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1. 发明申请

WO2022040209A1 COSMETIC CONTAINERS AND METHODS OF MANUFACTURE 审中-公开
公开(公告)号：WO2022040209A1
公开(公告)日：2022-02-24
申请号：PCT/US2021/046338
申请日：2021-08-17
申请人： HCT GROUP HOLDINGS LIMITED , VILLARREAL, Armando , CHUN, Thomas Sang , MAURIN, Denis Pierre
发明人： VILLARREAL, Armando , CHUN, Thomas Sang , MAURIN, Denis Pierre
IPC分类号： B29C65/02 , B29C48/08 , B29C48/18 , B29C48/00 , B29C65/00 , B29C65/78 , A45D40/26
摘要： Methods of manufacturing and fixtures for manufacturing containers, particularly for holding cosmetic products, using thin-walled tubes. One end of a container may be formed using an integral process, such as insert molding, while the other end of the container is formed using assembly steps, such as welding, to form a completed cosmetics container from a thin-walled tube.

2. 发明申请

WO2020060922A1 MAGNETIC COSMETIC APPLICATOR 审中-公开
公开(公告)号：WO2020060922A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/051288
申请日：2019-09-16
申请人： HCT GROUP HOLDINGS LIMITED , MAURIN, Denis Pierre , BIN, Jae , CHUN, Thomas Sang
发明人： MAURIN, Denis Pierre , BIN, Jae , CHUN, Thomas Sang
IPC分类号： A45D34/04 , A45D40/26 , A46B9/00 , A46B15/00 , B65D51/32
摘要： A cosmetic container and applicator system for magnetic cosmetic products may include a housing defining a reservoir for containing a magnetic cosmetic product, and an applicator configured to extend into the reservoir. The applicator includes a magnet. A wiper may extend into the reservoir and have a bottom end with an opening through which the applicator extends. The wiper may be configured to remove excess product from the applicator as the applicator is withdrawn from the reservoir.

3. 发明申请

WO2013030138A1 PYRROLOPYRAZINE KINASE INHIBITORS 审中-公开
标题翻译：吡咯啉激酶抑制剂
公开(公告)号：WO2013030138A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066567
申请日：2012-08-27
申请人： F. HOFFMANN-LA ROCHE AG , CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
发明人： CHEN, Shaoqing , DE VICENTE FIDALGO, Javier , HAMILTON, Matthew Michael , HERMANN, Johannes Cornelius , KENNEDY-SMITH, Joshua , LI, Hongju , LOVEY, Allen John , LUCAS, Matthew C. , LUK, Kin-Chun Thomas , LYNCH, Stephen M. , O'YANG, Counde , PADILLA, Fernando , SCHOENFELD, Ryan Craig , SIDDURI, Achyutharao , SOTH, Michael , WANG, Ce , WOVKULICH, Peter Michael , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5025 , A61P29/00
CPC分类号： C07D487/04
摘要： The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
摘要翻译：本发明涉及式I的新型吡咯并吡嗪衍生物的用途，其中所述变量如本文所述定义，其抑制JAK和SYK并且可用于治疗自身免疫和炎性疾病。

