专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005086808A3 NOVEL DICATIONIC IMIDAZO[1,2-a]PYRIDINES AND 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2a]PYRIDINES AS ANTIPROTOZOAL AGENTS 审中-公开
标题翻译：新颖的咪唑并[1,2-a]吡啶和5,6,7,8-四氢-1H-咪唑并[1,2a]吡啶作为抗真菌剂
公开(公告)号：WO2005086808A3
公开(公告)日：2006-02-23
申请号：PCT/US2005007566
申请日：2005-03-08
申请人： UNIV NORTH CAROLINA , UNIV GEORGIA STATE RES FOUND , BOYKIN DAVID W , TIDWELL RICHARD R , WILSON W DAVID , ISMAIL MOHAMED A
发明人： BOYKIN DAVID W , TIDWELL RICHARD R , WILSON W DAVID , ISMAIL MOHAMED A
IPC分类号： A61K31/4745 , C07D471/02 , C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： A method for treating a microbial infection, including an infection from a protozoan pathogen, such as Trypanosoma brucei rhodesiense and Plasmodium falciparum, in a subject in need thereof by administering to the subject an effective amount of a dicationic imidazopyridine compound or a dicationic tetrahydro-imidazopyridine compound. Processes for synthesizing dicationic imidazopyridines and dicationic tetrahydro-imidazopyridines and the novel dicationic imidazopyridine and dicationic tetrahydro-imidazopyridine compounds themselves.
摘要翻译：一种用于治疗微生物感染的方法，包括通过向受试者施用有效量的双阳离子咪唑并吡啶化合物或双阳离子四氢 - 咪唑并吡啶化合物，在有需要的受试者中治疗来自原生动物病原体（例如，罗氏黑曲霉和恶性疟原虫）的感染复合。双阳离子咪唑并吡啶和双阳离子四氢 - 咪唑并吡啶的合成方法以及新型的双阳离子咪唑并吡啶和双阳离子四氢 - 咪唑并吡啶化合物本身。

2. 发明申请

WO2005051296A3 FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS 审中-公开
公开(公告)号：WO2005051296A3
公开(公告)日：2005-06-09
申请号：PCT/US2004/038896
申请日：2004-11-18
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , BOYKIN, David, W. , TIDWELL, Richard, R. , WILSON, David, W. , BRUN, Reto , ARAFA, Reem, K. , STEPHENS, Chad, E.
发明人： BOYKIN, David, W. , TIDWELL, Richard, R. , WILSON, David, W. , BRUN, Reto , ARAFA, Reem, K. , STEPHENS, Chad, E.
IPC分类号： C07C279/18
摘要： Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum . Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.

3. 发明申请

WO2005033065A1 NOVEL AMIDINE COMPOUNDS FOR TREATING MICROBIAL INFECTIONS 审中-公开
标题翻译：用于治疗微生物感染的新型氨基化合物
公开(公告)号：WO2005033065A1
公开(公告)日：2005-04-14
申请号：PCT/US2003/027963
申请日：2003-09-05
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , TIDWELL, Richard, R. , BOYKIN, David , BRUN, Reto , STEPHENS, Chad, E. , KUMAR, Arvind
发明人： TIDWELL, Richard, R. , BOYKIN, David , BRUN, Reto , STEPHENS, Chad, E. , KUMAR, Arvind
IPC分类号： C07C257/00
CPC分类号： C07C257/18 , C07C259/18 , C07D235/20 , C07D307/52 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D409/14
摘要： Novel amidine and diamidine compounds are useful in the treatment of microbial infections, including mycobacterial, fungal and protozoal infections. Pharmaceutical formulations comprising these compounds can be used in methods of treating microbial infections.
摘要翻译：新型脒和脒化合物可用于治疗微生物感染，包括分枝杆菌，真菌和原生动物感染。包含这些化合物的药物制剂可用于治疗微生物感染的方法。

