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1. 发明申请

WO1989012231A1 ANTI-FC ASSAY FOR DETECTION OF ANTIBODIES 审中-公开
标题翻译：用于检测抗体的ANTI-FC测定
公开(公告)号：WO1989012231A1
公开(公告)日：1989-12-14
申请号：PCT/US1989002084
申请日：1989-05-15
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , HUNG, Chung-Ho , MARCIANI, Dante, Juan
IPC分类号： G01N33/563
CPC分类号： G01N33/6857 , G01N33/56988
摘要： This invention is an assay for detecting antibodies in a sample by first capturing, or binding, the antibodies to be detected at the Fc region of the antibodies. In the method of this invention, multiple antibodies may be detected in a single sample. Diagnostic assays involving the use of this method have therefore been developed for the detection of antibodies.

2. 发明申请

WO1988008037A1 METHOD FOR THE DETECTION OF BACTERIA AND FUNGI 审中-公开
标题翻译：检测细菌和真菌的方法
公开(公告)号：WO1988008037A1
公开(公告)日：1988-10-20
申请号：PCT/US1988001155
申请日：1988-04-08
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , WASKIEWICZ, David, E. , PATEL, Usha , MARCIANI, Dante, J.
IPC分类号： C12Q01/00
CPC分类号： C12Q1/04 , C12Q2304/24
摘要： A method for detecting bacteria and fungi in a sample by enzymatic activity of the bacteria and fungi. The suspected bacteria or fungi in the sample are first lysed with a combination of lytic enzyme and detergent to rupture the bacterial and fungal cell walls. The bacteria and fungi are then detected via the enzymatic activity of the bacteria and fungi by an enzyme detection assay.

3. 发明申请

WO1988009336A1 SAPONIN ADJUVANT 审中-公开
公开(公告)号：WO1988009336A1
公开(公告)日：1988-12-01
申请号：PCT/US1988001842
申请日：1988-05-31
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , KENSIL, Charlotte, A. , MARCIANI, Dante, J. , BELTZ, Gerald, A. , HUNG, Chung-Ho
IPC分类号： C07J17/00
CPC分类号： C07J17/005 , A61K39/39 , A61K2039/55577 , C07H15/256
摘要： Substantially pure saponins are disclosed. The saponins of the present invention are useful as immune adjuvants. Disclosed as well are immune response-provoking compositions comprising an antigen in admixture with the substantially pure saponins.
摘要翻译：公开了基本上纯的皂苷。本发明的皂苷可用作免疫佐剂。还公开了包含与基本上纯的皂苷混合的抗原的免疫应答发生组合物。

4. 发明申请

WO1991007664A1 DIAGNOSTIC PROTEINS TO TEST FOR MORE THAN ONE ANTIBODY 审中-公开
标题翻译：诊断蛋白质测试超过一个抗体
公开(公告)号：WO1991007664A1
公开(公告)日：1991-05-30
申请号：PCT/US1990006621
申请日：1990-11-13
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , YOUNG, Elihu, M. , STOREY, James, R. , BELTZ, Gerald, A.
IPC分类号： G01N33/569
CPC分类号： C07K14/005 , C12N2740/14022 , C12N2740/16222 , G01N33/56988
摘要： This invention is directed to the discovery that certain envelope peptide fragments of the Human Immunodeficiency Virus 2 (HIV-2) are particularly immunoreactive against HIV-2 antibodies. These fragments can therefore be applied to immunodiagnostic tests for the detection of antibodies to HIV-2. This invention is also directed to certain chimeric proteins that are made from immunogenic portions of the envelope gene of HIV-2, HIV-1, or HTLV-I that can be used to test for antibodies to HIV-2, HIV-1, and HTLV-I and HTLV-II.
摘要翻译：本发明涉及人类免疫缺陷病毒2（HIV-2）的某些包膜肽片段对HIV-2抗体特别免疫反应的发现。因此，这些片段可用于检测HIV-2抗体的免疫诊断试验。本发明还涉及由HIV-2，HIV-1或HTLV-1的包膜基因的免疫原性部分制备的某些嵌合蛋白，其可用于测试针对HIV-2，HIV-1和 HTLV-I和HTLV-II。

5. 发明申请

WO1987007301A1 METHOD OF PREPARATION AND USE FOR FELINE LEUKEMIA VIRUS ANTIGENS 审中-公开
标题翻译：制备和使用FELINE LEUKEMIA VIRUS抗原的方法
公开(公告)号：WO1987007301A1
公开(公告)日：1987-12-03
申请号：PCT/US1987001278
申请日：1987-05-29
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , BELTZ, Gerald , MARCIANI, Dante, J. , HUNG, Chung-Ho , KENSIL, Charlotte, A.
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/13022
摘要： Antigenic preparations useful for inducing the production of antibodies in a cat which will bind to epitopes on feline leukemia virus. Also disclosed are immunogenic compositions and methods for immunizing a cat to enable the production of antibodies to feline leukemia virus.

