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1. 发明申请

WO2011145923A1 ANALYTICAL APPARATUS COMPRISING AN ELECTROCHEMICAL FLOW CELL AND A STRUCTURE ELUCIDATION SPECTROMETER 审中-公开
标题翻译：包含电化学流动池和结构ELCEIDATION SPECTROMETER的分析装置
公开(公告)号：WO2011145923A1
公开(公告)日：2011-11-24
申请号：PCT/NL2010/050309
申请日：2010-05-21
申请人： ANTEC LEYDEN B.V. , BROUWER, Hendrik-Jan , KRAJ, Agnieszka , CHERVET, Jean-Pierre
发明人： BROUWER, Hendrik-Jan , KRAJ, Agnieszka , CHERVET, Jean-Pierre
IPC分类号： G01N27/42 , G01N27/49 , G01R33/46 , G01N24/08 , H01J49/04 , G01N30/72
CPC分类号： G01N24/08 , G01N24/088 , G01N30/7266 , G01R33/46 , G01R33/465 , G01R33/4808 , H01J49/00
摘要： The invention provides an apparatus for sequentially analyzing a plurality of samples containing electrochemically active substances, said apparatus comprising: a sample conduit (10); an electrochemical flow cell (20); a source of carrier fluid (30); a structure elucidation spectrometer (40) (MS or NMR); a conduit (60) and an in-line sample reservoir (50) (e.g. a sample loop), wherein the apparatus is arranged to operate in: a) a first operating modus wherein the sample conduit (10) is connected to the conduit (60) via the electrochemical flow cell (20) and the in-line sample reservoir (50), and the source of carrier fluid (30) is connected to the spectrometer (40) by-passing the in-line sample reservoir, and b) a second operating modus wherein the sample conduit (10) is connected to the conduit (60) by-passing the in-line sample reservoir, and the source of carrier fluid is connected to the structure elucidation spectrometer (40) via the in-line sample reservoir (50).
摘要翻译：本发明提供一种用于顺序分析含有电化学活性物质的多个样品的装置，所述装置包括：样品导管（10）; 电化学流通池（20）; 载体流体源（30）; 结构说明光谱仪（40）（MS或NMR）; 一个导管（60）和一个在线样品贮存器（50）（例如一个样品回路），其中该装置设置成在以下操作中操作：a）第一操作模式，其中样品管道（10）连接到导管 60）通过电化学流动池（20）和在线样品贮存器（50），并且载体流体源（30）连接到光谱仪（40）旁路在线样品储存器，并且b ）第二操作模式，其中所述样品管道（10）连接到所述导管（60）旁通所述在线样品容器，并且所述载体流体源经由所述内部样品贮存器连接到所述结构解析光谱仪（40）线样品池（50）。

2. 发明申请

WO2011025366A1 A METHOD OF SCREENING AGENTS FOR THEIR IMPACT ON NUCLEIC ACID OXIDATION REACTIONS 审中-公开
标题翻译：一种筛选其对核酸氧化反应的影响的方法
公开(公告)号：WO2011025366A1
公开(公告)日：2011-03-03
申请号：PCT/NL2010/050014
申请日：2010-01-12
申请人： ANTEC LEYDEN B.V. , OBERACHER, Herbert , PITTERL, Florian , CHERVET, Jean-Pierre
发明人： OBERACHER, Herbert , PITTERL, Florian , CHERVET, Jean-Pierre
IPC分类号： G01N33/50
CPC分类号： G01N33/5014
摘要： The invention provides a method of determining the impact of an agent on oxidation reactions of a nucleic acid species, said method comprising the steps of: - providing a reference sample containing a nucleic acid species; - providing a test sample containing the same nucleic acid species as the reference sample; - oxidizing the reference sample and the test sample by submitting each sample to identical electrochemical oxidation conditions; - on-line determining the oxidation profile of the electrochemically oxidized reference sample and of the electrochemically oxidized test sample using Electrospray Ionization-Mass Spectrometry (ESI-MS) or Matrix Assisted Laser Desorption Ionization-Mass Spectrometry (MALDI-MS); and - determining the impact of the agent on oxidation reactions of nucleic acid species by comparing the oxidation profiles of the reference sample and the test sample; wherein the agent is added to the test sample before the on-line determining of the oxidation profile. The present method is not only fast, but it is also extremely sensitive and it produces results that are highly predictive of the effect these same agents have on in vivo oxidation of nucleic acid species.
摘要翻译：本发明提供了一种确定试剂对核酸物质氧化反应的影响的方法，所述方法包括以下步骤：提供含有核酸物质的参照样品; - 提供含有与参考样品相同的核酸物质的测试样品; - 通过将每个样品提交到相同的电化学氧化条件来氧化参考样品和测试样品; - 使用电喷雾离子化质谱（ESI-MS）或基质辅助激光解吸电离质谱（MALDI-MS）在线确定电化学氧化的参考样品和电化学氧化的测试样品的氧化曲线; 以及 - 通过比较参考样品和测试样品的氧化曲线来确定试剂对核酸物质氧化反应的影响; 其中在氧化曲线的在线确定之前将试剂加入到测试样品中。本发明方法不仅速度快，而且也非常灵敏，产生了高度预测这些相同试剂对体内核酸物质氧化作用的影响。

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