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1. 发明申请

WO2011106696A3 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE 审中-公开
标题翻译：用于生产L-高香赖氨酸的组合物和方法
公开(公告)号：WO2011106696A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026315
申请日：2011-02-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
发明人： LIAO, James, C. , ZHANG, Kechun , CHO, Kwang, Myung
IPC分类号： C12N9/04 , C07K14/00 , C07H21/00
摘要： Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.
摘要翻译：医疗保健费用在全球范围内非常重要，许多患者由于其高昂的价格而被拒绝服用药物。解决此问题的一种方法涉及手性药物中间体的生物合成，这是一种环保型溶液，可用于以比传统技术低得多的成本生成药物。在这种情况下，本发明的实施方案包括设计成允许微生物生物合成非天然氨基酸L-高丙氨酸的方法和材料。如本领域所知，L-高丙氨酸是多种药学上有价值的化合物的手性前体，包括抗惊厥药物左乙拉西坦（以商品名Keppra销售）和布立西坦，以及乙胺丁醇（一种抑菌抗分枝杆菌药物，用于治疗结核。因此，本发明的实施例可以用于低成本，环境友好的工艺中以产生这些和其他有价值的化合物。

2. 发明申请

WO2011106696A2 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF L-HOMOALANINE 审中-公开
标题翻译：用于生产L-山梨醇的组合物和方法
公开(公告)号：WO2011106696A2
公开(公告)日：2011-09-01
申请号：PCT/US2011026315
申请日：2011-02-25
申请人： UNIV CALIFORNIA , LIAO JAMES C , ZHANG KECHUN , CHO KWANG MYUNG
发明人： LIAO JAMES C , ZHANG KECHUN , CHO KWANG MYUNG
IPC分类号： C12P13/06
CPC分类号： C12N9/0016 , C12P13/04 , C12P13/06 , C12Y104/01002 , Y02P20/52
摘要： Healthcare costs are a significant worldwide, with many patients being denied medications because of their high prices. One approach to addressing this problem involves the biosynthesis of chiral drug intermediates, an environmentally friendly solution that can be used to generate pharmaceuticals at much lower costs than conventional techniques. In this context, embodiments of the invention comprise methods and materials designed to allow microorganisms to biosynthesize the nonnatural amino acid L-homoalanine. As is known in the art, L-homoalanine is a chiral precursor of a variety of pharmaceutically valuable compounds including the anticonvulsant medications levetiracetam (sold under the trade name Keppra®) and brivaracetam, as well as ethambutol, a bacteriostatic antimycobacterial drug used to treat tuberculosis. Consequently, embodiments of the invention can be used in low cost, environmentally friendly processes to generate these and other valuable compounds.
摘要翻译：保健费用在世界范围内是重要的，许多患者由于价格高昂而被拒绝服用药物。解决这一问题的一种方法涉及手性药物中间体的生物合成，这是一种环境友好的解决方案，可以以比传统技术低得多的成本生产药物。在本文中，本发明的实施方案包括设计用于允许微生物生物合成非天然氨基酸L-高丙氨酸的方法和材料。如本领域已知的，L-高丙氨酸是各种药学上有价值的化合物的手性前体，包括抗惊厥药物左乙拉西坦（商品名为Keppra）和布立西坦（brivaracetam）），以及乙胺丁醇，用于治疗的抑菌抗分支杆菌药物结核。因此，本发明的实施方案可以用于低成本，环境友好的方法以产生这些和其它有价值的化合物。

3. 发明申请

WO2011057288A2 ISOBUTANOL PRODUCTION WITH CORYNEBACTERIUM GLUTAMICUM 审中-公开
标题翻译： ISOBUTANOL生产与CORYNEBACTERIUM GLUTAMICUM
公开(公告)号：WO2011057288A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/056068
申请日：2010-11-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , SMITH, Kevin, M. , CHO, Kwang-Myung
发明人： LIAO, James, C. , SMITH, Kevin, M. , CHO, Kwang-Myung
IPC分类号： C12N1/21 , C12N15/52 , C12P7/16 , C12R1/15
CPC分类号： C12P7/16 , C12N9/88 , C12P7/04 , C12P7/22 , Y02E50/10
摘要： Provided herein are metabolically-modif ied microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1- butanol, 1-propanol, 2-methyl-l-butanol, 3-methyl-l-butanol and 2- phenylethanol from a suitable substrate.
摘要翻译：本文提供了可用于生产生物燃料的代谢修饰的微生物。更具体地，本文提供了从合适的底物生产高级醇，包括异丁醇，1-丁醇，1-丙醇，2-甲基-1-丁醇，3-甲基-1-丁醇和2-苯基乙醇的方法。

