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1. 发明申请

WO2007068985A2 DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：大肠癌的诊断和预后
公开(公告)号：WO2007068985A2
公开(公告)日：2007-06-21
申请号：PCT/GB2006050460
申请日：2006-12-15
申请人： ELECTROPHORETICS LTD , JOUBERT RICHARD , PREFOT PETRA , BOEHM GITTE , ARNHOLD JUERGEN , HOEHLE CLAUDIA , NEUKUM ERHARD , SCHAEFER JURGEN
发明人： JOUBERT RICHARD , PREFOT PETRA , BOEHM GITTE , ARNHOLD JUERGEN , HOEHLE CLAUDIA , NEUKUM ERHARD , SCHAEFER JURGEN
CPC分类号： A61K38/17 , G01N33/57419
摘要： The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin C1 protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No. Q9UNM7); aldo-keto reductase family 1 member B10 (SwissProt Acc. No. O60218); fructosamine-3-kinase (SwissProt Acc. No. Q9H479); peripherin (SwissProt Acc. No. P41219); alpha-2-macroglobulin (SwissProt Acc. No. P01023); serpin C1 protein (SwissProt Acc. No. P01008); or apolipoprotein A IV (SwissProt Acc. No. P06727). The same proteins can be used for prognosis by detecting changes in their concentration in the course of treatment for colorectal cancer.
摘要翻译：本发明涉及一种诊断取自人受试者的有效身体组织的诊断样品中的结直肠癌的方法，其包括检测诊断样品中蛋白质浓度与对照，正常人样品，蛋白质是：转化生长因子-β诱导的蛋白质IG-H3（SwissProt Acc.No.Q15582）; SKP1同系物（亚型2）（SwissProt Acc.No.Q9Y2Z0-2）的G2等位基因抑制子; 假想蛋白质（URG4的一部分）（SwissProt Acc.No.Q9NWR7）; calponin-2（SwissProt登录号Q99439）; 热休克蛋白HSP90-β（SwissProt Acc.No.P08238）; 磷酸甘油酸变位酶1（SwissProt Acc.No.P18669）; 丝氨酸蛋白酶抑制剂C1蛋白（SwissProt Acc.No.P01008）; 或触珠蛋白前体（SwissProt Acc.No.P00738）; 或与正常人样品相比，诊断样品中蛋白质浓度降低，所述蛋白质是血清转铁蛋白（SwissProt Acc.No.P02787）; 26S蛋白酶体亚基p40.5（Swiss Prot Acc.No.Q9UNM7）; 醛酮还原酶家族1成员B10（SwissProt Acc.No.O60218）; 果糖胺-3-激酶（SwissProt Acc.No.Q9H479）; 外周蛋白（SwissProt Acc.No.P41219）; α-2-巨球蛋白（SwissProt Acc.No.P01023）; 丝氨酸蛋白酶抑制剂C1蛋白（SwissProt Acc.No.P01008）; 或载脂蛋白A IV（SwissProt Acc.No.P06727）。通过检测结肠直肠癌治疗过程中其浓度的变化，可以将相同的蛋白质用于预后。

2. 发明申请

WO2007068985A3 DIAGNOSIS AND PROGNOSIS OF COLORECTAL CANCER 审中-公开
公开(公告)号：WO2007068985A3
公开(公告)日：2007-06-21
申请号：PCT/GB2006/050460
申请日：2006-12-15
申请人： ELECTROPHORETICS LIMITED , JOUBERT, Richard , PREFOT, Petra , BOEHM, Gitte , ARNHOLD, Juergen , HOEHLE, Claudia , NEUKUM, Erhard , SCHAEFER, Jurgen
发明人： JOUBERT, Richard , PREFOT, Petra , BOEHM, Gitte , ARNHOLD, Juergen , HOEHLE, Claudia , NEUKUM, Erhard , SCHAEFER, Jurgen
IPC分类号： A61K38/17 , G01N33/574
摘要： The invention relates to a method of diagnosis of colorectal cancer in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being: transforming growth factor-beta induced protein IG-H3 (SwissProt Acc. No. Q15582); suppressor of G2 allele of SKP1 homolog (isoform 2) (SwissProt Acc. No. Q9Y2Z0-2); hypothetical protein (part of URG4) (SwissProt Acc. No. Q9NWR7); calponin-2 (SwissProt Acc. No. Q99439); heat shock protein HSP90-beta (SwissProt Acc. No. P08238); phosphoglycerate mutase 1 (SwissProt Acc. No. P18669); serpin C1 protein (SwissProt Acc. No. P01008); or haptoglobin precursor (SwissProt Acc. No. P00738); or a decreased concentration of a protein in the diagnostic sample, compared with a control, normal human sample, the protein being serotransferrin (SwissProt Acc. No. P02787); 26S proteasome subunit p40.5 (Swiss Prot Acc. No. Q9UNM7); aldo-keto reductase family 1 member B10 (SwissProt Acc. No. O60218); fructosamine-3-kinase (SwissProt Acc. No. Q9H479); peripherin (SwissProt Acc. No. P41219); alpha-2-macroglobulin (SwissProt Acc. No. P01023); serpin C1 protein (SwissProt Acc. No. P01008); or apolipoprotein A IV (SwissProt Acc. No. P06727). The same proteins can be used for prognosis by detecting changes in their concentration in the course of treatment for colorectal cancer.

3. 发明申请

WO0021505A3 COMPOSITION FOR THE PARENTERAL ADMINISTRATION OF ACTIVE AGENTS 审中-公开
标题翻译：组成代理商肠胃外施用
公开(公告)号：WO0021505A3
公开(公告)日：2000-09-21
申请号：PCT/EP9907300
申请日：1999-10-02
申请人： AVENTIS RES & TECH GMBH & CO , GRANDE JUERGEN , SCHUTH SILKE , BOEHM GITTE , BENGS HOLGER
发明人： GRANDE JUERGEN , SCHUTH SILKE , BOEHM GITTE , BENGS HOLGER
IPC分类号： A61K47/36 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/51 , A61K9/52 , A61K9/66 , A61K49/00
CPC分类号： A61K9/5161 , A61K9/10 , A61K9/1652
摘要： The invention relates to a composition for the parenteral administration of active agents, containing a support material and at least one active agent. The support material contains spherical microparticles with an average diameter of 1 nm to 100 mu m, said particles consisting entirely or partially of at least one water-insoluble linear polysaccharide, especially a linear polyglucan. The invention also relates to a suspension containing this composition, and to the use of the composition.
摘要翻译：本发明涉及用于活性物质的非肠道给药的组合物，包括基底和至少一种活性成分，其中所述载体材料，含具有1纳米至100微米的平均直径的球形微粒，所述线性完全或部分的至少一种水不溶性多糖，特别是直链的聚葡萄糖，编组，将含有悬浮液该组合物，及其用途。

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