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1. 发明申请

WO2021011653A1 INDEPENDENT PROXIMAL ELEMENT ACTUATION METHODS 审中-公开
公开(公告)号：WO2021011653A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042137
申请日：2020-07-15
申请人： EVALVE, INC. , KIZUKA, Koji , CHILDS, Richard , GONZALES, Gabriel , VAN HOVEN, Dylan , ABUNASSAR, Chad , MARSOT, Travis , MOSLEY, Rob , PATEL, Nisu , VALENCIA, Francisco
发明人： KIZUKA, Koji , CHILDS, Richard , GONZALES, Gabriel , VAN HOVEN, Dylan , ABUNASSAR, Chad , MARSOT, Travis , MOSLEY, Rob , PATEL, Nisu , VALENCIA, Francisco
IPC分类号： A61F2/24
摘要： Fixation system for fixation of leaflets of a heart valve including an implantable fixation device having a first arm and a second arm, a first proximal element moveable relative to the first arm between a first position and a second position, and a second proximal element moveable relative to the second arm between a first position and a second position. The fixation system includes a delivery device having a catheter, a first proximal element line and a second proximal element line, and a handle having a first and second proximal element line handles coupled to the first proximal element line and the second proximal element line, respectively. The handle can include an interlock moveable between an unlocked position and a locked position.

2. 发明申请

WO2007109583A2 COMPOSITIONS AND METHODS FOR PREVENTION OR TREATMENT OF NEOPLASTIC DISEASE IN A MAMMALIAN SUBJECT 审中-公开
标题翻译：用于预防或治疗哺乳动物疾病中的神经疾病的组合物和方法
公开(公告)号：WO2007109583A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/064237
申请日：2007-03-16
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CHILDS, Richard, William, Wyatt , TAKAHASHI, Yoshiyuki , KAJIGAYA, Sachiko , HARASHIMA, Nanae
发明人： CHILDS, Richard, William, Wyatt , TAKAHASHI, Yoshiyuki , KAJIGAYA, Sachiko , HARASHIMA, Nanae
IPC分类号： A61K39/21 , C12N5/06
CPC分类号： C12N5/0638 , A61K35/12 , A61K35/17 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/585 , C07K14/005 , C12N2740/10022 , C12N2740/10034
摘要： Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an enriched immune cell population reactive to a human endogenous retrovirus type E antigen on a tumor cell. A method of treating a neoplastic disease in a mammalian subject is provided which comprises administering to a mammalian subject a composition comprising an enriched immune cell population reactive to a human endogenous retrovirus type E antigen, in an amount effective to reduce or eliminate the neoplastic disease or to prevent its occurrence or recurrence.
摘要翻译：提供用于预防或治疗哺乳动物受试者的肿瘤疾病的组合物和方法。提供了一种组合物，其包含对肿瘤细胞上的人内源性逆转录病毒E型抗原具有反应性的富集的免疫细胞群体。提供了治疗哺乳动物受试者中的肿瘤疾病的方法，其包括向哺乳动物受试者施用包含有效减少或消除肿瘤性疾病的量的包含对人内源性逆转录病毒E型抗原具有反应性的富集的免疫细胞群的组合，或以防止其发生或复发。

3. 发明申请

WO2006050270A3 COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS 审中-公开
公开(公告)号：WO2006050270A3
公开(公告)日：2006-05-11
申请号：PCT/US2005/039282
申请日：2005-10-31
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES , CHILDS, Richard, William, Wyatt , IGARASHI, Takehito , WYNBERG, Jason, Benjamin
发明人： CHILDS, Richard, William, Wyatt , IGARASHI, Takehito , WYNBERG, Jason, Benjamin
IPC分类号： C12N5/06 , A61K35/12
摘要： The invention generally relates to a composition comprising an enriched NK cell population. The invention further relates to a method of treating a solid tumor or a hyperproliferative disorder by administering the enriched NK cell population to a mammalian subject in need thereof.

4. 发明申请

WO2006050270A2 COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISORDERS 审中-公开
标题翻译：治疗过度增殖性疾病的组合物和方法
公开(公告)号：WO2006050270A2
公开(公告)日：2006-05-11
申请号：PCT/US2005039282
申请日：2005-10-31
申请人： US GOV HEALTH & HUMAN SERV , CHILDS RICHARD WILLIAM WYATT , IGARASHI TAKEHITO , WYNBERG JASON BENJAMIN
发明人： CHILDS RICHARD WILLIAM WYATT , IGARASHI TAKEHITO , WYNBERG JASON BENJAMIN
IPC分类号： A61K31/704 , C12N5/0783
CPC分类号： A61K35/17 , A61K35/12 , A61K45/06 , C12N5/0646
摘要： The invention generally relates to a composition comprising an enriched NK cell population. The invention further relates to a method of treating a solid tumor or a hyperproliferative disorder by administering the enriched NK cell population to a mammalian subject in need thereof.
摘要翻译：本发明一般涉及包含富集的NK细胞群的组合物。本发明进一步涉及通过将富集的NK细胞群施用于有需要的哺乳动物受试者来治疗实体瘤或过度增殖性病症的方法。

