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1. 发明申请

WO2016046845A1 STEALTH, TARGETED NANOPARTICLES (STN) FOR ORAL DRUG DELIVERY 审中-公开
标题翻译： STEALTH，用于口服药物递送的靶向纳米颗粒（STN）
公开(公告)号：WO2016046845A1
公开(公告)日：2016-03-31
申请号：PCT/IN2015050114
申请日：2015-09-22
申请人： CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61K31/00 , A61K9/51 , A61K31/546 , A61K47/48
CPC分类号： A61K9/5161 , A61K9/0053 , A61K9/5123 , A61K9/5146 , A61K31/122 , A61K31/202 , A61K31/337 , A61K31/407 , A61K31/4164 , A61K31/43 , A61K31/436 , A61K31/4439 , A61K31/519 , A61K31/5383 , A61K31/546 , A61K31/7036 , A61K31/7048 , A61K31/714 , A61K38/05 , A61K38/12 , A61K38/14 , A61K45/06 , A61K47/551 , A61K47/6939
摘要： The present invention relates to a technology for oral delivery of Poorly Bio-Available Therapeutic Agents and the formulations derived using this technology. Poorly Bio-Available Therapeutic Agents may belong to BCS class III /IV drugs or nutraceutical or any other agent which is required to be orally delivered having challenge of bio-availability in body. Therefore, invention further relates to a targeted delivery technology for enhanced bio-availability and controlled release without being degraded. The present invention further relates to the processes for the preparation of said compositions and formulations made thereof. The formulations of the present invention are useful to treat related conditions.
摘要翻译：本发明涉及用于口服递送不良生物可用治疗剂的技术和使用该技术衍生的制剂。生物可用性差的治疗剂可能属于BCS III / IV类药物或营养药物或任何需要口服给药的其他可能对身体有生物利用度的挑战的药物。因此，本发明还涉及用于增强生物可利用性和受控释放而不降解的靶向递送技术。本发明还涉及制备所述组合物及其制剂的制剂的方法。本发明的制剂可用于治疗相关病症。

2. 发明申请

WO2013042140A3 NON ANTIBIOTIC,NON PEPTIDE COMPOUNDS FOR ANTIBIOTIC EFFICACY & SAFETY ENHANCEMENT 审中-公开
标题翻译：非抗生素，非肽类化合物，用于抗生素效能和安全性提高
公开(公告)号：WO2013042140A3
公开(公告)日：2013-05-23
申请号：PCT/IN2012000634
申请日：2012-09-24
申请人： CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61K31/197 , A61K31/60 , A61K33/22 , A61K45/06 , A61P31/00
CPC分类号： A61K31/60 , A61K31/197 , A61K33/22 , A61K45/06 , A61K2300/00
摘要： The present invention provides one or more non antibiotic non peptidic entity to augment antimicrobial activity of one or more antimicrobial agent for combating microbial resistance The non antibiotic non peptidic entity is used individually or in combination with one or more antibiotic as single unit dose or is presented through a suitable medium The non antibiotic non peptidic entity make one or more accompanying antibiotic effective by rendering eradication of antimicrobial resistance broadening spectrum and reducing multi bacterial resistance
摘要翻译：本发明提供了一种或多种非抗生素非肽实体，以增强一种或多种抗微生物剂抗微生物抗性的抗微生物活性。非抗生素非肽实体单独使用或与一种或多种抗生素组合用作单一单位剂量或呈现通过合适的培养基非抗生素非肽实体使一种或多种伴随的抗生素通过消除抗微生物药物抗性扩大光谱并降低多细菌耐药性而有效

3. 发明申请

WO2012066581A4 NOVEL CONJUGATES FOR TARGETED DRUG DELIVERY 审中-公开
标题翻译：目标药物递送的新型共轭物
公开(公告)号：WO2012066581A4
公开(公告)日：2012-11-01
申请号：PCT/IN2011000807
申请日：2011-11-21
申请人： VENUS REMEDIES LTD , CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61K47/48 , A61P35/00 , A61P43/00
CPC分类号： A61K47/642 , A61K47/60
摘要： The present invention relates to a novel drug delivery system comprising a drug(s)-protein- polymer triple conjugate. The triple conjugate employes a (i) protein moiety capable of binding selectively to a particular target site possessed by a cell/affected organ, (ii) a polymer moiety, covalently linked to the protein and (iii) an active drug moiety that includes one or more drug(s) covalently linked to either said polymer moiety or to a protein moiety. The conjugates of the present invention have target specificity and better selectivity to a defined population of cells/organs(s). The present invention further relates to methods of preparation and methods of treatment comprising administering said conjugate as a single unit. The conjugates of the present invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic applications.
摘要翻译：本发明涉及包含药物 - 蛋白质 - 聚合物三重偶联物的新型药物递送系统。三重偶联物采用（i）能够选择性结合细胞/受影响器官拥有的特定靶位点的蛋白质部分，（ii）与蛋白质共价连接的聚合物部分和（iii）包含一个或更多种药物共价连接到所述聚合物部分或蛋白质部分。本发明的缀合物对确定的细胞/器官群体具有目标特异性和更好的选择性。本发明进一步涉及制备方法和治疗方法，其包括将所述缀合物作为单一单位施用。本发明的缀合物有用地用于治疗以及非治疗，例如诊断应用。

