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1. 发明申请

WO2011017660A3 MAGNETIC CARBON NANOTUBE BASED BIODETECTION 审中-公开
标题翻译：基于磁性碳纳米管的生物保护
公开(公告)号：WO2011017660A3
公开(公告)日：2011-06-30
申请号：PCT/US2010044778
申请日：2010-08-06
申请人： NANOMIX INC , JOSHI KANCHAN , CHANG YING-LAN , JOHNSON BRADLEY N , RADTKEY RAY
发明人： JOSHI KANCHAN , CHANG YING-LAN , JOHNSON BRADLEY N , RADTKEY RAY
IPC分类号： B82B3/00 , C01B31/02 , G01N27/30 , G01N33/53
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/162 , C01B32/174 , G01N27/226
摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.
摘要翻译：本文提供了一种新的混合材料系统，mCNT，包括用于生物和医学感测应用的磁性碳纳米管。在某些实施例中，系统包括在碳纳米管（CNT）内部的磁性材料。碳纳米管内的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。外部CNT表面保持完整，用于生物分子附着或其他功能化。这种新型材料的性能增强包括改进的灵敏度，减少的响应时间和减少的样品体积。根据各种实施方案，mCNT是用于粘附参与这些测定的分子或作为主动感测元件的底物。还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

2. 发明申请

WO2008052104A3 SENSOR HAVING A THIN-FILM INHIBITION LAYER, NITRIC OXIDE CONVERTER AND MONITOR 审中-公开
标题翻译：具有薄膜抑制层，氮氧化物转换器和监测器的传感器
公开(公告)号：WO2008052104A3
公开(公告)日：2008-08-21
申请号：PCT/US2007082503
申请日：2007-10-25
申请人： NANOMIX INC , BRYANT CRAIG , CHANG YING-LAN , GABRIEL JEAN-CHRISTOPHE P , JOHNSON BRADLEY N , KUZMYCH OLEKSANDR , MICKELSON WILLIAM , PASSMORE JOHN LOREN , SKARUPO SERGIE , VALCKE CHRISTIAN
发明人： BRYANT CRAIG , CHANG YING-LAN , GABRIEL JEAN-CHRISTOPHE P , JOHNSON BRADLEY N , KUZMYCH OLEKSANDR , MICKELSON WILLIAM , PASSMORE JOHN LOREN , SKARUPO SERGIE , VALCKE CHRISTIAN
IPC分类号： G01N27/26
CPC分类号： B82Y30/00 , A61B5/08 , A61B5/082 , G01N27/4146
摘要： Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.
摘要翻译：提供适用于测量分析物，如生物分子，有机和无机物质的传感器和检测系统，包括环境和医学上相关的挥发物和气体，如NO，NO2，CO2，NH3，H2，CO等。纳米结构传感器系统的某些实施例被配置用于测量呼吸中的医学上重要的气体。应用包括测量呼吸中的内源性一氧化氮（NO），如用于监测或诊断哮喘和其他肺部疾病。

3. 发明申请

WO2009032534A1 HIGH EFFICIENCY, LOW LOSS NO TO NO2 CATALYTIC CONVERTER 审中-公开
标题翻译： NO2催化转化器的高效率，低损耗
公开(公告)号：WO2009032534A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/073746
申请日：2008-08-20
申请人： NANOMIX, INC. , CHANG, Ying-Lan , JOHNSON, Bradley, N. , BRYANT, Craig , MICKELSON, William
发明人： CHANG, Ying-Lan , JOHNSON, Bradley, N. , BRYANT, Craig , MICKELSON, William
IPC分类号： F02M25/06
CPC分类号： G01N1/28 , G01N33/0013
摘要： Provided herein are catalytic converters that have improved characteristics. According to various embodiments, the converters include high surface area catalyst supports conformally coated with nanoparticulate thin films of a catalyst (e.g., Pt, Pd and Rh). The films are continuous, preventing absorption of species within the converter on the catalyst support. The converters provide higher oxidation efficiency than conventional catalytic converters, in certain embodiments approaching the stoichiometric ratio for the reaction. The converters also provide minimal loss of chemical species within the converter. Also provided are novel methods of fabricating catalytic converters that involve atomic layer deposition of Pt or other catalyst on the support, as well as methods and devices for sensing NO in samples that involve catalytic conversion of NO to NO2.
摘要翻译：本文提供具有改进特征的催化转化器。根据各种实施方案，转化器包括保形涂覆有催化剂（例如Pt，Pd和Rh）的纳米颗粒薄膜的高表面积催化剂载体。膜是连续的，防止转化器内的物质在催化剂载体上的吸收。转换器提供比常规催化转化器更高的氧化效率，在某些实施方案中接近反应的化学计量比。转换器还可以在转换器内提供化学物质的最小损失。还提供了制造催化转化器的新方法，其涉及Pt或其它催化剂在载体上的原子层沉积，以及用于检测涉及NO向NO 2的催化转化的样品中的NO的方法和装置。

