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1. 发明申请

WO2012036732A1 METHOD AND APPARATUS FOR PERFORMING COLOR-BASED REACTION TESTING OF BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于执行生物材料的基于颜色的反应试验的方法和装置
公开(公告)号：WO2012036732A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/001581
申请日：2011-09-14
申请人： TECO DIAGNOSTICS , KAPOOR, Neeraj , CHEN, Stephen, L.
发明人： KAPOOR, Neeraj , CHEN, Stephen, L.
IPC分类号： G01N21/00
CPC分类号： G06K9/4652 , G01N21/274 , G01N21/78
摘要： Color-based reaction testing of biological materials may be performed by capturing, in an uncalibrated environment, a digital image of an exposed test strip, together with an adjacently-located reference color chart or on-strip color chart. The image data specifically representing the individual test pads on the test strip, as well as the reference color blocks on the reference chart, are then located within the captured image, and compared to identify any color matches between the test pads and the corresponding sequences of reference color block. Based on this comparison operation, a set of test results can be generated which effectively identifies which of the reference chart's color blocks most closely matches the color of the corresponding dipstick's test pads. The generated test results may then be provided to the user in a printed or displayed form. Alternatively, the test results may simply be stored for later retrieval.
摘要翻译：生物材料的基于颜色的反应测试可以通过在未校准的环境中捕获暴露的测试条的数字图像以及相邻位置的参考颜色图表或带状颜色图表来进行。然后将特别表示测试条上各个测试焊盘的图像数据以及参考图上的参考色块位于捕获的图像内，并进行比较以识别测试焊盘与相应序列之间的任何颜色匹配参考色块。基于该比较操作，可以产生一组测试结果，其有效地识别参考图的颜色块中的哪一个与相应的量油尺的测试垫的颜色最匹配。然后可以以打印或显示的形式将所生成的测试结果提供给用户。或者，可以简单地存储测试结果以供稍后检索。

2. 发明申请

WO2010057025A1 SYNTHETIC POLY D/L LYSINE FOR CONTROL OF DIRECTION AND RATE OF NEURITE GROWTH AND REGENERATION 审中-公开
标题翻译：合成聚D / L赖氨酸，用于控制神经生长和再生的方向和速率
公开(公告)号：WO2010057025A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064437
申请日：2009-11-13
申请人： CHILDRENS HOSPITAL LOS ANGELES , CHEN, Stephen, L. , SIMERLY, Richard, B.
发明人： CHEN, Stephen, L. , SIMERLY, Richard, B.
IPC分类号： C12M3/04 , A61F2/44
CPC分类号： A61L27/50 , A61L27/34 , A61L2430/32 , C08L77/04
摘要： The present invention provides for use of poly-D/L- lysine (PLL) to control the growth of neural cells in vitro and in vivo . The invention describes the activity of defined PLL lines on neural cells and the ability to use the compound to control the direction and rate of growth of neurites on solid substrates. High-throughput screening assays are provided as are medical devices and therapies for treatment of neuronal injury or malfunction.
摘要翻译：本发明提供聚-D / L-赖氨酸（PLL）在体外和体内控制神经细胞生长的用途。 >。本发明描述了神经细胞上定义的PLL线的活性以及使用该化合物控制固体基质上神经突生长的方向和速率的能力。提供高通量筛选试验，以及用于治疗神经元损伤或功能障碍的医疗设备和治疗。

3. 发明申请

WO2010057025A4 SYNTHETIC POLY D/L LYSINE FOR CONTROL OF DIRECTION AND RATE OF NEURITE GROWTH AND REGENERATION 审中-公开
标题翻译：用于控制神经生长和再生的方向和速率的合成聚D / L赖氨酸
公开(公告)号：WO2010057025A4
公开(公告)日：2010-07-15
申请号：PCT/US2009064437
申请日：2009-11-13
申请人： LOS ANGELES CHILDRENS HOSPITAL , CHEN STEPHEN L , SIMERLY RICHARD B
发明人： CHEN STEPHEN L , SIMERLY RICHARD B
IPC分类号： C12M3/04 , A61F2/44
CPC分类号： A61L27/50 , A61L27/34 , A61L2430/32 , C08L77/04
摘要： The present invention provides for use of poly-D/L- lysine (PLL) to control the growth of neural cells in vitro and in vivo. The invention describes the activity of defined PLL lines on neural cells and the ability to use the compound to control the direction and rate of growth of neurites on solid substrates. High-throughput screening assays are provided as are medical devices and therapies for treatment of neuronal injury or malfunction.
摘要翻译：本发明提供聚-D / L-赖氨酸（PLL）在体外和体内控制神经细胞生长的用途。本发明描述了定义的PLL线在神经细胞上的活性和使用化合物控制固体底物上神经突生长方向和速率的能力。提供高通量筛选测定法，用于治疗神经元损伤或功能障碍的医疗器械和治疗方法。

