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1. 发明申请

WO2009004297A2 PHANTOM FOR IMAGING APPARATUSES 审中-公开
标题翻译：用于成像设备的PHANTOM
公开(公告)号：WO2009004297A2
公开(公告)日：2009-01-08
申请号：PCT/GB2008002148
申请日：2008-06-23
申请人： KING S COLLEGE HOSPITAL NHS FO , CLARKE GILLIAN
发明人： CLARKE GILLIAN
IPC分类号： A61B6/00 , G01R33/58 , G09B23/28
CPC分类号： G01R33/58 , A61B6/4417 , A61B6/583 , G01R33/481 , G01R33/4812 , G09B23/286
摘要： A phantom for determining the alignment of two or more imaging apparatuses. The phantom comprises a vessel, wherein a cavity is defined by the inner surfaces of the vessel. The cavity is for holding a fluid therein. Two or more rods extend through the cavity, the rods being non-parallel with one another.
摘要翻译：用于确定两个或多个成像装置的对准的体模。该体模包括容器，其中空腔由容器的内表面限定。空腔用于在其中保持流体。两个或多个杆延伸穿过腔体，杆彼此不平行。

2. 发明申请

WO2009097443A3 LIQUID FORMULATIONS OF COMPOUNDS ACTIVE AT SULFONYLUREA RECEPTORS 审中-公开
标题翻译：化合物的液体配方在磺酰脲受体中有活性
公开(公告)号：WO2009097443A3
公开(公告)日：2009-12-10
申请号：PCT/US2009032455
申请日：2009-01-29
申请人： REMEDY PHARMACEUTICALS INC , JACOBSON SVEN MARTIN , CLARKE GILLIAN , MATHARU RAJINDER
发明人： JACOBSON SVEN MARTIN , CLARKE GILLIAN , MATHARU RAJINDER
IPC分类号： A61K9/08 , A61K31/64 , A61K47/10 , A61K47/34 , A61P3/10
CPC分类号： A61K31/64 , A61K9/0019 , A61K9/08 , A61K47/10 , A61K47/18 , A61K47/26
摘要： The invention provides liquid formulations of compounds that act at sulfonylurea receptors that are suitable for intravenous and intra-arterial infusion. Compounds active at a sulfonylurea receptor include glibenclamide, tolbutamide, repaglinide, nateglinide, meglitinide, midaglizole, LY397364, LY389382, glyclazide, and glimepiride. Liquid formulations may be concentrated solutions suitable for storage; may be diluted (e.g., dilution of 1 : 1 or 1 : 1.2) suitable for bolus injections, and may be further diluted (e.g., dilution of 1 : 10 or 1 : 20 or more) for intravenous and intra-arterial infusion over an extended period of time. For example, a liquid formulation may include at least about 0.05 mg/ml glibenclamide in a water-based solution including 40% polyethylene glycol 300, 10% Ethanol, 50% water, at about pH 9. The solution may include a buffer, and is suitable for storage in refrigerator or at room temperature. This solution may be diluted 1 : 1, or more (e.g., 1 :20) without precipitation of the glibenclamide.
摘要翻译：本发明提供了适用于静脉内和动脉内输注的磺酰脲受体的化合物的液体制剂。在磺酰脲受体中活性的化合物包括格列本脲，甲苯磺丁脲，瑞格列奈，那格列奈，麦格列奈，米格列齐，LY397364，LY389382，氯格列齐和格列美脲。液体制剂可以是适合储存的浓缩溶液; 可以稀释（例如，稀释1：1或1：1.2）适合于推注，并可进一步稀释（例如，稀释1:10或1:20或更高），用于静脉内和动脉内输注延长一段时间例如，液体制剂在包含40％聚乙二醇300,10％乙醇，50％水，约pH 9的水溶液中可包含至少约0.05mg / ml格列本脲。该溶液可包括缓冲液，和适用于冰箱或室温储存。该溶液可以以1:1或更多（例如1:20）稀释，而不会沉淀格列本脲。

3. 发明申请

WO2009097443A2 LIQUID FORMULATIONS OF COMPOUNDS ACTIVE AT SULFONYLUREA RECEPTORS 审中-公开
标题翻译：在磺酰脲类受体上具有活性的化合物的液体制剂
公开(公告)号：WO2009097443A2
公开(公告)日：2009-08-06
申请号：PCT/US2009/032455
申请日：2009-01-29
申请人： REMEDY PHARMACEUTICALS, INC. , JACOBSON, Sven, Martin , CLARKE, Gillian , MATHARU, Rajinder
发明人： JACOBSON, Sven, Martin , CLARKE, Gillian , MATHARU, Rajinder
IPC分类号： A61K9/08 , A61K31/64 , A61K47/10 , A61K47/34 , A61P3/10
CPC分类号： A61K31/64 , A61K9/0019 , A61K9/08 , A61K47/10 , A61K47/18 , A61K47/26
摘要： The invention provides liquid formulations of compounds that act at sulfonylurea receptors that are suitable for intravenous and intra-arterial infusion. Compounds active at a sulfonylurea receptor include glibenclamide, tolbutamide, repaglinide, nateglinide, meglitinide, midaglizole, LY397364, LY389382, glyclazide, and glimepiride. Liquid formulations may be concentrated solutions suitable for storage; may be diluted (e.g., dilution of 1 : 1 or 1 : 1.2) suitable for bolus injections, and may be further diluted (e.g., dilution of 1 : 10 or 1 : 20 or more) for intravenous and intra-arterial infusion over an extended period of time. For example, a liquid formulation may include at least about 0.05 mg/ml glibenclamide in a water-based solution including 40% polyethylene glycol 300, 10% Ethanol, 50% water, at about pH 9. The solution may include a buffer, and is suitable for storage in refrigerator or at room temperature. This solution may be diluted 1 : 1, or more (e.g., 1 :20) without precipitation of the glibenclamide.
摘要翻译：本发明提供了作用于适用于静脉内和动脉内输注的磺酰脲类受体的化合物的液体制剂。对磺酰脲受体具有活性的化合物包括格列本脲，甲苯磺丁脲，瑞格列奈，那格列奈，美格列奈，米格列唑，LY397364，LY389382，甘氨酰叠氮和格列美脲。液体制剂可以是适合储存的浓缩溶液; 可以被稀释（例如，1:1或1:1.2的稀释）适合于快速浓注，并且可以进一步稀释（例如1:10或1:20或更多的稀释）用于静脉内和动脉内输注延长一段时间。例如，液体制剂可以包含至少约0.05mg / ml格列本脲，所述基于水的溶液包含在约pH 9的40％聚乙二醇300,10％乙醇，50％水。该溶液可以包含缓冲剂，并且适合于在冰箱或室温下储存。该溶液可以1:1或更多（例如1:20）稀释而不沉淀格列本脲。

4. 发明申请

WO2009004297A3 PHANTOM FOR IMAGING APPARATUSES 审中-公开
公开(公告)号：WO2009004297A3
公开(公告)日：2009-01-08
申请号：PCT/GB2008/002148
申请日：2008-06-23
申请人： KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST , CLARKE, Gillian
发明人： CLARKE, Gillian
IPC分类号： A61B6/00 , G09B23/28 , G01R33/58
摘要： A phantom for determining the alignment of two or more imaging apparatuses. The phantom comprises a vessel, wherein a cavity is defined by the inner surfaces of the vessel. The cavity is for holding a fluid therein. Two or more rods extend through the cavity, the rods being non-parallel with one another.

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