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1. 发明申请

WO2008116219A2 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
标题翻译：单克隆抗体8H9的用途
公开(公告)号：WO2008116219A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/058030
申请日：2008-03-24
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHEUNG, Nai-Kong, V.
发明人： CHEUNG, Nai-Kong, V.
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , C07K16/2827 , C07K2317/565 , C07K2317/622
摘要： The present invention discloses monoclonal antibody 8H9 which binds to the 4Ig domain isoform of the human B7-homolog 3, 4Ig-B7H3. The present invention provides a method of improving the prognosis or prolonging the survival of a subject bearing tumor cells, the method comprises administering to the subject a composition comprising an effective amount of an agent capable of binding to an antigen recognized by monoclonal antibody 8H9.
摘要翻译：本发明公开了结合人B7-同系物3,4Ig-B7H3的4Ig结构域同种型的单克隆抗体8H9。本发明提供了改善携带肿瘤细胞的受试者的预后或延长存活的方法，所述方法包括给受试者施用包含有效量的能够结合由单克隆抗体8H9识别的抗原的试剂的组合物。 / p>

2. 发明申请

WO2003075846A3 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
公开(公告)号：WO2003075846A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/007004
申请日：2003-03-06
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHEUNG, Nai-Kong, V.
发明人： CHEUNG, Nai-Kong, V.
IPC分类号： C07K16/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a suitable carrier.This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier.This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides different uses of the monoclonal antibody 8H9 or its derivative.

3. 发明申请

WO2002092767A3 DETECTION OF GD2 SYNTHASE mRNA AND USES THEREOF 审中-公开
公开(公告)号：WO2002092767A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/015037
申请日：2002-04-19
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHEUNG, Irene, Y. , CHEUNG, Nai-Kong, V.
发明人： CHEUNG, Irene, Y. , CHEUNG, Nai-Kong, V.
IPC分类号： C12Q1/68
摘要： The present invention provides a method to measure GD2 synthase mRNA comprising steps of: (a) obtaining a mRNA sample; (b) performing real-time quantitative RT-PCR on the sample using appropriate primers of GD2 synthase; and (c) determining the amount of GD2 synthase mRNA. The invention also provides a method to diagnose a subject which bears cancer expressing GD2 synthase. Furthermore, this invention provides a method to stage a cancer expressing GD2 synthase in a subject. Finally, this invention provides a kit for detection of GD2 synthase.

4. 发明申请

WO2002058711A1 THERAPY-ENHANCING GLUCAN 审中-公开
标题翻译：治疗葡萄糖
公开(公告)号：WO2002058711A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/001276
申请日：2002-01-15
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHEUNG, Nai-Kong, V.
发明人： CHEUNG, Nai-Kong, V.
IPC分类号： A61K31/715
CPC分类号： A61K39/395 , A61K31/716 , A61K31/739 , A61K39/39558 , A61K39/44 , A61K31/715 , A61K2300/00
摘要： This invention provides a composition comprising an effective amount of glucan capable of enhancing efficacy of antibodies. This invention further provides the above compositions and a pharmaceutically acceptable carrier. This invention also provides a method fro treating a subject with cancer comprising administrating the above-described composition comprising effective amount of glucan capable of enhancing efficacy of vaccines. This invention provid a composition comprising effective amount of glucan capable of enhancing efficacy of vaccines. This invention also provides a method of treating a subject comprising administrating the above pharmaceutical composition to the subject. This invention provides a composition comprising effective amount of glucan capable of enhancing efficacy of natural antibodies. This invention provides a composition comprising effective amount of glucan capable of enhancing host immunity. This invention also provides a composition comprising effective amount of glucan capable of enhancing the action of an agent in preventing tissue rejection.
摘要翻译：本发明提供了包含能够增强抗体功效的有效量的葡聚糖的组合物。本发明还提供了上述组合物和药学上可接受的载体。本发明还提供了一种用癌症治疗受试者的方法，包括施用上述包含有效量的能增强疫苗功效的葡聚糖的组合物。本发明提供了包含能够增强疫苗功效的有效量的葡聚糖的组合物。本发明还提供一种治疗受试者的方法，包括向受试者施用上述药物组合物。本发明提供了包含有效量的能增强天然抗体功效的葡聚糖的组合物。本发明提供了包含有效量的能增强宿主免疫力的葡聚糖的组合物。本发明还提供一种组合物，其包含有效量的葡聚糖，其能够增强药剂在预防组织排斥反应中的作用。