4. 发明申请

WO2008052104A2 SENSOR HAVING A THIN-FILM INHIBITION LAYER, NITRIC OXIDE CONVERTER AND MONITOR 审中-公开
标题翻译：传感器具有薄膜抑制层，一氧化氮转换器和监测器
公开(公告)号：WO2008052104A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/082503
申请日：2007-10-25
申请人： NANOMIX, INC. , BRYANT, Craig , CHANG, Ying-lan , GABRIEL, Jean-christophe, P. , JOHNSON, Bradley, N. , KUZMYCH, Oleksandr , MICKELSON, William , PASSMORE, John, Loren , SKARUPO, Sergie , VALCKE, Christian
发明人： BRYANT, Craig , CHANG, Ying-lan , GABRIEL, Jean-christophe, P. , JOHNSON, Bradley, N. , KUZMYCH, Oleksandr , MICKELSON, William , PASSMORE, John, Loren , SKARUPO, Sergie , VALCKE, Christian
IPC分类号： A61B5/08 , G01N31/22
CPC分类号： B82Y30/00 , A61B5/08 , A61B5/082 , G01N27/4146
摘要： Sensors and detection systems suitable for measuring analytes, such as biomolecule, organic and inorganic species, including environmentally and medically relevant volatiles and gases, such as NO, NO2, CO2, NH3, H2, CO and the like, are provided. Certain embodiments of nanostructured sensor systems are configured for measurement of medically important gases in breath. Applications include the measurement of endogenous nitric oxide (NO) in breath, such as for the monitoring or diagnosis of asthma and other pulmonary conditions.
摘要翻译：传感器和检测系统适用于测量分析物，如生物分子，有机和无机物质，包括环境和医学相关的挥发物和气体，如NO，NO2，CO2，NH3，H2，CO和像，提供。纳米结构传感器系统的某些实施例被配置用于测量呼吸中医学上重要的气体。应用包括测量呼吸中的内源性一氧化氮（NO），例如用于监测或诊断哮喘和其他肺部疾病。

5. 发明申请

WO2011017660A2 MAGNETIC CARBON NANOTUBE BASED BIODETECTION 审中-公开
标题翻译：基于磁性碳纳米管的生物传感器
公开(公告)号：WO2011017660A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/044778
申请日：2010-08-06
申请人： NANOMIX, INC. , JOSHI, Kanchan , CHANG, Ying-Lan , JOHNSON, Bradley, N. , RADTKEY, Ray
发明人： JOSHI, Kanchan , CHANG, Ying-Lan , JOHNSON, Bradley, N. , RADTKEY, Ray
IPC分类号： B82B3/00 , C01B31/02 , G01N33/53 , G01N27/30
CPC分类号： G01N33/5438 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/16 , C01B32/162 , C01B32/174 , G01N27/226
摘要： Provided herein is a new hybrid material system, mCNT, including magnetic carbon nanotubes for biological and medical sensing applications. In certain embodiments, the systems include magnetic material on the interior of carbon nanotubes (CNTs). The amount of magnetic particles inside CNTs may be such that mCNT can respond to small, low cost, portable magnet. The exterior CNT surface is kept intact for biomolecular attachments or other functionalizations. Performance enhancement with this novel material includes improved sensitivity, reduced response time, and reduced sample volume. According to various embodiments, the mCNTs are substrates for the adherence of molecules participating in these assays or as active sensing elements. Also provided are methods of fabricating two-dimensional mCNT and CNT networks on printed electrodes.
摘要翻译：本文提供了新的混合材料系统mCNT，其包括用于生物和医学感测应用的磁性碳纳米管。在某些实施方案中，该系统包括在碳纳米管（CNT）内部的磁性材料。 CNT内部的磁性颗粒的量可以使得mCNT可以响应于小型，低成本的便携式磁体。对于生物分子附着或其他功能化，外部CNT表面保持完整。这种新型材料的性能增强包括提高灵敏度，缩短响应时间并减少样品量。根据各种实施方案，mCNT是参与这些测定的分子的粘附或作为有源感测元件的底物。还提供了在印刷电极上制造二维mCNT和CNT网络的方法。

