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1. 发明申请

WO2009114831A2 PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATING USING FIBRILLAR PROTEINS 审中-公开
标题翻译：生产纤维蛋白的方法和使用纤维蛋白处理的方法
公开(公告)号：WO2009114831A2
公开(公告)日：2009-09-17
申请号：PCT/US2009/037196
申请日：2009-03-13
申请人： ACADEMIA SINICA , LIANG, Shu-Mei , LIANG, Chi-Ming , CHEN, Yen-Po , HUANG, Chun-Yung
发明人： LIANG, Chi-Ming , CHEN, Yen-Po , HUANG, Chun-Yung
IPC分类号： C07K1/107 , C07K1/14 , C07K14/47 , A61K38/17 , A61P35/00
CPC分类号： C07K1/1136 , A61K38/162 , A61K38/38 , A61K38/39 , C07K14/765 , C07K14/78 , C12N2770/32122 , C12N2770/32151
摘要： A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.
摘要翻译：一种将球状蛋白结构变为纤维状蛋白结构的方法。该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向含有球状蛋白质的溶液中加入洗涤剂，将溶液施加至孔径至少为70kDa的分子筛分柱，并用含有洗涤剂的溶液。将展开的蛋白质结构改变成纤维蛋白结构的方法。该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向溶液中加入尿素以展开球状蛋白质，将溶液施加到分子筛分柱上并用含有洗涤剂的溶液洗脱。一种治疗癌症的方法，包括提供蛋白质，将蛋白质改变成纤维结构，以及向有需要的患者施用治疗有效量的纤维结构蛋白的步骤。一种用于生产疫苗佐剂或抗原佐剂的方法，包括提供蛋白质并将蛋白质变成纤维结构的步骤。

2. 发明申请

WO2009114831A3 PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATING USING FIBRILLAR PROTEINS 审中-公开
标题翻译：生产纤维蛋白蛋白的方法和使用纤维蛋白蛋白的治疗方法
公开(公告)号：WO2009114831A3
公开(公告)日：2009-10-22
申请号：PCT/US2009037196
申请日：2009-03-13
申请人： ACADEMIA SINICA , LIANG SHU MEI , LIANG CHI-MING , CHEN YEN-PO , HUANG CHUN-YUNG
发明人： LIANG CHI-MING , CHEN YEN-PO , HUANG CHUN-YUNG
IPC分类号： C07K1/107 , A61K38/17 , A61P35/00 , C07K1/14 , C07K14/47
CPC分类号： C07K1/1136 , A61K38/162 , A61K38/38 , A61K38/39 , C07K14/765 , C07K14/78 , C12N2770/32122 , C12N2770/32151
摘要： A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.
摘要翻译：一种将球状蛋白质结构变为纤维状蛋白质结构的方法。该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向含有球状蛋白质的溶液中加入去污剂，将该溶液应用于孔径至少为70kDa的分子筛分柱，并用含有清洁剂的溶液。一种将未折叠的蛋白质结构变为纤维状蛋白质结构的方法。该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向溶液中加入尿素以展开球状蛋白质，将溶液施加到分子大小柱上并用含有去污剂的溶液洗脱。一种治疗癌症的方法，包括以下步骤：提供蛋白质，将蛋白质变为纤维状结构，并将治疗有效量的纤维状结构蛋白给予有需要的患者。生产疫苗佐剂或抗原佐剂的方法，包括提供蛋白质和将蛋白质变成纤维状结构的步骤。

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