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1. 发明申请

WO2007145697A2 DIRECTED-FLOW ASSAY DEVICE 审中-公开
标题翻译：指向流测定装置
公开(公告)号：WO2007145697A2
公开(公告)日：2007-12-21
申请号：PCT/US2007008204
申请日：2007-03-29
申请人： QUANTUM DESIGN INC , LABORDE RONALD T , CHOW HERBERT S
发明人： LABORDE RONALD T , CHOW HERBERT S
IPC分类号： G01N33/551 , C12M3/00
CPC分类号： G01N33/558 , B01L3/5023 , B01L9/52 , B01L2200/026 , B01L2300/0825 , G01N33/54326 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S436/807 , Y10S436/808 , Y10S436/81
摘要： A diagnostic assay device that directs an applied sample to the analytical membrane of a lateral directed flow device. The assay device has a sample receiving port defined by layers of built-up material on one end of the test strip. The port contains the sample and specifically directs it to the membrane in a controlled fashion. Additional features include configuration of the housing in a general C-shape with the test strip spanning the opening of the C-shape to allow access by a reader device. A preferred method employs superparamagnetic particles to label the target analytes for detection and measurement by means of an electromagnetic reader device.
摘要翻译：将应用的样品引导到横向定向流动装置的分析膜的诊断测定装置。测定装置具有在测试条的一端上由积累材料层限定的样品接收端口。端口包含样品，并以受控的方式将其特异性地引导到膜上。附加特征包括外壳的一般C形结构，测试条横跨C形的开口以允许读取器装置进入。优选的方法使用超顺磁性粒子来标记目标分析物，以便通过电磁读取器装置进行检测和测量。

2. 发明申请

WO02063273A3 DEVICE AND METHOD FOR EVALUATING PLATELETS 审中-公开
标题翻译：用于评估板的装置和方法
公开(公告)号：WO02063273A3
公开(公告)日：2002-10-31
申请号：PCT/US0204545
申请日：2002-01-18
申请人： CHOW HERBERT S
发明人： CHOW HERBERT S
IPC分类号： G01N21/07 , G01N33/49 , G01N21/00
CPC分类号： G01N21/07 , G01N33/4905
摘要： A method and apparatus are disclosed for measuring platelet activation in a whole blood matrix under physiological conditions and independent of the activation of a coagulation cascade in the plasma. The system includes a thrombogenic test cartridge (90), and a shear device (94), for measuring the intensity of thrombus formation, and for providing quantitative measurement of platelet functions in a near-patient environment.
摘要翻译：公开了用于在生理条件下测量全血基质中的血小板活化并且与血浆中的凝血级联活化无关的方法和装置。该系统包括血栓形成测试盒（90）和用于测量血栓形成强度的剪切装置（94），并用于在近患者环境中提供血小板功能的定量测量。

3. 发明申请

WO2007145697A3 DIRECTED-FLOW ASSAY DEVICE 审中-公开
公开(公告)号：WO2007145697A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/008204
申请日：2007-03-29
申请人： QUANTUM DESIGN, INC. , LABORDE, Ronald T. , CHOW, Herbert S.
发明人： LABORDE, Ronald T. , CHOW, Herbert S.
IPC分类号： G01N33/53
摘要： A diagnostic assay device that directs an applied sample to the analytical membrane of a directed flow device. The device has a sample receiving port defined by layers of built-up material on one end of the test strip. The port contains the sample and specifically directs it to the membrane in a controlled fashion. Additional features include configuration of the housing in a general C-shape with the test strip spanning the opening of the C-shape to allow access by a reader device. See Figure 5. A preferred method employs superparamagnetic particles to label the target analytes for detection and measurement by means of an electromagnetic reader device.

