HAROLD
IPC分类号： A61K33/06
CPC分类号： A61K45/06 , A61K9/0014 , A61K9/0034 , A61K9/0043
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein are methods of inactivating a virus and methods of treating a viral infection. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in the gastrointestinal tract of an animal are also provided.
摘要翻译：层状页硅酸盐可用于吸附和/或结合病毒，从而使病毒失活。因此，本文提供了灭活病毒的方法和治疗病毒感染的方法。还提供了向哺乳动物受试者递送治疗剂的方法和在动物的胃肠道中灭活病毒的方法。

4. 发明申请

WO2008147468A2 VIRUS-INTERACTING LAYERED PHYLLOSILICATES AND METHODS OF USE 审中-公开
标题翻译：病毒相互作用的层状物质及其使用方法
公开(公告)号：WO2008147468A2
公开(公告)日：2008-12-04
申请号：PCT/US2007/087922
申请日：2007-12-18
申请人： AMCOL INTERNATIONAL , DARLINGTON, Jerald, W. , HUGHES, John , CONSTANTINIDES, Panayiotis, P. , FANG, Mingming , ST. ONGE, Jason, Harold
发明人： DARLINGTON, Jerald, W. , HUGHES, John , CONSTANTINIDES, Panayiotis, P. , FANG, Mingming , ST. ONGE, Jason, Harold
CPC分类号： A61K45/06 , A61K9/0014 , A61K9/0034 , A61K9/0043
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein are methods of inactivating a virus and methods of treating a viral infection. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in the gastrointestinal tract of an animal are also provided.
摘要翻译：层状页硅酸盐可用于吸附和/或结合病毒，从而使病毒失活。因此，本文提供了灭活病毒的方法和治疗病毒感染的方法。还提供了向哺乳动物受试者递送治疗剂的方法和在动物的胃肠道中灭活病毒的方法。

5. 发明申请

WO2007117556A3 PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：药物组合物及其用途
公开(公告)号：WO2007117556A3
公开(公告)日：2008-09-12
申请号：PCT/US2007008515
申请日：2007-04-05
申请人： ACTIVBIOTICS INC , MICHAELIS ARTHUR , CONSTANTINIDES PANAYIOTIS P
发明人： MICHAELIS ARTHUR , CONSTANTINIDES PANAYIOTIS P
IPC分类号： A61K31/535
CPC分类号： A61K31/535 , A61K9/4858 , A61K9/4866 , A61K31/355 , A61K31/538 , A61K31/5383 , A61K45/06 , A61K2300/00
摘要： The invention features pharmaceutical compositions including rifalazil, a surfactant, and a lipophilic antioxidant and methods of use thereof.
摘要翻译：本发明的特征在于包含利拉拉齐，表面活性剂和亲脂性抗氧化剂的药物组合物及其使用方法。

6. 发明申请

WO2006113505A3 PHARMACEUTICAL DELIVERY SYSTEMS FOR HYDROPHOBIC DRUGS AND COMPOSITIONS COMPRISING SAME 审中-公开
公开(公告)号：WO2006113505A3
公开(公告)日：2006-10-26
申请号：PCT/US2006/014207
申请日：2006-04-14
申请人： CLARUS THERAPEUTICS, INC. , DUDLEY, Robert, E. , CONSTANTINIDES, Panayiotis, P.
发明人： DUDLEY, Robert, E. , CONSTANTINIDES, Panayiotis, P.
IPC分类号： A61K31/56
摘要： A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.

7. 发明申请

WO2011129812A1 ORAL TESTOSTERONE ESTER FORMULATIONS AND METHODS OF TREATING TESTOTERONE DEFICIENCY COMPRISING SAME 审中-公开
标题翻译：口服维生素E制剂和治疗包含其中的测试物质缺乏症的方法
公开(公告)号：WO2011129812A1
公开(公告)日：2011-10-20
申请号：PCT/US2010/030788
申请日：2010-04-12
申请人： CLARUS THERAPEUTICS, INC. , DUDLEY, Robert, E. , CONSTANTINIDES, Panayiotis, P.
发明人： DUDLEY, Robert, E. , CONSTANTINIDES, Panayiotis, P.
IPC分类号： A61K9/107 , A61K9/48 , A61K31/568 , A61K47/12 , A61K47/14 , A61K47/44
CPC分类号： A61K9/1075 , A61K9/4858 , A61K31/568 , A61K47/12 , A61K47/44
摘要： A pharmaceutical formulation of testosterone undecanoate is provided. Methods of treating a testosterone deficiency or its symptoms with the inventive formulations are also provided.
摘要翻译：提供了十一酸睾酮的药物制剂。还提供了用本发明制剂治疗睾酮缺乏症或其症状的方法。

