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1. 发明申请

WO2004087734A2 STQ-PEPTIDES 审中-公开
标题翻译： STQ肽
公开(公告)号：WO2004087734A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009332
申请日：2004-03-26
申请人： NEW YORK UNIVERSITY , BROOKS, Peter, C. , AKALU, Abebe
发明人： BROOKS, Peter, C. , AKALU, Abebe
IPC分类号： C07K
CPC分类号： C07K7/08
摘要： The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured laminin with substantially greater affinity than to the native form of laminin. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo.
摘要翻译：本发明描述了通过施用与蛋白水解或变性层粘连蛋白特异性结合的拮抗剂，以比天然形式的层粘连蛋白具有更大的亲和力来抑制组织中血管生成的方法。还描述了利用这种拮抗剂治疗肿瘤生长，肿瘤转移或再狭窄的方法，以及在体内和体外在正常或患病组织中使用这些拮抗剂作为血管生成诊断标志物的方法。

2. 发明申请

WO2004087057A2 METHODS FOR INHIBITION OF ANGIOGENESIS 审中-公开
标题翻译：抑制血管生成的方法
公开(公告)号：WO2004087057A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009321
申请日：2004-03-26
申请人： THE SCRIPPS RESEARCH INSTITUTE , BROOKS, Peter C. , CHERESH, David A.
发明人： BROOKS, Peter C. , CHERESH, David A.
IPC分类号： A61K
CPC分类号： A61K31/5415 , A61K31/00 , A61K31/198 , A61K31/352 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/433 , A61K31/4439 , A61K31/47 , A61K31/498 , A61K31/538 , A61K38/04 , A61K38/16 , A61K38/4886 , C07C279/14 , C07C311/06 , C07C311/10 , C07C2602/42 , C07D263/38 , C07K14/75 , C07K16/2839 , C07K16/2848 , C12N9/6491
摘要： ABSTRACT The present invention describes methods for inhibition angiogenesis in tissues using organic peptidomimetic v 3 antagonists, and particularly for inhibiting angiogenesis in inflamed tissues and in tumor tissues and metastases using therapeutic compositions containing v 3 antagonists. The antagonists are organic compounds having a basic group and an acidic group spaced from one another by a distance in the range of about 10 Angstroms to about 100 Angstroms, as described in detail herein.
摘要翻译：摘要本发明描述了使用有机肽模拟物v 3拮抗剂抑制组织中血管生成的方法，特别是使用含有v 3拮抗剂的治疗组合物抑制发炎组织和肿瘤组织和转移中的血管生成。拮抗剂是具有碱性基团和酸性基团的有机化合物，其间距离在约10埃至约100埃的范围内，如本文详细描述的。

3. 发明申请

WO2004058241A1 INHIBITION OF MELANOGENESIS AND MELANOMA METASTASIS WITH P-AMINOBENZOIC ACID (PABA) 审中-公开
标题翻译：含有氨基苯甲酸（PABA）的成纤维细胞和MELANOMA METASTASIS的抑制
公开(公告)号：WO2004058241A1
公开(公告)日：2004-07-15
申请号：PCT/US2003/041179
申请日：2003-12-24
申请人： NEW YORK UNIVERSITY , BROOKS, Peter, C. , MORAIS, Danielle , RODRIGUEZ, Dorothy
发明人： BROOKS, Peter, C. , MORAIS, Danielle , RODRIGUEZ, Dorothy
IPC分类号： A61K31/195
CPC分类号： A61K31/195
摘要： The present invention relates to the inhibition of melanogenesis with paraaminobenzoic acid (PABA) and its use in treating melanotic cancer.
摘要翻译：本发明涉及用对氨基苯甲酸（PABA）抑制黑素生成及其在治疗黑素瘤中的用途。

4. 发明申请

WO2011049810A2 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND FIBROSIS 审中-公开
标题翻译：用于治疗炎症和纤维化的组合物和方法
公开(公告)号：WO2011049810A2
公开(公告)日：2011-04-28
申请号：PCT/US2010/052642
申请日：2010-10-14
申请人： MAINE MEDICAL CENTER , BROOKS, Peter, C. , OXBURG, Leif , ROTH, Jennifer, M.
发明人： BROOKS, Peter, C. , OXBURG, Leif , ROTH, Jennifer, M.
IPC分类号： A61K39/395 , A61P35/00 , A61P29/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K7/06 , C07K2317/24 , C07K2317/76
摘要： The present invention features compositions featuring agents that bind to denatured collagen and methods of using such agents to treat or prevent fibrosis or inflammation in a subject.
摘要翻译：本发明的特征在于特征在于与变性胶原结合的试剂的组合物和使用这些试剂治疗或预防受试者的纤维化或炎症的方法。