4. 发明申请

WO0236588A3 REVERSED AMIDINES AND METHODS OF USING FOR TREATING, PREVENTING, OR INHIBITING LEISHMANIASIS 审中-公开
标题翻译：反转的药物及其用于治疗，预防或抑制感染的方法
公开(公告)号：WO0236588A3
公开(公告)日：2003-08-28
申请号：PCT/US0142905
申请日：2001-11-05
申请人： US ARMY MED RES MAT COMMAND , WERBOVETZ KARL A , BRENDLE JAMES J , BOYKIN DAVID W , STEPHENS CHAD E
发明人： WERBOVETZ KARL A , BRENDLE JAMES J , BOYKIN DAVID W , STEPHENS CHAD E
IPC分类号： A61K31/341 , A61K31/381 , A61K31/4184 , A61K31/444 , A61K31/4709 , C07D307/52 , C07D333/20 , C07D405/04 , C07D405/12 , C07D405/14 , C07D405/00
CPC分类号： C07D405/04 , A61K31/341 , A61K31/381 , A61K31/4184 , A61K31/444 , A61K31/4709 , C07D307/52 , C07D333/20 , C07D405/12 , C07D405/14
摘要： Methods for treating, preventing or inhibiting leishmaniasis in a subject comprising administering to the subject a therapeutically effective amount of at least one compound having the structural formula (I) wherein Y is a heteroatom; R and R are independently H or an alkyl, cycloalkyl, heterocycloalkyl, aryl, amino or heteroaryl group; and X , X , and X3 are independently H or an alkyl, alkoxy, halo, amino, alkylamino, dialkylamino acylamino, alkylthio, sulfonyl, cyano, carboxy alkoxycarbonyl, or carbamoyl group are disclosed.
摘要翻译：用于治疗，预防或抑制受试者利什曼病的方法，包括向受试者施用治疗有效量的至少一种具有结构式（I）的化合物，其中Y为杂原子; R 1和R 2独立地为H或烷基，环烷基，杂环烷基，芳基，氨基或杂芳基; X 1，X 2和X 3独立地为H或烷基，烷氧基，卤素，氨基，烷基氨基，二烷基氨基酰氨基，烷硫基，磺酰基，氰基，羧基烷氧基羰基或氨基甲酰基。

5. 发明申请

WO0103685A3 NOVEL PRODRUGS FOR ANTIMICROBIAL AMIDINES 审中-公开
标题翻译：新型抗菌药物
公开(公告)号：WO0103685A3
公开(公告)日：2002-07-11
申请号：PCT/US0018499
申请日：2000-07-06
申请人： UNIV NORTH CAROLINA , BOYKIN DAVID W , RAHMATHULLAH M SYED , TIDWELL RICHARD R , HALL JAMES E
发明人： BOYKIN DAVID W , RAHMATHULLAH M SYED , TIDWELL RICHARD R , HALL JAMES E
IPC分类号： C07D307/52 , A61K31/341 , A61K31/357 , A61K47/48 , A61P31/00 , A61P31/04 , A61P31/06 , C07D307/54 , C07D407/12 , C07D407/14 , A61K31/40 , A61K31/34 , A61K31/38 , C07D207/32 , C07D333/24
CPC分类号： C07D407/14 , A61K31/341 , A61K47/54 , A61K47/555 , C07D307/54
摘要： A methods of treating an infection comprises administering a therapeutically effective amount of a compound described by Formula (I), wherein: X may be O, S, or NR' wherein R' is H or loweralkyl; R1 and R2 may be independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl; R3 and R4 are each independently selected from the group consisting of H, loweralkyl, halogen, oxyalkyl, oxyaryl, and oxyarylalkyl; R5 is represented by a formula selected from the group consisting of: (a) and (b), wherein: X1, X2, and X3 are independently selected from O and S; and R6 and R7 are independently selected from the group consisting of loweralkyl, aryl, alkylaryl, oxyaryl, an ester-containing substituent, and oxyalkyl; or a pharmaceutically acceptable salt thereof.
摘要翻译：治疗感染的方法包括施用治疗有效量的式（I）所述的化合物，其中：X可以是O，S或NR'，其中R'是H或低级烷基; R 1和R 2可以独立地选自H，低级烷基，烷氧基烷基，烷氧基烷基，环烷基，芳基，羟基烷基，氨基烷基和烷基氨基烷基; R 3和R 4各自独立地选自H，低级烷基，卤素，氧烷基，氧芳基和氧芳基烷基; R5由选自（a）和（b）的化合物表示，其中：X 1，X 2和X 3独立地选自O和S; R 6和R 7独立地选自低级烷基，芳基，烷芳基，氧芳基，含酯取代基和烷氧基烷基; 或其药学上可接受的盐。

6. 发明申请

WO1996040145A1 METHODS OF COMBATTING INFECTIOUS DISEASES USING DICATIONIC BIS-BENZIMIDAZOLES 审中-公开
标题翻译：使用双向双嘧达莫混合感染性疾病的方法
公开(公告)号：WO1996040145A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008084
申请日：1996-06-03
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , DUKE UNIVERSITY , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , DYKSTRA, Christine, C. , PERFECT, John, R. , BOYKIN, David, W. , WILSON, W., David , TIDWELL, Richard, R.
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , DUKE UNIVERSITY , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
IPC分类号： A61K31/55
CPC分类号： A61K31/427 , A61K31/4184 , A61K31/422 , A61K31/4439 , A61K31/497 , A61K31/506
摘要： The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprise administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
摘要翻译：本发明提供了在需要这种治疗的受试者中治疗新型隐球菌和白色念珠菌的方法。所述方法包括向患者施用有效治疗病症的量的双阳离子双苯并咪唑。

