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1. 发明申请

WO2018048914A1 BIASING OF A CURRENT GENERATION ARCHITECTURE FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗设备的电流生成架构的偏离
公开(公告)号：WO2018048914A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050296
申请日：2017-09-06
申请人： BOSTON SCIENTIFIC NEUROMODULATIONCORPORATION
发明人： MARNFELDT, Goran, N. , WEISS, Philip, L. , WEERAKOON, Pujitha , WAGENBACH, David, M. , FELDMAN, Emanuel , GURURAJ, Kiran, K.
IPC分类号： A61N1/02 , A61N1/36 , G06F3/05
摘要： Digital-to-analog converter (DAC) circuitry for providing currents at electrodes of an Implantable Pulse Generator (IPG) is disclosed. The DAC circuitry includes at least one PDAC for sourcing current to the electrodes, and at least one NDAC for sinking current from the electrodes. The PDACs are powered with power supplies VH (the compliance voltage) and Vssh in a high power domain, and the NDACs are powered with power supplies Vcc and ground in a low power domain. VH may change during IPG operation, and Vssh preferably also changes with a fixed difference with respect to VH. Digital control signals to the PDACs are formed (and possibly converted into) the high power domain, and transistors used to build the PDACs are biased in the high power domain, and thus may also change with VH. This permits transistors in the PDACs and NDACs to be made from normal low-voltage logic transistors.
摘要翻译：公开了用于在可植入脉冲发生器（IPG）的电极处提供电流的数字 - 模拟转换器（DAC）电路。 DAC电路包括至少一个用于向电极提供电流的PDAC，以及至少一个用于从电极吸收电流的NDAC。 PDAC由高功率域的电源VH（符合电压）和Vssh供电，NDAC由低电源域的电源Vcc和接地供电。 VH可能在IPG操作期间改变，并且Vssh优选地也相对于VH以固定差异改变。到PDAC的数字控制信号被形成（并且可能被转换成）高功率域，并且用于构建PDAC的晶体管偏置在高功率域中，并且因此也可能随着VH而改变。这允许PDAC和NDAC中的晶体管由普通的低压逻辑晶体管制成。

2. 发明申请

WO2020162990A2 VARYING STIMULATION PARAMETERS TO PREVENT TISSUE HABITUATION IN A SPINAL CORD STIMULATION SYSTEM 审中-公开
公开(公告)号：WO2020162990A2
公开(公告)日：2020-08-13
申请号：PCT/US2019/057012
申请日：2019-10-18
申请人： BOSTON SCIENTIFIC NEUROMODULATIONCORPORATION
发明人： MOFFITT, Michael, A. , HUERTAS FERNANDEZ, Ismael
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372

3. 发明申请

WO2018048916A1 PASSIVE CHARGE RECOVERY CIRCUITRY FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗设备的被动充电恢复电路
公开(公告)号：WO2018048916A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050299
申请日：2017-09-06
申请人： BOSTON SCIENTIFIC NEUROMODULATIONCORPORATION
发明人： FELDMAN, Emanuel , MARNFELDT, Goran, N. , PARRAMON, Jordi
IPC分类号： A61N1/36 , A61N1/37
摘要： Recovery circuitry for passively recovering charge from capacitances at electrodes in an Implantable Pulse Generator (IPG) is disclosed. The passive recovery circuitry includes passive recovery switches intervening between each electrode node and a common reference voltage, and each switch is in series with a variable resistance that may be selected based on differing use models of the IPG. The passive recovery switches may also be controlled in different modes. For example, in a first mode, the only recovery switches closed after a stimulation pulse are those associated with electrodes used to provide stimulation. In a second mode, all recovery switches are closed after a stimulation pulse, regardless of the electrodes used to provide stimulation. In a third mode, all recovery switches are closed continuously, which can provide protection when the IPG is in certain environments (e.g., MRI), and which can also be used during stimulation therapy itself.
摘要翻译：公开了用于被动恢复来自可植入脉冲发生器（IPG）中的电极处的电容的电荷的恢复电路。无源恢复电路包括介于每个电极节点和公共参考电压之间的无源恢复开关，并且每个开关与可以基于IPG的不同使用模型选择的可变电阻串联。被动恢复开关也可以以不同的模式进行控制。例如，在第一模式中，在刺激脉冲之后闭合的唯一恢复开关是与用于提供刺激的电极相关联的恢复开关。在第二种模式中，无论用于提供刺激的电极如何，所有恢复开关都在刺激脉冲后闭合。在第三种模式中，所有恢复开关都连续闭合，这可以在IPG处于某些环境（例如，MRI）时提供保护，并且其也可以在刺激治疗本身期间使用。

4. 发明申请

WO2023004256A1 INTERPOLATION METHODS FOR NEURAL RESPONSES 审中-公开
公开(公告)号：WO2023004256A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/073739
申请日：2022-07-14
申请人： BOSTON SCIENTIFIC NEUROMODULATIONCORPORATION
发明人： STEINKE, G., Karl , COSTELLO, Joseph
IPC分类号： A61N1/05 , A61N1/36
摘要： Methods and systems for using evoked neural response to inform aspects of deep brain stimulation therapy are disclosed. According to some embodiments, a series of evoked neural response signals are recorded, and one or more waveform features are extracted from each of the signals. The waveform features can be used as biomarkers and or control signals for informing aspects of the therapy, such as lead implantation/localization, optimization of stimulation parameters, and/or closed loop feedback for maintaining chronic therapy. Embodiments include a check to determine and classify if any of the recorded neural response signals or portions thereof are corrupted. In the event that any of the signals are corrupted, values for the waveform features for the corrupted signals are interpolated using uncorrupted neural response signals in the series and/or uncorrupted portions of the problem neural response signal.

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