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1. 发明申请

WO2004085994A3 ERYTHROCYTE SEDIMENTATION RATE (ESR) TEST MEASUREMENT INSTRUMENT OF UNITARY DESIGN AND METHOD OF USING THE SAME 审中-公开
公开(公告)号：WO2004085994A3
公开(公告)日：2004-10-07
申请号：PCT/US2004/008765
申请日：2004-03-22
申请人： HEMOVATION, LLC , BOUBOULIS, Denis, A
发明人： BOUBOULIS, Denis, A
IPC分类号： G01N33/86
摘要： An erythrocyte sedimentation rate (ESR) measurement instrument (1) having a Blood Collection Configuration and an ESR Measurement Configuration. The ESR measurement instrument (1) includes a sedimentation measurement tube (9) having a hollow interior volume containing a predetermined quantity of blood sample diluting agent therewithin and being air/fluid sealed with respect to the ambient environment; and a blood collection tube (2) having a hollow interior volume containing a predetermined quantity of anti-coagulant and being vacuum-sealed with respect to the ambient environment, and physically coupled to the air-sealed sedimentation measurement tube (9), by at least a portion of the sedimentation measurement tube (9) being inserted within a portion of the hollow interior volume of the blood collection tube (2). The sedimentation measurement tube (9) and the blood collection tube (2) are maintained stationarily fixed relative to each other as a unitary assembly having a syringe-like form factor when the ESR measurement instrument (1) is arranged in the Blood Collection Configuration.

2. 发明申请

WO2004085994A2 ERYTHROCYTE SEDIMENTATION RATE (ESR) TEST MEASUREMENT INSTRUMENT OF UNITARY DESIGN AND METHOD OF USING THE SAME 审中-公开
标题翻译：心脏设计速度（ESR）测试测量仪器及其使用方法
公开(公告)号：WO2004085994A2
公开(公告)日：2004-10-07
申请号：PCT/US2004008765
申请日：2004-03-22
申请人： HEMOVATION LLC , BOUBOULIS DENIS A
发明人： BOUBOULIS DENIS A
IPC分类号： G01N33/49 , G01N
CPC分类号： G01N33/491
摘要： An erythrocyte sedimentation rate (ESR) measurement instrument having a Blood Collection Configuration and an ESR Measurement Configuration. The ESR measurement instrument comprises a sedimentation measurement tube having an hollow interior volume containing a predetermined quantity of blood sample diluting agent therewithin and being air/fluid sealed with respect to the ambient environment; and a blood collection tube having a hollow interior volume containing a predetermined quantity of anti-coagulant and being vacuum-sealed with respect to the ambient environment, and physically coupled to the air-sealed sedimentation measurement tube, by at least a portion of the sedimentation measurement tube being inserted within a portion of the hollow interior volume of the blood collection tube. The sedimentation measurement tube and the blood collection tube are maintained stationarily fixed relative to, each other as a unitary assembly having a syringe-like form factor when the ESR measurement instrument is arranged in the Blood Collection Configuration. During this configuration, a needle-supporting connector can be connected to, the blood collection tube and a sample of whole blood from a patient vacuum-drawn and injected into the blood collection tube. After the sample of anti-coagulated blood has been collected in the blood collection tube and the needle-supporting connector is disconnected therefrom, the air/fluid seal of the sedimentation measurement tube can be broken and then the sedimentation measurement tube can be manually plunged into and to the bottom of the hollow interior volume of said blood collection tube, using a single-handed operation to rearrange the ESR measurement instrument into the ESR Measurement Configuration. The anti-coagulated sample of blood fills up a substantially portion of the sedimentation measurement tube and mixes with the blood sample diluting agent to enable the blood plasma/erythrocyte cell (P/E) interface level within the sedimentation measurement tube to, settle downwards toward the blood collection tube during a predetermined time period when said ESR measurement instrument is oriented in a gravity vertical position. By virtue of the present invention, the erythrocyte sedimentation rate (ESR) of the collected blood sample can be measured by determining how far the. P/E interface level has moved against graduation markings formed along the length of the sedimentation measurement tube during the predetermined time period.
摘要翻译：具有血液收集配置和ESR测量配置的红细胞沉降率（ESR）测量仪器。 ESR测量仪器包括沉降测量管，该沉淀测量管具有中空内部体积，其中含有预定量的血液样品稀释剂，并且相对于周围环境为空气/流体密封; 以及采血管，其具有包含预定量的抗凝剂并且相对于周围环境真空密封的中空内部体积，并通过至少一部分沉降物理耦合到空气密封沉降测量管测量管被插入在采集管的中空内部体积的一部分内。当ESR测量仪器被配置在采血配置中时，沉降测量管和采血管相对于彼此保持静止固定为具有注射器状形状的整体组件。在该结构中，可以将针支撑连接器连接到采血管和来自患者真空吸取并注射到采血管中的全血样品。在血液收集管中收集了抗凝血液样品并且将针支撑连接器断开之后，可以破坏沉降测量管的空气/流体密封，然后将沉降测量管手动地插入并且使用单手操作将ESR测量仪器重新排列到ESR测量配置中，并且到达采血管的中空内部容积的底部。血液的凝血样品充满了沉降测量管的大部分部分，并与血液样品稀释剂混合，使得沉降测量管内的血浆/红血球细胞（P / E）界面水平向下倾斜在所述ESR测量仪器在重力垂直位置定向的预定时间段内的采血管。根据本发明，收集的血液样本的红细胞沉降率（ESR）可以通过确定多少血液样本来测量。 P / E界面水平在预定时间段内沿着沉降测量管长度形成的刻度标记移动。

