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1. 发明申请

WO2012023955A1 PHOSPHOLIPID DEPOT 审中-公开
标题翻译：磷脂DEPOT
公开(公告)号：WO2012023955A1
公开(公告)日：2012-02-23
申请号：PCT/US2010/061015
申请日：2010-12-17
申请人： DR. REDDY'S LABORATORIES, LTD. , CHEN, Hailiang , CHEN, Andrew, Xian , SURAKANTI, Dushyanth , OKUMU, Franklin
发明人： CHEN, Hailiang , CHEN, Andrew, Xian , SURAKANTI, Dushyanth , OKUMU, Franklin
IPC分类号： A61K9/00 , A61K9/107 , A61K9/14 , A61K9/16 , A61K31/7036 , A61K38/14
CPC分类号： A61K9/107 , A61K9/0019 , A61K9/0024 , A61K9/1075 , A61K9/145 , A61K9/16 , A61K9/1617 , A61K9/1682 , A61K31/7036 , A61K38/14 , A61K47/10 , A61K47/24 , A61K47/44
摘要： The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about (4) wt % relative to the total weight of the depot and the depot has a pH of between about (3) and about (6), method of making and administering same.
摘要翻译：本发明提供了一种清洁剂，其包含至少一种选自万古霉素，庆大霉素，其药学上可接受的盐及其混合物的亲水性水溶性药物活性剂，水，磷脂，油，任选的pH调节药剂和选自乙醇，异丙醇及其混合物的粘度调节剂，其中存在于贮存库中的水相对于贮库和贮存库的总重量不大于约（4）重量％具有约（3）和约（6）之间的pH，其制备和施用方法。

2. 发明申请

WO2007133711B1 PHARMACEUTICAL COMPOSITIONS FOR VEIN IRRITATING DRUGS 审中-公开
标题翻译： VEIN刺激性药物的药物组合物
公开(公告)号：WO2007133711B1
公开(公告)日：2008-03-13
申请号：PCT/US2007011465
申请日：2007-05-11
申请人： ADVENTRX PHARMACEUTICALS INC , CHEN ANDREW XIAN
发明人： CHEN ANDREW XIAN
IPC分类号： A61K9/107 , A61K9/19 , A61K38/14
CPC分类号： A61K9/1075 , A61K9/0019 , A61K9/19 , A61K38/14
摘要： Non-vein irritating pharmaceutical formulations (e.g., oil-in-water emulsions, frozen formulations, and lyophilized formulations) of vancomycin and clarithromycin are provided. Also provided are methods for preparing and using such formulations.
摘要翻译：提供了万古霉素和克拉霉素的非静脉刺激性药物制剂（例如，水包油乳剂，冷冻制剂和冻干制剂）。还提供了用于制备和使用这种制剂的方法。

3. 发明申请

WO2007008752A2 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS FOR HIGHLY WATER SOLUBLE DRUGS 审中-公开
标题翻译：持续释放高度水溶性药物的药物组合物
公开(公告)号：WO2007008752A2
公开(公告)日：2007-01-18
申请号：PCT/US2006026666
申请日：2006-07-07
申请人： FARNAM CO INC , CHEN ANDREW XIAN , BLEDSOE DAVID L
发明人： CHEN ANDREW XIAN , BLEDSOE DAVID L
IPC分类号： A61K9/20 , A61K9/14 , A61K9/28 , A61K31/135 , A61K31/165 , A61K31/195 , A61K31/7008 , A61K31/737
CPC分类号： A61K9/2077 , A61K9/14 , A61K9/205 , A61K9/2054 , A61K9/2866 , A61K31/135 , A61K31/165 , A61K31/195 , A61K31/7008 , A61K31/737 , A61K45/06
摘要： The present invention provides pharmaceutical compositions for controlled release of pharmaceutically active agents, especially those with a high water solubility, high dose, and/or short half-life. In addition, the present application provides methods for preparing and using such pharmaceutical compositions.
摘要翻译：本发明提供用于药物活性剂的控制释放的药物组合物，特别是具有高水溶性，高剂量和/或短半衰期的药物活性剂。此外，本申请提供了制备和使用这种药物组合物的方法。

