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1. 发明申请

WO1994004674A1 HUMAN MELANOCYTE STIMULATING HORMONE RECEPTOR 审中-公开
标题翻译：人类MELANOCYTE刺激激素受体
公开(公告)号：WO1994004674A1
公开(公告)日：1994-03-03
申请号：PCT/DK1993000273
申请日：1993-08-20
申请人： WIKBERG, Jarl , CHHAJLANI, Vijay
IPC分类号： C12N15/12
CPC分类号： C07K16/2869 , A61K38/00 , C07K14/72 , C07K2317/34 , C07K2319/00
摘要： Novel DNA fragments encoding novel polypeptides having properties of melanotropic hormone receptors, especially DNA fragments encoding melanocyte stimulating hormone receptors (MSH receptors), as well as polypeptides which are MSH receptors, are disclosed. The use and engineering of melanotropic hormone receptor DNA and polypeptides for production of monoclonal antibodies for diagnostic and therapeutic purposes, as well as the engineering of drugs, cell lines, vectors and DNA for therapeutic and diagnostic purposes are also disclosed. Also disclosed are methods for therapy and diagnosis of malignant melanoma, skin cancer, vitiligo, pyretic condition, inflammatory condition, nociceptive condition, catatonic condition, impaired memory condition, reduced or increased skin tanning, pigmentation condition, epilepsy and nerve damage, using the DNA fragments, polypeptides and antibodies. Methods for selecting substances which interact with the receptors are also disclosed.
摘要翻译：公开了编码具有黑素激素受体特性，特别是编码黑素细胞刺激激素受体（MSH受体）的DNA片段以及作为MSH受体的多肽的新型多肽的新型DNA片段。还公开了用于诊断和治疗目的的用于产生单克隆抗体的黑素激素受体DNA和多肽的用途和工程，以及用于治疗和诊断目的的药物，细胞系，载体和DNA的工程。还公开了使用DNA的方法，用于治疗和诊断恶性黑素瘤，皮肤癌，白癜风，发炎病症，炎性病症，伤害性疾病，紧张状态，受损记忆状况，减少或增加的皮肤晒黑，色素沉着状况，癫痫和神经损伤片段，多肽和抗体。还公开了与受体相互作用的物质的选择方法。

2. 发明申请

WO2006001750A1 IMIDAZOLE VARIANTS AS MODULATORS OF GABA RECEPTOR FOR THE TREATMENT OF GI DISORDERS 审中-公开
标题翻译：作为治疗胃肠疾病的GABA受体调节剂的咪唑唑变体
公开(公告)号：WO2006001750A1
公开(公告)日：2006-01-05
申请号：PCT/SE2005/000951
申请日：2005-06-20
申请人： ASTRAZENECA AB , BAUER, Udo , BRAILSFORD, Wayne , CHHAJLANI, Vijay , EGNER, Bryan , FJELLSTRÖM, Ola , GUSTAFSSON, Linda , MATTSSON, Jan , NILSSON, Karolina , OLSSON, Thomas
发明人： BAUER, Udo , BRAILSFORD, Wayne , CHHAJLANI, Vijay , EGNER, Bryan , FJELLSTRÖM, Ola , GUSTAFSSON, Linda , MATTSSON, Jan , NILSSON, Karolina , OLSSON, Thomas
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D233/90 , C07D401/12 , C07D405/04 , C07D409/06 , C07D409/12 , C07D413/12
摘要： Box No. IV Text of the abstract (Continuation of item 5 of the first sheet) The present invention relates to novel compounds having a positive allosteric GÀBAB receptor (GDR) modulator effect, methods for the preparation of said compounds and to their use, optionally in combination with a GABAB agonist, for the inhibition of transient lower esophageal sphincter relaxations, for the treatment of gastroesophageal reflux disease, as well as for the treatment of functional gastrointestinal disorders and irritable bowel syndrome (IBS). A compound of the general formula I
摘要翻译：专栏第IV号摘要的文本（第一页的第5项的继续）本发明涉及具有正的变构GABA受体（GDR）调节剂效应的新化合物，可任选地用于制备所述化合物的方法及其用途与GABAB激动剂组合，用于抑制短暂食管括约肌松弛，用于治疗胃食管反流疾病，以及治疗功能性胃肠道疾病和肠易激综合征（IBS）。通式I的化合物

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