4. 发明申请

WO2010032266A4 NOVEL SINGLE UNIT CARBAPENEM AMINOGLYCOSIDE FORMULATIONS 审中-公开
标题翻译：新型单位卡巴匹林胺糖甙配方
公开(公告)号：WO2010032266A4
公开(公告)日：2010-08-26
申请号：PCT/IN2009000508
申请日：2009-09-15
申请人： CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61P31/04 , A61K31/43 , A61K31/7036
CPC分类号： A61K45/06 , A61K31/43 , A61K31/7036 , A61K2300/00
摘要： The present invention relates to pharmaceutical low dose, antibiotic combinations of two antibiotics selected from two different groups viz. a carbapenem and an aminoglycoside present as a single unit fixed low dose injection effective at very low concentrations for the treatment of bacterial/ multi- bacterial infections particularly suitable for neonates, children and other patients with low tolerance which are prone to serious fatal mixed multi bacterial infectious diseases where potential toxicity due to higher doses is a cause for concern.
摘要翻译：本发明涉及选自两个不同组的两种抗生素的药物低剂量抗生素组合，碳青霉烯和氨基糖苷以单一固定的低剂量注射剂形式存在，在极低浓度下有效用于治疗细菌/多细菌感染，特别适用于容易发生严重致命混合多细菌的新生儿，儿童和其他低耐受性患者因高剂量引起的潜在毒性是引起关注的传染病。

5. 发明申请

WO2006085337A1 PARENTERAL COMBINATION THERPY FOR INFECTIVE CONDITIONS WITH DRUG RESISTANT BACTERIUM 审中-公开
标题翻译：用于抗药性细菌感染性疾病的外周组合治疗
公开(公告)号：WO2006085337A1
公开(公告)日：2006-08-17
申请号：PCT/IN2006/000044
申请日：2006-02-08
申请人： VENUS REMEDIES LIMITED , CHAUDHARY, Manu
发明人： CHAUDHARY, Manu
IPC分类号： A61K31/00 , A61P31/04
CPC分类号： A61K45/06 , A61K31/546 , Y02A50/401 , Y02A50/402 , Y02A50/406 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： The invention describes a pharmaceutical composition to combat multiple-drug-resistant bacteria in non-ocular infective conditions. Compositions comprising glycopeptides, in particular vancomycin, and cephalosporins, in particular ceftriaxone, are disclosed. Such compositions are found to be useful for parenteral administration for hospitalized patients with serious infections. Specifically, this invention also discloses a pharmaceutical composition further including an excipient such as CVMC agent and is available in dry powder form for reconstitution before injection with a suitable solvent. The pharmaceutical compositions of this invention have been found normally to enhance resistance to precipitation in solutions to be administered parenterally. The invention also gives details of the dosage forms stored in sealed containers to be reconstituted before use. The invention further provides a process to manufacture these compositions and also a method of treating a subject having non-ocular infective conditions due to multi drug resistant bacterium.
摘要翻译：本发明描述了一种用于在非眼部感染病症中抗多种药物抗性细菌的药物组合物。包含糖肽，特别是万古霉素和头孢菌素，特别是头孢曲松的组合物被公开。发现这种组合物可用于有严重感染的住院患者的胃肠外给药。具体而言，本发明还公开了进一步包含赋形剂例如CVMC剂的药物组合物，并且可以以干粉形式获得用于在注射合适的溶剂之前重构。已经发现本发明的药物组合物通常能增强肠胃外施用的溶液中对沉淀的抗性。本发明还提供了储存在密封容器中的剂型的细节，其将在使用前重新配制。本发明进一步提供了制造这些组合物的方法以及治疗由于多重耐药细菌引起的具有非眼部感染症状的对象的方法。

