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1. 发明申请

WO2012103445A2 CONVALENTLY CROSS LINKED HYDROGELS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：相互交叉连接的水凝胶及其制备和使用方法
公开(公告)号：WO2012103445A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/022920
申请日：2012-01-27
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , ANSETH, Kristi , FAIRBANKS, Ben , BOWMAN, Christopher
发明人： ANSETH, Kristi , FAIRBANKS, Ben , BOWMAN, Christopher
IPC分类号： C08L101/16 , C08L101/02 , C08F38/00 , C08G75/14 , C08J3/075
CPC分类号： A61L27/18 , A61L27/22 , A61L27/52 , A61L27/54 , A61L2430/02 , A61L2430/06 , A61L2430/34 , C08F38/00 , C08G75/045 , C08G75/12 , C08J3/075 , C08J2300/16 , C08J2300/20 , C08J2371/02 , C08L81/02 , C08L101/02 , C08L101/16 , C12N5/0068
摘要： A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers.
摘要翻译：公开了硫醇聚合物材料和用于生产所述聚合物的方法。该材料通过具有炔烃和巯基官能团的单体的根本介导的聚合反应而产生。炔部分（内部或末端）可以与一个或两个硫醇反应。可降解单体可用于形成可降解聚合物。

2. 发明申请

WO2012074931A2 PHOTOLINDUCED ALKYNE-AZIDE CLICK REACTIONS 审中-公开
标题翻译：光催化亚烷基酸反应
公开(公告)号：WO2012074931A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062248
申请日：2011-11-28
申请人： UNIV COLORADO REGENTS , BOWMAN CHRISTOPHER , KLOXIN CHRISTOPHER J , ADZIMA BRIAN J
发明人： BOWMAN CHRISTOPHER , KLOXIN CHRISTOPHER J , ADZIMA BRIAN J
IPC分类号： C07D249/04
CPC分类号： G03F7/0085 , C07D249/04 , G03F7/20
摘要： The present invention includes a composition comprising an alkyne- based substrate, an azide-based substrate, a Cu(II) salt and a photoinducible reducing agent, The present invention further includes a method of immobilizing a chemical structure in a given pattern onto a section of the surface of a solid substrate, using the photoinducible Cu(I)-catalyzed azide-alkyne cycloaddition Click reaction.
摘要翻译：本发明包括一种包含基于炔的基底，叠氮化物基底，Cu（II）盐和光诱导还原剂的组合物。本发明还包括将给定图案中的化学结构固定在部分的固体底物的表面，使用光诱导的Cu（I）催化的叠氮炔 - 环炔加成反应。

3. 发明申请

WO2012061702A1 DUAL-CURE POLYMER SYSTEMS 审中-公开
标题翻译：双固化聚合物体系
公开(公告)号：WO2012061702A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059320
申请日：2011-11-04
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , BOWMAN, Christopher , NAIR, Devatha , CRAMER, Neil , SHANDAS, Robin
发明人： BOWMAN, Christopher , NAIR, Devatha , CRAMER, Neil , SHANDAS, Robin
IPC分类号： C08F8/00
CPC分类号： C08L81/02 , A61L27/14 , A61L27/50 , A61L2400/16 , C08F2/00 , C08F2/48 , C08G75/23 , C08G2280/00 , C08J3/243 , C08J3/244 , C08J3/28 , C08J2333/14 , C08L75/16 , G02B1/043
摘要： The present invention includes compositions that are useful to prepare dual-cure shape memory polymer systems. The present invention further provides methods of generating a shape memory polymer, optical device, polymer pad with an imprint, or suture anchor system.
摘要翻译：本发明包括可用于制备双重固化形状记忆聚合物体系的组合物。本发明还提供了产生形状记忆聚合物，光学装置，具有印记的聚合物垫或缝线锚定系统的方法。

4. 发明申请

WO2006071640A3 PHOTOLYTIC POLYMER SURFACE MODIFICATION 审中-公开
公开(公告)号：WO2006071640A3
公开(公告)日：2006-07-06
申请号：PCT/US2005/046147
申请日：2005-12-16
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , BOWMAN, Christopher N. , REDDY, Sirish , CRAMER, Neil , SEBRA, Robert P. , LU, Hui
发明人： BOWMAN, Christopher N. , REDDY, Sirish , CRAMER, Neil , SEBRA, Robert P. , LU, Hui
IPC分类号： C08F20/02 , C08C19/20
摘要： The present invention provides a method for modifying a surface of a polymer derived from a mixture comprising a thiol monomer and an olefinic monomer. The method comprises exposing at least a portion of the polymer surface to electromagnetic radiation of sufficient energy to modify the polymer surface. The present invention also provides a polymer derived from polymerizing a mixture of monomers comprising a thiol monomer, an olefinic monomer, and an iniferter.

