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1. 发明申请

WO2005116078A1 GLYCOSYLATED IMMUNOGLOBULIN AND IMMUNOADHESIN COMPRISING THE SAME 审中-公开
标题翻译：含有免疫球蛋白和免疫球蛋白的糖蛋白
公开(公告)号：WO2005116078A1
公开(公告)日：2005-12-08
申请号：PCT/KR2005/001627
申请日：2005-05-31
申请人： MEDEXGEN INC. , CHUNG, Yong-Hoon , YI, Ki-Wan , CHO, Hoon-Sik , PARK, Hong-Gyu , KIM, Kwang-Seong
发明人： CHUNG, Yong-Hoon , YI, Ki-Wan , CHO, Hoon-Sik , PARK, Hong-Gyu , KIM, Kwang-Seong
IPC分类号： C07K16/42
CPC分类号： A61K38/1774 , C07K2317/21 , C07K2317/41 , C07K2317/524 , C07K2317/526 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a glycosylated immunoglobulin or a fragment thereof, in which an immunoglobulin variant, comprising one or more amino acid modifications selected from the group consisting of M160N, A195N, T243N, E265N, Y299T, F331T and Q346N, is additionally glycosylated, and a gene encoding the same. Also, the present invention relates to a glycosylated fusion protein formed as a result of linkage of (a) a glycosylated immunoglobulin or a fragment thereof, in which an immunoglobulin variant having a modified amino acid sequence forming one or more Asn- X-Ser/Thr sequences is additionally glycosylated, with (b) at least one biologically active protein or a portion thereof, a gene encoding the same, a recombination expression vector comprising the gene, a host cell transformed or transfected with the recombinant expression vector, and a method of preparing a glycosylated fusion protein comprising culturing the transformant or transfectant and isolating the glycosylated fusion protein from the culture, and a pharmaceutical composition comprising the glycosylated fusion protein thus prepared.
摘要翻译：本发明涉及糖基化免疫球蛋白或其片段，其中包含一个或多个选自M160N，A195N，T243N，E265N，Y299T，F331T和Q346N的氨基酸修饰的免疫球蛋白变体另外被糖基化，和编码该基因的基因。此外，本发明涉及由（a）糖基化免疫球蛋白或其片段连接而形成的糖基化融合蛋白，其中具有形成一个或多个Asn-X-Ser / Thr序列另外被糖基化，（b）至少一种生物活性蛋白质或其部分，编码该基因的基因，包含该基因的重组表达载体，用重组表达载体转化或转染的宿主细胞，以及方法制备糖基化融合蛋白，包括培养转化体或转染子并从培养物中分离糖基化融合蛋白，以及包含如此制备的糖基化融合蛋白的药物组合物。

2. 发明申请

WO2005077415A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF IMMUNOLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗免疫缺陷病毒的药物组合物
公开(公告)号：WO2005077415A1
公开(公告)日：2005-08-25
申请号：PCT/KR2005/000457
申请日：2005-02-18
申请人： MEDEXGEN INC. , CHUNG, Yong-Hoon , CHO, Hoon-Sik , PARK, Hong-Gyu , YI, Ki-Wan
发明人： CHUNG, Yong-Hoon , CHO, Hoon-Sik , PARK, Hong-Gyu , YI, Ki-Wan
IPC分类号： A61K39/395
CPC分类号： C07K14/715 , A61K38/00 , C07K14/70503 , C07K2319/30
摘要： Disclosed is a pharmaceutical composition for treating immunological disorders by inhibiting the activation of T lymphocytes, comprising, as active ingredients, two or more selected from the group consisting of a substance capable of blocking binding of an MHC (Major Histocompatibility Complex) Class II molecule and a receptor thereof, a substance capable of blocking binding of a costimulatory molecule and a receptor thereof a substance capable of blocking binding of an adhesion molecule and a receptor thereof, and a substance capable of blocking binding of a cytokine and a receptor thereof.
摘要翻译：公开了通过抑制T淋巴细胞的活化来治疗免疫学障碍的药物组合物，其包含作为活性成分的两种或更多种选自以下的物质：能够阻断MHC（主要组织相容性复合物）II类分子和能够阻断共刺激分子及其受体的结合的物质，能够阻断粘附分子及其受体的结合的物质，以及能够阻断细胞因子及其受体的结合的物质。