4. 发明申请

WO1997031263A1 HORIZONTAL GEL ELECTROPHORESIS DEVICE WITH DIRECT COOLING 审中-公开
标题翻译：具有直接冷却的水平凝胶电泳装置
公开(公告)号：WO1997031263A1
公开(公告)日：1997-08-28
申请号：PCT/US1996013558
申请日：1996-08-21
申请人： CHEN, Stephen, L.
IPC分类号： G01N27/26
CPC分类号： G01N27/44708
摘要： A device (2) for horizontal submarine gel electrophoresis comprising: a first buffer chamber (1) including first wall (5) with first slot (15); a second buffer chamber (12) including second wall (a) with second slot (16); a gel bed (17); a gel matrix (7); a cooling water chamber (14) defined by the top of the gel matrix (7), first wall (5), and second wall (2); and electrodes (3, 11).
摘要翻译：一种用于水平海底凝胶电泳的装置（2），包括：第一缓冲室（1），包括具有第一槽（15）的第一壁（5）; 包括具有第二槽（16）的第二壁（a）的第二缓冲室（12）; 凝胶床（17）; 凝胶基质（7）; 由凝胶基体（7）的顶部，第一壁（5）和第二壁（2）限定的冷却水室（14）; 和电极（3,11）。

5. 发明申请

WO2012061650A3 ALL-IN-ONE SPECIMEN CUP WITH OPTICALLY READABLE RESULTS 审中-公开
标题翻译：具有光学可读结果的一体式样品杯
公开(公告)号：WO2012061650A3
公开(公告)日：2012-07-26
申请号：PCT/US2011059227
申请日：2011-11-03
申请人： TECO DIAGNOSTICS , CHEN STEPHEN L , CHEN KC , KAPOOR NEERAJ
发明人： CHEN STEPHEN L , CHEN KC , KAPOOR NEERAJ
IPC分类号： G01N21/75
CPC分类号： G06T7/0012 , A61B5/14539 , A61B5/14546 , A61B10/0051 , A61B10/0064 , A61B10/007 , A61B2010/0006 , A61B2562/0295 , B01L3/5023 , B01L2200/026 , B01L2300/023 , B01L2300/024 , B01L2300/027 , B01L2300/042 , B01L2300/046 , B01L2300/0832 , B01L2400/0457 , G01N21/78 , G01N21/8483
摘要： A biological material test strip and adjacently-located reference color chart are affixed to a lid portion of an all-in-one specimen cup to perform color-based reaction testing of collected biological specimens in an uncalibrated environment. After specimen collection, the lid portion is secured to a container portion of the specimen cup. The cup may then be rotated into an upside down position causing the specimen, under the force of gravity, to pass from the container portion and into a volume of the lid portion, such that the test strip is exposed to the specimen as it is received into the volume of the lid portion. An image of the exposed test strip and adjacently-located reference color chart may then be captured and processed to identify any color matches between the individual test pads on the test strip and the corresponding sequences of reference color blocks on the reference chart.
摘要翻译：将生物材料测试条和相邻位置的参考颜色图表固定在一体式样品杯的盖部分上，以在未校准的环境中对收集的生物样品进行基于颜色的反应测试。样本收集后，将盖部分固定在标本杯的容器部分上。然后可以将杯子旋转到倒置位置，导致样品在重力作用下从容器部分通过并进入盖部分的体积，使得测试条在接收时暴露于样品进入盖部分的体积。然后可以捕获并处理暴露的测试条和相邻位置的参考颜色图的图像，以识别测试条上的各个测试焊盘与参考图上的相应参考色块序列之间的任何颜色匹配。

