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1. 发明申请

WO2012075174A3 COMPOUNDS AND METHODS FOR SKIN REPAIR 审中-公开
标题翻译：化合物和方法进行皮肤修复
公开(公告)号：WO2012075174A3
公开(公告)日：2012-07-26
申请号：PCT/US2011062691
申请日：2011-11-30
申请人： ALLERGAN INC , BURK ROBERT M , IM WHA BIN , WHITCUP SCOTT M
发明人： BURK ROBERT M , IM WHA BIN , WHITCUP SCOTT M
IPC分类号： A61K31/381 , A61K8/37 , A61K8/42 , A61K8/49 , A61K9/00 , A61K31/167 , A61K31/22 , A61K31/343 , A61K31/4015 , A61K31/421 , A61K31/519 , A61P17/02 , A61Q19/08
CPC分类号： A61K9/0014 , A61K8/365 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4986 , A61K31/167 , A61K31/519 , A61K31/559 , A61K2800/78 , A61Q19/08
摘要： The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.
摘要翻译：本公开提供了治疗皮肤瑕疵的组合物和方法。组合物包含治疗有效量的用于治疗皮肤瑕疵如化合物，伤口，皱纹和皱纹的化合物。

2. 发明申请

WO2009100057A1 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY 审中-公开
标题翻译：具有PROSTAGLANDIN活性的取代环孢菌素
公开(公告)号：WO2009100057A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/032943
申请日：2009-02-03
申请人： ALLERGAN, INC. , BURK, Robert, M.
发明人： BURK, Robert, M.
IPC分类号： C07C405/00 , A61K31/192 , A61K31/047 , A61P27/06 , A61P27/02
CPC分类号： C07C405/00 , C07C405/0008
摘要： 11,15, 19-trihydroxy-9-halo-prostaglandin analogues and its use as ocular hypotensive agents. Ocular hypotensive agents are useful in the treatment of a number of various ocular hypertensive conditions, such as post-surgical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts.
摘要翻译： 11,15,19-三羟基-9-卤代 - 前列腺素类似物及其用作眼压降血压药。眼部降血压药物可用于治疗许多各种眼部高血压病症，如手术后和激光后小梁切除术眼高压发作，青光眼，以及作为手术前辅助治疗。

3. 发明申请

WO2009091764A3 BETA-LACTAMS FOR THE TREATMENT OF GLAUCOMA, OCULAR HYPERTENSION, BALDNESS AND HAIR LOSS 审中-公开
公开(公告)号：WO2009091764A3
公开(公告)日：2009-07-23
申请号：PCT/US2009/030894
申请日：2009-01-14
申请人： ALLERGAN, INC. , DINH, Danny, T. , OLD, David, W. , BURK, Robert, M.
发明人： DINH, Danny, T. , OLD, David, W. , BURK, Robert, M.
IPC分类号： C07D409/06 , C07D205/08 , A61K31/397 , A61P27/06 , A61P27/02 , A61P17/14
摘要： Compounds comprising Formula (I) or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, R, D, and n are as described. Disclosed herein are compounds useful in treating glaucoma, inflammatory bowel disease, the stimulation of hair growth, and the stimulation of the conversation of vellus hair to terminal hair.

4. 发明申请

WO2009091764A2 THERAPEUTIC BETA-LACTAMS 审中-公开
标题翻译：治疗性BETA-LACTAMS
公开(公告)号：WO2009091764A2
公开(公告)日：2009-07-23
申请号：PCT/US2009030894
申请日：2009-01-14
申请人： ALLERGAN INC , DINH DANNY T , OLD DAVID W , BURK ROBERT M
发明人： DINH DANNY T , OLD DAVID W , BURK ROBERT M
IPC分类号： C07D409/06 , A61K31/397 , A61P17/14 , A61P27/02 , A61P27/06 , C07D205/08
CPC分类号： C07D409/06 , C07D205/08
摘要： Compounds comprising Formula (I) or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, R, D, and n are as described. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：公开了包含式（I）化合物或其药学上可接受的盐或前药的化合物，其中Y，A，R，D和n如上所述。还公开了与之相关的方法，组合物和药物。

5. 发明申请

WO2009061811A8 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDING ACTIVITY 审中-公开
公开(公告)号：WO2009061811A8
公开(公告)日：2009-05-14
申请号：PCT/US2008/082469
申请日：2008-11-05
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H. , BURK, Robert, M.
IPC分类号： C07D263/34 , C07D333/40 , A61K31/381 , A61P27/06
摘要： Disclosed herein are compounds having a formula: (I) Therapeutic methods, medicaments, and compositions related thereto are also disclosed.

6. 发明申请

WO2008073752A3 CYCLOBUTYL DERIVATIVES FOR THE TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗GLAUCOMA的CYCLOBUTYL衍生物
公开(公告)号：WO2008073752A3
公开(公告)日：2008-10-02
申请号：PCT/US2007086326
申请日：2007-12-04
申请人： ALLERGAN INC , HOLOBOSKI MARK , BURK ROBERT M , POSNER MARI F
发明人： HOLOBOSKI MARK , BURK ROBERT M , POSNER MARI F
IPC分类号： C07C255/46 , A61K31/277 , A61K31/381 , A61P27/06 , C07D333/16 , C07D333/24 , C07D333/28 , C07D333/38
CPC分类号： C07D333/38 , C07C255/46 , C07C2601/04 , C07C2601/08 , C07D333/16 , C07D333/24 , C07D333/28
摘要： Compound having the formula below are disclosed herein:formula (I).Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：具有下式的化合物在本文中公开：式（I）。还公开了与其相关的治疗方法，组合物和药物。

