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1. 发明申请

WO2009059449A1 NOVEL THERMOSENSITIVE LIPOSOMES CONTAINING THERAPEUTIC AGENTS 审中-公开
标题翻译：含有治疗药物的新型保湿性脂质体
公开(公告)号：WO2009059449A1
公开(公告)日：2009-05-14
申请号：PCT/CN2007/003128
申请日：2007-11-05
申请人： CELSION CORPORATION , MEI, Xingguo , JIANG, Qingwei , YU, Weiping
发明人： MEI, Xingguo , JIANG, Qingwei , YU, Weiping
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K31/337 , A61K31/555
摘要： A thermosensitive liposome for the delivery of active agents and a composition thereof are disclosed, wherein the liposome comprises at least one phosphatidylcholine, at least one phosphatidylglycerol and at least one lysolipid, and the gel to liquid phase transition temperature of said liposome is 39.0 °C to 45 °C.
摘要翻译：公开了用于递送活性剂及其组合物的热敏脂质体，其中所述脂质体包含至少一种磷脂酰胆碱，至少一种磷脂酰甘油和至少一种溶脂剂，并且所述脂质体的凝胶 - 液相转变温度为39.0℃ 至45℃。

2. 发明申请

WO2005007000A1 METHOD AND APPARATUS FOR TREATMENT OF TISSUE ADJACENT A BODILY CONDUIT WITH A COMPRESSION BALLOON 审中-公开
标题翻译：用于治疗组织相似物的方法和装置具有压缩性气囊的体液
公开(公告)号：WO2005007000A1
公开(公告)日：2005-01-27
申请号：PCT/US2004/014768
申请日：2004-05-11
申请人： CELSION CORPORATION , MON, John
发明人： MON, John
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B18/04 , A61B18/1492 , A61B18/1815 , A61B18/22 , A61B2017/00274 , A61B2017/22051 , A61B2018/00547 , A61B2018/044
摘要： An apparatus for treatment of tissue within a body requiring thermotherapy includes a catheter to be inserted into a bodily conduit, an energy-emitting source disposed within the catheter, a compression balloon surrounding the energy-emitting source where the compression balloon has an inflated diameter that is greater than that of the bodily conduit in a relaxed state and an outside surface of the balloon is coated with one of gene modifiers and drug or medication, and means for activating the energy-emitting source to radiate energy to heat the drug-coated compression balloon and tissue to be treated whereby the heated drug-coated compression balloon effectively delivers the one of the gene modifiers and drug or medication to a target area of the diseased tissue. In addition, methods for using the above apparatus to treat diseased tissue are disclosed.
摘要翻译：一种用于治疗需要热疗的身体内的组织的装置，包括插入身体导管中的导管，设置在导管内的能量发射源，围绕能量发射源的压缩气囊，其中压缩气囊具有膨胀直径，大于处于松弛状态的身体管道，并且球囊的外表面涂覆有基因修饰剂和药物或药物之一，以及用于激活能量发射源以辐射能量以加热药物包被的压缩的装置气球和组织，由此加热的药物包被的压缩气囊将基因修饰剂和药物或药物中的一种有效地递送到患病组织的靶区域。此外，公开了使用上述装置来治疗患病组织的方法。

3. 发明申请

WO2003070298A3 METHOD AND APPARATUS TREATING TISSUE ADJACENT A BODILY CONDUIT WITH THERMOCOMPRESSION AND DRUGS 审中-公开
公开(公告)号：WO2003070298A3
公开(公告)日：2003-08-28
申请号：PCT/US2003/004512
申请日：2003-02-19
申请人： CELSION CORPORATION , MON, John , FENN, Alan, J.
发明人： MON, John , FENN, Alan, J.
IPC分类号： A61B18/04
摘要： A method and apparatus (100) of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source (110) heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43 °C for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source (110) activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy- emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

