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1. 发明申请

WO2011054011A4 FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM 审中-公开
标题翻译： FOOD和MOUD病病毒（FMDV）共识蛋白，其编码序列及其制备的疫苗
公开(公告)号：WO2011054011A4
公开(公告)日：2011-09-22
申请号：PCT/US2010055187
申请日：2010-11-02
申请人： UNIV PENNSYLVANIA , INOVIO PHARMACEUTICALS INC , WEINER DAVID B , FERRARO BERNADETTE , YAN JIAN , BROWN PATRICIA A , BOWLING RODNEY A , KERN DOUGLAS R , RAMANATHAN MATHURA P , SARDESAI NIRANJAN Y , MUTHUMANI KARUPPIAH
发明人： WEINER DAVID B , FERRARO BERNADETTE , YAN JIAN , BROWN PATRICIA A , BOWLING RODNEY A , KERN DOUGLAS R , RAMANATHAN MATHURA P , SARDESAI NIRANJAN Y , MUTHUMANI KARUPPIAH
IPC分类号： A61K39/125
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV substypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译：本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达序列。本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物进行解密的方法。

2. 发明申请

WO2005065722A2 REDUCING ARTHRITIS AND LAMENESS IN SUBJECTS BY GROWTH HORMONE RELEASING HORMONE (GHRH) SUPPLEMENTATION 审中-公开
标题翻译：通过生长激素释放激素（GHRH）补充来减少受试者的伤害程度和死亡率
公开(公告)号：WO2005065722A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/042497
申请日：2004-12-17
申请人： ADViSYS, INC. , DRAGHIA-AKLI, Ruxandra , BROWN, Patricia, A. , HOOD, David
发明人： DRAGHIA-AKLI, Ruxandra , BROWN, Patricia, A. , HOOD, David
IPC分类号： A61K48/00
CPC分类号： A61K48/005 , A61K31/713 , A61K38/25 , C07K14/60
摘要： One aspect of the current invention is a method of preventing and / or treating arthritis and / or preventing or treating lamenes in a subjetc. Additionally, subject quality of like and welfare, and body conditions scores are improved by utilizing methodology that administers the nucleic acid expression construct encoding a GHRH or functional biological equivalent to a subject throught a parental route of administration. Following a single dose of nucleic acid expression vector, subjects are healthier and effects demonstrated long term without additional administration(s) of the expression construct.
摘要翻译：本发明的一个方面是预防和/或治疗关节炎和/或预防或治疗子喷气板中的层板的方法。另外，通过使用通过父母给药途径施用编码GHRH的核酸表达构建体或与受试者的功能生物学等价物的方法，提高了类似和福利的受试者质量以及身体状况得分。在单剂量的核酸表达载体之后，受试者更健康，并且长期表现效果，而没有额外施用表达构建体。

3. 发明申请

WO2004067719A2 REDUCING CULLING IN HERD ANIMALS GROWTH HORMONE RELEASING HORMONE (GHRH) 审中-公开
标题翻译：减少激素在动物生长激素释放激素（GHRH）
公开(公告)号：WO2004067719A2
公开(公告)日：2004-08-12
申请号：PCT/US2004002134
申请日：2004-01-26
申请人： ADVISYS INC , BROWN PATRICIA A , DRAGHIA-AKLI RUXANDRA , CARPENTER ROBERT H
发明人： BROWN PATRICIA A , DRAGHIA-AKLI RUXANDRA , CARPENTER ROBERT H
IPC分类号： A61K38/25 , A61K48/00 , C07K14/60 , C12N
CPC分类号： A61K48/0016 , A61K38/25 , A61K48/00 , A61K48/0075 , A61K48/0083 , C07K14/60
摘要： One aspect of the current invention is a method of decreasing an involuntary cull rate in farm animals, wherein the involuntary cull results from infection, disease, morbidity, or mortality. Additionally, milk production, animal welfare, and body condition scores are improved by utilizing methodology that administers the isolated nucleic acid expression construct encoding a GHRH or functional biological equivalent to an animal through a parenteral route of administration. Following a single dose of nucleic acid expression vector, animals are healthier and effects are demonstrated long term without additional administration(s) of the expression construct.
摘要翻译：本发明的一个方面是减少农场动物中的非自愿剔除率的方法，其中非自愿宰杀来自感染，疾病，发病率或死亡率。此外，通过使用通过肠胃外给药途径施用编码GHRH的分离的核酸表达构建体或与动物的功能生物等价物的方法，提高了产奶量，动物福利和身体状况得分。在单剂量的核酸表达载体之后，动物更健康，并且长期表现效果，而没有额外施用表达构建体。