5. 发明申请

WO2011031921A1 TREATMENT OF CANCER USING THE SODIUM SALT OF A BENZOIC ACID DERIVATIVE 审中-公开
标题翻译：使用苯甲酸衍生物的钠盐治疗癌症
公开(公告)号：WO2011031921A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048356
申请日：2010-09-10
申请人： NEW YORK UNIVERSITY , BROOKS, Peter C. , CANARY, James , LIEBES, Leonard
发明人： BROOKS, Peter C. , CANARY, James , LIEBES, Leonard
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195
CPC分类号： A61K31/195
摘要： The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.
摘要翻译：本发明提供了使用苯甲酸衍生物的钠盐单独或与标准治疗如化学疗法和放射疗法联合治疗癌症的方法。

6. 发明申请

WO2007024921A2 COMBINATION THERAPIES FOR INHIBITING INTEGRIN-EXTRACELLULAR MATRIX INTERACTIONS 审中-公开
标题翻译：抑制整合细胞基质相互作用的组合治疗
公开(公告)号：WO2007024921A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032875
申请日：2006-08-22
申请人： CELL MATRIX , VAN, Epps, Dennis , FREIMARK, Bruce , BROOKS, Peter, C.
发明人： VAN, Epps, Dennis , FREIMARK, Bruce , BROOKS, Peter, C.
IPC分类号： A61K39/395 , A61K38/10 , A61P35/00
CPC分类号： A61K38/39 , A61K38/10 , A61K39/395 , A61K2039/505 , C07K16/18 , C07K16/2848 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application relates to compositions of ECM antagonists and their use in methods for treating angiogenic-dependent conditions. The ECM antagonists can bind the same or different ECM component. The present application also relates to compositions of ECM antagonists and cancer therapies and their use in methods for preventing, treating or managing angiogenic dependent conditions such as cancer.
摘要翻译：本申请涉及ECM拮抗剂的组合物及其在治疗血管生成依赖性病症的方法中的用途。 ECM拮抗剂可以结合相同或不同的ECM组分。本申请还涉及ECM拮抗剂和癌症疗法的组合物及其在预防，治疗或控制血管生成依赖性病症如癌症的方法中的用途。

7. 发明申请

WO2005070043A2 METHODS FOR TREATING NON-MELANOMA CANCERS WITH PABA 审中-公开
标题翻译：用PABA治疗非梅毒癌的方法
公开(公告)号：WO2005070043A2
公开(公告)日：2005-08-04
申请号：PCT/US2005003088
申请日：2005-01-21
申请人： UNIV NEW YORK , BROOKS PETER C , LIEBES LEONARD , KRAMER ELISSA , NG BRUCE
发明人： BROOKS PETER C , LIEBES LEONARD , KRAMER ELISSA , NG BRUCE
IPC分类号： A61K31/195 , A61K31/337 , A61K31/4745 , A61K31/7072 , A61K33/24 , A61K51/00 , A61N5/00
CPC分类号： A61K45/06 , A61K31/136 , A61K41/00 , A61K2300/00
摘要： The present invention relates to a method for treating non-melanotic cancers by administration of PABA. The present invention also relates to the potentiation of standard cancer treatment of radiation, radioimmunotherapy, and/or chemotherapy using PABA.
摘要翻译：本发明涉及通过施用PABA治疗非黑素瘤的方法。本发明还涉及使用PABA对辐射，放射免疫治疗和/或化学疗法的标准癌症治疗的增强。

8. 发明申请

WO2004087734A3 STQ-PEPTIDES 审中-公开
标题翻译： STQ肽
公开(公告)号：WO2004087734A3
公开(公告)日：2005-07-28
申请号：PCT/US2004009332
申请日：2004-03-26
申请人： UNIV NEW YORK , BROOKS PETER C , AKALU ABEBE
发明人： BROOKS PETER C , AKALU ABEBE
IPC分类号： A61K38/10 , A61P9/10 , A61P35/00 , A61P35/04 , C07K20060101 , C07K7/08 , C07K38/112
CPC分类号： C07K7/08
摘要： The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured laminin with substantially greater affinity than to the native form of laminin. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo.
摘要翻译：本发明描述了通过施用与蛋白水解或变性层粘连蛋白特异性结合的拮抗剂，以比天然形式的层粘连蛋白具有更大的亲和力来抑制组织中血管生成的方法。还描述了利用这种拮抗剂治疗肿瘤生长，肿瘤转移或再狭窄的方法，以及在体内和体外在正常或患病组织中使用这些拮抗剂作为血管生成诊断标志物的方法。