5. 发明申请

WO2005107626A1 DIMER ACID-DERIVED DIMETHACRYLATES AND USE IN DENTAL RESTORATIVE COMPOSITIONS 审中-公开
标题翻译：二元酸衍生的二甲基丙烯酸酯和用于牙齿恢复组合物
公开(公告)号：WO2005107626A1
公开(公告)日：2005-11-17
申请号：PCT/US2004/043828
申请日：2004-12-29
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , STANSBURY, Jeffrey, W. , BOWMAN, Christopher, N. , TRUJILLO, Marianela
发明人： STANSBURY, Jeffrey, W. , BOWMAN, Christopher, N. , TRUJILLO, Marianela
IPC分类号： A61C5/00
CPC分类号： A61K6/083 , C08L33/00
摘要： The present invention provides polymerizable dental compositions comprising a dimer acid-derived monomer such as a dimer acid-derived di(meth)acrylate monomer. In one embodiment, the dimer acid-derived monomer is of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from H and optionally substituted C 1 -C 25 straight-chained or branched aliphatic, optionally containing 1 or more double or triple bonds, wherein one or more carbons are optionally replaced by R* wherein R* is -C(O)-, -C(O)C(O)-, -C(O)NR 7 -, -C(O)NR 7 NR 8 -, -C(O)O-, -OC(O)-, -NR 7 CO 2 -, -O-, -NR 7 C(O)NR 8 -, -OC(O)NR 7 -, -NR 7 NR 8 -, -NR 7 C(O)-, -NR 7 C(O)O-, -S-, -SO-, -SO 2 -, -NR 7 -, -SO 2 NR 7 - or -NR 7 SO 2 -, where R 7 and R 8 are independently selected from H and optionally substituted aliphatic, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; provided that at least two of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are substituted C 1-25 straight-chained or branched aliphatic wherein at least one carbon is replaced by R* and at least one of the substituents is an alkenyl group.
摘要翻译：本发明提供包含二聚酸衍生的单体如二聚酸衍生的二（甲基）丙烯酸酯单体的可聚合牙科组合物。在一个实施方案中，二聚酸衍生的单体具有式（I）：其中R 1，R 2，R 3，R 4，R 5和R 6独立地选自H和任选取代的C 1 -C 25直链或支链脂族，任选含有 1或更多个双键或三键，其中一个或多个碳任选被R *取代，其中R *是-C（O） - ， - C（O）C（O） - ， - C（O）NR 7 - ， - C（O）NR 7 NR 8 - ， - C（O）O-，-OC（O） - ， - NR 7 CO 2 - ， - O - ， - NR 7 C （O）NR 8 - ， - OC（O）NR 7 - ，-NR 7 NR 8 - ，-NR 7 C（O） - ， - NR 7 C ）O - ， - S - ， - SO - ， - SO 2 - ， - NR 7 - ， - SO 2 NR 7 - 或-NR 7 SO 2 - ，其中R 7和R 8独立地选自H和任选取代的脂族，环烷基，杂环烷基，芳基或杂芳基; 条件是R 1，R 2，R 3，R 4，R 5和R 6中的至少两个是取代的C 1-2直链或支链脂族基，其中至少一个碳被R *代替，并且至少一个取代基是烯基。

6. 发明申请

WO2005024386A2 USE OF PHOTOPOLYMERIZATION FOR AMPLIFICATION AND DETECTION OF A MOLECULAR RECOGNITION EVENT 审中-公开
标题翻译：光聚合用于放大和检测分子识别事件的应用
公开(公告)号：WO2005024386A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029733
申请日：2004-09-09
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , ROWLEN, Kathy, L. , BIRKS, John, W. , BOWMAN, Christopher , SIKES, Hadley
发明人： ROWLEN, Kathy, L. , BIRKS, John, W. , BOWMAN, Christopher , SIKES, Hadley
IPC分类号： G01N
CPC分类号： C08F2/48 , C12Q1/682 , C12Q1/702 , G01N33/58 , C12Q2523/313
摘要： The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification.
摘要翻译：本发明提供检测分子识别事件的方法。本发明还提供了基于其与一种或多种探针物种的相互作用来检测靶物种的存在或鉴定目的物种的方法。本发明的方法基于由于每个分子识别事件引起的信号的放大。通过光聚合实现扩增，形成的聚合物与分子识别事件相关联。在一个实施方案中，荧光聚合物，磁性聚合物，放射性聚合物或导电聚合物可以形成检测和扩增的基础。在另一个实施方案中，用荧光溶液，磁性溶液，放射性溶液或导电溶液溶胀的聚合物凝胶可以形成检测和扩增的基础。

7. 发明申请

WO2007067189A2 SYSTEM AND METHODS FOR BIOLOGICAL ASSAYS 审中-公开
标题翻译：生物测定系统与方法
公开(公告)号：WO2007067189A2
公开(公告)日：2007-06-14
申请号：PCT/US2005/046822
申请日：2005-12-20
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , BOWMAN, Christopher N. , SEBRA, Robert P. , ANSETH, Kristi , MASTERS, Kristyn S.
发明人： BOWMAN, Christopher N. , SEBRA, Robert P. , ANSETH, Kristi , MASTERS, Kristyn S.
IPC分类号： A61F2/30
CPC分类号： G01N33/54353 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B82Y30/00
摘要： The present invention provides polymers and microfluidic devices comprising a covalently attached substrate binding element, and methods for producing and using the same.
摘要翻译：本发明提供包含共价连接的底物结合元件的聚合物和微流体装置及其制备和使用方法。

