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1. 发明申请

WO2006110589A2 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译：与癌症相关的巨噬细胞瘤
公开(公告)号：WO2006110589A2
公开(公告)日：2006-10-19
申请号：PCT/US2006013167
申请日：2006-04-07
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CALIFORNIA , SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
发明人： SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒的方法（例如，在个体中）; 识别抑制病毒的药剂的方法; 诱导对病毒的免疫应答的方法; 治疗与个体（例如癌症如前列腺癌）中XMRV存在相关的疾病的方法; 检测无症状癌症的方法（例如前列腺癌）; 识别患有癌症风险的个体（例如前列腺癌）的方法; 和用于检测病毒的工具包。

2. 发明申请

WO2004028346A2 DETECTION METHODS 审中-公开
标题翻译：检测方法
公开(公告)号：WO2004028346A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/030359
申请日：2003-09-25
申请人： AMERSHAM BIOSCIENCES (SV) CORP. , LOUKOLA, Anu-Maria , PENN, Sharron, Gaynor , RANK, David, Russell , HANZEL, David, Kagen , CASEY, Graham , WITTE, John, S.
发明人： LOUKOLA, Anu-Maria , PENN, Sharron, Gaynor , RANK, David, Russell , HANZEL, David, Kagen , CASEY, Graham , WITTE, John, S.
IPC分类号： A61B
CPC分类号： G01N33/57434 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/172 , G01N33/57415 , G01N2500/00 , G01N2800/52
摘要： The present invention relates to the prognosis, diagnosis and treatment of cancer, particularly prostate cancer. Polynucleotides having single nucleotide polymorphisms (SNPs) and haplotypes are provided which are of utility in the prognosis, diagnosis, prophylaxis and treatment of prostate and breast cancer.
摘要翻译：本发明涉及癌症，特别是前列腺癌的预后，诊断和治疗。提供具有单核苷酸多态性（SNPs）和单体型的多核苷酸，其可用于前列腺和乳腺癌的预后，诊断，预防和治疗。

3. 发明申请

WO2004028346A3 DETECTION METHODS 审中-公开
标题翻译：检测方法
公开(公告)号：WO2004028346A3
公开(公告)日：2006-09-08
申请号：PCT/US0330359
申请日：2003-09-25
申请人： AMERSHAM BIOSCIENCES SV CORP , LOUKOLA ANU-MARIA , PENN SHARRON GAYNOR , RANK DAVID RUSSELL , HANZEL DAVID KAGEN , CASEY GRAHAM , WITTE JOHN S
发明人： LOUKOLA ANU-MARIA , PENN SHARRON GAYNOR , RANK DAVID RUSSELL , HANZEL DAVID KAGEN , CASEY GRAHAM , WITTE JOHN S
IPC分类号： C07H21/04 , A61B20060101 , A61B1/00 , C07K16/00 , C12M1/34 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/00 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： G01N33/57434 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/172 , G01N33/57415 , G01N2500/00 , G01N2800/52
摘要： The present invention relates to the prognosis, diagnosis and treatment of cancer, particularly prostate cancer. Polynucleotides having single nucleotide polymorphisms (SNPs) and haplotypes are provided which are of utility in the prognosis, diagnosis, prophylaxis and treatment of prostate and breast cancer. Figure 1 illustrates the testosterone biosynthetic pathway.
摘要翻译：本发明涉及癌症，特别是前列腺癌的预后，诊断和治疗。提供了具有单核苷酸多态性（SNPs）和单体型的多核苷酸，其可用于前列腺和乳腺癌的预后，诊断，预防和治疗。图1显示了睾酮生物合成途径。