6. 发明申请

WO1987004726A1 PROCESS FOR PURIFYING RECOMBINANT PROTEINS, AND PRODUCTS THEREOF 审中-公开
标题翻译：净化重组蛋白的方法及其制品
公开(公告)号：WO1987004726A1
公开(公告)日：1987-08-13
申请号：PCT/US1987000223
申请日：1987-02-03
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , HUNG, Chung-Ho , THORN, Richard, M. , RIGGIN, Charles , MARCIANI, Dante, Juan
IPC分类号： C12P21/00
CPC分类号： C07K14/005 , A61K38/00 , C07K1/113 , C07K1/1133 , C07K1/1136 , C07K16/1045 , C08F8/42 , C12N2740/14022 , C12N2740/16122 , G01N33/54353 , G01N33/569 , G01N33/56988 , Y10S530/826
摘要： Process for recovering recombinant protein from refractile inclusion bodies of microorganisms which comprises disrupting cells, recovering refractile bodies containing recombinant protein, solubilizing the refractile bodies with a denaturant, protecting sulfhydryl groups of recombinant proteins, converting cationic amino groups of recombinant proteins to anionic carboxylic acid by derivatization with organic cyclic acid anhydrides, and recovering recombinant protein derivatives. The present invention also relates to the production of solid supports coated with recombinant protein recovered by the process of the invention, and the use of said devices for the detection and quantification of antibodies to said recombinant proteins in body fluids.

7. 发明申请

WO1991002589A1 REACTION APPARATUS AND METHOD EMPLOYING GRAVITATIONAL FLOW 审中-公开
标题翻译：反应装置和使用流失的方法
公开(公告)号：WO1991002589A1
公开(公告)日：1991-03-07
申请号：PCT/US1990004629
申请日：1990-08-16
申请人： CAMBRIDGE BIOSCIENCE CORPORATION
发明人： CAMBRIDGE BIOSCIENCE CORPORATION , ANDREWS, Robert, R.
IPC分类号： B01L03/00
CPC分类号： B01L3/502 , G01N33/5302
摘要： A diagnostic device provides the flow of a desired reaction mixture under the force of gravity through a channel. The flow of the reaction mixture gains necessary energy to bring about a physical or a chemical reaction of the reaction mixture. A viewing chamber at the end of the channel retains results of the reaction. The device allows a timed reaction to take place without application of external forces such as vibration, rocking, optical activation, heat or pulsing. Alternative chambers at an entry end of the channel are used to introduce a secondary reaction mixture or reagents. A vent to the channel provides an indication of volume of the reactants and can also function as a viewing area. Channel configurations include various paths of flow and various inner wall geometries.
摘要翻译：诊断装置通过通道在重力作用下提供所需反应混合物的流动。反应混合物的流动获得必要的能量以引起反应混合物的物理或化学反应。在通道末端的观察室保留反应结果。该装置允许定时反应发生，而不施加诸如振动，摇摆，光学激活，热或脉冲之类的外力。在通道的入口端的替代室用于引入第二反应混合物或试剂。通道的通风口提供了反应物体积的指示，也可以用作观察区域。通道配置包括各种流动路径和各种内壁几何形状。

8. 发明申请

WO1987004728A1 PEPTIDES FOR THE DIAGNOSIS OF HTLV-III ANTIBODIES, THEIR PREPARATION AND USE 审中-公开
标题翻译：用于诊断HTLV-III抗体的药物及其制备和使用
公开(公告)号：WO1987004728A1
公开(公告)日：1987-08-13
申请号：PCT/US1987000225
申请日：1987-02-03
申请人： CAMBRIDGE BIOSCIENCE CORPORATION , BELTZ, Gerald, A. , THORN, Richard, M. , MARCIANI, Dante, Juan , HUNG, Chung-Ho
发明人： CAMBRIDGE BIOSCIENCE CORPORATION
IPC分类号： C12Q01/68
CPC分类号： C07K14/005 , A61K38/00 , C07K1/113 , C07K1/1133 , C07K1/1136 , C07K16/1045 , C08F8/42 , C12N2740/14022 , C12N2740/16122 , G01N33/54353 , G01N33/569 , G01N33/56988 , Y10S530/826
摘要： Certain peptide fragments of the human T-cell leukemia (lymphotropic) virus (HTLV-III) are particularly immunoreactive to HTLV-III antibodies, and can therefore be applied to immunodiagnostic tests for the detection of antibodies to HTLV-III.

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