5. 发明申请

WO2003033670A2 METHOD FOR PREPARATION OF SINGLE CHAIN ANTIBODIES 审中-公开
标题翻译：单链抗体的制备方法
公开(公告)号：WO2003033670A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/033331
申请日：2002-10-17
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHEUNG, Nai-Kong, V. , GUO, Hong-Fen
发明人： CHEUNG, Nai-Kong, V. , GUO, Hong-Fen
IPC分类号： C12N
CPC分类号： C07K16/3053 , A01K2217/05 , A61K47/6865 , A61K47/6873 , A61K49/0004 , A61K49/0006 , A61K51/1045 , A61K2039/505 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/3084 , C07K16/4208 , C07K16/4266 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/77 , C07K2319/00
摘要： This invention provides a method for identifying cells expressing a target single chain antibody (scFv) directed against a target antigen from a collection of cells that includes cells that do not express the target scFv, comprising the step of combining the collection of cells with an anti- idiotype directed to an antibody specific for the target antigen and detecting interaction, if any, of the anti-idiotype with the cells, wherein the Occurrence of an interaction identifies the cell as one which expresses the target scFv. This invention also provides a method for making a single chain antibody (scFv) directed against an antigen, wherein the 15 selection of clones is made based upon interaction of those clones with an appropriate anti-idiotype, and heretofore inaccessible scFv so made. This invention provides the above , methods or any combination thereof. Finally, this invention! provides various uses of these methods.
摘要翻译：本发明提供了从包含不表达靶标scFv的细胞的细胞集合中鉴定表达靶抗原的目标单链抗体（scFv）的细胞的方法，包括将细胞收集与抗体 - 针对针对靶抗原特异性的抗体的独特型，并检测与细胞的抗独特型的相互作用（如果有的话），其中相互作用的发生将细胞识别为表达靶标scFv的细胞。本发明还提供了制备针对抗原的单链抗体（scFv）的方法，其中基于那些克隆与适当抗独特型的相互作用制备克隆的15种选择，并且如此制备的至今无法获得的scFv。本发明提供上述方法或其任何组合。最后，本发明！提供了这些方法的各种用途。

6. 发明申请

WO0232375A9 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
标题翻译：单克隆抗体8H9的用途
公开(公告)号：WO0232375A9
公开(公告)日：2003-01-03
申请号：PCT/US0132565
申请日：2001-10-18
申请人： SLOAN KETTERING INST CANCER , CHEUNG NAI-KONG V
发明人： CHEUNG NAI-KONG V
IPC分类号： A61K47/48 , A61K49/00 , A61P43/00 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/42 , A16K39/40 , C12P21/08 , A16K39/395 , A16K39/42
CPC分类号： C07K16/4208 , A01K2217/05 , A61K47/6865 , A61K47/6873 , A61K49/0004 , A61K49/0006 , C07K16/00 , C07K16/18 , C07K16/3053 , C07K16/4266 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.
摘要翻译：本发明提供了包含有效量的单克隆抗体8H9或其衍生物和合适的载体的组合物。本发明提供了包含有效量的单克隆抗体8H9或其衍生物和药学上可接受的载体的药物组合物。本发明还提供除单克隆抗体8H9之外的抗体，其包含能够与单克隆抗体8H9结合相同抗原的单克隆抗体8H9或其衍生物的互补决定区。本发明提供能够竞争性抑制单克隆抗体8H9结合的物质。本发明还提供单克隆抗体8H9或其衍生物的分离的scFv。本发明还提供了8H9抗原。本发明还提供抑制肿瘤细胞生长的方法，包括使所述肿瘤细胞与适量的单克隆抗体8H9或其衍生物接触。

7. 发明申请

WO0232375A2 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
标题翻译：单克隆抗体8H9的用途
公开(公告)号：WO0232375A2
公开(公告)日：2002-04-25
申请号：PCT/US0132565
申请日：2001-10-18
申请人： SLOAN KETTERING INST CANCER , CHEUNG NAI KONG V
发明人： CHEUNG NAI-KONG V
IPC分类号： A61K47/48 , A61K49/00 , A61P43/00 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/42 , A61K
CPC分类号： C07K16/4208 , A01K2217/05 , A61K47/6865 , A61K47/6873 , A61K49/0004 , A61K49/0006 , C07K16/00 , C07K16/18 , C07K16/3053 , C07K16/4266 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.
摘要翻译：本发明提供了包含有效量的单克隆抗体8H9或其衍生物和合适的载体的组合物。本发明提供了包含有效量的单克隆抗体8H9或其衍生物和药学上可接受的载体的药物组合物。本发明还提供了除单克隆抗体8H9以外的抗体，其包含能够与单克隆抗体8H9结合相同抗原的单克隆抗体8H9或其衍生物的互补决定区。本发明提供了能够竞争性抑制单克隆抗体8H9结合的物质。本发明还提供了单克隆抗体8H9或其衍生物的分离的scFv。本发明还提供了8H9抗原。本发明还提供了抑制肿瘤细胞生长的方法，包括使所述肿瘤细胞与适量的单克隆抗体8H9或其衍生物接触。