9. 发明申请

WO2007024921A3 COMBINATION THERAPIES FOR INHIBITING INTEGRIN-EXTRACELLULAR MATRIX INTERACTIONS 审中-公开
标题翻译：抑制整合细胞基质相互作用的组合治疗
公开(公告)号：WO2007024921A3
公开(公告)日：2007-06-14
申请号：PCT/US2006032875
申请日：2006-08-22
申请人： CELL MATRIX , VAN EPPS DENNIS , FREIMARK BRUCE , BROOKS PETER C
发明人： VAN EPPS DENNIS , FREIMARK BRUCE , BROOKS PETER C
IPC分类号： A61K39/395 , A61K38/10 , A61P35/00
CPC分类号： A61K38/39 , A61K38/10 , A61K39/395 , A61K2039/505 , C07K16/18 , C07K16/2848 , C07K2317/73 , C07K2317/76 , A61K2300/00
摘要： The present application relates to compositions of extracellular matrix (ECM) antagonists and their use in methods for treating angiogenic-dependent conditions. The ECM antagonists can bind the same or different ECM component. The present application also relates to compositions of ECM antagonists and cancer therapies and their use in methods for preventing, treating or managing angiogenic- dependent conditions such as cancer.
摘要翻译：本申请涉及细胞外基质（ECM）拮抗剂的组合物及其在治疗血管生成依赖性病症的方法中的用途。 ECM拮抗剂可以结合相同或不同的ECM组分。本申请还涉及ECM拮抗剂和癌症疗法的组合物及其在预防，治疗或控制血管生成依赖性病症如癌症的方法中的用途。

10. 发明申请

WO2006098987A2 METHODS OF INHIBITING ANGIOGENESIS AND TUMOR DEVELOPMENT 审中-公开
标题翻译：抑制血管生成和肿瘤发生的方法
公开(公告)号：WO2006098987A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/008266
申请日：2006-03-09
申请人： NEW YORK UNIVERSITY , BROOKS, Peter, C. , AKALU, Abebe , CRETU, Alexandra , POLICARPIO, Desiree
发明人： BROOKS, Peter, C. , AKALU, Abebe , CRETU, Alexandra , POLICARPIO, Desiree
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/567 , C07K16/44
CPC分类号： G01N33/574 , C07K16/18 , C07K2317/76 , G01N2333/515 , G01N2500/00
摘要： The invention provides methods for identifying genes and proteins modulated by an antagonist. The antagonist can be to a cryptic epitope of an ECM component that specifically binds to the ECM component or an antagonist of αvβ3 that inhibits binding of αvβ3 to an ECM component. It additionally provides methods for using the products of the identified genes, or for using the identified proteins, for inhibiting angiogenesis, tumor metastasis, and other tumor developmental processes, including cell migration, cell adhesion, cell proliferation, and tumor growth and for treating angiogenesis-dependent conditions. The present invention relates to antagonists of cryptic epitopes of ECM components, wherein binding of these antagonists to cryptic epitopes of ECM components results in modulation of the expression of IGFBP-4, TSP-I, Id-I, p27 KIP or p21 CIP . The present invention relates to antagonists of αvβ3, wherein binding of these antagonists to αvβ3 results in modulation of the expression of IGFBP- 4 or TSP-I. The present invention also relates to methods of using these antagonists for inhibiting angiogenesis, tumor metastasis, and other tumor development processes as well as for treating angiogenesis-dependent conditions. The invention provides compositions comprising IGFBP-4 and methods for inhibiting angiogenesis and tumor development processes, and for treating angiogenesis-dependent conditions, using an insulin growth factor binding protein, IGFBP-4.
摘要翻译：本发明提供鉴定拮抗剂调节的基因和蛋白质的方法。拮抗剂可以是特异性结合ECM组分的ECM组分的隐性表位或抑制avß3与ECM组分结合的avβ3拮抗剂。另外提供使用所鉴定的基因的产物或使用鉴定的蛋白质来抑制血管发生，肿瘤转移和其它肿瘤发展过程的方法，包括细胞迁移，细胞粘附，细胞增殖和肿瘤生长以及用于治疗血管生成依赖条件。本发明涉及ECM组分的隐蔽表位的拮抗剂，其中这些拮抗剂与ECM组分的神经表位的结合导致IGFBP-4，TSP-1，Id-1，p27KIP的表达的调节， SUP>或p21 CIP 。本发明涉及avß3的拮抗剂，其中这些拮抗剂与avß3的结合导致IGFBP-4或TSP-1的表达的调节。本发明还涉及使用这些拮抗剂抑制血管发生，肿瘤转移和其它肿瘤发展过程以及治疗血管生成依赖性病症的方法。本发明提供了包含IGFBP-4的组合物和用于抑制血管生成和肿瘤发展过程的方法，以及使用胰岛素生长因子结合蛋白IGFBP-4治疗血管生成依赖性病症的组合物。

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