4. 发明申请

WO2009110698A3 PRODUCTION METHOD FOR A MONOHYDRIC ALCOHOL FROM A MONOCARBOXYLIC ACID OR FROM A DERIVATIVE THEREOF 审中-公开
标题翻译：来自单羧酸或其衍生物的单醇的生产方法
公开(公告)号：WO2009110698A3
公开(公告)日：2009-11-19
申请号：PCT/KR2009000963
申请日：2009-02-27
申请人： KOREA RESERACH INST OF CHEMICA , LEE JUNG HO , CHANG JONG SAN , HWANG YOUNG KYU , SHIN HYUN KWAN , CHO KWANG MYUNG , SONG BONG KEUN , KIM YONG HWAN
发明人： LEE JUNG HO , CHANG JONG SAN , HWANG YOUNG KYU , SHIN HYUN KWAN , CHO KWANG MYUNG , SONG BONG KEUN , KIM YONG HWAN
IPC分类号： C07C29/147
CPC分类号： C07C29/149 , B01J23/626 , B01J23/6567 , B01J23/8966 , B01J37/0009 , B01J37/031 , B01J37/10 , B01J37/18 , B01J2523/00 , C07C31/12 , B01J2523/27 , B01J2523/43 , B01J2523/821 , B01J2523/74 , B01J2523/828 , B01J2523/845 , B01J2523/17 , B01J2523/47 , B01J2523/41
摘要： The present invention relates to a production method for a monohydric alcohol from a monocarboxylic acid or from a derivative thereof. In the present invention, use is made of a catalyst comprising Ru and Sn components on a zinc-oxide (ZnO) carrier, or a catalyst produced by further adding a limited amount of an inorganic binder such as a titanium oxide or else silica or alumina in order to make the catalyst comprising the components better formable, or a catalyst improved by further adding one or more enhancing component chosen from the group comprising reductive components such as Co, Ni, Cu, Ag, Rh, Pd, Re, Ir and Pt in order to enhance the reducing ability of the catalyst. In this way, the present invention makes it possible to produce a monohydric alcohol in a high yield whether or not water is contained in the monocarboxylic acid or the derivative thereof which constitutes the starting material, and makes it possible to produce a monohydric alcohol using a method which is economical since it exhibits high selectivity and high productivity even though it can be implemented under very much more moderate reaction conditions than catalysts of known inventions, and also makes it possible to use the catalyst to advantage in industrial production applications since the catalyst has outstanding long-term reaction stability.
摘要翻译：本发明涉及一元醇由一元羧酸或其衍生物的制备方法。在本发明中，使用在氧化锌（ZnO）载体上含有Ru和Sn成分的催化剂，或通过进一步添加有限量的无机粘合剂如二氧化钛或二氧化硅或氧化铝为了使包含组分的催化剂更好地形成，或者通过进一步添加一种或多种选自包括还原组分如Co，Ni，Cu，Ag，Rh，Pd，Re，Ir和Pt的增强组分来改进催化剂以提高催化剂的还原能力。以这种方式，本发明使得可以以高产率生产一元醇，无论水是由单一羧酸或其构成起始原料的衍生物所含有，并且可以使用方法是经济的，因为即使可以在比已知发明的催化剂更适宜的反应条件下实施，它具有高选择性和高生产率，并且还可以在工业生产应用中有利地使用催化剂，因为催化剂具有突出的长期反应稳定性。

5. 发明申请

WO2008091093A1 PROCESS FOR PRODUCING FERMENTATION PRODUCT FROM CARBON SOURCES CONTAINING GLYCEROL USING CORYNEBACTERIA 审中-公开
标题翻译：用含有谷氨酸的碳源生产发酵产品的方法
公开(公告)号：WO2008091093A1
公开(公告)日：2008-07-31
申请号：PCT/KR2008/000391
申请日：2008-01-22
申请人： CJ CHEILJEDANG CORPORATION , CHO, Kwang-myung , CHOI, Kyung-oh , BAE, Hyun-ae
发明人： CHO, Kwang-myung , CHOI, Kyung-oh , BAE, Hyun-ae
IPC分类号： C12N1/20
CPC分类号： C12P13/14 , C12N9/0006 , C12N9/1205 , C12P13/08 , C12Y101/05003 , C12Y207/0103
摘要： The present invention relates to a method for producing fermentation product from various carbon sources containing glycerol using Corynebacteria. More particurarly, the present invention relates to a method for producing fermentation product from carbon sources containing glycerol or a part of glycerol with high yield and high productivity, by fermenting Corynebacteria introduced with the foreign gene glpDFK facilitating the use of glycerol and accumulating industrially useful amino acids in the culture medium.
摘要翻译：本发明涉及使用棒杆菌从含有甘油的各种碳源生产发酵产物的方法。更具体地，本发明涉及通过发酵引入外源基因glpDFK的棒状杆菌来促进甘油的使用并积累工业上有用的氨基，从而生成含有甘油或甘油部分甘油的发酵产物的方法培养基中的酸。

