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1. 发明申请

WO1994024117A1 BENZOFURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：苯并呋喃羧酸衍生物和药物组合物
公开(公告)号：WO1994024117A1
公开(公告)日：1994-10-27
申请号：PCT/JP1994000664
申请日：1994-04-22
申请人： NIPPON SHINYAKU CO., LTD. , CHOKAI, Shoichi , NAKANE, Masayuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D307/80
CPC分类号： C07D307/80
摘要： A compound represented by general formula [I], a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the same as the active ingredient, wherein R represents hydrogen, alkyl, etc.; B represents -CO- or -CH(OH)-; A represents a group of formula [II], etc., wherein R , R , R , R and Y represent each hydrogen, alkyl, etc.; X represents -O-, etc.; and Z and Z represent each hydrogen, or Y, Z and Z are combined together to represent -CH=. The pharmaceutical composition is efficacious in preventing and treating arteriosclerosis, ischemic heart disease, cerebral infarction, and reconstruction after PTCA.
摘要翻译：由通式[I]表示的化合物，其药理学上可接受的盐和含有该化合物的药物组合物，其中R表示氢，烷基等; B表示-CO-或-CH（OH） - ; A表示式[II]等的基团，其中R 1，R 2，R 3，R 4和Y代表每个氢，烷基等; X表示-O-等。 Z 1和Z 2代表每个氢，或Y，Z 1和Z 2组合在一起代表-CH =。药物组合物在预防和治疗动脉硬化，缺血性心脏病，脑梗死和PTCA后重建方面是有效的。

2. 发明申请

WO1996007641A1 HETEROCYCLIC DERIVATIVE AND MEDICINE 审中-公开
标题翻译：杂环衍生物和药物
公开(公告)号：WO1996007641A1
公开(公告)日：1996-03-14
申请号：PCT/JP1995001792
申请日：1995-09-08
申请人： NIPPON SHINYAKU CO., LTD. , CHOKAI, Shoichi , UKAI, Yojiro , AOKI, Tomiyosi , IDEGUCHI, Kyoichi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D213/64
CPC分类号： C07D213/64 , C07D239/34 , C07D239/38 , C07D239/52 , C07D239/56 , C07D251/22 , C07D401/04 , C07D401/12 , C07D409/04
摘要： A medicine containing a compound represented by general formula (I) or a salt thereof as the active ingredient, having an excellent activity of inhibiting neuron necrosis, and being useful as a remedy for cerebrovascular disorder, wherein R represents aryl or heteroaryl; R represents hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, haloalkyl, alkoxy, alkylthio, amino, monoalkylamino, dialkylamino or phenyl; R and R represent each hydrogen or alkyl, or R and R are combined with the adjacent nitrogen atom to represent a 5- to 7-membered cyclic amino group NR R ; A represents C2-C10 alkylene; W represents O, S or (CH)n (wherein CH may be substituted by alkyl, and n represents 0, 1 or 2); and X, Y and Z represent each independently CH (wherein H may be replaced by alkyl) or N, provided the case where all of X, Y and Z are CH at the same time is excepted.
摘要翻译：含有由通式（I）表示的化合物或其盐作为活性成分的药物，具有优异的抑制神经元坏死的活性，可用作脑血管障碍的治疗剂，其中R 1表示芳基或杂芳基; R 2表示氢，烷基，烯基，环烷基，环烷基烷基，羟基烷基，卤代烷基，烷氧基，烷硫基，氨基，单烷基氨基，二烷基氨基或苯基; R 3和R 4各自代表氢或烷基，或R 3和R 4与相邻的氮原子结合，代表5-至7-元环氨基NR 3 R 4>; A表示C2-C10亚烷基; W表示O，S或（CH）n（其中CH可以被烷基取代，n表示0,1或2）。 X，Y和Z各自独立地表示CH（其中H可以被烷基取代）或N表示，只要X，Y和Z都同时为CH的情况除外。