6. 发明申请

WO2006054315A1 NONAQUEOUS LIQUID PARENTERAL ACECLOFENAC FORMULATION 审中-公开
标题翻译：非水性液体肠外制剂ACELLOFENAC制剂
公开(公告)号：WO2006054315A1
公开(公告)日：2006-05-26
申请号：PCT/IN2005/000339
申请日：2005-10-19
申请人： VENUS REMEDIES LIMITED , CHAUDHARY, Manu
发明人： CHAUDHARY, Manu
IPC分类号： A61K9/08 , A61K31/19 , A61K31/216 , A61K47/00 , C07C229/42 , C07C57/38
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/19 , A61K31/216
摘要： A nonaqueous liquid parenterally deliverable pharmaceutical formulation, and more particularly a nonaqueous liquid parenteral Aceclofenac formulation comprising the selective NSAID Aceclofenac, is disclosed. A process of preparing Aceclofenac formulation, the therapeutic dosage form and storage of dose, and the method of treating a subject having a condition or a disorder wherein treatment with NSAID is indicated, are also disclosed. Diclofenac formed by conversion of Aceclofenac is solubilized by the nonaqueous solubilizer(s), which are substantially inert with respect to such conversion. The composition has Aceclofenac salt stabilizing means for inhibiting precipitation of Aceclofenac. The compositions disclosed in the present invention are stable upon storage at room temperature and at refrigerated temperatures. Compositions disclosed in the present invention, whether ready-to-use or requiring dilution prior to administration, can be prepared by inexpensive processes disclosed herein.
摘要翻译：公开了一种非水液体肠胃外递送药物制剂，并且更具体地公开了包含选择性NSAID醋氯芬酸的非水液体肠胃外醋氯芬酸配方。还公开了制备醋氯芬酸制剂的方法，治疗剂型和剂量储存方法，以及治疗患有其中用NSAID治疗的病症或障碍的对象的方法。通过醋氯芬酸转化形成的双氯芬酸由非水增溶剂溶解，所述非水增溶剂对于这种转化基本上是惰性的。该组合物具有醋氯芬酸盐稳定装置，用于抑制醋氯芬酸的沉淀。本发明公开的组合物在室温和冷藏温度下贮存时是稳定的。本发明中公开的组合物，无论准备使用还是需要在给药前稀释，都可以通过本文公开的廉价方法来制备。

7. 发明申请

WO2021117065A1 FORMULATIONS OF POLYBASIC DRUGS TO REDUCE MULTI-ORGAN TOXICITY 审中-公开
公开(公告)号：WO2021117065A1
公开(公告)日：2021-06-17
申请号：PCT/IN2020/051027
申请日：2020-12-13
申请人： CHAUDHARY, Manu
发明人： CHAUDHARY, Manu
IPC分类号： A61K31/765
摘要： The present invention relates to compositions and formulations of polybasic drugs to reduce multiorgan toxicity by making supramolecular cationic complex without covalent bond formation, without conjugation and without chemical modification of macromolecular entity used. The compositions and formulations made thereof act by multiple mechanisms simultaneously to reduce toxicity of cationic antibiotic drugs.

8. 发明申请

WO2013042140A2 NON ANTIBIOTIC,NON PEPTIDE COMPOUNDS FOR ANTIBIOTIC EFFICACY & SAFETY ENHANCEMENT 审中-公开
标题翻译：用于抗生素和安全性增强的非抗生素，非肽类化合物
公开(公告)号：WO2013042140A2
公开(公告)日：2013-03-28
申请号：PCT/IN2012000634
申请日：2012-09-24
申请人： CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61K31/197
CPC分类号： A61K31/60 , A61K31/197 , A61K33/22 , A61K45/06 , A61K2300/00
摘要： The present invention provides one or more non antibiotic non peptidic entity to augment antimicrobial activity of one or more antimicrobial agent for combating microbial resistance The non antibiotic non peptidic entity is used individually or in combination with one or more antibiotic as single unit dose or is presented through a suitable medium The non antibiotic non peptidic entity make one or more accompanying antibiotic effective by rendering eradication of antimicrobial resistance broadening spectrum and reducing multi bacterial resistance
摘要翻译：本发明提供一种或多种非抗生素非肽实体以增强一种或多种抗微生物剂抗微生物抗性的抗微生物活性。非抗生素非肽实体单独或与一种或多种抗生素组合用作单一单位剂量或呈现通过适当的培养基非抗生素非肽实体通过消除抗菌剂扩大谱并减少多细菌耐药性而使一种或多种伴随的抗生素有效