6. 发明申请

WO2008002053A1 METHOD FOR PRODUCING AMINO ACIDS USING GLYCEROL 审中-公开
标题翻译：使用甘油生产氨基酸的方法
公开(公告)号：WO2008002053A1
公开(公告)日：2008-01-03
申请号：PCT/KR2007/003082
申请日：2007-06-26
申请人： CJ CORPORATION , PARK, Young Hoon , CHO, Kwang Myung , SHIN, Yong Uk , BAE, Hyun Ae , CHANG, Jin Sook , JU, Jae Yeong
发明人： PARK, Young Hoon , CHO, Kwang Myung , SHIN, Yong Uk , BAE, Hyun Ae , CHANG, Jin Sook , JU, Jae Yeong
IPC分类号： C12P13/04 , C12N1/20
CPC分类号： C12P13/08 , C07K14/245 , C12N1/32 , C12P13/04 , C12P13/12
摘要： The present invention relates to an amino acid-producing microorganism capable of simultaneously utilizing glycerol as a carbon source, a method for preparing the microorganism, and a method for producing amino acids using the microorganism. According to the present invention, amino acids can be efficiently produced using a byproduct of biodiesel production, glycerol, thereby substituting a cheaper material for the conventional fermentation materials such as glucose.
摘要翻译：本发明涉及能够同时利用甘油作为碳源的氨基酸生产微生物，微生物的制备方法和使用该微生物的氨基酸的制造方法。根据本发明，可以使用生物柴油生产的副产物甘油有效地生产氨基酸，从而用较便宜的原料代替常规发酵材料如葡萄糖。

7. 发明申请

WO2005103262A1 A NOVEL DIOL DEHYDRATASE GENE CLUSTER IN LISTERIA GENUS 审中-公开
标题翻译：一种新的DIOL脱氢酶基因组在LISTERIA GENUS
公开(公告)号：WO2005103262A1
公开(公告)日：2005-11-03
申请号：PCT/KR2004/000901
申请日：2004-04-20
申请人： CJ CORP. , PARK, Young-Hoon , CHO, Kwang-Myung , KANG, Seong-Uk
发明人： PARK, Young-Hoon , CHO, Kwang-Myung , KANG, Seong-Uk
IPC分类号： C12N15/53
CPC分类号： C12Y101/01006 , C12N9/0006 , C12N9/88 , C12Y101/01202 , C12Y207/01029 , C12Y402/0103
摘要： This invention provides polynucleotide sequences coding diol dehydratase set forth as SEQ ID NO.1 or SEQ ID NO.6. this invention also provides vector and host cell comprising the polynucleotide.
摘要翻译：本发明提供编码如SEQ ID NO.1或SEQ ID NO.6所示的二醇脱水酶的多核苷酸序列。本发明还提供了包含多核苷酸的载体和宿主细胞。