4. 发明申请

WO2004093920A3 GHRH FOR USE IN TREATING CHRONIC RENAL FAILURE 审中-公开
标题翻译： GHRH用于治疗慢性肾衰竭
公开(公告)号：WO2004093920A3
公开(公告)日：2005-07-28
申请号：PCT/US2004012159
申请日：2004-04-20
申请人： ADVISYS INC , DRAGHIA-AKLI RUXANDRA , SCOTT CLARA , BROWN PATRICIA A
发明人： DRAGHIA-AKLI RUXANDRA , SCOTT CLARA , BROWN PATRICIA A
IPC分类号： A61K48/00 , A61K38/25 , A61P13/12
CPC分类号： A61K48/005
摘要： The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and methods are useful for treatment or prevention of kidney failure, treatment of anemia, and other conditions commonly associated with kidney failure in order to increase survival and improve welfare in subjects with chronic renal failure. Overall, the embodiments of the invention can be accomplished by delivering an isolated nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of a subject and allowing expression of the encoded gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the subject, tissue specific constitutive expression is achieved. The embodiments of the invention also encompass delivery of a recombinant GHRH polypeptide or functional biological equivalent thereof. The preferred method for delivering the constitutive or inducible nucleic acid encoding sequences of GHRH or the functional biological equivalents thereof is directly into the cells of the subject by the process of in vivo electroporation.
摘要翻译：本发明涉及用于质粒介导的补充的组合物和方法。组合物和方法可用于治疗或预防肾衰竭，治疗贫血以及通常与肾功能衰竭相关的其它病症，以增加患有慢性肾功能衰竭的受试者的生存率和改善福利。总的来说，本发明的实施方案可以通过将编码GHRH或其功能生物等同物的分离的核酸表达构建体递送到受试者的组织中并允许编码的基因在动物中表达来实现。例如，当将这样的核酸序列递送到受试者的特定细胞时，实现组织特异性组成型表达。本发明的实施方案还包括递送重组GHRH多肽或其功能生物学等同物。递送GHRH的组成型或诱导型核酸编码序列或其功能生物学等同物的优选方法通过体内电穿孔的方法直接进入受试者的细胞。

5. 发明申请

WO2004067719A3 GROWTH HORMONE RELEASING HORMONE (GHRH) FOR USE IN REDUCING CULLING IN HERD ANIMALS 审中-公开
公开(公告)号：WO2004067719A3
公开(公告)日：2004-08-12
申请号：PCT/US2004/002134
申请日：2004-01-26
申请人： ADViSYS, INC. , BROWN, Patricia, A. , DRAGHIA-AKLI, Ruxandra , CARPENTER, Robert, H.
发明人： BROWN, Patricia, A. , DRAGHIA-AKLI, Ruxandra , CARPENTER, Robert, H.
IPC分类号： A61K48/00
摘要： One aspect of the current invention is a method of decreasing an involuntary cull rate in farm animals, wherein the involuntary cull results from infection, disease, morbidity, or mortality. Additionally, milk production, animal welfare, and body condition scores are improved by utilizing methodology that administers the isolated nucleic acid expression construct encoding a GHRH or functional biological equivalent to an animal through a parenteral route of administration. Following a single dose of nucleic acid expression vector, animals are healthier and effects are demonstrated long term without additional administration(s) of the expression construct.