7. 发明申请

WO2018045104A1 ANTI-PARASITIC COMPOUNDS 审中-公开
标题翻译：抗寄生虫化合物
公开(公告)号：WO2018045104A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049491
申请日：2017-08-30
申请人： OHIO STATE INNOVATION FOUNDATION , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION , WERBOVETZ, Karl A. , BOYKIN, David W. , FARAHAT, Abdelbasset , ABDULHAMEED, Ahmed , CHEN, Ching-Shih
发明人： WERBOVETZ, Karl A. , BOYKIN, David W. , FARAHAT, Abdelbasset , ABDULHAMEED, Ahmed , CHEN, Ching-Shih
IPC分类号： A61K31/4545 , A61K31/4725 , A61K31/498
CPC分类号： A61K31/4545 , A61K31/4725 , A61K31/498 , C07D401/12 , C07D405/14 , Y02A50/409
摘要： Provided are compounds, methods, and pharmaceutical compositions useful for treatment of parasites, e.g., Leishmania . For example, the compound may he represented by Ar—C(=NR 1 )NR 2 —A—X—Y—Het 2 , and pharmaceutically acceptable salts thereof. Ar may be an optionally substituted, aryl or nitrogen-containing heteroaryl. R 1 and R 2 may independently represent H, optionally substituted C 1 -C 6 alkyl, or optionally substituted C 3 -C 6 cycloalkyl. A may be a bond or an optionally substituted linking moiety comprising 1, 2, or 3 rings. Each ring in the optionally substituted linking moiety may independently be one of: aryl, cycloalkyl, heterocycloalkyl, and heteroaryl. X may be O, S, amide, or a bond. Y may be optionally substituted C 1 -C 14 alkyl or optionally substituted C 2 -C 14 alkenyl. Het 2 may be an optionally substituted five-membered nitrogen-containing heteroaromatic ring comprising 1, 2, or 3 ring heteroatoms.
摘要翻译：提供可用于治疗寄生虫例如利什曼原虫的化合物，方法和药物组合物。例如，该化合物可以由Ar-C（= NR 1）NR 2 2 -A-X-Y-Het 2 2表示，及其药学上可接受的盐。 Ar可以是任选取代的芳基或含氮杂芳基。 R 1和R 2可以独立地表示H，任选取代的C 1 -C 6烷基或任选取代的 C 3 -C 6 - 环烷基。 A可以是包含1,2或3个环的键或任选取代的连接部分。任选取代的连接部分中的每个环可以独立地为以下之一：芳基，环烷基，杂环烷基和杂芳基。 X可以是O，S，酰胺或键。 Y可以是任选取代的C 1 -C 14烷基或任选取代的C 2 -C 14链烯基。 Het 2可以是任选取代的含有1,2或3个环杂原子的五元含氮杂芳环。

8. 发明申请

WO2005086754A3 DICATIONIC COMPOUNDS FOR ACTIVITY AGAINST TRICHOMONAS VAGINALIS 审中-公开
标题翻译：针对三氯乙烯VACINALIS的活性化合物
公开(公告)号：WO2005086754A3
公开(公告)日：2006-09-08
申请号：PCT/US2005007316
申请日：2005-03-07
申请人： UNIV GEORGIA STATE RES FOUND , US GOV HEALTH & HUMAN SERV , BOYKIN DAVID W , STEPHENS CHAD E , SECOR W EVAN , CROWELL ANDREA L , KUMAR ARVIND
发明人： BOYKIN DAVID W , STEPHENS CHAD E , SECOR W EVAN , CROWELL ANDREA L , KUMAR ARVIND
IPC分类号： A61K31/341
CPC分类号： A61K31/341 , A61K31/4184 , C07D235/20 , C07D413/14
摘要： Dicationic compounds for the treatment of T. vaginalis infections are described. The presently described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. Furthermore, the presently described compounds demonstrate IC 50 concentrations that were not elevated in the metronidazole resistant isolate, suggesting that their activity is not affected by parasite mechanisms that confer resistance to 5-nitroimidizoles.
摘要翻译：描述了用于治疗阴道炎感染的阳离子化合物。目前描述的化合物显示针对甲硝唑敏感和抗性阴道分泌物的体外活性。此外，目前描述的化合物表现出在甲硝唑抗性分离物中未升高的IC 50浓度，表明它们的活性不受赋予5-硝基亚氨基咪唑抗性的寄生虫机制的影响。