8. 发明申请

WO2007018486A1 SYSTEM AND METHOD FOR BENEFIT PLAN ADMINISTRATION 审中-公开
标题翻译：利益计划管理的制度与方法
公开(公告)号：WO2007018486A1
公开(公告)日：2007-02-15
申请号：PCT/US2005/025791
申请日：2005-07-20
申请人： PRINCIPAL FINANCIAL SERVICES, INC. , KELLY, William, J. , FRANKLIN, Stacie, J. , THOMANN, Susie , ELLIS, Angela, M. , HAYS, Eric, W. , KLIEGL, Patricia, M. , ASHTON, David, M. , BEER, Michael, J. , BOWMAN, Christopher, J. , HASAN, Sheri, L. , HINDERS, Kent, R. , KLEPPE, Debra, Lynn , KRAKAU, Beth, Ellen , PERKINS, Bobbi, J. , RIPPERGER, Jerry, L. , VAN BAALE, Jeffery, A.
发明人： KELLY, William, J. , FRANKLIN, Stacie, J. , THOMANN, Susie , ELLIS, Angela, M. , HAYS, Eric, W. , KLIEGL, Patricia, M. , ASHTON, David, M. , BEER, Michael, J. , BOWMAN, Christopher, J. , HASAN, Sheri, L. , HINDERS, Kent, R. , KLEPPE, Debra, Lynn , KRAKAU, Beth, Ellen , PERKINS, Bobbi, J. , RIPPERGER, Jerry, L. , VAN BAALE, Jeffery, A.
IPC分类号： G06F9/46
CPC分类号： G06Q10/00
摘要： Methods and system of providing benefit plan administration (14). A method of providing benefit plan administration to a first sponsor (16) having at least one participant (12) enrolled in a benefit plan can include electronically receiving benefit plan information from the first sponsor (12), electronically providing benefit plan information to the first sponsor (16), and electronically providing benefit plan information to the at least one participant (12).
摘要翻译：提供福利计划管理的方法和制度（14）。向具有登记在福利计划中的至少一个参与者（12）的第一赞助者（16）提供福利计划管理的方法可以包括从第一赞助者（12）电子地接收福利计划信息，电子地向第一赞助者提供福利计划信息给第一赞助者（16），并且向所述至少一个参与者（12）电子地提供福利计划信息。

9. 发明申请

WO2006086646A2 STRESS RELAXATION IN CROSSLINKED POLYMERS 审中-公开
标题翻译：交联聚合物中的应力松弛
公开(公告)号：WO2006086646A2
公开(公告)日：2006-08-17
申请号：PCT/US2006004756
申请日：2006-02-10
申请人： UNIV COLORADO REGENTS , BOWMAN CHRISTOPHER N , SCOTT TIMOTHY F
发明人： BOWMAN CHRISTOPHER N , SCOTT TIMOTHY F
IPC分类号： C08L51/00
CPC分类号： C08F2/50 , C08F2/38 , C08F293/005 , C08L51/003 , C08L53/00 , Y10S522/904 , C08L2666/02
摘要： The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.
摘要翻译：本发明提供诱导交联聚合物材料中聚合物链可逆链断裂的方法。聚合物主链的可逆切割能够缓解聚合物材料中的应力，因为键在较小的应力状态下改性。本发明还提供了制备能够进行可逆链断裂的聚合材料的方法，通过本发明的方法制备的材料和可用于本发明的材料和方法的可逆链裂解基团的线型单体。

10. 发明申请

WO2006071640A2 PHOTOLYTIC POLYMER SURFACE MODIFICATION 审中-公开
标题翻译：光聚合物表面改性
公开(公告)号：WO2006071640A2
公开(公告)日：2006-07-06
申请号：PCT/US2005046147
申请日：2005-12-16
申请人： UNIV COLORADO , BOWMAN CHRISTOPHER N , REDDY SIRISH , CRAMER NEIL , SEBRA ROBERT P , LU HUI
发明人： BOWMAN CHRISTOPHER N , REDDY SIRISH , CRAMER NEIL , SEBRA ROBERT P , LU HUI
IPC分类号： C08J7/12
CPC分类号： C08J7/12 , C08F283/00 , C08F291/00 , C08F291/18 , C08J2341/00 , Y10T428/2457
摘要： The present invention provides a method for modifying a surface of a polymer derived from a mixture comprising a thiol monomer and an olefinic monomer. The method comprises exposing at least a portion of the polymer surface to electromagnetic radiation of sufficient energy to modify the polymer surface. The present invention also provides a polymer derived from polymerizing a mixture of monomers comprising a thiol monomer, an olefinic monomer, and an iniferter.
摘要翻译：本发明提供一种改性衍生自包含硫醇单体和烯属单体的混合物的聚合物的表面的方法。该方法包括将聚合物表面的至少一部分暴露于具有足够能量以改变聚合物表面的电磁辐射。本发明还提供了一种衍生自聚合包含硫醇单体，烯属单体和引发剂的单体混合物的聚合物。

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