8. 发明申请

WO2012061653A9 BIOFUEL AND CHEMICAL PRODUCTION BY RECOMBINANT MICROORGANISMS VIA FERMENTATION OF PROTEINACIOUS BIOMASS 审中-公开
标题翻译：通过发酵蛋白质生物量的重组微生物的生物化学和化学生产
公开(公告)号：WO2012061653A9
公开(公告)日：2012-07-19
申请号：PCT/US2011059231
申请日：2011-11-03
申请人： UNIV CALIFORNIA , LIAO JAMES C , CHO KWANG MYUNG , YAN YAJUN , HUO YIXIN
发明人： LIAO JAMES C , CHO KWANG MYUNG , YAN YAJUN , HUO YIXIN
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19 , C12N15/52 , C12N15/63 , C12P7/00 , C12P13/00
CPC分类号： C12N15/815 , C12N1/20 , C12N9/0016 , C12N9/1096 , C12N15/63 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/80 , C12N15/81 , C12P7/04 , C12P7/16 , C12P7/24 , C12P7/40 , C12P13/04 , Y02E50/10 , Y02E50/17 , Y02P20/582
摘要： Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed results in the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources. More specifically, provided herein are methods of producing alcohols, acetaldehyde, acetate, isobutyraldehyde, isobutyric acid, n- butyraldehyde, n-butyric acid, 2-methyl-l-butyraldehyde, 2-methyl-l -butyric acid, 3- methyl-l-butyraldehyde, 3 -methyl- 1 -butyric acid, ammonia, ammonium, amino acids, 2,3-butanediol, 1,4-butanediol, 2-methyl-l, 4-butanediol, 2-methyl- 1,4-butanediamine, isobutene, itaconate, acetoin, acetone, isobutene, 1,5-diaminopentane, L-lactic acid, D- lactic acid, shikimic acid, mevalonate, polyhydroxybutyrate (PHB), isoprenoids, fatty acids, homoalanine, 4-aminobutyric acid (GABA), succinic acid, malic acid, citric acid, adipic acid, p-hydroxy-cinnamic acid, tetrahydrofuran, 3-methyl-tetrahydrofuran, gamma-butyrolactone, pyrrolidinone, n-methylpyrrolidone, aspartic acid, lysine, cadeverine, 2-ketoadipic acid, and/or S-adenosyl-methionine (SAM) from a suitable nitrogen rich biomass.
摘要翻译：本文提供了代谢修饰的微生物，其特征在于与野生型生物体相比具有增加的酮酸通量，并且包含至少一种编码酶的多核苷酸，当表达导致产生更大量的化学产品时，与野生型生物体。重组微生物可用于从各种含氮生物质组合物和其它碳源生产大量化学成分。更具体地，本文提供了生产醇，乙醛，乙酸酯，异丁醛，异丁酸，正丁醛，正丁酸，2-甲基-1-丁醛，2-甲基-1-丁酸，3-甲基-1-丁酸， 1-丁醇，3-甲基-1-丁酸，氨，铵，氨基酸，2,3-丁二醇，1,4-丁二醇，2-甲基-1,4-丁二醇，2-甲基-1,4-丁二醇，丁二胺，异丁烯，衣康酸酯，乙偶姻，丙酮，异丁烯，1,5-二氨基戊烷，L-乳酸，D-乳酸，莽草酸，甲羟戊酸，聚羟基丁酸（PHB），类异戊二烯，脂肪酸，高丙氨酸，4-氨基丁酸 GABA），琥珀酸，苹果酸，柠檬酸，己二酸，对羟基肉桂酸，四氢呋喃，3-甲基 - 四氢呋喃，γ-丁内酯，吡咯烷酮，正 - 甲基吡咯烷酮，天冬氨酸，赖氨酸，仙茅素，2-酮己二酸酸和/或S-腺苷 - 甲硫氨酸（SAM）。

9. 发明申请

WO2011088425A3 ELECTRO-AUTOTROPHIC SYNTHESIS OF HIGHER ALCOHOLS 审中-公开
标题翻译：电高自溶合成高级醇
公开(公告)号：WO2011088425A3
公开(公告)日：2011-11-24
申请号：PCT/US2011021436
申请日：2011-01-15
申请人： UNIV CALIFORNIA , LIAO JAMES C , CHO KWANG-MYUNG
发明人： LIAO JAMES C , CHO KWANG-MYUNG
IPC分类号： C12N1/21 , C12N15/52 , C12P7/04 , C12P7/16
CPC分类号： C12P7/22 , C12N9/0006 , C12N9/88 , C12P7/04 , C12P7/16 , C12Y101/01001 , C12Y401/01072 , Y02E50/10 , Y02P20/134 , Y02P20/52 , Y02P20/59
摘要： The disclosure provides a process that converts CO2 to higher alcohols (e.g. isobutanol) using electricity as the energy source. This process stores electricity (e.g. from solar energy, nuclear energy, and the like) in liquid fuels that can be used as high octane number gasoline substitutes. Instead of deriving reducing power from photosynthesis, this process derives reducing power from electrically generated mediators, either H2 or formate. H2 can be derived from electrolysis of water. Formate can be generated by electrochemical reduction of CO2. After delivering the reducing power in the cell, formate becomes CO2 and recycles back. Therefore, the biological CO2 fixation process can occur in the dark.
摘要翻译：本公开提供了使用电作为能源将CO 2转化成高级醇（例如异丁醇）的方法。该过程将电能（例如来自太阳能，核能等）储存在可用作高辛烷值汽油替代品的液体燃料中。该过程不是从光合作用中获得还原能力，而是从电生成的介体（H2或甲酸盐）中获得还原能力。 H2可以来源于水的电解。甲酸盐可以通过电化学还原CO2产生。在细胞内传递还原力后，甲酸盐变成二氧化碳并回收。因此，生物CO2固定过程可以在黑暗中发生。

10. 发明申请

WO2011137369A1 PRODUCTION OF GAMMA-AMINOBUTYRIC ACID BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：通过重组微生物生产游离氨基酸
公开(公告)号：WO2011137369A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034612
申请日：2011-04-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , CHO, Kwang, Myung
发明人： LIAO, James, C. , CHO, Kwang, Myung
IPC分类号： C12N1/21 , C12N9/88 , C12P13/00
CPC分类号： C12N9/88 , C12P13/005
摘要： Provided herein are metabolically-modified microorganisms useful for producing gamma-aminobutyric acid.
摘要翻译：本文提供了可用于产生γ-氨基丁酸的代谢修饰的微生物。

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