9. 发明申请

WO2004050018A3 DICATIONIC 2,5-DIARYLFURAN AZA-ANALOGS AS ANTI-PROTOZOAN AGENTS 审中-公开
标题翻译：作为抗真菌药物的二异丙基呋喃亚胺类似物
公开(公告)号：WO2004050018A3
公开(公告)日：2004-07-08
申请号：PCT/US0337691
申请日：2003-11-25
申请人： UNIV NORTH CAROLINA , UNIV GEORGIA STATE RES FOUND , BOYKIN DAVID W , TIDWELL RICHARD R , ISMAIL MOHAMED A , BRUN RETO
发明人： BOYKIN DAVID W , TIDWELL RICHARD R , ISMAIL MOHAMED A , BRUN RETO
IPC分类号： A61K20060101 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/443 , A61K31/4436 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , C07D405/04 , C07D409/04
CPC分类号： C07D307/38 , C07D307/54 , C07D333/08 , C07D405/04 , C07D405/14 , C07D407/04 , C07D407/14 , C07D409/04 , C07D409/14
摘要： A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR where R is hydrogen or lower alkyl; C , C , A, and Y are CH, N, NR O, or S, wherein C and C are the same or different; D , D , B, and Z are CH, N, or NR wherein D and D are the same or different; provided that B, Z, or both B and Z are not present when A, Y, or both A and Y are O, S, or NR ; R ,R , R , R , R and R are selected from the group consisting of H, lower alkyl, halogen, alkoxyl, aryloxyl, aralkoxy and hydroxyl; R and R are each independently selected from the group consisting of H, hydroxy, lower alkyl, cycloalkyl, aryl, aralkyl, alkoxyl, hydroxycycloalkyl, alkoxycycloalkyl, hydroxyalkyl, aminoalkyl, acyloxy, acetoxy, and alkylaminoalkyl; and R , R , R and R are each independently selected from the group consisting of H, lower alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, hydroxyalkyl, aminoalkyl, and alkylaminoalkyl, or R and R together or R and R together represent a C2 to C10 alkyl, hydroxyalkyl, or alkylene, or R and R together or R and R together are: wherein n is a number from 1 to 3, and R is H or-CONHR NR R , wherein R , is lower alkyl and R and R are each independently selected from the group consisting of H and lower alkyl.
摘要翻译：式（I）的化合物：其中：X选自O，S和NR 17，其中R 17是氢或低级烷基; C 1，C 2，A和Y是CH，N，NR 17，O或S，其中C 1和C 2相同或不同; D 1，D 2，B和Z是CH，N或NR 17，其中D 1和D 2是相同或不同的; 条件是当A，Y或A和Y都为O，S或NR 17时，B，Z或两者均不存在B和Z。 R 13，R 14，R 15，R 16，R 1和R 8选自H，低级烷基，卤素，烷氧基，芳氧基，芳烷氧基和羟基 ; R 3和R 6各自独立地选自H，羟基，低级烷基，环烷基，芳基，芳烷基，烷氧基，羟基环烷基，烷氧基环烷基，羟基烷基，氨基烷基，酰氧基，乙酰氧基和烷基氨基烷基。和R 2，R 4，R 5和R 7各自独立地选自H，低级烷基，烷氧基烷基，环烷基，芳基，芳烷基，羟基烷基，氨基烷基和烷基氨基烷基，或 R 2和R 4一起或R 5和R 7一起代表C 2至C 10烷基，羟烷基或亚烷基，或R 3和R 4一起或R 6和 R 7一起是：其中n是1至3的数，R 9是H或-CONHR 10 NR 11 R 12，其中R 10是低级烷基和R <11>和R 12各自独立地选自H和低级烷基。

10. 发明申请

WO1996040997A1 METHOD OF FLUORESCENT DETECTION OF NUCLEIC ACIDS AND CYTOSKELETON ELEMENTS USING BIS-DICATIONIC ARYL FURANS 审中-公开
标题翻译：使用双歧杆菌ARYL FURANS检测核酸和CYTOSKELETON元素的荧光检测方法
公开(公告)号：WO1996040997A1
公开(公告)日：1996-12-19
申请号：PCT/US1996008462
申请日：1996-06-03
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , DYKSTRA, Christine, C. , TIDWELL, Richard, R. , BOYKIN, David, W. , WILSON, W., David
发明人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
IPC分类号： C12Q01/68
CPC分类号： A61K31/505 , A61K31/506 , C07D307/54 , C07D403/10 , C07D403/14 , C07D405/14 , C09B23/0075 , G01N33/52 , Y10S435/81
摘要： Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
摘要翻译：公开了一种荧光检测核酸的方法。所述方法包括使所述核酸与双阳离子芳基呋喃接触，并将所述核酸以一定频率曝光以诱导所述化合物的荧光。还公开了细胞骨架元件的荧光检测方法，以及新型的双 - 二盐酸芳基呋喃化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式