8. 发明申请

WO2003057128A2 LIPID PARTICLES AND SUSPENSIONS AND USES THEREOF 审中-公开
标题翻译：脂质颗粒和悬浮液及其用途
公开(公告)号：WO2003057128A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/039661
申请日：2002-12-11
申请人： DOR BIOPHARMA, INC. , CONSTANTINIDES, Panayiotis, P. , PATIL, Reena, T. , LIANG, Likan
发明人： CONSTANTINIDES, Panayiotis, P. , PATIL, Reena, T. , LIANG, Likan
IPC分类号： A61J
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/127
摘要： The present invention relates to formulations and methods for the mucosal and parenteral administration of lipid particles and suspensions. The formulations of this invention are stable lipid particles useful for oral delivery of water-insoluble therapeutic agents, vaccines and diagnostics. The compositions of this invention promote the mucosal absorption of biologically active molecules across mucosal epithelial barriers. Stabilization of lipid particles is achieved by coating the hydrophobic central core with a polymer shell. The polymer shell can include bioadhesive agents, ligands, and absorption promoting agents. This invention relates to oral drug delivery systems for hydrophobic drugs, and in particular is concerned with improving the bioavailability of hydrophobic drugs from such systems. Using this system, anticancer drugs such as taxanes are orally effective.
摘要翻译：本发明涉及用于脂质颗粒和悬浮液的粘膜和肠胃外给药的制剂和方法。本发明的制剂是用于口服递送水不溶性治疗剂，疫苗和诊断剂的稳定的脂质颗粒。本发明的组合物促进跨越粘膜上皮屏障的生物活性分子的粘膜吸收。脂质颗粒的稳定化通过用聚合物壳包覆疏水中心核来实现。聚合物壳可以包括生物粘附剂，配体和吸收促进剂。本发明涉及用于疏水性药物的口服药物递送系统，并且具体涉及提高来自这种系统的疏水性药物的生物利用度。使用此系统，抗癌药物如紫杉烷口服有效。

9. 发明申请

WO2009110940A3 VIRUS-, BACTERIA-, AND FUNGI-INTERACTING LAYERED PHYLLOSILICATES AND METHODS OF USE 审中-公开
公开(公告)号：WO2009110940A3
公开(公告)日：2009-09-11
申请号：PCT/US2008/086330
申请日：2008-12-11
申请人： AMCOL INTERNATIONAL CORPORATION , DARLINGTON JR., Jerald, W. , HUGHES, John , CONSTANTINIDES, Panayiotis, P. , FANG, Mingming , ST. ONGE, Jason, Harold
发明人： DARLINGTON JR., Jerald, W. , HUGHES, John , CONSTANTINIDES, Panayiotis, P. , FANG, Mingming , ST. ONGE, Jason, Harold
IPC分类号： A61K33/06 , A61K33/12 , A61K35/02 , A01N59/00 , A61P31/04
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses, bacteria and fungi. Accordingly, provided herein are methods of inactivating a virus, bacteria or fungus and methods of treating a viral, bacterial or fungal infection. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in the gastrointestinal tract of an animal are also provided.

10. 发明申请

WO2009110940A2 VIRUS-, BACTERIA-, AND FUNGI-INTERACTING LAYERED PHYLLOSILICATES AND METHODS OF USE 审中-公开
标题翻译：病毒，细菌和真菌相互作用的层状物质及其使用方法
公开(公告)号：WO2009110940A2
公开(公告)日：2009-09-11
申请号：PCT/US2008086330
申请日：2008-12-11
申请人： AMCOL INTERNATIONAL CORP , DARLINGTON JR JERALD W , HUGHES JOHN , CONSTANTINIDES PANAYIOTIS P , FANG MINGMING , ST ONGE JASON HAROLD
发明人： DARLINGTON JR JERALD W , HUGHES JOHN , CONSTANTINIDES PANAYIOTIS P , FANG MINGMING , ST ONGE JASON HAROLD
IPC分类号： A61K33/06 , A01N59/00 , A61K33/12 , A61K35/02 , A61P31/04
CPC分类号： A61K35/02 , A01N59/00 , A61K33/06 , A61K33/12
摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses, bacteria and fungi. Accordingly, provided herein are methods of inactivating a virus, bacteria or fungus and methods of treating a viral, bacterial or fungal infection. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in the gastrointestinal tract of an animal are also provided.
摘要翻译：层状页硅酸盐可用于吸附和/或结合病毒，细菌和真菌，从而灭活病毒，细菌和真菌。因此，本文提供了灭活病毒，细菌或真菌的方法以及治疗病毒，细菌或真菌感染的方法。还提供了向哺乳动物受试者递送治疗剂的方法和在动物的胃肠道中灭活病毒的方法。

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