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1. 发明申请

WO2007090076A8 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：用于鉴别具有OVARIAN癌症和其组合物的增加的患者的患者的方法
公开(公告)号：WO2007090076A8
公开(公告)日：2011-03-03
申请号：PCT/US2007061205
申请日：2007-01-29
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
IPC分类号： G01N33/574
CPC分类号： G01N33/57449
摘要： Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了鉴定患卵巢癌可能性增加的筛查方法。筛选方法涉及检测体内样品中多种生物标志物的表达，其中生物标志物的过表达表明卵巢癌的可能性增加。筛选方法还可以包括两步分析。感兴趣的生物标志物包括例如参与DNA复制/细胞周期控制，细胞生长和增殖，逃避凋亡，血管生成或淋巴发生的缺陷或癌细胞运动和侵袭的机制的基因和蛋白质。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测生物标志物的表达。本文进一步公开了患者卵巢癌检测方法。还提供了用于实施本发明的方法的试剂盒。

2. 发明申请

WO2008112514A1 HE4 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 审中-公开
标题翻译： HE4单克隆抗体及其使用方法
公开(公告)号：WO2008112514A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056132
申请日：2008-03-07
申请人： TRIPATH IMAGING, INC. , CHEEK, Robert, L. , FISCHER, Timothy, J. , GROELKE, John, W.
发明人： CHEEK, Robert, L. , FISCHER, Timothy, J. , GROELKE, John, W.
IPC分类号： C07K16/30 , C07K14/47 , C12N15/12 , G01N33/574 , G01N33/577
CPC分类号： C07K16/3069 , C07K2317/34 , G01N33/57415 , G01N33/57449
摘要： Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal^ antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.
摘要翻译：提供了一种用于诊断患者卵巢癌和用于鉴定患卵巢癌可能性增加的患者的组合物和方法。组合物包括特异性结合HE4的单克隆抗体及其变体和片段。进一步提供具有本发明的HE4抗体的结合特性的单克隆抗体。产生本发明的HE4单克隆抗体的杂交瘤细胞系也在本文中公开。该组合物用于诊断方法以及用于鉴定具有增加卵巢癌可能性的患者的筛选方法。还提供了包含一种或多种所公开的HE4单克隆抗体和用于实施本发明的方法的试剂盒。包含HE4表位的氨基酸序列的多肽和在产生抗体中使用这些多肽的方法也包括在本发明中。

3. 发明申请

WO2007090076A3 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：用于鉴别具有OVARIAN癌症和其组合物的增加的患者的患者的方法
公开(公告)号：WO2007090076A3
公开(公告)日：2007-11-08
申请号：PCT/US2007061205
申请日：2007-01-29
申请人： TRIPATH IMAGING INC , FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
发明人： FISCHER TIMOTHY J , MALINOWSKI DOUGLAS P , HE QIN , WHITEHEAD CLARK M , CHEEK ROBERT L , GROELKE JOHN W
IPC分类号： G01N33/574
CPC分类号： G01N33/57449
摘要： Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了鉴定患卵巢癌可能性增加的筛查方法。筛选方法涉及检测体内样品中多种生物标志物的表达，其中生物标志物的过表达表明卵巢癌的可能性增加。筛选方法还可以包括两步分析。感兴趣的生物标志物包括例如参与DNA复制/细胞周期控制，细胞生长和增殖，逃避凋亡，血管生成或淋巴发生的缺陷或癌细胞运动和侵袭的机制的基因和蛋白质。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测生物标志物的表达。本文进一步公开了患者卵巢癌检测方法。还提供了用于实施本发明的方法的试剂盒。

4. 发明申请

WO2010102177A1 GLYCODELIN MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF OVARIAN CANCER 审中-公开
标题翻译：谷维素单克隆抗体及其在检测卵巢癌中的应用
公开(公告)号：WO2010102177A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026319
申请日：2010-03-05
申请人： BECTON, DICKINSON AND COMPANY , CHEEK, Robert, L. , DIXON, Eric, P. , FISCHER, Timothy, J. , GROELKE, John, W. , KNAPP, Steven, L. , SIMKINS, Stephen, G. , WHITEHEAD, Clark, M.
发明人： CHEEK, Robert, L. , DIXON, Eric, P. , FISCHER, Timothy, J. , GROELKE, John, W. , KNAPP, Steven, L. , SIMKINS, Stephen, G. , WHITEHEAD, Clark, M.
IPC分类号： C07K16/18 , C07K16/30 , G01N33/577
CPC分类号： C07K16/3069 , C07K16/18 , C07K2317/34 , G01N33/57449
摘要： Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.
摘要翻译：提供了一种用于诊断患者卵巢癌和用于鉴定患卵巢癌可能性增加的患者的组合物和方法。组合物包括特异性结合糖链蛋白的新型单克隆抗体及其变体和片段。进一步提供具有本发明的糖链蛋白抗体的结合特征的单克隆抗体和与所公开的抗体的糖链蛋白表位结合的单克隆抗体。本文还公开了产生本发明的糖链蛋白单克隆抗体的杂交瘤细胞系。该组合物用于诊断方法以及用于鉴定具有增加卵巢癌可能性的患者的筛选方法。进一步提供包含一种或多种所公开的糖链素单克隆抗体并用于实施本发明方法的试剂盒。包含所公开的单克隆糖蛋白抗体的糖链蛋白表位的氨基酸序列的多肽和在制备糖链蛋白抗体中使用这些多肽的方法也包括在本发明中。