6. 发明申请

WO2012061650A2 ALL-IN-ONE SPECIMEN CUP WITH OPTICALLY READABLE RESULTS 审中-公开
标题翻译：带有光学可读结果的一体式样本杯
公开(公告)号：WO2012061650A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/059227
申请日：2011-11-03
申请人： TECO DIAGNOSTICS , CHEN, Stephen, L. , CHEN, Kc , KAPOOR, Neeraj
发明人： CHEN, Stephen, L. , CHEN, Kc , KAPOOR, Neeraj
IPC分类号： G06K9/00 , G01N21/78
CPC分类号： G06T7/0012 , A61B5/14539 , A61B5/14546 , A61B10/0051 , A61B10/0064 , A61B10/007 , A61B2010/0006 , A61B2562/0295 , B01L3/5023 , B01L2200/026 , B01L2300/023 , B01L2300/024 , B01L2300/027 , B01L2300/042 , B01L2300/046 , B01L2300/0832 , B01L2400/0457 , G01N21/78 , G01N21/8483
摘要： A biological material test strip and adjacently-located reference color chart are affixed to a lid portion of an all-in-one specimen cup to perform color-based reaction testing of collected biological specimens in an uncalibrated environment. After specimen collection, the lid portion is secured to a container portion of the specimen cup. The cup may then be rotated into an upside down position causing the specimen, under the force of gravity, to pass from the container portion and into a volume of the lid portion, such that the test strip is exposed to the specimen as it is received into the volume of the lid portion. An image of the exposed test strip and adjacently-located reference color chart may then be captured and processed to identify any color matches between the individual test pads on the test strip and the corresponding sequences of reference color blocks on the reference chart.
摘要翻译：将生物材料测试条和相邻定位的参考颜色图表粘贴到一体化样品杯的盖部分上，以在未校准的环境中对收集的生物样品进行基于颜色的反应测试。样本收集后，将盖部分固定到样本杯的容器部分。杯然后可以旋转到倒置位置，使得样本在重力作用下从容器部分通过并进入盖部分的体积中，使得测试条在被接收时暴露于样本进入盖子部分的容积中。然后可以捕获并处理暴露的测试条和邻近定位的参考色彩图的图像，以识别测试条上的各个测试垫与参考图上相应的参考色块序列之间的任何颜色匹配。

7. 发明申请

WO1997020202A1 DEVICE AND METHOD FOR BIOMOLECULE PURIFICATION 审中-公开
标题翻译：用于生物分子纯化的装置和方法
公开(公告)号：WO1997020202A1
公开(公告)日：1997-06-05
申请号：PCT/US1996019096
申请日：1996-11-27
申请人： CHEN, Stephen, L.
IPC分类号： G01N27/26
CPC分类号： B01D57/02 , G01N27/44756
摘要： A preparative gel electrophoresis device comprising: a lower chamber (11) containing a first buffer (21) and an electrode (10); a balance chamber (22) sealable by tape (28); an upper chamber (7) including an inlet (27) sealable by tape (28), the upper chamber (7) containing a second buffer (26) and an electrode (5); a gas chamber (12) containing second buffer (26) and three electrodes (13, 14, 18); a silicon diode (23); a vent (25) sealable by tape (28); a buffer channel (8, 15); a gas channel (16); a column channel (4); a gel column (1) fitted in column channel (4); a gap (3) between gel column (1) and column channel (4); and a fraction storage tubing (31).
摘要翻译：一种制备性凝胶电泳装置，包括：含有第一缓冲液（21）和电极（10）的下室（11）; 平衡室（22），可由胶带（28）密封; 上部腔室（7），其包括可由带子（28）密封的入口（27），所述上部腔室（7）包含第二缓冲器（26）和电极（5）; 包含第二缓冲器（26）和三个电极（13,14,18）的气室（12）; 硅二极管（23）; 通过胶带（28）密封的通气孔（25）; 缓冲通道（8,15）; 气体通道（16）; 列通道（4）; 安装在柱通道（4）中的凝胶柱（1）; 凝胶柱（1）和柱通道（4）之间的间隙（3）; 和部分储存管（31）。

8. 发明申请

WO1997020201A1 GEL CASTING AND ELECTROPHORESIS IN A SINGLE ENCLOSURE 审中-公开
标题翻译：单一外壳中的凝胶铸造和电泳
公开(公告)号：WO1997020201A1
公开(公告)日：1997-06-05
申请号：PCT/US1996018906
申请日：1996-11-25
申请人： CHEN, Stephen, L.
IPC分类号： G01N27/26
CPC分类号： G01N27/44704
摘要： A device and method for vertical slab gel casting and electrophoresis in a single enclosure is provided. Air is utilized as a sealing medium to seal the bottom of a gel space (10) for gel casting by constructing an air-tight connection between a sealable lower buffer chamber (11) and a gel space (10) via a junction (12). The air is automatically released when a buffer is introduced into the lower buffer chamber, so that the bottom of the gel is in direct contact with the buffer without manually removing a solid sealing device from the bottom of the gel, which enables the gel to be directly used for the electrophoresis without any movement of the gel space (10).
摘要翻译：提供了一种用于单个外壳中的垂直板式凝胶浇铸和电泳的装置和方法。空气被用作密封介质，以通过经由结（12）构造可密封的下缓冲室（11）和凝胶空间（10）之间的气密连接来密封用于凝胶浇铸的凝胶空间（10）的底部，。当将缓冲液引入下缓冲室时，空气自动释放，使得凝胶的底部与缓冲液直接接触，而无需从凝胶底部手动除去固体密封装置，这使凝胶成为直接用于电泳，无任何运动的凝胶空间（10）。

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