4. 发明申请

WO1997045727A1 METHOD OF DETECTING GYNECOLOGICAL CARCINOMAS 审中-公开
标题翻译：检测妇科癌症的方法
公开(公告)号：WO1997045727A1
公开(公告)日：1997-12-04
申请号：PCT/US1997009604
申请日：1997-05-30
申请人： CLEVELAND CLINIC FOUNDATION , XU, Yan , CASEY, Graham
发明人： CLEVELAND CLINIC FOUNDATION
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , G01N33/57407 , G01N33/57449 , G01N33/57488 , G01N33/92 , G01N2030/025 , Y10T436/16 , Y10T436/163333 , Y10T436/166666 , Y10T436/25375
摘要： The present invention provides a new method for detecting the presence of gynecological carcinomas in a patient. The method, which comprises detecting the presence of lysophosphatidic acid in a plasma sample of the patient, is useful for detecting ovarian carcinoma, cervical carcinoma, endometrial carcinoma, and peritoneal carcinoma. In a preferred embodiment the method comprises: providing a blood specimen from the patient, obtaining a plasma sample from the blood specimen under conditions which minimize the release of lysophosphatidic acid from the platelets in the blood specimen into the plasma, extracting lipids from the plasma, and detecting the presence of lysophosphatidic acid in the lipid extract. A new method for extracting lysophosphatidic acid from a biological fluid is also provided. The method which comprises acidifying the biological fluid and extracting the lysophosphatidic acid from the acidified sample with an organic solvent is useful for extracting greater than 80 % of the lysophosphatidic acid in the biological fluid.
摘要翻译：本发明提供了一种用于检测患者中妇科癌存在的新方法。该方法包括检测患者血浆样品中溶血磷脂酸的存在，可用于检测卵巢癌，子宫颈癌，子宫内膜癌和腹膜癌。在优选实施方案中，该方法包括：从患者提供血液标本，在使血液样本中血小板中溶血磷脂酸释放到血浆中的条件下从血液标本获得血浆样品，从血浆中提取脂质，并检测脂质提取物中溶血磷脂酸的存在。还提供了一种从生物液体中提取溶血磷脂酸的新方法。包括酸化生物流体并用有机溶剂从酸化样品中提取溶血磷脂酸的方法可用于提取生物流体中大于80％的溶血磷脂酸。

5. 发明申请

WO2006110589A3 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
公开(公告)号：WO2006110589A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/013167
申请日：2006-04-07
申请人： THE CLEVELAND CLINIC FOUNDATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
发明人： SILVERMAN, Robert , KLEIN, Eric, A. , DERISI, Joseph , GANEM, Don , CASEY, Graham
IPC分类号： C12N7/00 , C12N15/11 , C07K14/15 , C12N15/63 , C12N5/10 , C12Q1/68 , G01N33/569 , G01N33/50 , A61K39/21 , C12N7/02
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

6. 发明申请

WO2006110589A8 GAMMARETROVIRUS ASSOCIATED WITH CANCER 审中-公开
标题翻译： GAMMARETROVIRUS与癌症相关
公开(公告)号：WO2006110589A8
公开(公告)日：2007-03-01
申请号：PCT/US2006013167
申请日：2006-04-07
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CALIFORNIA , SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
发明人： SILVERMAN ROBERT , KLEIN ERIC A , DERISI JOSEPH , GANEM DON , CASEY GRAHAM
IPC分类号： C12N7/00 , A61K39/21 , C07K14/15 , C12N5/10 , C12N7/02 , C12N15/11 , C12N15/63 , C12Q1/68 , G01N33/50 , G01N33/569
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K16/1036 , C12N9/22 , C12N2740/13021 , C12N2740/13022 , C12Q1/6886 , C12Q1/70 , C12Q1/701 , C12Q2600/136
摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.
摘要翻译：本发明提供了编码病毒的分离的核酸序列; 包含病毒的氨基酸序列的分离的多肽; 包含病毒核酸序列的载体; 包含载体的细胞; 对病毒具有结合特异性的抗体及其抗原结合片段; 检测或筛选病毒（例如在个体中）的方法; 鉴定抑制病毒的物质的方法; 诱导对病毒的免疫应答的方法; 治疗与个体中XMRV存在相关的疾病（例如癌症，例如前列腺癌）的方法; 检测无症状癌症（例如前列腺癌）的方法; 鉴定处于发展成癌症风险中的个体（例如前列腺癌）的方法; 和检测病毒的工具包。

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