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1. 发明申请

WO2009023270A3 COMPOSITIONS AND METHODS FOR MODIFYING PROPERTIES OF BIOLOGICALLY ACTIVE POLYPEPTIDES 审中-公开
标题翻译：用于修饰生物活性多肽的性质的组合物和方法
公开(公告)号：WO2009023270A3
公开(公告)日：2009-05-07
申请号：PCT/US2008009787
申请日：2008-08-15
申请人： AMUNIX INC , BOGIN OREN , STEMMER WILLEM P , SCHELLENBERGER VOLKER , YIN YONG , WANG CHIA-WEI , GEETHING NATHAN C
发明人： BOGIN OREN , STEMMER WILLEM P , SCHELLENBERGER VOLKER , YIN YONG , WANG CHIA-WEI , GEETHING NATHAN C
IPC分类号： C12N15/09
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译：本发明涉及与一种或多种辅助多肽连接的生物活性多肽。本发明还提供重组多肽，包括编码受试蛋白质实体的载体，以及包含载体的宿主细胞。主题组合物具有各种实用性，包括一系列药物应用。

2. 发明申请

WO2003094835A2 FGF VARIANTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译： FGF变量及其使用方法
公开(公告)号：WO2003094835A2
公开(公告)日：2003-11-20
申请号：PCT/IL2003/000379
申请日：2003-05-09
申请人： PROCHON BIOTECH LTD. , BOGIN, Oren , YAYON, Avner
发明人： BOGIN, Oren , YAYON, Avner
IPC分类号： A61K
CPC分类号： A61K38/1825 , A61K38/22 , C07K14/50 , C07K14/501 , C07K14/503 , C07K14/575 , C12N5/0655 , C12N5/0658 , C12N2501/115 , C12N2506/1346
摘要： The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided.
摘要翻译：本发明提供证明增强的受体亚型特异性和/或亲和力的成纤维细胞生长因子变体。优选的实施方案包括具有增强活性的两种变体，其作为改善的激动剂和具有降低的作为拮抗剂的活性的变体。提供了利用优选的FGF变体在制备用于治疗骨骼障碍（包括骨骼发育不良，骨质疏松症和增强骨折愈合和软骨愈合过程）的药物中的方法。

3. 发明申请

WO2003020698A2 PROTEIN TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：蛋白酪氨酸激酶抑制剂
公开(公告)号：WO2003020698A2
公开(公告)日：2003-03-13
申请号：PCT/IL2002/000740
申请日：2002-09-05
申请人： PROCHON BIOTECH LTD. , EREN, Doron , ZALIANI, Andrea , PE'ER, David , BOGIN, Oren , YAYON, Avner
发明人： EREN, Doron , ZALIANI, Andrea , PE'ER, David , BOGIN, Oren , YAYON, Avner
IPC分类号： C07D
CPC分类号： C07D263/57 , A61K31/4184 , A61K31/423 , C07D235/18 , C07D491/04
摘要： The present invention provides heterocyclic compounds which can act as protein tyrosine kinase inhibitors. Preferred embodiments include both novel and known substituted 2-aryl benzimidazole and benzofuro [3,2-c ] quinoline compounds. Methods of utilizing preferred compounds in preparation of medicaments for the treatment of proliferative, skeletal and metabolic diseases and disorders associated with abnormal protein tyrosine kinase activity, including cancer and skeletal dysplasia, are provided.
摘要翻译：本发明提供可作为蛋白酪氨酸激酶抑制剂的杂环化合物。优选的实施方案包括新的和已知的取代的2-芳基苯并咪唑和苯并呋喃并[3,2-c]喹啉化合物。提供了利用优选化合物制备用于治疗与异常蛋白酪氨酸激酶活性（包括癌症和骨骼发育不良）相关的增殖性，骨骼和代谢疾病和病症的药物的方法。