4. 发明申请

WO2004034925A2 THERMOTHERAPY METHOD FOR TREATMENT AND PREVENTION OF CANCER IN MALE AND FEMALE PATIENTS AND COSMETIC ABLATION OF TISSUE 审中-公开
标题翻译：用于治疗和预防男性和女性患者的癌症和组织化学吸收的热保护方法
公开(公告)号：WO2004034925A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/026681
申请日：2003-08-27
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John
发明人： FENN, Alan, J. , MON, John
IPC分类号： A61F
CPC分类号： A61N5/02
摘要： A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioining at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.
摘要翻译：用于治疗身体或器官的癌症或良性病症的方法使用能量选择性地照射身体组织。该方法包括以下步骤：监测邻近身体的皮肤表面的温度，使身体周围的至少一个能量施加器定位，向至少一个能量施加器输送能量以选择性地用能量照射身体组织，并且治疗癌症中的至少一种以及身体的良性状态，基于所监测的皮肤温度，调整在治疗期间被输送到至少一个能量施加器的功率水平，监测传送到至少一个能量施加器的能量，确定传递给所述至少一个能量施加器的总能量至少一个能量施加器，并且当所述至少一个能量施加器被递送到所述身体时，完成所述治疗。

5. 发明申请

WO2004026098A2 METHOD FOR ADMINISTERING THERMOTHERAPY TO PREVENT THE GROWTH OF TUMORS 审中-公开
标题翻译：用于管理热保护以预防肿瘤生长的方法
公开(公告)号：WO2004026098A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/028898
申请日：2003-09-16
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John
发明人： FENN, Alan, J. , MON, John
IPC分类号： A61B
CPC分类号： A61B18/18 , A61B8/06 , A61B8/12 , A61B18/1815 , A61B18/24 , A61B2017/00022 , A61B2017/00092 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/1861 , A61B2090/378 , A61M25/04 , A61M25/1011 , A61M29/02 , A61M2205/3368 , A61N5/04 , A61N5/045 , A61N7/02 , A61N2005/067
摘要： In order to reduce blood flow thereby accumulating additional equivalent thermal dose following the step of heating an organ or appendage by irradiating microwaves at the organ or appendage, the step of compressing the organ or aplpendage following the heating step is added to thertherapy treatment. In a preferred embodiment, the organ is the prostate and periodic prostate compression is employed to reduce the prostate blood flow thereby allowing chemotherapy, thermosensitive liposome-encapsulated chemotherapy, or gene therapy to accumulate in the prostate region during thermotherapy. Doppler ultrasound imaging may be used to measure tumor blood flow rate and then serve as real-time feedback to assist in adjusting the amount of balloon catheter inflation and to assess damage to the tumor vasculature during the treatment.
摘要翻译：为了减少血液流动，从而在通过在器官或附属物上照射微波加热器官或附属物的步骤后积累额外的等效热剂量，将加热步骤之后的器官或物质的压缩步骤加入到治疗治疗中。在优选的实施方案中，器官是前列腺，并且使用周期性前列腺压缩来减少前列腺血流量，从而允许化疗，热敏脂质体包封的化学疗法或基因治疗在热疗期间在前列腺区积累。多普勒超声成像可用于测量肿瘤血流速率，然后作为实时反馈，以协助调整球囊导管充气量，并评估治疗期间对肿瘤脉管系统的损伤。

6. 发明申请

WO2004022159A1 MONOPOLE PHASED ARRAY THERMOTHERAPY APPLICATOR FOR DEEP TUMORS 审中-公开
标题翻译： OPOPLE阵列热应激剂适用于深部肿瘤
公开(公告)号：WO2004022159A1
公开(公告)日：2004-03-18
申请号：PCT/US2003/026964
申请日：2003-08-29
申请人： CELSION CORPORATION , FENN, Alan, J. , MON, John , SMITH, Dennis
发明人： FENN, Alan, J. , MON, John , SMITH, Dennis
IPC分类号： A61N1/40
CPC分类号： A61N1/403
摘要： A monopole phased array thermotherapy applicator radiating radiofrequency energy for inducing a temperature rise in a target within a body includes a plurality of monopole elements for transmitting electric-field radiation; a metallic waveguide with an RF reflecting ground plane surface with a plurality of circular holes for mounting the monopole elements where the metallic waveguide forms an aperture for receiving a body to be treated; a waveform generator providing a source of electric field coupled to each monopole radiation element through a respective phase and power weighting network; at least one electric field probe positioned on a skin surface of the body for detecting electric field radiation from the plurality of monopole elements; and a controller circuit coupled to the electric field probe received feedback signals to adjust the phase and power delivered to the plurality of monopole elements so that one or more adaptive nulls are formed on the surface of the body and a focus is formed at the target tissue to be treated with thermotherapy.
摘要翻译：辐射射频能量的单极相控阵热疗器施加在体内的靶内引起温度升高，包括用于传输电场辐射的多个单极子元件; 具有RF反射接地平面表面的金属波导，具有用于安装单极元件的多个圆形孔，其中金属波导形成用于接收待处理物体的孔; 波形发生器，通过相应的相位和功率加权网络提供耦合到每个单极辐射元件的电场源; 位于所述主体的皮肤表面上的至少一个电场探针，用于检测来自所述多个单极元件的电场辐射; 以及耦合到电场探针的控制器电路接收的反馈信号以调节传递到多个单极子元件的相位和功率，使得在身体的表面上形成一个或多个自适应零点，并且在目标组织处形成焦点用热疗治疗。