3. 发明申请

WO2007084466A2 ERYTHROCYTE SEDIMENTATION RATE (ESR) TEST MEASUREMENT INSTRUMENT OF UNITARY DESIGN AND METHOD OF USING THE SAME 审中-公开
标题翻译：心脏设计速度（ESR）测试测量仪器及其使用方法
公开(公告)号：WO2007084466A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001049
申请日：2007-01-16
申请人： HEMOVATIONS, LLC , BOUBOULIS, Denis, A.
发明人： BOUBOULIS, Denis, A.
IPC分类号： G01N33/50
CPC分类号： G01N33/491 , G01N15/05 , G01N2015/0073
摘要： A disposable erythrocyte sedimentation rate (ESR) measurement instrument comprising a sedimentation measurement tube having a plunger portion, a blood collection tube having an upper portion, and an integrated locking mechanism provided between the blood collection tube and the sedimentation measurement tube. The locking mechanism permits the blood collection tube to be plunged into the blood collection tube upon rotating the sedimentation tube and the blood collection tube relative to each other, and thereafter pushing the sedimentation measurement tube into the blood collection tube. In a pre-evacuated embodiment of the present invention, the blood collection is pre-evacuated to withdraw a predetermined amount of blood during blood collection operations. In non- evacuated embodiment of the present invention, the plunger portion of the sedimentation measurement tube is inserted within the upper portion of the blood collection tube, at the time of assembly and manufacture, and is ready to be withdrawn by a predetermined about in order to manually evacuate the blood collection tube prior to use so that the blood collection tube is vacuum-pressurized to automatically draw a predetermined quantity of blood from a patient during blood collection operations.
摘要翻译：一次性红细胞沉降率（ESR）测量仪器，包括具有柱塞部分的沉降测量管，具有上部的采血管，以及设置在采血管和沉降测量管之间的集成锁定机构。锁定机构允许在使沉降管和采血管相对于彼此旋转时将采血管插入采血管，之后将沉降测量管推入采血管。在本发明的预先抽真空的实施例中，在采集血液的过程中，血液采集被预抽真空以提取预定量的血液。在本发明的非抽真空的实施例中，沉降测量管的柱塞部分在组装和制造时被插入在采集管的上部内，并准备好按预定的顺序取出在使用前手动抽血采集管，使得采血管被真空加压以在采血操作期间自动地从患者中抽取血液。

4. 发明申请

WO2007084466A3 ERYTHROCYTE SEDIMENTATION RATE TEST MEASUREMENT INSTRUMENT 审中-公开
标题翻译： ERYTHROCYTE SEDIMENTATION RATE测试测量仪器
公开(公告)号：WO2007084466A3
公开(公告)日：2007-12-13
申请号：PCT/US2007001049
申请日：2007-01-16
申请人： HEMOVATIONS LLC , BOUBOULIS DENIS A
发明人： BOUBOULIS DENIS A
IPC分类号： B01L3/00 , B32B5/02 , B32B27/04 , B32B27/12
CPC分类号： G01N33/491 , G01N15/05 , G01N2015/0073
摘要： A disposable erythrocyte sedimentation rate (ESR) measurement instrument comprising a sedimentation measurement tube having a plunger portion, a blood collection tube having an upper portion, and an integrated locking mechanism provided between the blood collection tube and the sedimentation measurement tube. The locking mechanism permits the blood collection tube to be plunged into the blood collection tube upon rotating the sedimentation tube and the blood collection tube relative to each other, and thereafter pushing the sedimentation measurement tube into the blood collection tube. In a pre-evacuated embodiment of the present invention, the blood collection is pre-evacuated to withdraw a predetermined amount of blood during blood collection operations. In non- evacuated embodiment of the present invention, the plunger portion of the sedimentation measurement tube is inserted within the upper portion of the blood collection tube, at the time of assembly and manufacture, and is ready to be withdrawn by a predetermined about in order to manually evacuate the blood collection tube prior to use so that the blood collection tube is vacuum-pressurized to automatically draw a predetermined quantity of blood from a patient during blood collection operations.
摘要翻译：一次性红细胞沉降率（ESR）测量仪器，包括具有柱塞部分的沉降测量管，具有上部的采血管，以及设置在采血管和沉降测量管之间的集成锁定机构。锁定机构允许在使沉降管和采血管相对于彼此旋转时将采血管插入血液采集管中，然后将沉降测量管推入采血管中。在本发明的预先抽真空的实施例中，在采集血液的过程中，血液采集被预抽真空以取出预定量的血液。在本发明的非抽真空的实施例中，沉降测量管的柱塞部分在组装和制造时被插入在采集管的上部内，并且准备好按预定的顺序取出在使用之前手动抽血采集管，使得采血管被真空加压以在采血操作期间自动地从患者抽取血液。

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