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    • 3. 发明申请
    • BIOCATALYTIC MANUFACTURING OF (METH)ACRYLIC ESTERS
    • (甲基)丙烯酸酯的生物化学制造
    • WO2007039415A1
    • 2007-04-12
    • PCT/EP2006/066260
    • 2006-09-12
    • CIBA SPECIALTY CHEMICALS HOLDING INC.SYMES, Kenneth CharlesCOLLIER, Simon AndrewARMITAGE, Yvonne ChristineMISTRY, RajeshBARANYAI, Robert
    • SYMES, Kenneth CharlesCOLLIER, Simon AndrewARMITAGE, Yvonne ChristineMISTRY, RajeshBARANYAI, Robert
    • C12P7/62
    • C12P7/62
    • The invention relates to a biocatalytic method or process for the synthesis of esters of acrylic acid and/or methacrylic acid free of positively chargeable/charged groups, comprising reacting one or more alcohols (alcohol starting materials) which are free of positively chargeable or charged groups with (meth)acrylyl-CoA, preferably in the presence of a catalyst (inorganic, organic or organometallic, or preferably a biocatalyst) capable of effecting the transfer of an alcohol radical from an alcohol starting material as defined above or below to (meth)acrylyl CoA under removal of the CoA moiety transferase activity, such as an enzyme of the transferase or hydrolase class of enzymes. The (meth)acrylyl-CoA is preferably formed by reaction of (meth)acrylic acid or its salts with coenzyme A in the presence of an energy providing substance and a biocatalyst e.g. with S-acetyl coenzyme A synthetase activity or by reaction of acrylate or methacrylate produced metabolically in the presence of a biocatalyst or metabolically.
    • 本发明涉及用于合成不带正电荷/带电基团的丙烯酸和/或甲基丙烯酸酯的生物催化方法或方法,包括使一种或多种不含可带正电荷或带电基团的醇(醇原料) (甲基)丙烯酰辅酶A,优选在能够使醇自由基从上述或下述定义的醇原料转移至(甲基)丙烯酰辅酶A的催化剂(无机,有机或有机金属或优选生物催化剂) 除去CoA部分转移酶活性的丙烯酰辅酶A,例如酶的转移酶或水解酶类。 (甲基)丙烯酰辅酶A优选通过在提供能量的物质和生物催化剂的存在下使(甲基)丙烯酸或其盐与辅酶A反应形成。 通过S-乙酰辅酶A合成酶活性或通过在生物催化剂或代谢物存在下代谢产生的丙烯酸酯或甲基丙烯酸酯反应。