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1. 发明申请

WO2023076967A2 RNA-EDITING COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2023076967A2
公开(公告)日：2023-05-04
申请号：PCT/US2022/078740
申请日：2022-10-26
申请人： SHAPE THERAPEUTICS INC. , SAVVA, Yiannis , DEAN, Jason Thaddeus , BOOTH, Brian John , SULLIVAN, Richard Thomas , BRIGGS, Adrian Wrangham , BAGEPALLI, Lina Rajili , ROVIRA GONZALEZ, Yazmin Ines , GUO, Lan
发明人： SAVVA, Yiannis , DEAN, Jason Thaddeus , BOOTH, Brian John , SULLIVAN, Richard Thomas , BRIGGS, Adrian Wrangham , BAGEPALLI, Lina Rajili , ROVIRA GONZALEZ, Yazmin Ines , GUO, Lan
IPC分类号： C12N15/113
摘要： Provided herein are engineered guides configured, upon hybridization to target RNA molecules, to form double stranded RNA substrates comprising (i) a region comprising at least one structural feature; and (ii) a first internal loop and a second internal loop, wherein the double stranded RNA substrates recruit RNA editing entities and facilitate chemical modifications of base nucleotides in the target RNA molecules. Also provided herein are compositions, vectors, and cells comprising the engineered guides disclosed herein. Also provided herein are methods of introducing the engineered guides described herein into cells and methods of treating a disease or condition in a subject in need thereof comprising administering to the subject the engineered guides, polynucleotides encoding the engineered guides, delivery vehicles comprising such engineered guides or such polynucleotides, or pharmaceutical compositions comprising any one of these as described herein.

2. 发明申请

WO2022251097A1 ENGINEERED GUIDE RNAS AND POLYNUCLEOTIDES 审中-公开
公开(公告)号：WO2022251097A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030503
申请日：2022-05-23
申请人： SHAPE THERAPEUTICS INC. , BRIGGS, Adrian , BOOTH, Brian , SULLIVAN, Richard , ROVIRA GONZALEZ, Yazmin, Ines
发明人： SAVVA, Yiannis
IPC分类号： C12N15/113 , C12N9/78 , A61K31/7105 , A61P21/00
摘要： Disclosed herein are engineered guide RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered guide RNAs or pharmaceutical compositions described herein.

3. 发明申请

WO2021242903A2 COMPOSITIONS AND METHODS FOR MODIFYING TARGET RNAS 审中-公开
公开(公告)号：WO2021242903A2
公开(公告)日：2021-12-02
申请号：PCT/US2021/034323
申请日：2021-05-26
申请人： SHAPE THERAPEUTICS INC. , BRIGGS, Adrian , BOOTH, Brian
发明人： BOSE, Debojit , HUSS, David , SAVVA, Yiannis , SULLIVAN, Richard
IPC分类号： C12N15/113 , A61K31/7088 , A61P25/16 , C12N2310/11
摘要： Provided herein are compositions and methods that can be utilized to ameliorate, treat, or at least partially eliminate diseases and conditions that can arise from genomic mutations. Subject compositions and methods can be used to edit RNA to ameliorate, treat, or at least partially eliminate the disease and conditions in a subject.

4. 发明申请

WO2017151890A1 TECHNIQUES FOR USER-CONTROLLED REAL-TIME DATA PROCESSING 审中-公开
标题翻译：用户控制的实时数据处理技术
公开(公告)号：WO2017151890A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020405
申请日：2017-03-02
申请人： BOOTH, Brian
发明人： BOOTH, Brian
IPC分类号： G06Q30/00
摘要： An automated method adapted to associate a consumer with a rewards program is described. The method includes: providing a bill to the consumer using a processing device; receiving payment information regarding the consumer; receiving biographical information regarding the consumer; and updating information regarding a user account associated with the rewards program. A software application adapted to process a payment and update rewards program information includes sets of instructions for: generating a bill for a set of goods or services provided to a consumer; receiving a method of payment from the consumer; determining an account associated with the method of payment; and updating the rewards program information associated with the account. An automated method of facilitating a redemption associated with a rewards program includes: receiving a bill associated with a consumer purchase; receiving payment information from the consumer; and applying at least a portion of a redemption balance to the bill.
摘要翻译：描述了适用于将消费者与奖励计划相关联的自动化方法。该方法包括：使用处理设备向消费者提供账单; 接收关于消费者的支付信息; 接收关于消费者的传记信息; 以及更新关于与奖励程序相关联的用户账户的信息。适用于处理支付和更新奖励程序信息的软件应用程序包括用于以下操作的指令集：为提供给消费者的一组货物或服务生成帐单; 接收来自消费者的支付方法; 确定与支付方法相关的账户; 并更新与账户相关的奖励计划信息。促进与奖励计划相关联的兑换的自动化方法包括：接收与消费者购买相关联的账单; 接收来自消费者的支付信息; 并将至少一部分赎回余额应用于账单。

