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    • 7. 发明申请
    • USE OF POLYMERIC MATERIALS FOR SIMULATING SKIN, PARTICULARLY IN A DIFFUSION CELL
    • 用于模拟皮肤的聚合材料的使用,特别是在扩散细胞中
    • WO1997021097A1
    • 1997-06-12
    • PCT/FR1996001952
    • 1996-12-06
    • LVMH RECHERCHEGUILLAUME, BrunoBONTE, FrédéricMEYBECK, Alain
    • LVMH RECHERCHE
    • G01N33/15
    • A61Q19/00A61K8/8152A61Q17/04
    • The use of a polymeric material consisting of a cross-linked acrylic or methacrylic polymer produced by polymerising a monofunctional acrylic or methacrylic monomer having a molecular weight of 50-900 and a polyfunctional acrylic or methacrylic monomer having at least two polymerisable double bonds, as an agent for simulating a skin or mucosal barrier to determine the behaviour of topical pharmaceuticals or cosmetics, is disclosed. In particular, the use of said polymers for studying the diffusion of a cosmetic or dermatological product, and measuring the sun protection coefficient or occlusive properties thereof, as well as the use of said polymers as a carrier for topical cosmetic or pharmaceutical and particularly dermatological compositions, are disclosed. Cells for measuring the penetration and/or diffusion of the products to be tested, wherein the above-mentioned polymers are used as the receiving portion, are also disclosed.
    • 使用通过聚合分子量为50-900的单官能丙烯酸或甲基丙烯酸单体和具有至少两个可聚合双键的多官能丙烯酸或甲基丙烯酸单体制备的交联的丙烯酸或甲基丙烯酸聚合物组成的聚合物材料作为 公开了用于模拟皮肤或粘膜屏障以确定局部药物或化妆品的行为的试剂。 特别地,所述聚合物用于研究化妆品或皮肤病学产品的扩散,以及测量其防晒系数或闭塞性能的用途,以及所述聚合物作为局部化妆品或药物和特别是皮肤病学组合物的载体的用途 ,被披露。 还公开了用于测量待测产品的渗透和/或扩散的细胞,其中上述聚合物用作接收部分。