4. 发明申请

WO2006015120A3 STABLE INJECTABLE COMPOSITION OF ALPHA TOCOPHERYL SUCCINATE, ANALOGUES AND SALTS THEREOF 审中-公开
标题翻译： α-生育酚琥珀酸钠，其类似物及其盐的稳定注射组合物
公开(公告)号：WO2006015120A3
公开(公告)日：2006-05-18
申请号：PCT/US2005026783
申请日：2005-07-28
申请人： SD PHARMACEUTICALS INC , CHEN ANDREW XIAN
发明人： CHEN ANDREW XIAN
IPC分类号： A61K31/355
CPC分类号： A61K9/0019 , A61K9/10 , A61K9/1075 , A61K31/337 , A61K31/355
摘要： The present invention provides compositions that comprise alpha-tocopheryl succinate or its analogue or salt and methods for preparing and using such compositions.
摘要翻译：本发明提供了包含琥珀酸α-生育酚酯或其类似物或盐的组合物以及制备和使用该组合物的方法。

5. 发明申请

WO2005074947A3 ANTI-VIRAL PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：抗病毒药物组合物
公开(公告)号：WO2005074947A3
公开(公告)日：2005-09-22
申请号：PCT/US2004041117
申请日：2004-12-08
申请人： CHEN ANDREW XIAN
发明人： CHEN ANDREW XIAN
IPC分类号： A61K31/14 , A61K31/722 , A61K33/00 , A61K33/30 , A61K45/06 , A61P31/12 , A61P31/16
CPC分类号： A61K45/06 , A61K31/14 , A61K31/722 , A61K33/00 , A61K33/30 , A61K2300/00
摘要： The present invention provides antiviral compositions that comprise one or more of an ionic multivalent metal component, e.g. ionic zinc or a ferric salt, a cationic polymer such as chitosan or poly (dimethylaminoethylmetacrylate), and a cationic surfactant such as benzakonium chloride or benethonium. The present invention also provides methods for making and using such antiviral compositions.
摘要翻译：本发明提供了包含一种或多种离子多价金属组分的抗病毒组合物，离子锌或铁盐，阳离子聚合物如壳聚糖或聚（二甲基氨基乙基甲基丙烯酸酯），和阳离子表面活性剂如苯甲酸铵或苯甲醚。本发明还提供了制备和使用这些抗病毒组合物的方法。

6. 发明申请

WO2005074947A2 ANTI-VIRAL PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：抗病毒药物组合物
公开(公告)号：WO2005074947A2
公开(公告)日：2005-08-18
申请号：PCT/US2004/041117
申请日：2004-12-08
申请人： CHEN, Andrew, Xian
发明人： CHEN, Andrew, Xian
IPC分类号： A61K33/00
CPC分类号： A61K45/06 , A61K31/14 , A61K31/722 , A61K33/00 , A61K33/30 , A61K2300/00
摘要： The present invention provides antiviral compositions that comprise one or more of an ionic multivalent metal component, a cationic polymer, and a cationic surfactant. The present invention also provides methods for making and using such antiviral compositions.
摘要翻译：本发明提供包含一种或多种离子多价金属组分，阳离子聚合物和阳离子表面活性剂的抗病毒组合物。本发明还提供了制备和使用这些抗病毒组合物的方法。

7. 发明申请

WO2015123272A1 PARENTERAL COMPOSITIONS OF CELECOXIB 审中-公开
标题翻译： CELECOXIB的配方组成
公开(公告)号：WO2015123272A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015379
申请日：2015-02-11
申请人： DR. REDDY'S LABORATORIES LTD. , OKUMU, Franklin , CHU, Jan-Jon , WEBB, Julie Ann , SABINO, Rafael Anthony , CHEN, Andrew Xian
发明人： OKUMU, Franklin , CHU, Jan-Jon , WEBB, Julie Ann , SABINO, Rafael Anthony , CHEN, Andrew Xian
IPC分类号： A61K9/107 , A61K31/415
CPC分类号： A61K31/635 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K31/415 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/44
摘要： Parenteral (injectable) celecoxib emulsions and nanoemulsions are disclosed as are their use to treat pain in patients so afflicted. The emulsions are generally oil in water emulsions often comprised of an oil phase including an oil and a lecithin wherein the mean droplet size of the discontinuous oil phase is about 200 nanometers or less.
摘要翻译：公开了肠胃外（可注射）塞来昔布乳剂和纳米乳剂，它们用于治疗患有疼痛的患者的疼痛。乳液通常是水包油乳液，其通常由包含油和卵磷脂的油相组成，其中不连续油相的平均液滴尺寸为约200纳米或更小。