7. 发明申请

WO2007134085A3 ISOTHIAZOLIDINES USEFUL IN THE TREATMENT OF OCULAR HYPERTENSIVE CONDITIONS 审中-公开
标题翻译：同位素治疗OCULAR HYPERTENSIVE条件有效
公开(公告)号：WO2007134085A3
公开(公告)日：2008-01-10
申请号：PCT/US2007068518
申请日：2007-05-09
申请人： ALLERGAN INC , BURK ROBERT M , OLD DAVID W , GAC TODD S
发明人： BURK ROBERT M , OLD DAVID W , GAC TODD S
IPC分类号： C07D275/06 , A61K31/425 , A61P9/12 , C07D417/12 , C07D417/14 , C07D471/06
CPC分类号： C07D417/12 , C07D275/06 , C07D417/06 , C07D417/14
摘要： Disclosed herein is a compound having a structure (I) or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：本文公开了具有结构（I）或其药学上可接受的盐或其前药的化合物。还公开了与之相关的治疗方法，组合物和药物。

8. 发明申请

WO2007024611A2 NOVEL SULFONAMIDES 审中-公开
标题翻译：新型磺化物
公开(公告)号：WO2007024611A2
公开(公告)日：2007-03-01
申请号：PCT/US2006032096
申请日：2006-08-17
申请人： ALLERGAN INC , BURK ROBERT M
发明人： BURK ROBERT M
IPC分类号： C07C311/06 , A61K31/20 , A61K31/23 , A61P27/06
CPC分类号： C07C311/06 , C07C2601/04
摘要： The present invention provides wherein R 1 is selected from the group consisting of C 1 -C 10 alkoxy, OH and NR 4 R 5 ; R 2 is selected from the group consisting of C 1 -C 10 alkyl and (CH 2 ) n OH; R 3 is selected from the group consisting of C 1 C 10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R 4 and R 5 are independently selected from the group consisting of H, C 1 -C 10 alkyl, C 1 -C 10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.
摘要翻译：本发明提供其中R 1选自C 1 -C 10烷氧基，OH和NR 4， / SUP> - [R ^{5 ; R 2选自C 1 -C 10烷基和（CH 2 N 2）N 2 >名词 OH; R 3选自C 1 -C 10烷基，杂芳基，例如C 1 -C 6烷基。噻吩基，呋喃基和吡啶基，苯基，单，二 - ，三取代的苯基和杂芳基; R 4和R 5独立地选自H，C 1 -C 10烷基， C 1 -C 10烷基羟基; C 1 -C 10烷基羟基; m为0或1至3的整数，n为1至4的整数。这些化合物可用于降低眼内压和/或治疗青光眼或向人类患者的眼睛提供神经保护作用。}

9. 发明申请

WO2006124695A3 3, 7 OR 3 AND 7 THIA OR OXA PROSTANOIC ACID DERIVATIVES COMBINED WITH ANOTHER DRUG FOR LOWERING INTRAOCULAR PRESSURE 审中-公开
标题翻译： 3，7 OR 3和7 THIA或OXA PROSTANOIC酸衍生物与其他药物联合用于降低内分泌压
公开(公告)号：WO2006124695A3
公开(公告)日：2007-02-22
申请号：PCT/US2006018585
申请日：2006-05-15
申请人： ALLERGAN INC , BURK ROBERT M , HOLOBOSKI MARK , WHITCUP SCOTT M , IM WHA-BIN
发明人： BURK ROBERT M , HOLOBOSKI MARK , WHITCUP SCOTT M , IM WHA-BIN
IPC分类号： A61K31/5575 , A61K31/557 , A61K31/559 , A61K31/66 , A61K31/675 , A61P27/06
CPC分类号： A61K31/559 , A61K31/557 , A61K31/5575 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： A method is disclosed herein comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound represented by the general formula I; wherein A, B, D, X, Y, Z, R 1 , R 3 and R 4 are as defined in the specification.
摘要翻译：本文公开的方法包括向哺乳动物的眼睛施用化合物和第二药物用于治疗青光眼或降低眼内压，所述通式I表示的化合物; 其中A，B，D，X，Y，Z，R 1，R 3和R 4如说明书中所定义。

10. 发明申请

WO2006121822B1 USE OF ß-LACTAMS FOR THE TREATMENTOF IBD AND GLAUCOMA 审中-公开
标题翻译：用于治疗IBD和GLAUCOMA的β-LACTAMS的使用
公开(公告)号：WO2006121822B1
公开(公告)日：2007-01-18
申请号：PCT/US2006017336
申请日：2006-05-02
申请人： ALLERGAN INC , OLD DAVID W , DINH DANNY T , BURK ROBERT M
发明人： OLD DAVID W , DINH DANNY T , BURK ROBERT M
IPC分类号： A61K31/397 , A61P1/00 , A61P27/08 , C07D205/08
CPC分类号： C07D205/08 , A61K31/397
摘要： The use of compounds of the general formula (I) or a pharmaceutically acceptable salt or a prodrug thereof for the treatment of IBD and glaucoma is disclosed, wherein Y, A, R, D, and n are as described. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：公开了将通式（I）的化合物或其药学上可接受的盐或前体药物用于治疗IBD和青光眼，其中Y，A，R，D和n如上所述。还公开了与之相关的方法，组合物和药物。

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