9. 发明申请

WO2012056476A4 A DETOXIFIER HERBAL FORMULATION 审中-公开
标题翻译：脱氧剂草药配方
公开(公告)号：WO2012056476A4
公开(公告)日：2012-07-19
申请号：PCT/IN2011000744
申请日：2011-10-25
申请人： CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61K36/185 , A61K36/19 , A61K36/28 , A61K36/29 , A61K36/59 , A61K36/74 , A61K47/34
CPC分类号： A61K36/28 , A61K9/0056 , A61K36/00 , A61K36/185 , A61K36/19 , A61K36/24 , A61K36/29 , A61K36/48 , A61K36/482 , A61K36/59 , A61K36/74 , A61K36/888 , A61K2300/00
摘要： The present invention provides a non parenteral and non ocular herbal synergistic detoxifier composition effective for blood purification, blood detoxification and in the treatment and management of disorders related to accumulation of toxins in the body. The present invention also provided a method of preparation of this formulation. In a preferred embodiment, the composition comprises Echinacea purpurea leaves, Andrographis paniculata leaves, Boerhaavia diffusa whole plant, Arctium lappa root, Rubia cordifolia root; effective amount of one or more bio - availability enhancer. The bio - availability enhancer may be of herbal origin or chemical origin. The bio - availability enhancer of herbal origin may selected from the group includingextract or powder of Berberis aristata stem and Tinospora cordifolia stem. The bio - availability enhancer of chemical origin may be selected from the group including gluceryl mono oleate, poly vinyl alcohol, Span 80, Tween 80, Tween 20 and PEG 200 to PEG 6000 or a combination thereof. The composition may further contain Pothos aureus, leaves of Ixora coccinea, stems of Jacaranda mimosifolia, roots of Hemidesmus indicus, heartwood of Acacia catechu, stem of Cassia biflorain, leaf of Cassia seamia and flower of Dahlia pinnata.
摘要翻译：本发明提供了一种非肠胃外和非眼部草药协同解毒剂组合物，其有效用于血液净化，血液解毒以及治疗和管理与身体中毒素积累相关的疾病。本发明还提供了该制剂的制备方法。在一个优选的实施方案中，组合物包括紫锥花叶，穿心莲（Andrographis paniculata）叶，波尔瓦氏菌（Boerhaavia diffusa）全植物，牛蒡根，茜草（Rubia cordifolia）根; 有效量的一种或多种生物利用增强剂。生物利用度增强剂可能是草药来源或化学来源。草药起源的生物利用度增强剂可以选自小檗提取物和小檗茎秆的提取物或粉末。化学来源的生物可利用性增强剂可以选自包括葡糖酸单油酸酯，聚乙烯醇，Span 80，吐温80，吐温20和PEG 200至PEG 6000或其组合的组。组合物可以进一步包含Pothos金黄色葡萄球菌，Ixora coccinea的叶子，Jacaranda mimosifolia的茎，Hemidesmus indicus的根，相思树的心材，Cassia biflorain的茎，Cassia seamia的叶和Dahlia pinnata的花。

10. 发明申请

WO2006120705A3 TREATMENT AND CONTROL OF SEVERE INFECTIONS INCLUDING CYSTIC FIBROSIS 审中-公开
标题翻译：严重感染包括囊性纤维化的治疗和控制
公开(公告)号：WO2006120705A3
公开(公告)日：2007-03-29
申请号：PCT/IN2006000158
申请日：2006-05-08
申请人： VENUS REMEDIES LTD , CHAUDHARY MANU
发明人： CHAUDHARY MANU
IPC分类号： A61K31/545 , A61K9/00 , A61K31/7036 , A61P31/04
CPC分类号： A61K31/545 , A61K9/0019 , A61K31/7036 , A61K45/06 , A61K47/12 , A61K47/183 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising antibiotic combination products for delivering two or more different antibiotics simultaneously, wherein the two different antibiotics comprise one which consisting of concentration dependent killing and the other concentration independent killing or time dependant killing activity. The invention has been worked out utilizing pharmacokinetic and pharmacodynamic principles to optimize antibiotic regimen , to improve clinical results and to potentially decrease the development of resistance. Combination of ceftazidime and tobramycin has been evolved to specifically illustrate the invention.
摘要翻译：本发明提供了一种药物组合物，其包含用于同时递送两种或更多种不同抗生素的抗生素组合产品，其中两种不同的抗生素包含由浓度依赖性杀伤和另一浓度非依赖性杀伤或时间依赖性杀伤活性组成的抗生素。本发明利用药代动力学和药效学原理来优化抗生素方案，改善临床结果并潜在地降低抗性的发展。已经发展了头孢他啶和妥布霉素的组合以具体说明本发明。

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