8. 发明申请

WO2012006081A1 ORAL FORMULATION OF KINASE INHIBITORS 审中-公开
标题翻译：激素抑制剂口服制剂
公开(公告)号：WO2012006081A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/042162
申请日：2011-06-28
申请人： PONIARD PHARMACEUTICALS, INC. , CHEN, Andrew Xian , TSAI, Yali J.
发明人： CHEN, Andrew Xian , TSAI, Yali J.
IPC分类号： A61K9/00
CPC分类号： A61K9/107 , A61K31/435 , A61K31/5377 , C07D213/74
摘要： The invention is directed to formulations of bioactive compounds of limited water solubility, inhibitors of focal adhesion kinase (FAK) of the 2,4-diaminopyridine class, adapted for oral administration to patients. The formulations are self-emulsifying in the gastrointestinal tract of the patients, providing enhanced absorption and bioavailability of the bioactive compounds as dispersions or emulsions in an oil base. For example, esters of PEG-ylated glycerol can be used as the oil, in conjunction with surfactants such as lecithin and TEPG succinate and solubilizers such as PEG 400 to provide useful oral formulations for administration to patients having a malcondition wherein inhibition of FAK is medically indicated, such as cancer or arthritis.
摘要翻译：本发明涉及适于口服给患者的2,4-二氨基吡啶类的局限性水溶性生物活性化合物的制剂，2,4-二氨基吡啶类的粘着斑激酶（FAK）抑制剂。制剂在患者的胃肠道中自乳化，提供生物活性化合物作为油基中的分散体或乳液的增强的吸收和生物利用度。例如，可以使用PEG-取代的甘油的酯作为油，与表面活性剂如卵磷脂和TEPG琥珀酸酯以及增溶剂如PEG 400一起使用，以提供用于给予具有恶化条件的患者的有用的口服制剂，其中FAK的抑制是医学上表明，如癌症或关节炎。

9. 发明申请

WO2011075623A1 ONE - PHASE GEL COMPOS ITION COMPRI S ING PHOS PHOLI PIDS 审中-公开
标题翻译：单相凝胶组合物COMPA S ING PHOS PHOLI PIDS
公开(公告)号：WO2011075623A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060964
申请日：2010-12-17
申请人： LATITUDE PHARMACEUTICALS, INC. , CHEN, Andrew, Xian , CHEN, Hailiang
发明人： CHEN, Andrew, Xian , CHEN, Hailiang
IPC分类号： A61K9/06 , A61K47/24 , A61K9/00 , A61K38/28
CPC分类号： A61K47/24 , A61K9/0019 , A61K9/06 , A61K9/107 , A61K9/1617 , A61K31/138 , A61K31/167 , A61K31/192 , A61K31/337 , A61K31/4174 , A61K31/445 , A61K31/485 , A61K31/519 , A61K31/546 , A61K31/5513 , A61K31/573 , A61K31/727 , A61K38/1816 , A61K38/215 , A61K38/26 , A61K38/27 , A61K38/28 , A61K47/02 , A61K47/10 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/28 , A61K47/44 , C07K16/241 , C07K2317/21
摘要： The present invention is directed to compositions and methods of preparation of phospholipid depots that are injectable through a fine needle.
摘要翻译：本发明涉及可通过细针注射的磷脂贮库的制备方法和组合物。

10. 发明申请

WO2011031462A2 COMPOSITIONS FOR DELIVERY OF INSOLUBLE AGENTS 审中-公开
标题翻译：用于递送不合格试剂的组合物
公开(公告)号：WO2011031462A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/046552
申请日：2010-08-24
申请人： LATITUDE PHARMACEUTICALS INCORPORATED , CHEN, Hailiang , CHEN, Andrew Xian
发明人： CHEN, Hailiang , CHEN, Andrew Xian
IPC分类号： A61K47/22 , A61K47/38 , A61K47/42 , A61K9/16 , A61K9/14
CPC分类号： A61K47/22 , A61K31/5517
摘要： Compositions and methods of making the same for improving the bioavailability of a substantially water-insoluble pharmacologically active agent are described. The composition includes a substantially water-insoluble pharmacologically active agent, and a substantially water-insoluble matrix forming material comprising enzyme digestible or bile soluble nutrients, wherein the substantially water-insoluble pharmacologically active agent is dispersed in a solid matrix and wherein said pharmacologically active agent in said matrix is substantially free of the original crystalline form.
摘要翻译：描述了制备其以提高基本上不溶于水的药理学活性剂的生物利用度的组合物和方法。该组合物包括基本上不溶于水的药理活性剂和基本上不溶于水的基质形成材料，其包含酶可消化或胆汁可溶性营养物质，其中基本上不溶于水的药理学活性剂分散在固体基质中，其中所述药理活性剂在所述基质中基本上不含原始的结晶形式。

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