4. 发明申请

WO2009020764A1 TISSUE LOCATING GUIDE WITH RADIOPAQUE REFERENCE MARKERS 审中-公开
标题翻译：带放射性标记的组织定位指南
公开(公告)号：WO2009020764A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/070726
申请日：2008-07-22
申请人： MEDTRONIC, INC. , STETZ, Eric M. , BONDE, Eric H. , TROPSHA, Yelena , CHUN, Thomas
发明人： STETZ, Eric M. , BONDE, Eric H. , TROPSHA, Yelena , CHUN, Thomas
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B90/11 , A61B2090/376 , A61B2090/3916 , A61B2090/3983 , A61N1/0551 , A61N1/08
摘要： A locating guide (150) for locating a target tissue site within a patient includes a body (122), a first substantially radiopaque reference marker (124A-B, 126A-B, 128,130) on the body, and a second substantially radiopaque reference marker (154, 156) extending from a major surface of the body. The reference markers provide reference points that extend in at least two dimensions, and may be useful for registering a medical image of tissue with an actual location on or within the patient in order to more accurately and precisely locate a target tissue site within the patient. In some embodiments, the second reference marker is oriented at a predetermined angle relative to the major surface of the body, and provides a guide that a clinician may reference in order to orient a medical- element introducer (152) when introducing the introducer into the patient to access a particular target tissue site.
摘要翻译：用于定位患者内的目标组织部位的定位引导件（150）包括主体（122），身体上的第一基本上不透射线的参考标记（124A-B，126A-B，128,130）和第二基本上不透射线的参考标记（154,156）从主体的主表面延伸。参考标记提供在至少两个维度上延伸的参考点，并且可用于将具有实际位置的组织的医学图像登记在患者身上或内部，以便更精确地和精确地定位患者内的目标组织部位。在一些实施例中，第二参考标记物相对于主体的主表面以预定角度定向，并且提供临床医生可引用的引导件，以便在将导引器引入到引导器时定向医疗元件引导器（152）患者进入特定的目标组织部位。

5. 发明申请

WO2008113711A1 SUBSTITUTED PYRIMIDODIAZEPINES USEFUL AS PLK1 INHIBITORS 审中-公开
标题翻译：取代的吡咯烷酮可用作PLK1抑制剂
公开(公告)号：WO2008113711A1
公开(公告)日：2008-09-25
申请号：PCT/EP2008/052847
申请日：2008-03-11
申请人： F. HOFFMANN-LA ROCHE AG , CAI, Jianping , CHEN, Shaoqing , CHU, Xin-Jie , LE, Kang , LUK, Kin-Chun Thomas , WOVKULICH, Peter Michael
发明人： CAI, Jianping , CHEN, Shaoqing , CHU, Xin-Jie , LE, Kang , LUK, Kin-Chun Thomas , WOVKULICH, Peter Michael
IPC分类号： C07D471/18 , C07D487/04 , C07D487/18 , A61K31/551 , A61K31/5517 , A61P35/00
CPC分类号： C07D487/04 , C07D471/18 , C07D487/18
摘要： The present invention provides PLK1 inhibitor compounds of formula (I). Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas.
摘要翻译：本发明提供式（I）的PLK1抑制剂化合物。可用于治疗或控制细胞增殖性疾病，特别是肿瘤疾病。含有这些化合物的这些化合物和制剂可用于治疗或控制实体瘤，例如乳腺癌，结肠癌，肺癌和前列腺肿瘤以及其它肿瘤疾病如非霍奇金淋巴瘤。

6. 发明申请

WO2012123470A1 IMIDAZO PYRAZINES 审中-公开
标题翻译：咪唑啉吡啶
公开(公告)号：WO2012123470A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054415
申请日：2012-03-14
申请人： F. HOFFMANN-LA ROCHE AG , LUK, Kin-Chun, Thomas , SOTH, Michael
发明人： LUK, Kin-Chun, Thomas , SOTH, Michael
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/02
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/506
摘要： There are provided the compounds of formula I and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of AML.
摘要翻译：提供了式I化合物及其药学上可接受的盐，以及含有所述化合物及其药学上可接受的盐的药物组合物，以及所述化合物和药物组合物用于治疗，控制或改善AML的用途。

7. 发明申请

WO2012098068A1 PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS 审中-公开
标题翻译： PYRAZOLO PYRIMIDINES作为DYRK1A和DYRK1B抑制剂
公开(公告)号：WO2012098068A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050545
申请日：2012-01-16
申请人： F. HOFFMANN-LA ROCHE AG , LIU, Wenjian , LUK, Kin-Chun Thomas , ZHANG, Xiaohu
发明人： LIU, Wenjian , LUK, Kin-Chun Thomas , ZHANG, Xiaohu
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P35/00
CPC分类号： C07D487/04
摘要： Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
摘要翻译：本发明描述了式及其药学上可接受的盐的化合物，以及含有所述化合物及其药学上可接受的盐的药物组合物，以及所述化合物和药物组合物用于治疗，控制或改善增殖性疾病（包括癌症）Down 综合征或早发性阿尔茨海默氏病。