6. 发明申请

WO2010121072A1 BREATH CONDENSATE SAMPLER AND DETECTOR AND BREATH/BREATH CONDENSATE SAMPLER AND DETECTOR 审中-公开
标题翻译：呼吸冷凝器和探测器和呼吸器/呼吸器冷凝器和检测器
公开(公告)号：WO2010121072A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/031307
申请日：2010-04-15
申请人： NANOMIX, INC. , JOHNSON, Bradley, N. , JOSHI, Kanchan , CHANG, Ying-Lan , RADTKEY, Ray
发明人： JOHNSON, Bradley, N. , JOSHI, Kanchan , CHANG, Ying-Lan , RADTKEY, Ray
IPC分类号： G01N27/00
CPC分类号： A61B5/097 , A61B5/0803 , A61B5/082 , A61B5/14539 , B82Y30/00 , G01N33/497 , G01N2001/2282
摘要： The present invention provides a direct sampler and detector for analytes found in exhaled breath condensate. Analytes in the breath condensate are detected instantaneously as they condense prior to reaching the sensor surface or condense directly on the sensor surface. Because the analysis or assay is performed immediately after patient exhalation, analyte stability is significantly improved providing accurate, reliable, consistent, and clinically applicable results. In certain embodiments, combined breath condensate/breath samplers and detectors are provided, enabling multiplexed analysis of condensed and vapor-phase analytes provided in a single sampling session. Breath is collected and directed to one or more subsystems. Within each subsystem, the breath portion is either condensed or prevented from condensing. The technique also allows real-time continuous monitoring, thus allowing immediate feedback to both medical professionals and additional hardware such as ventilators, anesthesia machines, drug infusion systems and cardiac pacemakers.
摘要翻译：本发明提供了一种用于呼出凝结水中分析物的直接取样器和检测器。呼吸冷凝液中的分析物在到达传感器表面之前凝结，或直接凝结在传感器表面上，立即被检测到。因为在患者呼气后立即进行分析或测定，所以分析物的稳定性得到显着改善，可提供准确，可靠，一致和临床适用的结果。在某些实施方案中，提供组合的呼吸冷凝物/呼吸取样器和检测器，使得能够对在单个采样会话中提供的冷凝和气相分析物进行复用分析。呼吸被收集并引导到一个或多个子系统。在每个子系统内，呼吸部分被冷凝或防止冷凝。该技术还允许实时连续监测，从而立即向医疗专业人员和附加硬件（如呼吸机，麻醉机，药物输注系统和心脏起搏器）提供反馈。

7. 发明申请

WO2008039165A3 CARBON DIOXIDE NANOSENSOR, AND RESPIRATORY CO2 MONITORS 审中-公开
标题翻译：二氧化碳纳米传感器和呼吸二氧化碳监测器
公开(公告)号：WO2008039165A3
公开(公告)日：2008-08-07
申请号：PCT/US2006028079
申请日：2006-07-18
申请人： NANOMIX INC , CHANG DANIEL M , CHANG YING-LAN , GABRIEL JEAN-CHRISTOPHE P , JOSHI VIKRAM , MICKELSON WILLIAM , NIEMANN JOSEPH , PASSMORE JOHN LOREN , STAR ALEXANDER , VALCKE CHRISTIAN
发明人： CHANG DANIEL M , CHANG YING-LAN , GABRIEL JEAN-CHRISTOPHE P , JOSHI VIKRAM , MICKELSON WILLIAM , NIEMANN JOSEPH , PASSMORE JOHN LOREN , STAR ALEXANDER , VALCKE CHRISTIAN
IPC分类号： C30B25/00 , G01N27/12 , G01N33/543 , H01L27/108
CPC分类号： G01N33/004 , B82Y30/00 , G01N27/4146 , G01N33/497
摘要： An electronic system (800') for detecting analytes (801), such as carbon dioxide, is provided, using a nanostructure (106) sensor (CO2 sensor 802) The CO2 sensor (802) may comprise a substrate (104) and a nanostructure (106), such as a one or more carbon nanotubes disposed over the substrate (104) (e g, as a network) One or more conductive elements (110, 112) may electrically communicate with the nanostructure (106). A counter or gate electrode may be positioned adjacent the nanostructure (106). A functional ization material (120) reactive with carbon dioxide may be included, either disposed in contact with the nanostructure (106) or isolated by a dielectric The sensor may be connected to a circuit (122) responsive to changes in CO2 concentration in the environment.
摘要翻译：使用纳米结构（106）传感器（CO 2传感器802），提供用于检测诸如二氧化碳的分析物（801）的电子系统（800'）.CO 2传感器（802）可以包括基底（104）和纳米结构（106），例如设置在衬底（104）上的一个或多个碳纳米管（例如，作为网络）。一个或多个导电元件（110,112）可以与纳米结构（106）电连通。计数器或栅电极可以邻近纳米结构（106）定位。可以包括与二氧化碳反应的官能化材料（120），其与纳米结构（106）接触或通过电介质隔离。传感器可以响应于环境中的CO 2浓度的变化而连接到回路（122）。