5. 发明申请

WO2010102167A1 MATRIX METALLOPROTEINASE-7 (MMP-7) MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF OVARIAN CANCER 审中-公开
标题翻译：基质金属蛋白酶-7（MMP-7）单克隆抗体及其用于检测OVARIAN癌症的方法
公开(公告)号：WO2010102167A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026300
申请日：2010-03-05
申请人： BECTON, DICKINSON AND COMPANY , BAKER, Jeffrey, P. , CHEEK, Robert, L. , DIXON, Eric, P. , FISCHER, Timothy, J. , KNAPP, Steven, L. , SIMKINS, Stephen, G. , WHITEHEAD, Clark, M.
发明人： BAKER, Jeffrey, P. , CHEEK, Robert, L. , DIXON, Eric, P. , FISCHER, Timothy, J. , KNAPP, Steven, L. , SIMKINS, Stephen, G. , WHITEHEAD, Clark, M.
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , G01N33/57449 , G01N2333/96494
摘要： Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MMP-7. Monoclonal antibodies having the binding characteristics of an MMP-7 antibody of the invention and monoclonal antibodies that bind to an MMP-7 epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce an MMP-7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed MMP-7 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MMP-7 epitope of a disclosed monoclonal MMP-7 antibody and methods of using these polypeptides in the production of MMP-7 antibodies are also encompassed by the present invention.
摘要翻译：提供用于诊断患者卵巢癌的组合物和方法，并且用于鉴定具有增加的卵巢癌可能性的患者。组合物包括特异性结合MMP-7的新单克隆抗体及其变体和片段。进一步提供具有本发明的MMP-7抗体的结合特征的单克隆抗体和与公开的抗体的MMP-7表位结合的单克隆抗体。本文还公开了产生本发明的MMP-7单克隆抗体的杂交瘤细胞系。该组合物可用于诊断方法以及用于鉴定具有增加卵巢癌可能性的患者的筛选方法。还提供了包含一种或多种所公开的MMP-7单克隆抗体并用于实施本发明方法的试剂盒。包含所公开的单克隆MMP-7抗体的MMP-7表位的氨基酸序列的多肽和在产生MMP-7抗体中使用这些多肽的方法也包括在本发明中。

6. 发明申请

WO2007090076A2 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：识别患有卵巢癌的增加的可能性的患者的方法及其组合物
公开(公告)号：WO2007090076A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/061205
申请日：2007-01-29
申请人： TRIPATH IMAGING, INC. , FISCHER, Timothy, J. , MALINOWSKI, Douglas, P. , HE, Qin , WHITEHEAD, Clark, M. , CHEEK, Robert, L. , GROELKE, John, W.
发明人： FISCHER, Timothy, J. , MALINOWSKI, Douglas, P. , HE, Qin , WHITEHEAD, Clark, M. , CHEEK, Robert, L. , GROELKE, John, W.
CPC分类号： G01N33/57449
摘要： Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods may further comprise a two-step analysis. Biomarkers of interest include genes and proteins that are, for example, involved in defects in DNA replication/cell cycle control, cell growth and proliferation, escape from apoptosis, angiogenesis or lymphogenesis, or the mechanisms of cancer cell motility and invasion. In some aspects of the invention, expression of a biomarker is detected at the protein level using a biomarker-specific antibody or at the nucleic acid level using nucleic acid hybridization techniques. Methods for detecting ovarian cancer in patients are further disclosed herein. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供筛选方法用于鉴定患有卵巢癌可能性增加的患者。筛选方法涉及检测身体样品中多种生物标志物的表达，其中生物标志物的过度表达表示具有卵巢癌的可能性增加。筛选方法可以进一步包括两步分析。感兴趣的生物标志物包括例如涉及DNA复制/细胞周期控制，细胞生长和增殖中的缺陷，逃脱细胞凋亡，血管生成或淋巴生成，或癌细胞运动性和侵入机制的基因和蛋白质。在本发明的一些方面中，使用生物标志物特异性抗体在蛋白质水平检测生物标志物的表达或使用核酸杂交技术在核酸水平检测生物标志物的表达。本文进一步公开了检测患者卵巢癌的方法。进一步提供用于实践本发明方法的试剂盒。

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