8. 发明申请

WO2012098066A1 1,6- AND 1,8-NAPHTHYRIDINES USEFUL AS DYRK1 INHIBITORS 审中-公开
标题翻译： 1,6-和1,8-萘啶可用作DYRK1抑制剂
公开(公告)号：WO2012098066A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050541
申请日：2012-01-16
申请人： F. HOFFMANN-LA ROCHE AG , LUK, Kin-Chun Thomas
发明人： LUK, Kin-Chun Thomas
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds of formula I, and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.
摘要翻译：本发明描述了式I化合物及其药学上可接受的盐，以及含有所述化合物及其药学上可接受的盐的药物组合物，以及所述化合物和药物组合物用于治疗，控制或改善增殖性疾病（包括癌症）的用途，唐氏综合征或早发性阿尔茨海默氏病。

9. 发明申请

WO2010121675A3 THIAZOLYL-BENZIMIDAZOLES 审中-公开
标题翻译：噻唑苯并咪唑类
公开(公告)号：WO2010121675A3
公开(公告)日：2011-02-24
申请号：PCT/EP2009066579
申请日：2009-12-08
申请人： HOFFMANN LA ROCHE , CAI JIANPING , CHEN SHAOQING , CHEN YI , CHU XIN-JIE , GOODNOW ROBERT ALAN JR , LE KANG , LUK KIN-CHUN THOMAS , MISCHKE STEVEN GREGORY , WOVKULICH PETER MICHAEL
发明人： CAI JIANPING , CHEN SHAOQING , CHEN YI , CHU XIN-JIE , GOODNOW ROBERT ALAN JR , LE KANG , LUK KIN-CHUN THOMAS , MISCHKE STEVEN GREGORY , WOVKULICH PETER MICHAEL
IPC分类号： C07D417/04 , A61K31/427 , A61P35/00 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, methods for the preparation of said compounds, as well as their use as medicaments, in particular for the treatment of cancer.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐，制备所述化合物的方法，以及它们作为药物的用途，特别是用于治疗癌症。

10. 发明申请

WO2009153197A1 HALO-SUBSTITUTED PYRIMIDODIAZEPINES AS PLKL INHIBITORS 审中-公开
标题翻译：作为PLKL抑制剂的HALO取代的吡咯烷酮
公开(公告)号：WO2009153197A1
公开(公告)日：2009-12-23
申请号：PCT/EP2009/057144
申请日：2009-06-10
申请人： F. HOFFMANN-LA ROCHE AG , CAI, Jianping , CHEN, Shaoqing , CHU, Xin-Jie , LUK, Kin-Chun Thomas , MISCHKE, Steven Gregory , SUN, Hongmao , WOVKULICH, Peter Michael
发明人： CAI, Jianping , CHEN, Shaoqing , CHU, Xin-Jie , LUK, Kin-Chun Thomas , MISCHKE, Steven Gregory , SUN, Hongmao , WOVKULICH, Peter Michael
IPC分类号： C07D487/04 , A61K31/5513 , A61K35/00
CPC分类号： C07D487/04
摘要： The present invention provides PLK1 inhibitor compounds of formula (I): useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the treatment or control of solid tumors, such as, for example, breast, colon, lung and prostate tumors and other oncological diseases such as non-Hodgkin's lymphomas. Also provided are intermediate compounds useful in the synthesis of compounds of formula (I).
摘要翻译：本发明提供式（I）的PLK1抑制剂化合物：可用于治疗或控制细胞增殖性疾病，特别是肿瘤疾病。含有这些化合物的这些化合物和制剂可用于治疗或控制实体瘤，例如乳腺癌，结肠癌，肺癌和前列腺肿瘤以及其它肿瘤疾病如非霍奇金淋巴瘤。还提供了可用于合成式（I）化合物的中间体化合物。

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