6. 发明申请

WO2011054011A2 FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM 审中-公开
标题翻译：口蹄疫病毒（FMDV）共识蛋白，其编码序列及由此产生的疫苗
公开(公告)号：WO2011054011A2
公开(公告)日：2011-05-05
申请号：PCT/US2010055187
申请日：2010-11-02
申请人： UNIV PENNSYLVANIA , INOVIO PHARMACEUTICALS INC , WEINER DAVID B , FERRARO BERNADETTE , YAN JIAN , BROWN PATRICIA A , BOWLING RODNEY A , KERN DOUGLAS R , RAMANATHAN MATHURA P , SARDESAI NIRANJAN Y
发明人： WEINER DAVID B , FERRARO BERNADETTE , YAN JIAN , BROWN PATRICIA A , BOWLING RODNEY A , KERN DOUGLAS R , RAMANATHAN MATHURA P , SARDESAI NIRANJAN Y
IPC分类号： C12Q1/70 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and- mouth disease FMDV VP 1-4 coat proteins of FMDV substypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译：本文提供了包含FMDV亚型A，Asia 1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP 1-4外壳蛋白的共有氨基酸序列的核酸以及表达质粒和疫苗序列。本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法，以及用疫苗和用FMDV感染的接种哺乳动物之间解密的方法。

7. 发明申请

WO2008048632A8 ELECTROPORATION DEVICES AND METHODS OF USING SAME FOR ELECTROPORATION OF CELLS IN MAMMALS 审中-公开
标题翻译：电动装置及其使用方法用于哺乳动物细胞的电穿孔
公开(公告)号：WO2008048632A8
公开(公告)日：2008-10-02
申请号：PCT/US2007022139
申请日：2007-10-17
申请人： VGX PHARMACEUTICALS INC , DRAGHIA-AKLI RUXANDRA , KHAN AMIR S , POPE MELISSA A , BROWN PATRICIA A
发明人： DRAGHIA-AKLI RUXANDRA , KHAN AMIR S , POPE MELISSA A , BROWN PATRICIA A
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0476
摘要： Aspects of the present invention relate to electroporation devices and methods of using same to effectively facilitate the introduction of a biomolecule into cells of a selected tissue in a body, in particular skin such as intradermic or subcutaneous tissue. In some aspects, the present invention is a skin EP device, which produces a pulse of energy and delivers same to the skin tissue using a skin electrode array and maintains a constant current in the same skin tissue based on user input, including a preset current, and allows the storage and acquisition of current waveform data.
摘要翻译：本发明的各方面涉及电穿孔装置和使用其的有效促进将生物分子引入体内选定组织的细胞中的方法，特别是皮肤如皮内或皮下组织。在一些方面，本发明是皮肤EP装置，其产生能量脉冲并使用皮肤电极阵列将皮肤组织递送到皮肤组织并且基于包括预设电流的用户输入在同一皮肤组织中维持恒定电流，并允许存储和采集当前的波形数据。

8. 发明申请

WO2008048632A1 ELECTROPORATION DEVICES AND METHODS OF USING SAME FOR ELECTROPORATION OF CELLS IN MAMMALS 审中-公开
标题翻译：电动装置和使用它们的方法用于电动鸡蛋中的细胞
公开(公告)号：WO2008048632A1
公开(公告)日：2008-04-24
申请号：PCT/US2007/022139
申请日：2007-10-17
申请人： VGX PHARMACEUTICALS, INC. , BROWN, Patricia, A. , DRAGHIA-AKLI, Ruxandra , KHAN, Amir, S. , POPE, Melissa, A.
发明人： BROWN, Patricia, A. , DRAGHIA-AKLI, Ruxandra , KHAN, Amir, S. , POPE, Melissa, A.
IPC分类号： A61N1/32
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0476
摘要： Aspects of the present invention relate to electroporation devices and methods of using same to effectively facilitate the introduction of a biomolecule into cells of a selected tissue in a body, in particular skin such as intradermic or subcutaneous tissue. In some aspects, the present invention is a skin EP device, which produces a pulse of energy and delivers same to the skin tissue using a skin electrode array and maintains a constant current in the same skin tissue based on user input, including a preset current, and allows the storage and acquisition of current waveform data.
摘要翻译：本发明的方面涉及电穿孔装置及其使用方法，以有效促进将生物分子引入体内特别是皮肤例如皮内或皮下组织的选定组织的细胞中。在一些方面，本发明是皮肤EP装置，其产生能量脉冲并且使用皮肤电极阵列将其递送到皮肤组织，并且基于包括预设电流的用户输入在同一皮肤组织中保持恒定电流，并允许存储和获取当前波形数据。