4. 发明申请

WO0236732A2 ACTIVE VARIANTS OF FGF WITH IMPROVED SPECIFICITY 审中-公开
标题翻译： FGF的主动变量具有改进的特异性
公开(公告)号：WO0236732A2
公开(公告)日：2002-05-10
申请号：PCT/IL0100962
申请日：2001-10-18
申请人： PROCHON BIOTECH LTD , BOGIN OREN , ADAR RIVKA , YAYON AVNER
发明人： BOGIN OREN , ADAR RIVKA , YAYON AVNER
IPC分类号： C07K14/50 , C12N
CPC分类号： C07K14/50
摘要： The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.
摘要翻译：本发明提供了表现出增强的受体亚型特异性的活性成纤维细胞生长因子变体。优选的新型变体保留结合FGF受体3型（FGFR3），引发细胞内下游机制导致生物反应的激活。提供了利用优选的FGF突变体制备用于治疗恶性肿瘤和骨骼疾病（包括骨质疏松症和增强骨折愈合和伤口愈合过程）的药物的方法。

5. 发明申请

WO0236732A9 ACTIVE VARIANTS OF FGF WITH IMPROVED SPECIFICITY 审中-公开
标题翻译： FGF的主动变量具有改进的特异性
公开(公告)号：WO0236732A9
公开(公告)日：2007-07-12
申请号：PCT/IL0100962
申请日：2001-10-18
申请人： PROCHON BIOTECH LTD , BOGIN OREN , ADAR RIVKA , YAYON AVNER
发明人： BOGIN OREN , ADAR RIVKA , YAYON AVNER
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50
摘要： The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.
摘要翻译：本发明提供了表现出增强的受体亚型特异性的活性成纤维细胞生长因子变体。优选的新型变体保留结合FGF受体3型（FGFR3），引发细胞内下游机制，导致生物反应的激活。提供了利用优选的FGF突变体制备用于治疗恶性肿瘤和骨骼疾病（包括骨质疏松症和增强骨折愈合和伤口愈合过程）的药物的方法。

6. 发明申请

WO2009023270A2 COMPOSITIONS AND METHODS FOR MODIFYING PROPERTIES OF BIOLOGICALLY ACTIVE POLYPEPTIDES 审中-公开
标题翻译：修饰生物活性多肽性质的组合物和方法
公开(公告)号：WO2009023270A2
公开(公告)日：2009-02-19
申请号：PCT/US2008/009787
申请日：2008-08-15
申请人： AMUNIX, INC. , BOGIN, Oren , STEMMER, Willem, P. , SCHELLENBERGER, Volker , YIN, Yong , WANG, Chia-wei , GEETHING, Nathan, C.
发明人： BOGIN, Oren , STEMMER, Willem, P. , SCHELLENBERGER, Volker , YIN, Yong , WANG, Chia-wei , GEETHING, Nathan, C.
IPC分类号： C12P21/00 , C12N15/09 , C12N1/00 , C07H21/00 , A61K38/16 , A61K38/28 , A61K38/21 , A61P43/00 , C07K14/00 , C40B40/10
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
摘要翻译：本发明涉及与一种或多种辅助多肽连接的生物活性多肽。本发明还提供了重组多肽，包括编码主题蛋白质实体的载体，以及包含载体的宿主细胞。主题组合物具有各种用途，包括一系列药物应用。

7. 发明申请

WO2002036732A3 ACTIVE VARIANTS OF FGF WITH IMPROVED SPECIFICITY 审中-公开
公开(公告)号：WO2002036732A3
公开(公告)日：2002-05-10
申请号：PCT/IL2001/000962
申请日：2001-10-18
申请人： PROCHON BIOTECH LTD. , BOGIN, Oren , ADAR, Rivka , YAYON, Avner
发明人： BOGIN, Oren , ADAR, Rivka , YAYON, Avner
IPC分类号： A61K38/18 , C07K14/50
摘要： The present invention provides active fibroblast growth factor variants demonstrating enhanced receptor subtype specificity. The preferred novel variants retain binding to FGF Receptor Type 3 (FGFR3) triggering intracellular downstream mechanisms leading to activation of a biological response. Methods of utilizing preferred FGF mutants in preparation of medicaments for the treatment of malignancies and skeletal disorders including osteoporosis and enhancing fracture healing and wound healing processes are provided.