4. 发明申请

WO2002063273A2 DEVICE AND METHOD FOR EVALUATING PLATELETS 审中-公开
标题翻译：用于评估血小板的装置和方法
公开(公告)号：WO2002063273A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/004545
申请日：2002-01-18
申请人： CHOW, Herbert, S.
发明人： CHOW, Herbert, S.
IPC分类号： G01N
CPC分类号： G01N21/07 , G01N33/4905
摘要： A method and apparatus are disclosed for measuring platelet activation in a whole blood matrix under physiological conditions and independent of the activation of a coagulation cascade in the plasma. The method and system measure the propensity of cells in a biological fluid to form adherent cells aggregates and thrombin. The method accommodates both citrated and native venous blood. The system includes a simple, low-cost, single-use thrombogenic test cartridge for measuring the intensity of thrombus formation, and for providing quantitative measurement of platelet functions in a near-patient environment. Hemostatic activity of platelets in a biological fluid sample is assessed by monitoring the degree of adherent thrombus formation after cells are exposed to platelet agonists in a shear stress environment. The system may be configured to monitor the therapeutic effects of anti-platelet agents, to assess primaryhemostasis response of platelets, and to assess thrombotic potential of platelets.
摘要翻译：公开了一种用于在生理条件下测量全血基质中的血小板活化并且独立于血浆中凝血级联的激活的方法和设备。该方法和系统测量生物流体中的细胞倾向于形成贴壁细胞聚集体和凝血酶。该方法容纳柠檬酸和天然静脉血。该系统包括简单，低成本的一次性血栓形成测试盒，用于测量血栓形成的强度，并提供在患者附近环境中的血小板功能的定量测量。生物液体样品中血小板的止血活性通过监测细胞在剪切应力环境中暴露于血小板激动剂后的附着血栓形成程度来评估。该系统可以配置为监测抗血小板剂的治疗效果，评估血小板的原发性止血反应并评估血小板的血栓形成潜力。

5. 发明申请

WO1992022802A1 MULTIPLE REACTION WELL CARTRIDGE 审中-公开
标题翻译：多重反应盒
公开(公告)号：WO1992022802A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005103
申请日：1992-06-12
申请人： ABBOTT LABORATORIES , CHOW, Herbert, S. , WILSON, Thomas, J. , ALSBERG, Keith, D. , McCOY, Jimmy, D. , SEBESTA, Esward, E.
发明人： ABBOTT LABORATORIES
IPC分类号： G01N21/03
CPC分类号： G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
摘要： A reaction cartridge (10) for an automatic analysis apparatus having a plurality of reaction wells (16) having different reagents disposed thereon, at least one sample well (11a, 11b), a well (12) containing magnetically separable particles for binding the sample, a fluorophore containing well (13), and a wash area (15) for washing a probe.
摘要翻译：一种用于自动分析装置的反应盒（10），具有设置在其上的具有不同试剂的多个反应孔（16），至少一个样品阱（11a，11b），含有用于结合样品的可磁分离颗粒的孔（12），含有荧光团（13）的荧光团和用于洗涤探针的洗涤区域（15）。

6. 发明申请

WO1992022801A1 AUTOMATED SPECIMEN ANALYZING APPARATUS AND METHOD 审中-公开
标题翻译：自动样本分析装置和方法
公开(公告)号：WO1992022801A1
公开(公告)日：1992-12-23
申请号：PCT/US1992005028
申请日：1992-06-11
申请人： ABBOTT LABORATORIES , CHOW, Herbert, S. , WILSON, Thomas, J. , WROBLEWSKI, Mieczyslaw , KOTLARIK, John, J. , ALSBERG, Keith, D. , McCOY, Jimmy, D. , LADD, Jimmy, L. , CORBETT, Kevin, M.
发明人： ABBOTT LABORATORIES
IPC分类号： G01N21/01
CPC分类号： G01N35/109 , B01L3/0262 , B01L3/5085 , G01N15/1468 , G01N21/82 , G01N35/0095 , G01N35/0098 , G01N35/028 , G01N35/1004 , G01N2035/042 , G01N2035/0425 , G01N2035/0491 , G01N2035/1018 , G01N2035/1025 , G01N2035/1034 , G01N2201/0446 , G01N2201/0461 , G01N2201/0492 , G02B7/28 , Y10T137/7306 , Y10T436/115831
摘要： An apparatus is provided for moving a reaction cartridge (10) to different processing areas (36, 38, 42) of the apparatus. Robots (34, 40) for moving the reaction cartridge to the various areas (30, 32, 36, 38, 42, 46) of the apparatus. An image forming device (42) is provided to detect images which indicate whether specific reactions have occurred in reaction wells (16) of the reaction cartridge (10). The apparatus also includes a mechanism (36) for aspirating and dispensing liquids which includes a liquid level detecting mechanism (70, 72, 74, 76, 78, 80, 82, 84). The device further includes a microprocessor and logic (44) for controlling the apparatus operation and analyzing the information received from the image forming device (42) to generate a visual indication of assay results.
摘要翻译：提供了一种用于将反应盒（10）移动到设备的不同处理区域（36,38,42）的装置。用于将反应盒移动到设备的各个区域（30,32,36,38,42,46）的机器人（34,40）。提供图像形成装置（42）以检测指示反应盒（10）的反应孔（16）中是否发生特定反应的图像。该装置还包括用于吸入和分配液体的机构（36），该机构包括液面检测机构（70,72,74,76,78,80,82,84）。该装置还包括微处理器和逻辑（44），用于控制装置操作并分析从图像形成装置（42）接收的信息以产生测定结果的视觉指示。

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