9. 发明申请

WO2005065722A3 REDUCING ARTHRITIS AND LAMENESS IN SUBJECTS BY GROWTH HORMONE RELEASING HORMONE (GHRH) SUPPLEMENTATION 审中-公开
标题翻译：生长激素释放激素（GHRH）补充剂减轻对象的关节炎和斑块
公开(公告)号：WO2005065722A3
公开(公告)日：2005-09-09
申请号：PCT/US2004042497
申请日：2004-12-17
申请人： ADVISYS INC , DRAGHIA-AKLI RUXANDRA , BROWN PATRICIA A , HOOD DAVID
发明人： DRAGHIA-AKLI RUXANDRA , BROWN PATRICIA A , HOOD DAVID
IPC分类号： A61K31/713 , A61K38/00 , A61K38/16 , A61K38/25 , A61K48/00 , C07K14/60 , A61K31/70 , C12N15/12
CPC分类号： A61K48/005 , A61K31/713 , A61K38/25 , C07K14/60
摘要： One aspect of the current invention is a method of preventing and / or treating arthritis and / or preventing or treating lamenes in a subjetc. Additionally, subject quality of like and welfare, and body conditions scores are improved by utilizing methodology that administers the nucleic acid expression construct encoding a GHRH or functional biological equivalent to a subject throught a parental route of administration. Following a single dose of nucleic acid expression vector, subjects are healthier and effects demonstrated long term without additional administration(s) of the expression construct.
摘要翻译：本发明的一个方面是预防和/或治疗关节炎和/或预防或治疗患者中的跛子的方法。另外，通过利用通过亲本给药途径给予受试者的编码GHRH或功能生物学等价物的核酸表达构建体的方法，改善了类似和福利的患者质量以及身体状况评分。在单剂量的核酸表达载体之后，受试者健康并且长期表现出效果，而不需要额外施用表达构建体。

10. 发明申请

WO2004093920A2 PLASMID MEDIATED GHRH SUPPLEMENTATION FOR RENAL FAILURES 审中-公开
标题翻译：慢性损伤补体治疗
公开(公告)号：WO2004093920A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012159
申请日：2004-04-20
申请人： ADVISYS, INC. , DRAGHIA-AKLI, Ruxandra , SCOTT, Clara , BROWN, Patricia, A.
发明人： DRAGHIA-AKLI, Ruxandra , SCOTT, Clara , BROWN, Patricia, A.
IPC分类号： A61K48/00
CPC分类号： A61K48/005
摘要： The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and methods are useful for treatment or prevention of kidney failure, treatment of anemia, and other conditions commonly associated with kidney failure in order to increase survival and improve welfare in subjects with chronic renal failure. Overall, the embodiments of the invention can be accomplished by delivering an isolated nucleic acid expression construct that encodes a GHRH or functional biological equivalent thereof into a tissue of a subject and allowing expression of the encoded gene in the animal. For example, when such a nucleic acid sequence is delivered into the specific cells of the subject, tissue specific constitutive expression is achieved. The embodiments of the invention also encompass delivery of a recombinant GHRH polypeptide or functional biological equivalent thereof. The preferred method for delivering the constitutive or inducible nucleic acid encoding sequences of GHRH or the functional biological equivalents thereof is directly into the cells of the subject by the process of in vivo electroporation.
摘要翻译：本发明涉及用于质粒介导的补充的组合物和方法。组合物和方法可用于治疗或预防肾衰竭，治疗贫血以及通常与肾功能衰竭相关的其它病症，以增加患有慢性肾功能衰竭的受试者的生存率和改善福利。总的来说，本发明的实施方案可以通过将编码GHRH或其功能生物等价物的分离的核酸表达构建体递送到受试者的组织中并允许编码的基因在动物中表达来实现。例如，当将这样的核酸序列递送到受试者的特定细胞时，实现组织特异性组成型表达。本发明的实施方案还包括递送重组GHRH多肽或其功能生物学等同物。递送GHRH的组成型或诱导型核酸编码序列或其功能生物学等同物的优选方法通过体内电穿孔的方法直接进入受试者的细胞。

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