8. 发明申请

WO2008116219A3 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
标题翻译：单克隆抗体8H9的用途
公开(公告)号：WO2008116219A3
公开(公告)日：2008-12-11
申请号：PCT/US2008058030
申请日：2008-03-24
申请人： SLOAN KETTERING INST CANCER , CHEUNG NAI-KONG V
发明人： CHEUNG NAI-KONG V
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K16/30 , C07K16/2827 , C07K2317/565 , C07K2317/622
摘要： The present invention discloses monoclonal antibody 8H9 which binds to the 4Ig domain isoform of the human B7-homolog 3, 4Ig-B7H3. The present invention provides a method of improving the prognosis or prolonging the survival of a subject bearing tumor cells, the method comprises administering to the subject a composition comprising an effective amount of an agent capable of binding to an antigen recognized by monoclonal antibody 8H9.
摘要翻译：本发明公开了与人B7同源物3,4Ig-B7H3的4Ig结构域同种型结合的单克隆抗体8H9。本发明提供改善患有肿瘤细胞的患者的预后或延长存活的方法，所述方法包括向受试者施用包含有效量的能够与由单克隆抗体8H9识别的抗原结合的试剂的组合物。

9. 发明申请

WO2002092767A2 DETECTION OF GD2 SYNTHASE mRNA AND USES THEREOF 审中-公开
标题翻译：检测GD2合成酶mRNA及其用途
公开(公告)号：WO2002092767A2
公开(公告)日：2002-11-21
申请号：PCT/US2002/015037
申请日：2002-04-19
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , CHEUNG, Irene, Y. , CHEUNG, Nai-Kong, V.
发明人： CHEUNG, Irene, Y. , CHEUNG, Nai-Kong, V.
IPC分类号： C12N
CPC分类号： C12Q1/6886 , C12Q2561/113 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16
摘要： The present invention provides a method to measure GD2 synthase mRNA comprising steps of: (a) obtaining a mRNA sample; (b) performing real-time quantitative RT-PCR on the sample using appropriate primers of GD2 synthase; and (c) determining the amount of GD2 synthase mRNA. The invention also provides a method to diagnose a subject which bears cancer expressing GD2 synthase. Furthermore, this invention provides a method to stage a cancer expressing GD2 synthase in a subject. Finally, this invention provides a kit for detection of GD2 synthase.
摘要翻译：本发明提供了测量GD2合酶mRNA的方法，包括以下步骤：（a）获得mRNA样品; （b）使用GD2合酶的合适引物对样品进行实时定量RT-PCR; 和（c）确定GD2合酶mRNA的量。本发明还提供了诊断承受表达GD2合酶的癌症的受试者的方法。此外，本发明提供了在受试者中分期表达GD2合酶的癌症的方法。最后，本发明提供了用于检测GD2合酶的试剂盒。

10. 发明申请

WO0232375A8 USES OF MONOCLONAL ANTIBODY 8H9 审中-公开
公开(公告)号：WO0232375A8
公开(公告)日：2002-09-12
申请号：PCT/US0132565
申请日：2001-10-18
申请人： SLOAN KETTERING INST CANCER , CHEUNG NAI-KONG V
发明人： CHEUNG NAI-KONG V
IPC分类号： A61K47/48 , A61K49/00 , A61P43/00 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/42 , A16K39/40 , C12P21/08 , A16K39/395 , A16K39/42
CPC分类号： C07K16/4208 , A01K2217/05 , A61K47/6865 , A61K47/6873 , A61K49/0004 , A61K49/0006 , C07K16/00 , C07K16/18 , C07K16/3053 , C07K16/4266 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2319/00
摘要： This invention provides a composition comprising an effective amount of monoclonal antibody 8H9 or derivative thereof and a suitable carrier. This invention provides a pharmaceutical composition comprising an effective amount of monoclonal antibody 8H9 or a derivative thereof and a pharmaceutically acceptable carrier. This invention also provides an antibody other than the monoclonal antibody 8H9 comprising the complementary determining regions of monoclonal antibody 8H9 or a derivative thereof, capable of binding to the same antigen as the monoclonal antibody 8H9. This invention provides a substance capable of competitively inhibiting the binding of monoclonal antibody 8H9. This invention also provides an isolated scFv of monoclonal antibody 8H9 or a derivative thereof. This invention also provides the 8H9 antigen. This invention also provides a method of inhibiting the growth of tumor cells comprising contacting said tumor cells with an appropriate amount of monoclonal antibody 8H9 or a derivative thereof.

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