5. 发明申请

WO2007109583A3 COMPOSITIONS AND METHODS FOR PREVENTION OR TREATMENT OF NEOPLASTIC DISEASE IN A MAMMALIAN SUBJECT 审中-公开
标题翻译：预防或治疗哺乳动物中肿瘤性疾病的组合物和方法
公开(公告)号：WO2007109583A3
公开(公告)日：2007-12-27
申请号：PCT/US2007064237
申请日：2007-03-16
申请人： US GOV HEALTH & HUMAN SERV , CHILDS RICHARD WILLIAM WYATT , TAKAHASHI YOSHIYUKI , KAJIGAYA SACHIKO , HARASHIMA NANAE
发明人： CHILDS RICHARD WILLIAM WYATT , TAKAHASHI YOSHIYUKI , KAJIGAYA SACHIKO , HARASHIMA NANAE
IPC分类号： A61K39/21 , C07K14/15 , G01N33/574
CPC分类号： C12N5/0638 , A61K35/12 , A61K35/17 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/585 , C07K14/005 , C12N2740/10022 , C12N2740/10034
摘要： Compositions and methods are provided for preventing or treating neoplastic disease in a mammalian subject. A composition is provided which comprises an enriched immune cell population reactive to a human endogenous retrovirus type E antigen on a tumor cell. A method of treating a neoplastic disease in a mammalian subject is provided which comprises administering to a mammalian subject a composition comprising an enriched immune cell population reactive to a human endogenous retrovirus type E antigen, in an amount effective to reduce or eliminate the neoplastic disease or to prevent its occurrence or recurrence.
摘要翻译：提供了用于预防或治疗哺乳动物受试者中的肿瘤疾病的组合物和方法。提供了一种组合物，其包含对肿瘤细胞上的人内源性逆转录病毒E型抗原具有反应性的富集的免疫细胞群。提供了治疗哺乳动物受试者中肿瘤疾病的方法，其包括以有效减少或消除肿瘤疾病的量向哺乳动物受试者施用包含对人内源性逆转录病毒E型抗原有反应性的富集免疫细胞群的组合物，或防止其发生或复发。

6. 发明申请

WO1984001222A1 ALCOHOL BREATH TESTER 审中-公开
公开(公告)号：WO1984001222A1
公开(公告)日：1984-03-29
申请号：PCT/US1983001454
申请日：1983-09-22
申请人： CHILDS, Robert, L. , CHILDS, Richard, W.
IPC分类号： G01N31/06
CPC分类号： G01N33/98 , G01N33/4972
摘要： Apparatus for determining the alcohol content in the breath of a human subject. The apparatus comprises a clear cartridge (30) having a top and a bottom, a first oneway valve (36) disposed in the bottom of the container (30) and oriented to permit only ingress to the container (30). An alcohol - sensitive solution (37) is disposed in the container (30) and such solution (37) is formulated to change color in accordance with alcohol combined with the solution (37). A mouthpiece (24) and a body member (12) are also provided having a passageway (14) connecting the mouthpiece (24) to the oneway valve (36) whereby, when the subject exhales through the mouthpiece (24), the breath enters the solution (37) through the oneway valve (36) and flows through the solution (37). The color of the solution (37) then changes in accordance with the quantity of alcohol in the subject's breath.
摘要翻译：用于确定人类受试者呼吸中的酒精含量的装置。该设备包括具有顶部和底部的清洁盒（30），设置在容器（30）的底部中并定向成仅允许进入容器（30）的第一单向阀（36）。酒精敏感溶液（37）设置在容器（30）中，并且这种溶液（37）被配制为根据与溶液（37）组合的醇改变颜色。吸嘴（24）和本体构件（12）还设有具有将接口（24）连接到单向阀（36）的通道（14），由此当被检者通过接口管（24）呼出时，呼吸进入溶液（37）通过单向阀（36）并流过溶液（37）。然后溶液（37）的颜色根据受试者呼吸中的酒精量而变化。

7. 发明申请

WO2022098718A1 MODIFIED NK CELLS WITH REDUCED CCR5 EXPRESSION AND METHODS OF THEIR USE 审中-公开
公开(公告)号：WO2022098718A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/057845
申请日：2021-11-03
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CHILDS, Richard W. , LEVY, Emily R. , CLARA, Joseph
发明人： CHILDS, Richard W. , LEVY, Emily R. , CLARA, Joseph
IPC分类号： C12N5/0783
摘要： Modified NK cells with reduced expression of CCR5 are provided. Methods of treating a subject with cancer with the modified NK cells are also provided. In some examples, the modified NK cells also have reduced expression of one or more of CCR1, CXCR6, and CD38, increased expression of one or more of CXCR4, CCR7, and CXCR3, and/or express a chimeric antigen receptor.