8. 发明申请

WO2003094835A3 FGF VARIANTS AND METHODS FOR USE THEREOF 审中-公开
公开(公告)号：WO2003094835A3
公开(公告)日：2003-11-20
申请号：PCT/IL2003/000379
申请日：2003-05-09
申请人： PROCHON BIOTECH LTD. , BOGIN, Oren , YAYON, Avner
发明人： BOGIN, Oren , YAYON, Avner
IPC分类号： A61K38/00
摘要： The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided.

9. 发明申请

WO2003020698A3 PROTEIN TYROSINE KINASE INHIBITORS 审中-公开
公开(公告)号：WO2003020698A3
公开(公告)日：2003-03-13
申请号：PCT/IL2002/000740
申请日：2002-09-05
申请人： PROCHON BIOTECH LTD. , EREN, Doron , ZALIANI, Andrea , PE'ER, David , BOGIN, Oren , YAYON, Avner
发明人： EREN, Doron , ZALIANI, Andrea , PE'ER, David , BOGIN, Oren , YAYON, Avner
IPC分类号： A61K31/4184
摘要： The present invention provides heterocyclic compounds which can act as protein tyrosine kinase inhibitors. Preferred embodiments include both novel and known substituted 2-aryl benzimidazole and benzofuro [3,2-c ] quinoline compounds. Methods of utilizing preferred compounds in preparation of medicaments for the treatment of proliferative, skeletal and metabolic diseases and disorders associated with abnormal protein tyrosine kinase activity, including cancer and skeletal dysplasia, are provided.

10. 发明申请

WO0222779A3 HIGH LEVEL EXPRESSION OF HETEROLOGOUS PROTEINS 审中-公开
标题翻译：异位蛋白的高水平表达
公开(公告)号：WO0222779A3
公开(公告)日：2003-01-09
申请号：PCT/IL0100870
申请日：2001-09-16
申请人： PROCHON BIOTECH LTD , YEDA RES & DEV , BOGIN OREN , YAYON AVNER , PERETZ MOSHE , BURSTEIN YIGAL
发明人： BOGIN OREN , YAYON AVNER , PERETZ MOSHE , BURSTEIN YIGAL
IPC分类号： C12N1/21 , C12N9/02 , C12N15/67 , C07H21/02 , C07K1/00 , C12N1/20 , C12N5/00 , C12N15/00 , C12N15/09
CPC分类号： C12N9/0004 , C12N15/67
摘要： The present invention discloses the isolation and use of a specific bacterial promoter region suitable for use in constructs for the high level production of heterologous proteins. This promoter is derived from the bacterial gene encoding for alcohol dehydrogenase, in particular the alcohol dehydrogenase genes isolated from the thermophilic bacterial strain T. brockii and the mesophilic bacterial strain Clostridium beijerinckii. It is now disclosed that using either the intact promoter region or certain specific fragments consisting of at least a 88bp DNA sequence in the upstream untranslated region of the bacterial alcohol dehydrogenase gene, operatively linked to the nucleic acid sequences encoding a heterologous protein, and insertion into a DNA plasmid or any other suitable vector system, hereologous genes can be expressed in high levels in host cells. Heterologous proteins or peptides can be expessed constitutively at high levels. The proteins are obtained in their active folded form.
摘要翻译：本发明公开了分离和使用适用于高产量异源蛋白质的构建体的特异性细菌启动子区域。该启动子源自编码醇脱氢酶的细菌基因，特别是从嗜热细菌菌株T. brockii和嗜温细菌菌株Clostridium beijerinckii分离的醇脱氢酶基因。现在公开了在细菌醇脱氢酶基因的上游非翻译区域中使用完整启动子区域或由至少88bp DNA序列组成的某些特异性片段，其与编码异源蛋白质的核酸序列可操作地连接，并插入到 DNA质粒或任何其他合适的载体系统，异源基因可以在宿主细胞中以高水平表达。异源蛋白质或肽可以高度组成型表达。以活性折叠形式获得蛋白质。

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