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1. 发明申请

WO2010023458A1 METHOD OF DIAGNOSING OR PROGNOSING EPITHELIAL OVARIAN CANCER 审中-公开
标题翻译：诊断或预防上皮癌的方法
公开(公告)号：WO2010023458A1
公开(公告)日：2010-03-04
申请号：PCT/GB2009/002098
申请日：2009-09-01
申请人： IMMUNOVIA AB , BORREBAECK, Carl, Arne, Krister , EK, Sara, Charlotte, Andersson , BRENNAN, Donal, John
发明人： BORREBAECK, Carl, Arne, Krister , EK, Sara, Charlotte, Andersson , BRENNAN, Donal, John
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2500/00 , G01N2800/56
摘要： The present invention provides a binding moiety which selectively binds to Sox11 protein and/or mRNA for imaging, diagnosis or prognosis of epithelial ovarian cancer (EOC). Optionally, the moiety is an antibody or antigen-binding fragment thereof. Advantageously, moiety comprises a further, readily detectable moiety. The invention also provides methods of imaging EOC cells as well as methods of diagnosing or prognosing EOC in an individual. A further aspect of the present invention provides a method of identifying cells associated with EOC, the method comprising analysing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known lymphomas cells. Preferably, the cells to be tested are identified as EOC cells if the expression of Sox11 is up-regulated compared to normal B-cells. Preferably EOC cells are identified as improved recurrence-free survival-associated if expression of Sox11 is up-regulated compared with non-cancerous epithelial ovarian cells. Preferably, EOC cells are identified as diminished recurrence-free survival-associated if expression of Sox11 is similar to, or down-regulated, compared with non-cancerous epithelial ovarian cells.
摘要翻译：本发明提供了选择性结合Sox11蛋白和/或mRNA用于成像，诊断或预后的上皮性卵巢癌（EOC）的结合部分。任选地，该部分是抗体或其抗原结合片段。有利地，部分包含另外易于检测的部分。本发明还提供对EOC细胞进行成像的方法以及在个体中诊断或预测EOC的方法。本发明的另一方面提供了鉴定与EOC相关的细胞的方法，所述方法包括分析待测试细胞样品中基因表达的模式，并将其与已知淋巴瘤细胞样品中基因表达的模式进行比较。如果与正常B细胞相比，如果Sox11的表达被上调，则待测试的细胞被鉴定为EOC细胞。如果与非癌性上皮性卵巢细胞相比，如果Sox11的表达上调，则优选EOC细胞被鉴定为改善的无复发存活相关性。优选地，与非癌性上皮性卵巢细胞相比，如果Sox11的表达与非癌性上皮性卵巢细胞相似或下调，则EOC细胞被鉴定为减少的无复发存活相关。

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