8. 发明申请

WO2021011655A1 PROXIMAL ELEMENT ACTUATOR FIXATION AND RELEASE MECHANISMS 审中-公开
公开(公告)号：WO2021011655A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/042139
申请日：2020-07-15
申请人： EVALVE, INC. , CHILDS, Richard , KIZUKA, Koji , GONZALES, Gabriel , VAN HOVEN, Dylan , MAHMOUD, Tamer , ABUNASSAR, Chad , PRABHU, Santosh
发明人： CHILDS, Richard , KIZUKA, Koji , GONZALES, Gabriel , VAN HOVEN, Dylan , MAHMOUD, Tamer , ABUNASSAR, Chad , PRABHU, Santosh
IPC分类号： A61F2/24
摘要： Fixation system for engaging tissue of a patient including an implantable fixation device having a first arm and a second arm, a first proximal element, a second proximal element, and a coupling member. The system includes a delivery device having a catheter, a shaft extending through the at least one lumen of the catheter, a first proximal element actuator and a second proximal element actuator. The second end portions of the first proximal element actuator and second proximal element actuator can be coupled to at least one of the shaft and the coupling member.

9. 发明申请

WO2010129569A1 SELECTIVE ACCESS TO CRYOPRESERVED SAMPLES 审中-公开
标题翻译：选择性获得CRYOPRESERVED样品
公开(公告)号：WO2010129569A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033575
申请日：2010-05-04
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , AMERICAN FLUOROSEAL CORPORATION , CHILDS, Richard, W. , CULLIS, Herb , VASU, Sumithira , BROUSSARD, Phillippe, Jean , CLARK, Kevin, Douglas , HARTING, Eric, Kelsey
发明人： CHILDS, Richard, W. , CULLIS, Herb , VASU, Sumithira , BROUSSARD, Phillippe, Jean , CLARK, Kevin, Douglas , HARTING, Eric, Kelsey
IPC分类号： G01N1/28 , A01N1/02 , A01M1/02 , B29C65/00
CPC分类号： B65B17/00 , A01N1/0252 , A01N1/0257 , A61M1/0281 , B29C63/18 , B29C65/04 , B29C65/08 , B29C65/14 , B29C65/1412 , B29C65/18 , B29C65/224 , B29C65/228 , B29C65/743 , B29C65/7443 , B29C65/7841 , B29C66/0044 , B29C66/024 , B29C66/0242 , B29C66/1122 , B29C66/348 , B29C66/43 , B29C66/431 , B29C66/4312 , B29C66/43121 , B29C66/53262 , B29C66/7373 , B29C66/73921 , B29C66/8122 , B29C66/81261 , B29C66/81427 , B29C66/818 , B29C66/8181 , B29C66/81811 , B29C66/81821 , B29C66/81831 , B29C66/81871 , B29C66/8242 , B29C66/8322 , B29C66/91213 , B29C66/91221 , B29C66/91231 , B29C66/91421 , B29C66/91423 , B29C66/91441 , B29C66/91445 , B29C66/9161 , B29C66/91655 , B29C66/919 , B29C66/9221 , B29C66/9231 , B29C66/9241 , B29C66/92445 , B29C66/94 , B29C66/949 , B29C66/961 , B29C2035/0822 , B29C2793/0054 , B29L2031/7148 , G01N1/286 , Y10T83/041 , Y10T83/283 , B29C65/00 , B29K2827/18 , B29K2827/12 , B29K2909/02
摘要： Methods and apparatus for selectively accessing a portion of a sterile cryopreserved sample are disclosed. The apparatus may include a container configured to receive the cryopreserved sample and having a first portion and a second portion, a heat sink chamber surrounding the first portion of the container, and a heat source adjacent to the second portion of the container. The chamber may be configured to maintain a non-accessed portion of the sample in a cryopreserved state. The heat source may be configured to separating an accessed portion of the sample from the non-accessed portion of the sample while maintaining the viability of the accessed portion while the non-accessed portion is maintained in the cryopreserved state.
摘要翻译：公开了用于选择性访问无菌冷冻保存样品的一部分的方法和装置。该装置可以包括容纳构造成接收冷冻保存样品并具有第一部分和第二部分的容器，围绕容器的第一部分的散热室以及与容器的第二部分相邻的热源。腔室可以被配置为将样品的未被接近的部分保持在冷冻保存状态。热源可以被配置为将样本的被访问部分与样本的未访问部分分离，同时保持所访问部分的可行性，同时将未访问部分保持在冷冻保存状态。

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