3. 发明申请

WO1993001180A1 BENZOFURAN DERIVATIVE AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：苯并呋喃衍生物和药物组合物
公开(公告)号：WO1993001180A1
公开(公告)日：1993-01-21
申请号：PCT/JP1992000875
申请日：1992-07-08
申请人： NIPPON SHINYAKU CO., LTD. , CHOKAI, Shoichi , OHMACHI, Shinji , TAIRA, Masafumi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D307/80
CPC分类号： C07D307/80
摘要： A compound represented by general formula (I), a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing the same as the active ingredient, wherein R represents hydrogen, halogen or alkyl; R represents alkoxycarbonyl, aralkyloxycarbonyl, carboxyl, hydroxyalkyl or acyloxyalkyl; Y represents CHOH, CHOZ, CH2 or C=O; and Z represents acyl. The composition is effective in preventing and treating arteriosclerosis, ischemic heart diseases, cerebral infarction, and restenosis after PTCA.
摘要翻译：由通式（I）表示的化合物，其药学上可接受的盐和含有该化合物的药物组合物，其中R 1表示氢，卤素或烷基; R 2表示烷氧基羰基，芳烷氧基羰基，羧基，羟基烷基或酰氧基烷基; CH2表示CHOH，符号CHOZ，符号CH2或标记C = O; Z表示酰基。该组合物有效预防和治疗PTCA后的动脉硬化，缺血性心脏病，脑梗死和再狭窄。

4. 发明申请

WO1992004347A1 INDOLE DERIVATIVE AND MEDICINE 审中-公开
标题翻译： INDOLE DIVIVATIVE和MEDICINE
公开(公告)号：WO1992004347A1
公开(公告)日：1992-03-19
申请号：PCT/JP1991001148
申请日：1991-08-29
申请人： NIPPON SHINYAKU CO., LTD. , CHOKAI, Shoichi , AOKI, Tomiyoshi , UKAI, Yojiro
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D453/02
CPC分类号： C07D453/02
摘要： A novel serotonin-antagonistic indolecarboxamide derivative represented by general formula (I) and a serotonin antagonist containing the same as the active ingredient wherein R represents lower alkyl and R hydrogen, halogen, lower alkyl or lower alkoxy. It is efficacious as a regulatory agent for gastrointestinal motility, a therapeutic agent for migraine, an antipsychotic drug, an antianxiety drug, etc., and also as an antidemential drug and a therapeutic agent for orthostatic hypotension.
摘要翻译：由通式（I）表示的新型5-羟色胺拮抗性吲哚克酰胺衍生物和含有与活性成分相同的5-羟色胺拮抗剂，其中R 1表示低级烷基和R 2氢，卤素，低级烷基或低级烷氧基。作为胃肠蠕动的调节剂，偏头痛治疗剂，抗精神病药，抗焦虑药等，作为抗静脉药物和直立性低血压的治疗剂是有效的。

5. 发明申请

WO1992004333A1 PYRIMIDINE DERIVATIVE AND MEDICINE 审中-公开
标题翻译：吡嗪衍生物和药物
公开(公告)号：WO1992004333A1
公开(公告)日：1992-03-19
申请号：PCT/JP1991001152
申请日：1991-08-29
申请人： NIPPON SHINYAKU CO., LTD. , CHOKAI, Shoichi , AOKI, Tomiyoshi , KIMURA, Kiyoshi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D239/34
CPC分类号： C07D453/02 , C07D239/34 , C07D239/42 , C07D401/12
摘要： The invention aims at obtaining a novel compound which is excellent in central nervous system selectivity and reduced in side effects and has an activity of improving the function of learning and memory, thus providing an excellent medicine for dementia. The invention relates to a compound represented by general formula (I), a pharmacologically acceptable salt thereof, and an agent for remedying the disturbance of learning and memory containing the same as the active ingredient of formula (I), wherein R?1 and R2¿ may be the same or different from each other and each represents hydrogen, hydroxy, alkoxy, trifluoromethyl or halogen; A represents methyl, trifluoromethyl or tertbutyl; and Y represents O or NH.

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