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    • 1. 发明申请
    • MICROFLUIDIC ASSAY DEVICES
    • 微流感测定装置
    • WO2006071307A1
    • 2006-07-06
    • PCT/US2005/034168
    • 2005-09-23
    • KIMBERLY-CLARK WORLDWIDE, INC.COHEN, David, SamuelFEASTER, Shawn, Ray
    • COHEN, David, SamuelFEASTER, Shawn, Ray
    • B01L3/00
    • B01L3/502746B01L2300/069B01L2300/0803B01L2300/0816B01L2300/0864B01L2400/0406
    • A microfluidic assay device for determining the presence or absence of an analyte within a fluid test sample is provided. The present invention provides a technique for achieving continuous flow in a microfluidic device by using at least one input channel, an analysis zone, and a plurality of wicking channels disposed about the perimeter of the analysis zone. In one embodiment, for example, the wicking channels extend radially from the analysis zone. As a result of the particular configuration of the microfluidic device, an assay may performed in a "single step" without the need for active forces, such as a pressure source, electrokinetic force, etc., to induce flow of the fluid test sample through the device. Likewise, flow rate is controlled so that the dwell time of the fluid test sample within the analysis zone is long enough to allow for the desired reactions and/or detection.
    • 提供了用于确定流体测试样品中分析物的存在或不存在的微流控测定装置。 本发明提供了一种通过使用至少一个输入通道,分析区和围绕分析区的周边设置的多个芯吸通道来实现微流体装置中的连续流动的技术。 在一个实施例中,例如,芯吸通道从分析区域径向延伸。 作为微流体装置的特定构造的结果,可以以“单步”进行测定,而不需要诸如压力源,电动力等的主动力来引起流体测试样品通过的流动 装置。 同样地,控制流速,使得分析区内的流体测试样品的停留时间足够长以允许所需的反应和/或检测。