8. 发明申请

WO2008039165A2 IMPROVED CARBON DIOXIDE NANOSENSOR, AND RESPIRATORY CO2 MONITORS 审中-公开
标题翻译：改进的二氧化碳纳米传感器和呼吸二氧化碳监测器
公开(公告)号：WO2008039165A2
公开(公告)日：2008-04-03
申请号：PCT/US2006/028079
申请日：2006-07-18
申请人： NANOMIX, INC. , CHANG, Daniel, M. , CHANG, Ying-Lan , GABRIEL, Jean-christophe, P. , JOSHI, Vikram , MICKELSON, William , NIEMANN, Joseph , PASSMORE, John, Loren , STAR, Alexander , VALCKE, Christian
发明人： CHANG, Daniel, M. , CHANG, Ying-Lan , GABRIEL, Jean-christophe, P. , JOSHI, Vikram , MICKELSON, William , NIEMANN, Joseph , PASSMORE, John, Loren , STAR, Alexander , VALCKE, Christian
IPC分类号： G01N31/22
CPC分类号： G01N33/004 , B82Y30/00 , G01N27/4146 , G01N33/497
摘要： An electronic system and method for detecting analytes, such as carbon dioxide, is provided, using an improved nanostructure sensor (CO2 sensor). The CO2 sensor may comprise a substrate and a nanostructure, such as a one or more carbon nanotubes disposed over the substrate (e.g., as a network). One or more conductive elements may electrically communicate with the nanostructure. A counter or gate electrode may be positioned adjacent the nanostructure. A functionalization material reactive with carbon dioxide may be included, either disposed in contact with the nanostructure or isolated by a dielectric. The sensor may be connected to a circuit responsive to changes in CO2 concentration in the environment. Embodiments are described of medical sensing systems including one or more CO2 sensors. One embodiment comprises a breath sampling cannula which is connected to a sensor unit. In an alternative, the cannula permits supplemental oxygen to be administered, while recovering and measuring analytes in breath samples. The cannula may connect to a portable processor-display unit for monitoring one or more analytes, such as CO2. Another embodiment includes a cannula configured for the monitoring of sleep disorders, such as apnea, comprising one or more sensors disposed adjacent a breath sampling channel, optionally including flow rate or other sensors. The sensors may be connected by wired or wireless links for to a processor/input/display unit. Any of the embodiments may include filters, selectively permeable membranes, absorbents, and the like to precondition the breath sample, may be configured to include complementary chemistry measurements.
摘要翻译：提供了一种用于检测分析物（如二氧化碳）的电子系统和方法，使用改进的纳米结构传感器（CO2传感器）。 CO 2传感器可以包括衬底和纳米结构，例如设置在衬底上的一个或多个碳纳米管（例如，作为网络）。一个或多个导电元件可以与纳米结构电连通。计数器或栅电极可以邻近纳米结构定位。可以包括与二氧化碳反应的官能化材料，其与纳米结构接触或通过电介质隔离。传感器可以响应于环境中二氧化碳浓度的变化而连接到电路。描述了包括一个或多个CO 2传感器的医学感测系统的实施例。一个实施例包括连接到传感器单元的呼吸取样套管。在替代方案中，套管允许补充氧气，同时在呼吸样本中回收和测量分析物。套管可以连接到便携式处理器显示单元，用于监测一个或多个分析物，例如CO 2。另一个实施例包括配置用于监测睡眠障碍（例如呼吸暂停）的插管，其包括邻近呼吸采样通道设置的一个或多个传感器，可选地包括流速或其它传感器。传感器可以通过有线或无线链路连接到处理器/输入/显示单元。任何实施方案可以包括过滤器，选择性渗透膜，吸收剂等以预处理呼吸样品，可以被配置为包括互补的化学测量。

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