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    • 6. 发明申请
    • HIGH PRESSURE FLASH CHROMATOGRAPHY
    • 高压闪光色谱
    • WO2008027587A9
    • 2008-07-31
    • PCT/US2007019275
    • 2007-11-20
    • THAR INSTR INCCHORDIA LALITSIDHU HARBAKSHPALCIC TODDWHELAN JOHN
    • CHORDIA LALITSIDHU HARBAKSHPALCIC TODDWHELAN JOHN
    • B01D15/08C02F1/28
    • B01D15/165B01D15/20
    • A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the, separated sample after the mobile phase exi,ts the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.
    • 提供了使用高压快速色谱法分离样品的方法。 该方法包括以下步骤:i)提供含有吸附材料的加压容器; ii)对可压缩流体(任选地含有助溶剂)加压以产生流动相; iii)用流动相预先混合样品或任选地将样品置于加压容器中; iv)通过加压容器洗脱流动相,得到分离的样品; v)在流动相exi之后加热含有分离的样品的流动相,加压容器以除去可压缩流体; 和iv)收集分离的样品。 加压容器含有粒度为10-100微米的吸附材料,并且在洗脱期间吸附容器的压力保持在50-350巴。 还提供了一种用于执行上述方法的装置。
    • 7. 发明申请
    • HIGH PRESSURE FLASH CHROMATOGRAPHY
    • 高压闪烁色谱
    • WO2008027587A2
    • 2008-03-06
    • PCT/US2007019275
    • 2007-11-20
    • THAR INSTR INCCHORDIA LALITSIDHU HARBAKSHPALCIC TODDWHELAN JOHN
    • CHORDIA LALITSIDHU HARBAKSHPALCIC TODDWHELAN JOHN
    • B01D15/08
    • B01D15/165B01D15/20
    • A method for separating a sample using high pressure flash chromatography is provided. The method comprises the steps of: i) providing a pressurized vessel containing an adsorption material; ii) pressurizing a compressible fluid, optionally containing a cosolvent, to create a mobile phase; iii) premixing the sample with the mobile phase or optionally placing the sample in the pressurized vessel; iv) eluting the mobile phase through the pressurized vessel, to obtain a separated sample; v) heating the mobile phase containing the, separated sample after the mobile phase exi,ts the pressurized vessel to remove the compressible fluid; and iv) collecting the separated sample. The pressurized vessel contains an adsorption material having a particle size of 10-100 microns, and the pressure of the adsorption vessel is held at 50-350 bar during elution. Also provided is an apparatus for carrying out the above method.
    • 提供了使用高压快速色谱法分离样品的方法。 该方法包括以下步骤:i)提供含有吸附材料的加压容器; ii)对任选含有共溶剂的可压缩流体加压以产生流动相; iii)将样品与流动相预混合或可选地将样品放置在加压容器中; iv)通过加压容器洗脱流动相,以获得分离的样品; v)在流动相外,加热含有分离样品的流动相,加压容器以除去可压缩流体; 和iv)收集分离的样品。 加压容器含有粒径为10-100微米的吸附材料,在洗脱过程中吸附容器的压力保持在50-350巴。 还提供了用于执行上述方法的设备。