5. 发明申请

WO2023086902A1 MACHINE-LEARNING BASED DESIGN OF ENGINEERED GUIDE SYSTEMS FOR ADENOSINE DEAMINASE ACTING ON RNA EDITING 审中-公开
公开(公告)号：WO2023086902A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/079663
申请日：2022-11-10
申请人： SHAPE THERAPEUTICS, INC. , BRIGGS, Adrian Wrangham , HAUSE Jr., Ronald James , BOOTH, Brian John , BAGEPALLI, Lina Rajili , JIANG, Yue , SAVVA, Yiannis , BANJANIN, Bora , RUPP, Katherine , SULLIVAN, Richard Thomas
发明人： GUO, Lan , DEAN, Jason Thaddeus
IPC分类号： G16B30/00 , G16B35/10 , G16B35/20
摘要： Systems and methods for predicting deamination efficiency or specificity associated with a guide RNA (gRNA) are provided. A nucleic acid sequence for the gRNA is received. Responsive to inputting a data structure into a model, a metric for an efficiency or specificity of deamination by a first Adenosine Deaminase Acting on RNA (ADAR) protein of a target nucleotide position in mRNA transcribed from a target gene is obtained as output from the model. The data structure includes an encoding of the nucleic acid sequence for the gRNA.

6. 发明申请

WO2023077013A1 ENGINEERED RNAS 审中-公开
公开(公告)号：WO2023077013A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/078801
申请日：2022-10-27
申请人： SHAPE THERAPEUTICS INC. , BOOTH, Brian John , SULLIVAN, Richard Thomas , BRIGGS, Adrian Wrangham
发明人： BYRNE, Susan
IPC分类号： C12N15/11 , C12N15/113
摘要： Disclosed herein are engineered RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered RNAs, polynucleotides encoding the described engineered RNAs, or pharmaceutical compositions described here.

7. 发明申请

WO2021146320A1 ANTIBODY MOLECULES TO C5AR1 AND USES THEREOF 审中-公开
公开(公告)号：WO2021146320A1
公开(公告)日：2021-07-22
申请号：PCT/US2021/013284
申请日：2021-01-13
申请人： VISTERRA, INC. , VISWANATHAN, Karthik , BOOTH, Brian , RAMAKRISHNAN, Boopathy , WOLLACOTT, Andrew , BABCOK, Gregory , SHRIVER, Zachary
发明人： VISWANATHAN, Karthik , BOOTH, Brian , RAMAKRISHNAN, Boopathy , WOLLACOTT, Andrew , BABCOK, Gregory , SHRIVER, Zachary
IPC分类号： C07K16/28 , A61P35/00 , A61P37/00 , C07K16/46 , A61K39/395 , A61K2039/505 , C07K16/2896 , C07K2317/33 , C07K2317/34 , C07K2317/35 , C07K2317/76
摘要： Antibody molecules that specifically bind to C5aRl are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

8. 发明申请

WO1982002881A1 MOULD ARRANGEMENT FOR A GLASSWARE FORMING MACHINE 审中-公开
标题翻译：玻璃成型机的模具布置
公开(公告)号：WO1982002881A1
公开(公告)日：1982-09-02
申请号：PCT/GB1982000047
申请日：1982-02-22
申请人： EMHART IND INC , FENTON FRANK ALAN , BOOTH BRIAN , JONES STANLEY PETER , GENNARD DEREK
发明人： EMHART IND INC
IPC分类号： C03B09/38
CPC分类号： C03B9/3875 , C03B9/353 , C03B9/3537 , C03B9/3816
摘要： Dans la disposition de moule, un dispositif electrique de detection de temperature (TC1, TC2, TC3) est monte sur une partie du moule (30; 70) et envoie des signaux aux dispositifs de commande de l'ensemble. Le dispositif de commande lit le signal provenant du dispositif de detection (TC1, TC2, TC3) a un point determine dans le cycle de fonctionnement de la machine, selectionne de maniere a se verifier lorsque la partie de moule (30; 70) est stationnaire, et commande une partie du fonctionnement de la machine, par exemple le fonctionnement de l'organe de refroidissement du moule, par rapport a la valeur du signal.

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