3. 发明申请

WO2007111419A1 METHOD FOR WINDING UNDER-THREAD OF SEWING MACHINE AND BOBBIN WOUND WITH UNDER-THREAD USING THE METHOD 审中-公开
标题翻译：使用方法用下螺纹缠绕缝纫机和BOBBIN绕线的方法
公开(公告)号：WO2007111419A1
公开(公告)日：2007-10-04
申请号：PCT/KR2007/001055
申请日：2007-03-02
申请人： CHO, Hoon Sik
发明人： CHO, Hoon Sik
IPC分类号： D05B59/00
CPC分类号： D05B59/00
摘要： The present invention relates to a method for winding an under thread of a sewing machine and a bobbin wound with the under thread by the same method, and more particularly to a method for winding an under thread of a sewing machine on a bobbin in order to secure the under thread remains and a bobbin wound with the under thread by the said method. The method for winding an under thread of a sewing machine so as to easily sense the finish of the under thread during a sewing operation, includes the steps of: (a) winding an under thread around a part of the surface of a bobbin, the under thread being left by a given length around the bobbin when alarming the under thread reaching its end; and (b) winding the said under thread continuously around the remaining surface of the bobbin except the part of the surface of the bobbin wound with the under thread at the step (a), the continuously wound under thread being used to sense its finish.
摘要翻译：本发明涉及一种通过相同的方法卷绕缝纫机的底线和缠绕在底线上的筒管的方法，更具体地涉及一种将缝纫机的底线卷绕在筒管上的方法，以便通过所述方法固定下螺纹保持件和与下螺纹缠绕的绕线筒。在缝纫操作期间卷绕缝纫机的下线以便容易地感知底线的方法包括以下步骤：（a）在线轴表面的一部分周围卷绕下线，当线下到达其末端时，下线在线圈周围留有给定的长度; 和（b）在步骤（a）中，除了缠绕在底线的筒管的表面部分之外，将所述底线连续地卷绕在线轴的剩余表面上，连续卷绕的线被用于感测其整理。

4. 发明申请

WO2008063032A1 END POINT DETECTING APPARATUS AND METHOD OF BOBBIN PRINTING BAR CODE AND WINDING DIVISION THREAD 审中-公开
标题翻译：端点检测装置和BOBBIN打印条形码和卷绕部分螺纹的方法
公开(公告)号：WO2008063032A1
公开(公告)日：2008-05-29
申请号：PCT/KR2007/005962
申请日：2007-11-23
申请人： CHO, Hoon-Sik
发明人： CHO, Hoon-Sik
IPC分类号： D05B59/02
CPC分类号： D05B59/02
摘要： An apparatus for detecting the tail end of bobbin thread wound in separate regions around a barcode-printed bobbin is provided. Bars of a barcode are printed separately in multiple sections on the outer surface of the bobbin, and store respective position information of the multiple sections. The thread is wound to predetermined lengths respectively in separate regions around the bobbin, divided into the sections according to the printed bars, while covering the barcode. A detector includes an LED and a light receiving sensor provided in a side opening of a bobbin case. The LED emits light to the printed barcode when the thread is exhausted and the light receiving sensor detects returning light. A controller includes a decoder, setting unit, and processor. The decoder converts a barcode value read by the detector into digital. The setting unit receives a preset value corresponding to a position of one of sequential remaining amounts of thread represented by the barcode. The processor determines whether the digital value is identical to the preset value. A notification unit includes a speaker and lamp for notifying, when the wound thread is exhausted, the worker of the exhaustion according to the digital value.
摘要翻译：提供一种用于检测缠绕在条形码印刷线轴周围的分离区域中的底线尾端的装置。条形码条在筒管的外表面上以多个部分分别印刷，并存储多个部分的相应位置信息。螺纹线分别围绕绕线筒缠绕到预定长度上，分成根据印刷条的部分，同时覆盖条形码。检测器包括设置在梭壳的侧开口中的LED和光接收传感器。当线路耗尽时，LED会向打印的条形码发光，并且光接收传感器检测到返回光。控制器包括解码器，设置单元和处理器。解码器将由检测器读取的条形码值转换成数字。设置单元接收与由条形码表示的线程的连续剩余量中的一个的位置对应的预设值。处理器确定数字值是否等于预设值。通知单元包括扬声器和灯，用于当伤口线被耗尽时，根据数字值通知工作人员的疲劳。

5. 发明申请

WO2007126205A1 APPARATUS AND METHOD FOR DETECTING AN ENDING-POINT OF BOBBIN THREAD FOR SEWING MACHINE USING BAR CODE 审中-公开
标题翻译：使用条码检测缝纫机的BOBBIN螺纹端点的装置和方法
公开(公告)号：WO2007126205A1
公开(公告)日：2007-11-08
申请号：PCT/KR2007/001046
申请日：2007-03-02
申请人： CHO, Hoon Sik
发明人： CHO, Hoon Sik
IPC分类号： D05B59/02
CPC分类号： D05B59/00 , D05B57/28 , D05B59/02 , D05D2205/12 , D05D2305/14
摘要： The present invention relates to an apparatus and a method for detecting the ending-point of a bobbin thread for a sewing machine using a bar code, which is capable of alerting a sewing operator of his/her desiring bobbin thread remains when they are left enough to finish sewing under operation. The present invention of the apparatus for detecting the ending-point of a bobbin thread for a sewing machine using a bar code so as to sense the ending-point of a bobbin thread during a sewing operation, comprises a bobbin to wind a bobbin thread therearound and at least one bar code to indicate a position in the surface of a bobbin, of which the bar code is printed on one or both side(s).
摘要翻译：本发明涉及一种用于使用条形码检测用于缝纫机的底线的终点的装置和方法，其能够警告他/她期望的底线的缝纫操作者在足够的时候保持其希望的底线完成缝纫操作。用于使用条形码检测用于缝纫机的底线的终点以便在缝纫操作期间感测底线的终点的装置的本发明包括绕其绕线轴的筒管以及至少一个条形码，以指示在一个或两个侧面上打印条形码的线轴的表面中的位置。

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