7. 发明申请

WO2013123407A1 THERMOSENSITIVE NANOPARTICLE FORMULATIONS AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：耐热纳米材料制剂及其制备方法
公开(公告)号：WO2013123407A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/026453
申请日：2013-02-15
申请人： CELSION CORPORATION , REED, Robert, A. , SU, Daishui
发明人： REED, Robert, A. , SU, Daishui
IPC分类号： A61K9/127
CPC分类号： A61K31/704 , A61K9/127 , A61K9/1271 , A61K9/1278
摘要： The present invention relates to a formulation of thertnosensiiive liposomes, and more specifically to a formulation of liposomes comprising phospholipids and a surface active agent, wherein the liposomes support long term storage at temperatures less than or equal to about 8 °C, control degradate formation to maximize product potency and release their contents at mild hyperthermic temperatures. Methods of making formulations are also described.
摘要翻译：本发明涉及热敏脂质体的制剂，更具体地涉及包含磷脂和表面活性剂的脂质体的制剂，其中所述脂质体在小于或等于约8℃的温度下支持长期储存，控制降解形成至使产品效能最大化并在温和的高热温度下释放其内容物。还描述了制备制剂的方法。

8. 发明申请

WO2009062398A1 NOVEL THERMOSENSITIVE LIPOSOMES CONTAINING THERAPEUTIC AGENTS 审中-公开
标题翻译：含有治疗药物的新型保湿性脂质体
公开(公告)号：WO2009062398A1
公开(公告)日：2009-05-22
申请号：PCT/CN2008/001846
申请日：2008-11-05
申请人： CELSION CORPORATION , MEI, Xingguo , JIANG, Qingwei , YU, Weiping
发明人： MEI, Xingguo , JIANG, Qingwei , YU, Weiping
IPC分类号： A61K9/127 , A61K47/24 , A61K31/337 , A61P35/00
CPC分类号： A61K9/127 , A61K31/337 , A61K31/555
摘要： A thermosensitive liposome for the delivery of active agents and a composition thereof are disclosed, wherein the liposome comprises at least one phosphatidylcholine, at least one phosphatidylglycerol and at least one lysolipid, and the gel to liquid phase transition temperature of said liposome is from 39 0°C to 45°C.
摘要翻译：公开了用于递送活性剂及其组合物的热敏脂质体，其中所述脂质体包含至少一种磷脂酰胆碱，至少一种磷脂酰甘油和至少一种溶脂剂，并且所述脂质体的凝胶 - 液相转变温度为39± ℃至45℃。

9. 发明申请

WO2007024826A3 METHOD OF STORING NANOPARTICLE FORMULATIONS 审中-公开
公开(公告)号：WO2007024826A3
公开(公告)日：2007-03-01
申请号：PCT/US2006/032714
申请日：2006-08-23
申请人： CELSION CORPORATION , YU, Weiping , MON, John
发明人： YU, Weiping , MON, John
IPC分类号： A61K9/127 , A61K9/19
摘要： The present invention is a method for storing a liposome or nanoparticle formulation formed by the combination of at least one phospholipid, at least one sufactant and at least one hydrophilic polymer. The method incldes freezing such a formulation, and storing it for a period of at least three days.

10. 发明申请

WO2004007021A2 METHOD FOR IMPROVED SAFETY IN EXTERNALLY FOCUSED MICROWAVE THERMOTHERAPY FOR TREATING BREAST CANCER 审中-公开
标题翻译：用于治疗乳腺癌的外部聚焦微波治疗中改进安全性的方法
公开(公告)号：WO2004007021A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/022104
申请日：2003-07-15
申请人： CELSION CORPORATION
发明人： FENN, Alan, J. , MON, John , SMITH, Dennis
IPC分类号： A61N5/02
CPC分类号： A61N5/02

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